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| 1 | Schistosoma mansoni proteins attenuate gastrointestinal motility disturbances during experimental colitis in mice显示文摘AIM:To investigate the therapeutic effect of Schistosoma mansoni(S.mansoni) soluble worm proteins on gastrointestinal motility disturbances during experimental colitis in mice. METHODS:Colitis was induced by intrarectal injection of trinitrobenzene sulphate(TNBS) and 6 h later,mice were treated ip with S.mansoni proteins.Experiments were performed 5 d after TNBS injection.Inflammationwas quantified using validated inflammation parameters. Gastric emptying and geometric center were measured to assess in vivo gastrointestinal motility.Peristaltic activity of distal colonic segments was studied in vitro using a modified Trendelenburg set-up.Cytokine profiles of T-lymphocytes isolated from the colon were determined by real time reverse transcriptase-polymerase chain reaction. RESULTS:Intracolonic injection of TNBS caused severe colitis.Treatment with S.mansoni proteins significantly ameliorated colonic inflammation after 5 d.TNBS did not affect gastric emptying but significantly decreased the geometric center and impaired colonic peristaltic activity 5 d after the induction of colitis.Treatment with S.mansoni proteins ameliorated these in vivo and in vitro motility disturbances.In addition,TNBS injection caused a downregulation of effector T cell cytokines after 5 d,whereas a S.mansoni protein effect was no longer observed at this time point. CONCLUSION:Treatment with S.mansoni proteins attenuated intestinal inflammation and ameliorated motility disturbances during murine experimental colitis. | Nathalie E Ruyssers Benedicte Y De Winter Joris G De Man Natacha D Ruyssers Ann J Van Gils Alex Loukas Mark S Pearson Joel V Weinstock Paul A Pelckmans Tom G Moreels | 2010 | World Journal of Gastroenterology2010，16，6： | 11 |
| 2 | Neuroanatomy of lower gastrointestinal pain disorders显示文摘Chronic abdominal pain accompanying intestinal inflammation emerges from the hyperresponsiveness of neuronal,immune and endocrine signaling pathways within the intestines,the peripheral and the central nervous system.In this article we review how the sensory nerve information from the healthy and the hypersensitive bowel is encoded and conveyed to the brain.The gut milieu is continuously monitored by intrinsic enteric afferents,and an extrinsic nervous network comprising vagal,pelvic and splanchnic afferents.The extrinsic afferents convey gut stimuli to second order neurons within the superficial spinal cord layers.These neurons cross the white commissure and ascend in the anterolateral quadrant and in the ipsilateral dorsal column of the dorsal horn to higher brain centers,mostly subserving regulatory functions.Within the supraspinal regions and the brainstem,pathways descend to modulate the sensory input.Because of this multiple level control,only a small proportion of gut signals actually reaches the level of consciousness to induce sensation or pain.In inflammatory bowel disease(IBD)and irritable bowel syndrome(IBS)patients,however,long-term neuroplastic changes have occurred in the brain-gut axis which results in chronic abdominal pain.This sensitization may be driven on the one hand by peripheral mechanisms within the intestinal wall which encompasses an interplay between immunocytes,enterochromaffin cells,resident macrophages,neurons and smooth muscles.On the other hand,neuronal synaptic changes along with increased neurotransmitter release in the spinal cord and brain leads to a state of central wind-up.Also life factors such as but not limited to inflammation and stress contribute to hypersensitivity.All together,the degree to which each of these mechanisms contribute to hypersensitivity in IBD and IBS might be diseaseand even patient-dependent.Mapping of sensitization throughout animal and human studies may significantly improve our understanding of sensitization in IBD and IBS.On the long run,this knowledge can be put forward in potential therapeutic targets for abdominal pain in these conditions. | Wim Vermeulen Joris G De Man Paul A Pelckmans Benedicte Y De Winter | 2014 | World Journal of Gastroenterology2014，20，4： | 7 |
| 3 | 早发急性心肌梗死的长期结局和风险评估:10年随访研究显示文摘早发急性心肌梗死(acute myocardial infarction,AMI)是一种罕见的疾病,发病率和死亡率很高。该文在再灌注治疗广泛应用的大环境下,纳入前瞻性研究人群进行早发AMI的预后研究。方法:这项前瞻性多中心研究中连续纳入102例AMI存活者(≤40岁),临床预后通过奥地利死亡登记处和维也纳集中患者管理系统进行查询。 | 刘莉 叶鹏 Winter MP Blessberger H Alimohammadi A Pavo N Huber K Wojta J Lang IM Wiesbauer F Goliasch G | 2017 | 中华高血压杂志2017，25，4： | 5 |
| 4 | DGAT1, a new positional and functional candidate gene for intramuscular fat deposition in cattle显示文摘 | Kuhn C Winter A | 2003 | Anim Genet2003，34，5： | 1 |
| 5 | Stable hydrogen and oxygen isotope ratios of bottled waters of the world显示文摘 | Bowen G J Winter D A Spero H J | 2005 | Rapid communications in mass spectrometry2005，19，23： | 1 |
| 6 | Trajectory of thebody COG and COP during initiation and termination of gait显示文摘 | J1AN Y WINTER D A ISHAC M G | 1993 | Gait Posture1993，1，1： | 1 |
| 7 | Phage antibodies: filamentous phage displaying anti-body variable domains显示文摘 | Mccafferty J Griffiths A D Winter G | 1990 | Nature1990，348，： | 1 |
| 8 | The Econom- ics of Franchise Contracts 显示文摘 | MATHEWSON G F WINTER R A | 1985 | Journal of Law and Economics1985，28，3： | 1 |
| 9 | Disturbed structural connectivity in schizophrenia primary factor in pathology or epiphenomenon?显示文摘 | Konrad A Winterer G | 2008 | Schizophr Bull2008，34，1： | 1 |
| 10 | A Salmo- nella virulence factor activates the NOD1/NOD2 signaling path- way显示文摘 | Keestra A M Winter M G Klein-Douwel D | 2011 | MBio2011，2，00： | 1 |
| 11 | An integratedchemical biology approach identifies specific vulnerabili-ty of Ewing's sarcoma to combined inhibition of Aurorakinases A and B显示文摘 | Winter G E Rix U Lissat A | 2011 | Mol Cancer Ther2011，10，10： | 1 |
| 12 | Making antibody by phage display technology 显示文摘 | Winter G Griffiths A D | 1994 | Ann Rev Immunol1994，12，： | 1 |
| 13 | Gene expression analysis of plant host-pathogen interactions by SuperSAGE显示文摘 | Matsumura H Reich S Ito A Saitoh H Kamoun S Winter P Kahl G Reuter M Kruger DH Terauchi R | 2003 | Proc Natl Acad Sci U S A2003，100，15： | 1 |
| 14 | Behaviour of Stainless Steel Columns and Beams 显示文摘 | Johnson A L Winter G | 1966 | Journal of the Structural Division ASCE1966，92，5： | 1 |
| 15 | Phage antibodies: filamentous phage displaying antibody variable domains显示文摘 | Griffiths A D Winter G | 1990 | Nature1990，348，6301： | 1 |
| 16 | Phage antibodies: filamentous phage displaying antibody variable domains 显示文摘 | Griffiths A D Winter G | 1990 | Nature1990，348，： | 1 |
| 17 | Expression of a splicing variant in the 5'-UTR of the human ERCC1 gene is not cancer related显示文摘 | WINTER A G DORGAN C MELTON D W | 2005 | Oncogene2005，24，： | 1 |
| 18 | Protection of BALB/c Mice against homologous and heterologous species of Brucella by rough strain vaccines derived from Brucella melitesis and Brucella suis biovar显示文摘 | Winter A J Schurig G G Boyle S M | 1996 | Am J Vet Res1996，57，： | 1 |
| 19 | The binding site for Clq on IgG显示文摘 | Duncan A R Winter G | 1988 | Nature1988，332，6166： | 1 |
| 20 | Making antibodies by phage display technology显示文摘 | Griffiths A D Hawkins R E | 1994 | Annu Rev Immunol1994，12，： | 1 |
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