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| 1 | Single Nucleotide Polymorphism of FSHβ Gene Associated with Reproductive Traits in Japanese Flounder (Paralichthys olivaceus)显示文摘Follicle stimulating hormone β (FSHβ) of Japanese flounder (Paralichthys olivaceus) plays a key role in the regulation of gonadal development.This study aimed to investigate molecular genetic characteristics of the FSHβ gene and elucidate the effects of single nucleotide polymorphisms (SNPs) of FSHβ on reproductive traits in Japanese flounder.We used polymerase chain reaction single-strand conformation polymorphism (PCR-SSCP) and sequencing of the FSHβ gene in 60 individuals.We identified only an SNP (T/C) in the coding region of exon3 of FSHβ.The SNP (T/C) did not lead to amino acid changes at the position 340 bp of FSHβ gene.Statistical analysis showed that the SNP was significantly associated with testosterone (T) level and gonadosomatic index (GSI) (P<0.05).Individuals with genotype TC of the SNP had significantly higher serum T levels and GSI (P<0.05) than that of genotype CC.Therefore, FSHβ gene could be a useful molecular marker in selection for prominent reproductive trait in Japanese Flounder. | HE Feng WEN Haishen YU Dahui LI Jifang SHI Bao CHEN Caifang ZHANG Jiaren JIN Guoxiong CHEN Xiaoyan Shi Dan Yang Yanping | 2010 | Journal of Ocean University of China2010，9，4： | 4 |
| 2 | Neurological function following intra-neural injection of fluorescent neuronal tracers in rats显示文摘Fluorescent neuronal tracers should not be toxic to the nervous system when used in long-term labeling.Previous studies have addressed tracer toxicity,but whether tracers injected into an intact nerve result in functional impairment remains to be elucidated.In the present study,we examined the functions of motor,sensory and autonomic nerves following the application of 5% Fluoro-Gold,4% True Blue and 10% Fluoro-Ruby (5μL) to rat tibial nerves via pressure injection.A set of evaluation methods including walking track analysis,plantar test and laser Doppler perfusion imaging was used to determine the action of the fluorescent neuronal tracers.Additionally,nerve pathology and ratio of muscle wet weight were also observed.Results showed that injection of Fluoro-Gold significantly resulted in loss of motor nerve function,lower plantar sensibility,increasing blood flow volume and higher neurogenic vasodilatation.Myelinated nerve fiber degeneration,unclear boundaries in nerve fibers and high retrograde labeling efficacy were observed in the Fluoro-Gold group.The True Blue group also showed obvious neurogenic vasodilatation,but less severe loss of motor function and degeneration,and fewer labeled motor neurons were found compared with the Fluoro-Gold group.No anomalies of motor and sensory nerve function and no myelinated nerve fiber degeneration were observed in the Fluoro-Ruby group.Experimental findings indicate that Fluoro-Gold tracing could lead to significant functional impairment of motor,sensory and autonomic nerves,while functional impairment was less severe following True Blue tracing.Fluoro-Ruby injection appears to have no effect on neurological function. | Wen Hu Dan Liu Yanping Zhang Zhongyi Shen Tianwen Gu Xiaosong Gu Jianhui Gu | 2013 | Neural Regeneration Research2013，8，14： | 3 |
| 3 | Synthesis,characterization and cell imaging properties of rare earth compounds based on hydroxamate ligand显示文摘Six binuclear rare earth compounds were synthesized through the ligand of 4-Bromo-N-hydroxy-Nmethyl-benzamide(sH_2 bha). Compounds 1-3 are isomorphous, and compound 1 is crystallized in the monoclinic system with the P2_1/c space group. Compounds 4 and 5 are isomorphous, and compound 4 is crystallized in the triclinic system with the P-1 space group. Compound 6 is crystallized in the triclinic system with the P-1 space group. The compounds were characterized by thermogravimetric analysis(TGA) and IR spectroscopy. The fluorescence spectrum in the visible area shows characteristic peaks of Eu, Tb, and Dy compounds. The efficiency of Eu compound on the viability of PC3 cells was assessed using CCK8 assays. From the CCK8 results, ionic concentration may have a great effect on PC3 cells' proliferation. Eu compound shows red fluorescence in the cytoplasm of PC3 cell. As for Eu compound, it might have potential application in cell imaging technology. | Linyan Yang Yanping Zhang Liwei Hu Yunhe Zong Ruili Zhao Tianming Jin Wen Gu | 2018 | Journal of Rare Earths2018，36，4： | 3 |
| 4 | Surface Roughness and Roundness of Bearing Raceway Machined by Floating Abrasive Polishing and Their Effects on Bearing's Running Noise显示文摘As the two most important indexes of bearing raceway,surface roughness and roundness have significant influence on bearing noise.Some researchers have carried out studies in this field,however,reason and extent of the influence of raceway surface geometric characteristics on bearing running noise are not perfectly clear up to now.In this paper,the raceway of 6309 type bearing’s inner and outer ring is machined by floating abrasive polishing adopting soft abrasive pad.Surface roughness parameters,arithmetical mean deviation of the profile Ra,the point height of irregularities Rz,maximum height of the profile Rmax and roundness f of raceways,are measured before and after machining,and the change rules of the measured results are studied.The study results show that the floating abrasive polishing can reduce the surface geometric errors of bearing raceway evidently.The roundness error is reduced by 25%,Rmax value is reduced by 35.5%,Rz value is reduced by 22%and Ra value is reduced by 5%.By analyzing the change of the geometrical parameters and the shape difference of the raceway before and after machining,it is found that the floating abrasive polishing method can affect the roundness error mainly by modifying the local deviation of the raceway’s surface profile.Bearings with different raceway surface geometrical parameter value are assembled and the running noise is tested.The test results show that Ra has a little,Rmax and Rz have a measurable,and the roundness error has a significant influence on the running noise.From the viewpoint of controlling bearings’running noise,raceway roundness error should be strictly controlled,and for the surface roughness parameters,Rmax and Rz should be mainly controlled.This paper proposes an effective method to obtain the low noise bearing by machining the raceway with floating abrasive polishing after super finishing. | PANG Guibing QI Xuezhi MA Qinyi ZHAO Xiujun WEN Chunsheng XU Wenji PENG Yanping | 2014 | Chinese Journal of Mechanical Engineering2014，27，3： | 3 |
| 5 | Studies on MB-SAR 3D imaging algorithm using Yule-Walker method显示文摘Multibaseline synthetic aperture radar(MB-SAR) can form a synthetic aperture in the height direction with multiple parallel observations,so it has the resolving capability in the height direction and can realize three-dimensional(3D) imaging for the target.The analytic model of MB-SAR based on spectrum estimation is analyzed in this paper.Based on the more general geometric model,we derive the signal model for MB-SAR 3D imaging.And then Yule-Walker algorithm is proposed to realize MB-SAR 3D imaging meanwhile the principle is analyzed and the steps of Yule-Walker algorithm are given.This algorithm can get the 3D image of the target with high resolution using fewer observations.Finally,the experimental results of MB-SAR 3D imaging using Yule-Walker algorithm are presented,which are generated with the simulated data and the data collected in anechoic chamber. | WANG Bin WANG YanPing HONG Wen TAN WeiXian WU YiRong | 2010 | Science China(Information Sciences)2010，53，9： | 3 |
| 6 | A durable 4-1BB-based CD19 CAR-T cell for treatment of relapsed or refractory non-Hodgkin lymphoma显示文摘Objective:Previous studies reported that 4-1BB-based CD19 chimeric antigen receptor(CAR)-T cells were more beneficial for the clinical outcomes than CD28-based CAR-T cells,especially the lower incidence rate of severe adverse events.However,the median progression-free survival(mPFS)of 4-1BB-based product Kymriah was shorter than that of CD28-based Yescarta(2.9 months vs.5.9 months),suggesting that Kymriah was limited in the long-term efficacy.Thus,a safe and durable 4-1BB-based CD19 CAR-T needs to be developed.Methods:We designed a CD19-targeted CAR-T(named as IM19)which consisted of an FMC63 scFv,4-1BB and CD3ζintracellular domain and was manufactured into a memory T-enriched formulation.A phase I/II clinical trial was launched to evaluate the clinical outcomes of IM19 in relapsed or refractory(r/r)B cell non-Hodgkin lymphoma(B-NHL).Dose-escalation investigation(at a dose of 5×10^(5)/kg,1×10^(6)/kg and 3×106/kg)was performed in 22 r/r B-NHL patients.All patients received a single infusion of IM19 after 3-day conditional regimen.Results:At month 3,the overall response rate(ORR)was 59.1%,the complete response rate(CRR)was 50.0%.The mPFS was 6 months and the 1-year overall survival rate was 77.8%.Cytokine release syndrome(CRS)occurred in 13 patients(59.1%),with 54.5%of grade 1−2 CRS.Only one patient(4.5%)experienced grade 3 CRS and grade 3 neurotoxicity.Conclusions:These results demonstrated the safety and durable efficacy of a 4-1BB-based CD19 CAR-T,IM19,which is promising for further development and clinical investigation. | Zhitao Ying Ting He Shanzhao Jin Xiaopei Wang Wen Zheng Ningjing Lin Meifeng Tu Yan Xie Lingyan Ping Weiping Liu Lijuan Deng Yanping Ding Xuelian Hu Bing Bu Xin’an Lu Yuqin Song Jun Zhu | 2022 | Chinese Journal of Cancer Research2022，34，1： | 2 |
| 7 | On the methods of information resources visualization显示文摘 | ZHOU Ning WEN Yanping LIU Wei | 2002 | The Proceedings of Digital Library-IT Opportunities and Challenges in the New Millennium2002，，7： | 1 |
| 8 | Inhibitory effects of glutathi- one on dengue virus production 显示文摘 | Yanping T Wen J Na G | 2010 | Biochem Bioph Res Co2010，397，3： | 1 |
| 9 | Discovery of New Thioviridamide-Like Compounds with Antitumor Activities显示文摘Thioviridamide is a structurally unique compound with potent antitumor activity.The biosynthesis of thioviridamide follows a typical pathway as ribosomally synthesized and post-transiationally modified peptides,making the genome mining-based discovery of thioviridamide-like compounds rational.Taking advantage of the linkage between the precursor peptide and the metabolite skeleton,we identified a new biosynthetic gene cluster in Streptomyces sp.NRRL S-87 that could encode thioviridamide analogues.Overexpression of the whole gene cluster led to the isolation and structure elucidation of TVA-YJ-4 and TVA-YJ-5,two novel thioviridamide-like compounds featuring N-terminal capping groups.Chemical screening of the fermentation extracts also detected TVA-YJ-6,another new thioviridamide-like compound with representative methionine sulfoxide.Detailed analysis further revealed that these structural modifications were introduced during the compound extraction process instead of through genuine enzymatic reactions.TVA-YJ-4 and TVA-YJ-5 display slightly reduced cytotoxic activities against a panel of tumor cell lines in comparison with their parental natural product,TVA-YJ-2.Our work will expand the membership of this rare class of compounds and promote related biosynthetic studies. | Yuqing Li Jingyu Liu Haoyu Tang Yanping Qiu Dandan Chen Wen Liu | 2019 | Chinese Journal of Chemistry2019，37，10： | 1 |
| 10 | Inhibitory effects of glutathione on dengue virus production显示文摘 | Yanping T Wen J Na G | 2010 | Biochem Bioph Res Co2010，397，3： | 1 |
| 11 | Synthesis,Characterizations,Magnetism and Thermal Degradation of a 2-Fold Interpenetrated 3D Cobalt-Organic Framework显示文摘A new coordination polymer,[Co_(2)(L)_(2)(4,4'-bipy)]_(n)·3nH_(2)O(1)based on 5-(3-methyl-5-phenyl-4H-1,2,4-tri-azol-4-yl)isophthalic acid(H_(2)L)and 4,4'-bipyridine(4,4'-bipy)has been hydrothermally synthesized and character-ized by single-crystal X-ray diffraction,XRPD,IR,and elemental analysis.Temperature-dependent magnetic sus-ceptibility and thermal degradation for 1 were also studied.The asymmetric unit of compound 1 consists of two crystallographically independent Co(II)ion,two L^(2−)ligand,one 4,4'-bipy ligand,and three lattice water molecules.The 2D triangle networks were linked by the bridging 4,4'-bipy ligand to give rise to a 2-fold interpenetrated 3D architecture.The simplest cyclic motif of the 2D networks is a triangle ring consisting of three Co(II)cations and three L^(2−)ligands.So we can define Co(II)ions as 4-connected nodes and the L^(2−)ligands as 3-connected nodes.Thus,the 3D structure can be described as a 2-fold parallel interpenetrated ins InS 3,4-conn topology. | Linyan Yang Liangliang Xin Wen Gu Shengyun Liao Peiyao Du Jinlei Tian Yanping Zhang Rui Lv Xiaohua Wei Xin Liu Daizheng Liao | 2014 | Chinese Journal of Chemistry2014，32，3： | 1 |
| 12 | DOWNWARD LOOKING SPARSE LINEAR ARRAY 3D SAR IMAGING ALGORITHM BASED ON BACK-PROJECTION AND CONVEX OPTIMIZATION显示文摘Downward Looking Sparse Linear Array Three Dimensional SAR(DLSLA 3D SAR) is an important form of 3D SAR imaging, which has a widespread application field. Since its practical equivalent phase centers are usually distributed sparsely and nonuniformly, traditional 3D SAR algorithms suffer from low resolution and high sidelobes in cross-track dimension. To deal with this problem, this paper introduces a method based on back-projection and convex optimization to achieve 3D high accuracy imaging reconstruction. Compared with traditional SAR algorithms, the proposed method sufficiently utilizes the sparsity of the 3D SAR imaging scene and can achieve lower sidelobes and higher resolution in cross-track dimension. In the simulated experiments, the reconstructed results of both simple and complex imaging scene verify that the proposed method outperforms 3D back-projection algorithm and shows satisfying cross-track dimensional resolution and good robustness to noise. | Bao Qian Peng Xueming Wang Yanping Tan Weixian Hong Wen | 2014 | Journal of Electronics(China)2014，31，4： | 1 |
| 13 | Sintering Behavior of Hot-Pressed Ca-αSialon Ceramics 显示文摘 | Zhou Yanping Zhuang Hanrui Wen Shulin | 1999 | Journal of Materials Synthesis and Processing1999，，1： | 1 |
| 14 | Maximal effective baseline for polarimetric interferometric SAR forest height estimation显示文摘The concepts of critical baseline and maximal effective baseline have been defined for interferometric SAR (InSAR) DEM application based on the spatial decorrelation (which is a function of baseline).This paper puts forward these two concepts to polarimetric interferometric SAR (Pol-InSAR) forest height estimation application.The application makes use of volume decorrelation,which is also a function of baseline.So both the spatial decorrelation and volume decorrelation are considered to determine Pol-InSAR critical and maximal effective baseline.Firstly various decorrelation effects are discussed.Then the calculation formula of Pol-InSAR maximal effective baseline are presented and compared to that of InSAR.For validation,RVoG-based and PolSARpro-based simulation data and DLR ESAR data are used.The concept of Pol-InSAR maximal effective baseline is of practical significance in selection of Pol-InSAR image pairs as well as in the design of further Pol-InSAR systems. | ZHOU YongSheng HONG Wen WANG YanPing WU YiRong | 2012 | Science China(Information Sciences)2012，55，4： | 1 |
| 15 | Synthesis of electrically conductive polypyrrole-polystyrene composites using supercritical carbon dioxide 显示文摘 | Tang Muoi Wen Tsungyao Chen Yanping | 2003 | Eur Polym J2003，39，2： | 1 |
| 16 | Positive solutions for second-order m-point boundary value problems显示文摘 | Shan Wen rui Ge weigao | 2003 | J Math Anal Appl2003，151，： | 1 |
| 17 | An Acetylcholinesterase Biosensor Based on Graphene/ Polyaniline Composite Film for Detection of Pesticides显示文摘这个工作报导为通过与 acetylcholinesterase (疼痛) 修改玻璃质的碳电极制作的 organophosphate 杀虫剂(OP ) 的一个敏感安培计的生物传感器在 graphene/polyaniline (G/PANI ) 上使合成电影不能调动。获得的 G/PANI 合成电影显示出大特定的区域,高传导性,好 biocompatibility,和快氧化还原作用性质并且有完美的分层、包含的结构。同样准备的生物传感器与 0.20 mmol/L 的 Michaelis-Menten 经常的价值显示出高亲密关系到 acetylthiocholine (ATCl ) 。基于酉维因(一个种杀虫剂) 的模型混合物引起的酶的活动(使不能调动的疼痛) 的抑制,而且,酉维因的抑制活动与它从 38 ~ 194 ng·mL −1的集中成正比,这被发现。发达生物传感器为 OP 察觉显示出 20 ng·mL −1(S/N=3 ) 的察觉限制并且展出象好重制度和可接受的稳定性那样的好性能,它使为酶禁止者的分析提供一个新、有希望的工具可能。 | Yanping Li Yuyu Zhang Gaoyi Han Yaoming Xiao Miaoyu Li Wen Zhou | 2016 | Chinese Journal of Chemistry2016，34，1： | 1 |
| 18 | A novel low RCS mobius-band monopole antenna显示文摘 | JIANG Wen GONG Shuxi LI Yanping | 2009 | Journal of Electromagnetic Waves and Applications2009，23，1415： | 1 |
| 19 | Polar format imaging algorithm with wave-front curvature phase error compensation for airborne DLSLA three-dimensional SAR 显示文摘 | PENG Xueming HONG Wen WANG Yanping | 2014 | IEEE Geoscience and Remote Sensing Letters2014，11，6： | 1 |
| 20 | Generalized pseudopolar format algorithm for radar imaging with highly suboptimal aperture length显示文摘Different from conventional spaceborne or airborne synthetic aperture radar(SAR) with optimal aperture length, an imaging radar with highly suboptimal aperture length acquires the data in short bursts by a geometry spreading over a large range. A polarlike or pseudopolar format grid is introduced to sample data close to the resolution, which presents the design of a separable kernel for efficient FFT implementation.The proposed imaging algorithm formulates the reflectivity image of the target scene as an interpolation-free double image series expansion with two usual approximation-induced phase error terms being taken into account,whereby more generalized application scenarios with high frequency, large bandwidth or larger aperture length for imaging a target scene located within either the far-field or the near-field of the radar aperture are processable with high accuracy. In addition, convergence acceleration methods in computational mathematics are introduced to accelerate the convergence of the image series expansion, so as to make the algorithm more efficient. The proposed algorithm has been validated both qualitatively and quantitatively with an extensive collection of numerical simulations and field measurements of ground-based SAR(GB-SAR) data set. | HAN KuoYe WANG YanPing CHANG XiangKe TAN WeiXian HONG Wen | 2015 | Science China(Information Sciences)2015，58，4： | 1 |
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