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637篇 您的检索式：作者名="Winter P"

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	题名	作者	年代	出处	被引量
1	Cyclooxygenase-2 plays a central role in the genesis of pancreatitis and associated lung injury显示文摘BACKGROUND: The exact mechanism by which cyclooxy- genase-2 (COX-2) promotes inflammation in pancreatitis in obscure. This study was undertaken to investigate the role of COX-2 inhibition in an animal model of pancreati- tis , a disease process characterized by a systemic inflamma- tory response and ensuing neutrophil-mediated lung injury. METHODS: Pancreatitis was induced in 24 Sprague-Daw- ley rats by intraperitoneal injection of 20% L-arginine (500 mg/100 g body weight). The animals were randomized into 3 groups (8 rats in each group); controls and rats with pancreatitis intravenously resuscitated with either normal saline (0.9% NaCl 3 ml/kg) at 24 and 48 hours or COX-2 inhibitor (parecoxib 1 mg/kg). Pancreatic and lung inju- ries were assessed histologically. Lung injury was assessed utilizing wet;dry ratio and myeloperoxidase activity to in- dicate pulmonary neutrophil infiltration. A Western blot was used to determine COX-2 protein expression in pancrea- tic tissue. RESULTS: The animals treated with COX-2 inhibitors dis- played significantly less pancreatic and lung injuries than their normal saline counterparts. Histological pancreatic and lung injury scores were significantly reduced (P <0.05) in the COX-2 treated group. Lung wet: dry ratios were sig- nificantly improved and pulmonary neutrophil infiltration was attenuated in the COX-2 group (P<0.05). Western blot analysis confirmed attenuated COX-2 protein expression. CONCLUSION: This study shows, for the first time in a rat model, that adjuvant COX-2 inhibition significandy attenu- ates the severity of both pancreatitis and its associated sys- temic inflammatory response and end-organ injury.	Gavin O'Brien Conor J Shields Desmond C Winter John P Dillon	2005	Hepatobiliary & Pancreatic Diseases International2005，4，1：	12
2	Modified carbons for improved anodes in lithium ion cells显示文摘	BUQA H GOLOB P WINTER M	2001	J Power Sources2001，，9798：	2
3	Phenotypic instability and rapid gene silencing in newly formed Arabidopsis alloteraploids显示文摘	Comai L Tyagi A P Winter K Holmes-Davis R Reynolds S H Stevens Y Byers B	2000	Plant Cell2000，12，9：	2
4	Soil microarthropods in longterm no-tillage and conventional corn production显示文摘	Winter J P Voroney R P Ainsworth D A	1990	Canadian Journal of Soil Science1990，70，：	1
5	Contrast enhanced MR angiography in the assessment of relevant steneses in occlusive disease of the pelvic and lower limb arteries:diagnostic value of a two-step examination protocol in comparison to conventional DSA显示文摘	Winterer JT Schaefer O Uhrmeister P	2002	Eur J Radiology2002，41，：	1
6	Sequence and expression of routine type I hair keratins mHa2 and mHa3显示文摘	Winter H Siry P Tobiasch E	1994	Exp Cell Res1994，212，：	1
7	'Diabodies':small bivalent and bispecific antibody fragments显示文摘	Prospero T Winter G	1993	Proc Natl Acad Sci USA1993，90，14：	1
8	Graphites for lithium-ion cells:the correlation of the first-cycle charge loss with the brunauer-emmett-teller surface area显示文摘	Winter M Novak P Monnier A	1998	J Electrochemical Society1998，145，2：	1
9	显示文摘	Winter CC Gumperz JE Parham P	1998	J Immunol1998，161，2：	1
10	Enhancement of ionic conductivity by the addition of plasticizers in cationic monoconducting polymer electrolytes显示文摘	Chung S H Heitjans P Winter R	1998	Solid State Ionics1998，112，：	1
11	Graphites for lithium-ion cells:the Correlation of the first-cycle charge loss with the Brunauer-Emmett-Teller surface area显示文摘	WINTER M NAVAK P MONNIER A	1998	J Electrochem Soc1998，145，：	1
12	Steiner Problem in Networks:A Survey显示文摘	Winter P	1987	Networks1987，17，：	1
13	Cosmic ray production rates of tBe and 26A1 in quartz from glacially polished roeks 显示文摘	Nishiizumi K Winterer E L Kohl C P	1989	Journal of Geophysical Research1989，94，17：	1
14	Lung Injury in Acute Pancreatitis: Mechanisms, Prevention, and Therapy显示文摘	Shields C J Winter D C Redmond H P	2002	Curr Opin Crit Care2002，8，2：	1
15	Critical pressure and multiphase flow in Blake Ridge gas hydrates 显示文摘	Flemings B P Liu X Winters W J	2003	Geology2003，31，：	1
16	The relationship between social anxiety and social support in adoleseents:A test of competing causal models显示文摘	Calsyn R J Winter J P Burger G K	2005	Adolescents2005，40，157：	1
17	Attachment of Vibrio cholerae under various environmental conditions and to selected substrates 显示文摘	Hood M A Winter P A	1997	FEMS Microbiol Ecol1997，22，3：	1
18	Stable isotope geochemistry of carbonate fracture fills in the Monterey Formation,California显示文摘	Winter B L Knauth L P	1992	Journal of Sedimentary Petrology1992，62，2：	1
19	Evaluation of competence-based teaching in higher education:From theory to practice显示文摘	Bergsmann E Schultes MT Winter P	2015	Eval Program Plann2015，52，：	1
20	Spontaneous intracranial hypotension due to thoracic disc herniation 显示文摘	Winter SC Maartens NF Anslow P	2002	J Neurosurg2002，96，：	1

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