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| 1 | The enhanced X-ray Timing and Polarimetry mission—eXTP显示文摘In this paper we present the enhanced X-ray Timing and Polarimetry mission—eXTP. eXTP is a space science mission designed to study fundamental physics under extreme conditions of density, gravity and magnetism. The mission aims at determining the equation of state of matter at supra-nuclear density, measuring effects of QED, and understanding the dynamics of matter in strong-field gravity. In addition to investigating fundamental physics, eXTP will be a very powerful observatory for astrophysics that will provide observations of unprecedented quality on a variety of galactic and extragalactic objects. In particular, its wide field monitoring capabilities will be highly instrumental to detect the electro-magnetic counterparts of gravitational wave sources.The paper provides a detailed description of:(1) the technological and technical aspects, and the expected performance of the instruments of the scientific payload;(2) the elements and functions of the mission, from the spacecraft to the ground segment. | ShuangNan Zhang Andrea Santangelo Marco Feroci YuPeng Xu FangJun Lu Yong Chen Hua Feng Shu Zhang Sφren Brandt Margarita Hernanz Luca Baldini Enrico Bozzo Riccardo Campana Alessandra De Rosa YongWei Dong Yuri Evangelista Vladimir Karas Norbert Meidinger Aline Meuris Kirpal Nandra Teng Pan Giovanni Pareschi Piotr Orleanski QiuShi Huang Stephane Schanne Giorgia Sironi Daniele Spiga Jiri Svoboda Gianpiero Tagliaferri Christoph Tenzer Andrea Vacchi Silvia Zane Dave Walton ZhanShan Wang Berend Winter Xin Wu Jean J.M.in't Zand Mahdi Ahangarianabhari Giovanni Ambrosi Filippo Ambrosino Marco Barbera Stefano Basso Jörg Bayer Ronaldo Bellazzini Pierluigi Bellutti Bruna Bertucci Giuseppe Bertuccio Giacomo Borghi XueLei Cao Franck Cadoux Francesco Ceraudo TianXiang Chen Yu Peng Chen Jerome Chevenez Marta Civitani Wei Cui WeiWei Cui Thomas Dauser Ettore Del Monte Sergio Di Cosimo Sebastian Diebold Victor Doroshenko Michal Dovciak YuanYuan Du Lorenzo Ducci QingMei Fan Yannick Favre Fabio Fuschino JoséLuis Ga'lvez Min Gao MingYu Ge Olivier Gevin Marco Grassi QuanYing Gu YuDong Gu DaWei Han Bin Hong Wei Hu Long Ji ShuMei Jia WeiChun Jiang Thomas Kennedy Ingo Kreykenbohm Irfan Kuvvetli Claudio Labanti Luca Latronico Gang Li MaoShun Li Xian Li Wei Li ZhengWei Li Olivier Limousin HongWei Liu XiaoJing Liu Bo Lu Tao Luo Daniele Macera Piero Malcovati Adrian Martindale Malgorzata Michalska Bin Meng Massimo Minuti Alfredo Morbidini Fabio Muleri Stephane Paltani Emanuele Perinati Antonino Picciotto Claudio Piemonte JinLu Qu Alexandre Rachevski Irina Rashevskaya Jerome Rodriguez Thomas Schanz ZhengXiang Shen LiZhi Sheng JiangBo Song LiMing Song Carmelo Sgro Liang Sun Ying Tan Phil Uttley Bo Wang DianLong Wang GuoFeng Wang Juan Wang LangPing Wang YuSa Wang Anna L.Watts XiangYang Wen Jörn Wilms ShaoLin Xiong JiaWei Yang Sheng Yang YanJi Yang Nian Yu WenDa Zhang Gianluigi Zampa Nicola Zampa Andrzej A.Zdziarski AiMei Zhang ChengMo Zhang Fan Zhang Long Zhang Tong Zhang Yi Zhang XiaoLi Zhang ZiLiang Zhang BaoSheng Zhao ShiJie Zheng Yu Peng Zhou Nicola Zorzi J.Frans Zwart | 2019 | Science China(Physics,Mechanics & Astronomy)2019，62，2： | 11 |
| 2 | Observations of the Karimata Strait througflow from December 2007 to November 2008显示文摘In order to quantitatively estimate the volume and property transports between the South China Sea and Indonesian Seas via the Karimata Strait, two trawl-resistant bottom mounts, with ADCPs embedded, were deployed in the strait to measure the velocity profile as part of the South China Sea-Indonesian Seas transport/exchange (SITE) program. A pair of surface and bottom acoustic modems was employed to transfer the measured velocity without recovering the mooring. The advantage and problems of the instruments in this field work are reported and discussed. The field observations confirm the existence of the South China Sea branch of Indonesian throughflow via the Karimata Strait with a stronger southward flow in boreal winter and weaker southward bottom flow in boreal summer, beneath the upper layer northward (reversal) flow. The estimate of the averaged volume, heat and freshwater transports from December 2007 to March 2008 (winter) is (-2.7 ± 1.1) × 10 6 m3/s, (-0.30 ± 0.11) PW, (-0.18 ± 0.07) × 106m3/s and from May to September 2008 (summer) is (1.2 ± 0.6) × 106m3/s, (0.14 ± 0.03) PW, (0.12 ± 0.04) × 106m3/s and for the entire record from December 2007 to October 2008 is (-0.5 ± 1.9) × 10 6 m3/s, (-0.05 ± 0.22) PW, (-0.01 ± 0.15) × 106m3/s (negative/positive represents southward/northward transport), respectively. The existence of southward bottom flow in boreal summer implies that the downward sea surface slope from north to south as found by Fang et al. (2010) for winter is a year-round phenomenon. | SUSANTO R Dwi WEI Zexun ADI Rameyo T FAN Bin LI Shujiang FANG Guohong | 2013 | Acta Oceanologica Sinica2013，32，5： | 9 |
| 3 | 肾素-血管紧张素-醛固酮轴在血管瘤组织中的表达及其对普萘洛尔治疗的影响显示文摘普萘洛尔治疗婴幼儿血管瘤(IH)的机制尚不清楚。该文作者假设这一非选择性β受体阻滞剂通过下调肾素-血管紧张素一醛固酮(RAA)轴系统的表达。抑制血管新生,促进IH消退。 | Dornhoffer JR Wei T Zhang H 张凌 | 2017 | 中国口腔颌面外科杂志2017，15，3： | 5 |
| 4 | RFP-mediated ubiquitination of PTEN modulates its effect on AKT activation显示文摘PTEN 肿瘤 suppressor 是在调整 phosphatidylinositol-3-kinase (PI3K ) 有一个中央角色的类脂化合物磷酸酶信号 transduction 串联。不过, PTEN 活动被在房间调整的机制需要进一步的说明。尽管以前的研究证明了 PTEN 的 ubiquitination 能调制它的稳定性和 subcellular 本地化,在 PTEN 功能的最批评的方面的 ubiquitination 的角色,它的磷酸酶活动,充分没被探讨。这里,我们识别 PTEN 的新奇 E3 ubiquitin ligase,沤手指蛋白质(RFP ) ,那能支持 PTEN 的不正常的 polyubiquitinations。这些 ubiquitinations 不导致 PTEN 不稳定性或本地化,但是相当显著地禁止 PTEN 磷酸酶活动因此调制它的能力调整 PI3K 信号 transduction 串联。确实, RFP overexpression 在 AKT 激活上减轻调停 PTEN 的禁止的效果;相反,调停 RNAi 内长的 RFP 击倒提高 PTEN 的能力压制 AKT 激活。而且, PTEN 的调停 RFP 的 ubiquitination 禁止小道表示的 PTEN 依赖的激活并且也压制它的能力导致 apoptosis。我们的调查结果在控制 PTEN 表明调停 RFP 的 ubiquitination 的一个关键角色活动。 | James T Lee Jing Shan Jiayun Zhong Muyang Li Brenda Zhou Amanda Zhou Ramon Parsons Wei Gu | 2013 | Cell Research2013，23，4： | 5 |
| 5 | Remifentanil Induces Systemic Arterial Vasodilation which is Not Associated with Alterations in Concentrations of Histamine, Nitric Oxide and Prostacyclin in Patients undergoing Cardiopulmonary Bypass显示文摘 | Lin P T Zhang B.J Wei W Li J Liu J | 2010 | 麻醉与监护论坛2010，17，4： | 3 |
| 6 | PROBLEMS AND COUNTERMEASURES OF WATER RESOURCES FOR SUSTAINABLE UTILIZATION IN CHINA显示文摘According to the theory of sustainable development,the current situation and existent problems of the expl oita-tion of water resources were analyze d in this paper.The results show that the contradiction between supply an d demand of water resources is continually aggravating,water pollution is incre asingly serious,water environment is worse,the over-extraction area of the underground water is expanding and water crisis stands out gradually,so it is imp erative under the situation to actualize the susta inable exploitation strategies of water resources.It is necessary for s ustainable utilizing water resources to introduce the mod el of sustainable utilization of water resources-the model of wealth transferring be-tween the generations of water resou rces,establish water-saving socie ty system and water market,form tech nology sys-tems,management systems and evaluation systems for many sorts of water r esources,improve the utilization r atio of water resources,transform waste water in to resources and maintain and restore the water space of water environmen t. | DENG Wei,BAI Jun-hong,YAN Min-hua(Changchun Institute of Geography,t he Chinese Academy of Sciences,Changchun 130012,P.R.China) | 2002 | Chinese Geographical Science2002，12，4： | 3 |
| 7 | Monocyte recruitment and myelin removal are delayed following spinal cord injury in mice with CCRz chemokine receptor deletion显示文摘 | Ma M Wei T Boring L | 2002 | J Neurosci Res2002，68，6： | 2 |
| 8 | Multicenter evaluation of recurrence in endoscopic submucosal dissection and endoscopic mucosal resection in the colon:A Western perspective显示文摘BACKGROUND While colon endoscopic mucosal resection(EMR)is an effective technique,removal of larger polyps often requires piecemeal resection,which can increase recurrence rates.Endoscopic submucosal dissection(ESD)in the colon offers the ability for en bloc resection and is well-described in Asia,but there are limited studies comparing ESD vs EMR in the West.AIM To evaluate different techniques in endoscopic resection of large polyps in the colon and to identify factors for recurrence.METHODS The study is a retrospective comparison of ESD,EMR and knife-assisted endoscopic resection performed at Stanford University Medical Center and Veterans Affairs Palo Alto Health Care System between 2016 and 2020.Knife-assisted endoscopic resection was defined as use of electrosurgical knife to facilitate snare resection,such as for circumferential incision.Patients≥18 years of age undergoing colonoscopy with removal of polyp(s)≥20 mm were included.The primary outcome was recurrence on follow-up.RESULTS A total of 376 patients and 428 polyps were included.Mean polyp size was greatest in the ESD group(35.8 mm),followed by knife-assisted endoscopic resection(33.3 mm)and EMR(30.5 mm)(P<0.001).ESD achieved highest en bloc resection(90.4%)followed by knife-assisted endoscopic resection(31.1%)and EMR(20.2%)(P<0.001).A total of 287 polyps had follow-up(67.1%).On follow-up analysis,recurrence rate was lowest in knife-assisted endoscopic resection(0.0%)and ESD(1.3%)and highest in EMR(12.9%)(P=0.0017).En bloc polyp resection had significantly lower rate of recurrence(1.9%)compared to non-en bloc(12.0%,P=0.003).On multivariate analysis,ESD(in comparison to EMR)adjusted for polyp size was found to significantly reduce risk of recurrence[adjusted hazard ratio 0.06(95%CI:0.01-0.57,P=0.014)].CONCLUSION In our study,EMR had significantly higher recurrence compared to ESD and knife-assisted endoscopic resection.We found factors including resection by ESD,en bloc removal,and use of circumferential incision were associated with significantly decreased recurrence.While further studies are needed,we have demonstrated the efficacy of ESD in a Western population. | Mike T Wei Margaret J Zhou Andrew A Li Andrew Ofosu Joo Ha Hwang Shai Friedland | 2023 | World Journal of Gastrointestinal Endoscopy2023，15，6： | 2 |
| 9 | Widespread use of gastric acid inhibitors in infants:Are they needed? Are they safe?显示文摘Gastroesophageal reflux is a common phenomenon in infants,but the differentiation between gastro-esophageal reflux and gastroesophageal reflux disease can be difficult.Symptoms are non-specific and there is increasing evidence that the majority of symptoms may not be acid-related.Despite this,gastric acid inhibitors such as proton pump inhibitors are widely and increasingly used,often without objective evidence or investigations to guide treatment.Several studies have shown that these medications are ineffective at treating symptoms associated with reflux in the absence of endoscopically proven oesophagitis.With a lack of evidence for efficacy,attention is now being turned to the potential risks of gastric acid suppression.Previously assumed safety of these medications is being challenged with evidence of potential side effects including GI and respiratory infections,bacterial overgrowth,adverse bone health,food allergy and drug interactions. | Mark Safe Wei H Chan Steven T Leach Lee Sutton Kei Lui Usha Krishnan | 2016 | World Journal of Gastrointestinal Pharmacology and Therapeutics2016，7，4： | 2 |
| 10 | Artificial intelligence applications in inflammatory bowel disease:Emerging technologies and future directions显示文摘Inflammatory bowel disease(IBD)is a complex and multifaceted disorder of the gastrointestinal tract that is increasing in incidence worldwide and associated with significant morbidity.The rapid accumulation of large datasets from electronic health records,high-definition multi-omics(including genomics,proteomics,transcriptomics,and metagenomics),and imaging modalities(endoscopy and endomicroscopy)have provided powerful tools to unravel novel mechanistic insights and help address unmet clinical needs in IBD.Although the application of artificial intelligence(AI)methods has facilitated the analysis,integration,and interpretation of large datasets in IBD,significant heterogeneity in AI methods,datasets,and clinical outcomes and the need for unbiased prospective validations studies are current barriers to incorporation of AI into clinical practice.The purpose of this review is to summarize the most recent advances in the application of AI and machine learning technologies in the diagnosis and risk prediction,assessment of disease severity,and prediction of clinical outcomes in patients with IBD. | John Gubatan Steven Levitte Akshar Patel Tatiana Balabanis Mike T Wei Sidhartha R Sinha | 2021 | World Journal of Gastroenterology2021，27，17： | 2 |
| 11 | Lithium niobate: summary of physical properties and crystal structure 显示文摘 | WEIS R S GAYLORD T K | 1985 | Appl Phys A1985，37，： | 2 |
| 12 | A Fundamental Solution Method For Inverse Heat Conduction Problem显示文摘 | Hon Y C Wei T | 2004 | Engineering Analysis with Boundary Elements2004，28，5： | 1 |
| 13 | Thermogravimetric study on the kinetics of rice hull pyrolysis and influence of water treatment显示文摘 | Wei Y | 1998 | Ind Eng Chem Res1998，37，： | 1 |
| 14 | Effect of base strength and basicity on catalytic behavior of solid bases for synthesis of dimethyl carbonate from propylene carbonate and methanol显示文摘 | WEI T WANG M H WEI W SUN Y H ZHONG B | 2003 | Fuel Processing Technology2003，83，13： | 1 |
| 15 | Joint optimization of relay strategies and resource allocation in cooperative cellular networks显示文摘 | NG T C Y YU Wei | 2007 | IEEE Journal on Selected Areas in Communications2007，25，2： | 1 |
| 16 | Time-dependent numerical code for extended Bonssinesq equations 显示文摘 | Wei G Kirby J T | 1995 | Journal of Waterway Port Coastal and Ocean Engineering ASCE1995，121，5： | 1 |
| 17 | Mechanisms of apoptosis in rat cerebellar granule cells induced by hydroxyl radicals and the effects of EGb761 and its constituents显示文摘 | Xin W Wei T Chen C | 2000 | Toxicology2000，148，23： | 1 |
| 18 | Synthesis of Thiosemicarbazone Derivatives of Benzo-15-crown-5 and Their Anion Recognition Properties 显示文摘 | Y Q Zhou T B Wei Y M Zhang | 2008 | Phosphorus Sulfur and Silicon2008，183，6： | 1 |
| 19 | Iron-induced oxidative damage and apoptosis in cerebellar granule cells:attenuation by tetramethylpyrazine and ferulic acid显示文摘 | Zhang Z Wei T Hou J | 2003 | Eur J Pharmacol2003，467，： | 1 |
| 20 | Synthesis and antibacterial activity of peptide deformylase inhibitors显示文摘 | Huntington K M Yi T Wei Y | 2000 | Biochemistry2000，39，15： | 1 |
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