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33篇 您的检索式：作者名="WINTER O C"

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	题名	作者	年代	出处	被引量
1	Cyclooxygenase-2 plays a central role in the genesis of pancreatitis and associated lung injury显示文摘BACKGROUND: The exact mechanism by which cyclooxy- genase-2 (COX-2) promotes inflammation in pancreatitis in obscure. This study was undertaken to investigate the role of COX-2 inhibition in an animal model of pancreati- tis , a disease process characterized by a systemic inflamma- tory response and ensuing neutrophil-mediated lung injury. METHODS: Pancreatitis was induced in 24 Sprague-Daw- ley rats by intraperitoneal injection of 20% L-arginine (500 mg/100 g body weight). The animals were randomized into 3 groups (8 rats in each group); controls and rats with pancreatitis intravenously resuscitated with either normal saline (0.9% NaCl 3 ml/kg) at 24 and 48 hours or COX-2 inhibitor (parecoxib 1 mg/kg). Pancreatic and lung inju- ries were assessed histologically. Lung injury was assessed utilizing wet;dry ratio and myeloperoxidase activity to in- dicate pulmonary neutrophil infiltration. A Western blot was used to determine COX-2 protein expression in pancrea- tic tissue. RESULTS: The animals treated with COX-2 inhibitors dis- played significantly less pancreatic and lung injuries than their normal saline counterparts. Histological pancreatic and lung injury scores were significantly reduced (P <0.05) in the COX-2 treated group. Lung wet: dry ratios were sig- nificantly improved and pulmonary neutrophil infiltration was attenuated in the COX-2 group (P<0.05). Western blot analysis confirmed attenuated COX-2 protein expression. CONCLUSION: This study shows, for the first time in a rat model, that adjuvant COX-2 inhibition significandy attenu- ates the severity of both pancreatitis and its associated sys- temic inflammatory response and end-organ injury.	Gavin O'Brien Conor J Shields Desmond C Winter John P Dillon	2005	Hepatobiliary & Pancreatic Diseases International2005，4，1：	12
2	Oestrogen and the colon: potential mechanisms for cancer prevention显示文摘	Rory Kennelly Dara O Kavanagh Aisling M Hogan Desmond C Winter	2008	Lancet Oncology2008，，4：	1
3	Rapid effects of aldosterone on sodium-hydrogen exchange in isolated colonic crypts显示文摘	Winter D C Schneider M F O'Sullivan G C	1999	J Membr Biol1999，170，1：	1
4	Biological behaviour and clinical implications of micrometastases显示文摘	Kell M R Winter D C O'Sullivan G C	2000	Br J Surg2000，87，12：	1
5	Constitutive genetic deletion of the growth regulator Nogo-A in- duces schizophrenia-related en- dophenotypes显示文摘	Willi R Weinmann O Winter C	2010	J Neurosci2010，30，：	1
6	Chylothorax显示文摘	Merrigan B A Winter D C O'Sullivan G C	1997	Br Surg1997，84，：	1
7	Thyrotropin expression in hypophyseal pars tuberalis-specific cells is 3,5,3′-triiodothyronine,thyrotropin-releasing hormone,and pit-1 independent显示文摘	Bockmann J B(o)ckers T M Winter C		0，，03：	1
8	Augmented tem- perature degrading effect of rare earth magnets arranged in segmented halbach arrays 显示文摘	WINTER O KRAL C SCHMIDT E	2012	IEEE Transactions on Magnetics2012，48，11：	1
9	Tumour angiogenesis pathways:related clinical issues andimplications for nuclear medicine imaging显示文摘	Van De Wiele C Oltenfreiter R De Winter O	2002	Eur J NuclMed Mol Imaging2002，29，69：	1
10	Oestrogen and the colon: potential mechanisms for cancer prevention显示文摘	Rory Kennelly Dara O Kavanagh Aisling M Hogan Desmond C Winter	2008	Lancet Oncology2008，，4：	1
11	The design and use of a hydraulic potentiomanometer for direct measurement of fferences in hydraulic-bead between ground water and surface water 显示文摘	Winter T C Labangh J W Rosenberry D O	1980	Limnology and Oceanography1980，33，5：	1
12	A nu- merical study of powered swing-bys around the moon 显示文摘	FERREIRA A F D S PRADO A F B A WINTER O C	2015	Ad- vances in Space Research2015，56，2：	1
13	A Detailed Heat and Fluid Flow Analysis of an Internal Permanent Magnet Synchronous Machine by Means of Computational fluid Dynamics显示文摘	JUNGREUTHMAYER C BUML T WINTER O	2012	IEEE Transactions on Industrial Electronics2012，59，12：	1
14	Desmond Tumours显示文摘	SHIELDS C J WINTER D C KIRWAN W O	2001	EJSO2001，27，：	1
15	Outcomes in squamous cell carcinoma with advanced neck disease显示文摘	Keir J A Whiteside O J Winter S C	2007	Ann R Coil Surg Engl2007，89，7：	1
16	Where doesthe ground water in small watersheds come from? 显示文摘	Winter T C Rosenberry D O LaBaugh W	2003	Groundwater2003，41，7：	1
17	Regulation of mucosal immune responses by recombinant interleukin 10 produced by intestinal epithelial cells in mice 显示文摘	De Winter H Elewaut D Turovskaya O Huflejt M Shimeld C Hagenbaugh A Binder S Takahashi I Kronenberg M Cheroutre H	2002	Gastroenterology2002，122，：	1
18	Cyclooxygen- ase-2 plays a central role in the genesis of pancreatitis and associated lung injury显示文摘	O' Brien G Shields C J Winter DC	2005	Hepatobiliary Pancreat Dis Int2005，4，1：	1
19	Subthalamic high frequency stimulation induced mtatious are differentially mediated by D1 and D2 receptors 显示文摘	Bergnann O Winter C Meissner W et L	2004	Neuropharmacol2004，46，7：	1
20	The biological behavious and clinical implications of micrometastases显示文摘	Kell M R Winter D C O'Sullivan G C	2000	Br J Surg2000，87，12：	1

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