|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Relationship between Th17 immune response and cancer显示文摘Cancer is the second leading cause of death worldwide and epidemiological projections predict growing cancer mortality rates in the next decades.Cancer has a close relationship with the immune system and,although Th17 cells are known to play roles in the immune response against microorganisms and in autoimmunity,studies have emphasized their roles in cancer pathogenesis.The Th17 immune response profile is involved in several types of cancer including urogenital,respiratory,gastrointestinal,and skin cancers.This type of immune response exerts pro and antitumor functions through several mechanisms,depending on the context of each tumor,including the protumor angiogenesis and exhaustion of T cells and the antitumor recruitment of T cells and neutrophils to the tumor microenvironment.Among other factors,the paradoxical behavior of Th17 cells in this setting has been attributed to its plasticity potential,which makes possible their conversion into other types of T cells such as Th17/Treg and Th17/Th1 cells.Interleukin(IL)-17 stands out among Th17-related cytokines since it modulates pathways and interacts with other cell profiles in the tumor microenvironment,which allow Th17 cells to prevail in tumors.Moreover,the IL-17 is able to mediate pro and antitumor processes that influence the development and progression of various cancers,being associated with variable clinical outcomes.The understanding of the relationship between the Th17 immune response and cancer as well as the singularities of carcinogenic processes in each type of tumor is crucial for the identification of new therapeutic targets. | Hanna Santos Marques Breno Bittencourt de Brito Filipe Antônio França da Silva Maria Luísa Cordeiro Santos Júlio César Braga de Souza Thiago Macêdo Lopes Correia Luana Weber Lopes Nayara Silva de Macêdo Neres Rafael Santos Dantas Miranda Dórea Anna Carolina Saúde Dantas Lorena Lôbo Brito Morbeck Iasmin Souza Lima Amanda Alves de Almeida Maiara Raulina de Jesus Dias Fabrício Freire de Melo | 2021 | World Journal of Clinical Oncology2021，12，10： | 5 |
| 2 | Chronic myeloid leukemia-from the Philadelphia chromosome to specific target drugs:A literature review显示文摘Chronic myeloid leukemia(CML)is a myeloproliferative neoplasm and was the first neoplastic disease associated with a well-defined genotypic anomaly―the presence of the Philadelphia chromosome.The advances in cytogenetic and molecular assays are of great importance to the diagnosis,prognosis,treatment,and monitoring of CML.The discovery of the breakpoint cluster region(BCR)-Abelson murine leukemia(ABL)1 fusion oncogene has revolutionized the treatment of CML patients by allowing the development of targeted drugs that inhibit the tyrosine kinase activity of the BCR-ABL oncoprotein.Tyrosine kinase inhibitors(known as TKIs)are the standard therapy for CML and greatly increase the survival rates,despite adverse effects and the odds of residual disease after discontinuation of treatment.As therapeutic alternatives,the subsequent TKIs lead to faster and deeper molecular remissions;however,with the emergence of resistance to these drugs,immunotherapy appears as an alternative,which may have a cure potential in these patients.Against this background,this article aims at providing an overview on CML clinical management and a summary on the main targeted drugs available in that context. | Mariana Miranda Sampaio Maria Luísa Cordeiro Santos Hanna Santos Marques Vinícius Lima de Souza Gonçalves Glauber Rocha Lima Araújo Luana Weber Lopes Jonathan Santos Apolonio Camilo Santana Silva Luana Kauany de SáSantos Beatriz Rocha Cuzzuol Quézia Estéfani Silva Guimarães Mariana Novaes Santos Breno Bittencourt de Brito Filipe Antônio França da Silva Márcio Vasconcelos Oliveira Cláudio Lima Souza Fabrício Freire de Melo | 2021 | World Journal of Clinical Oncology2021，12，2： | 3 |
| 3 | Specific consumption of liquid biofuels in gasoline fuelled engines显示文摘 | Renato Catalufia Rosngela da Silva Eliana Weber de Menezes | 2008 | Fuel2008，87，1516： | 1 |
| 4 | Factors regulating collagen synthesis and degradation during second-intention healing of wounds in the thoracic region and the distal aspect of the forelimb of horses显示文摘 | Schwartz AJ Wilson DA Weber KT | 2002 | Am J Vet Res2002，63，11： | 1 |
| 5 | The role of cis dimerization of signal regulatory protein alpha(SIRPalpha)in binding to CD47显示文摘 | Lee WY Weber DA Laur O | 2010 | J Biol Chem2010，285，37： | 1 |
| 6 | Clinical performance of a newly developed spectrophotometric system on tooth color reproduction显示文摘 | Da Silva JD Park SE Weber HP | 2008 | J Prosthet Dent2008，99，5： | 1 |
| 7 | The contribution of Chinese exports to climate change显示文摘 | Weber Christopher L Peters Glen P Da B Guan | 2008 | Energy Policy2008，，36： | 1 |
| 8 | DM enhances peptide bin-ding to class Ⅱ MHC by release of invariant chain-derived peptide显示文摘 | Sherman MA Weber DA Jensen PE | 1995 | Immunity1995，3，2： | 1 |
| 9 | Sewed revascularization for arterialized liver transplantation in mice显示文摘 | Humar B Raptis DA Weber A | | 0，，02： | 1 |
| 10 | Clinical performance of a newly developed spectrophotometric system on tooth color reproduction 显示文摘 | Da Silva JD Park SE Weber HP | 2008 | J Prosthet Dent2008，99，5： | 1 |
| 11 | Ultrahigh-resolution imaging of small animals: Implications for preclinical and research studies显示文摘 | Weber DA Ivanovic M | 1999 | J Nucl Med1999，6，3： | 1 |
| 12 | Biological and chemical attributes of soils under forest species in Northeast Brazil显示文摘Timber forests contribute to the sustainable development of the biomes in tropical regions.The aim of this study was to evaluate the biological and chemical properties of the soil as a consequence of the cover with native and non-native species in the Acarau basin,a transition area from the coast to the Brazilian semi-arid region.Areas planted with four native species(Anadenanthera colubrina,Astronium fraxinifolium,Handroanthus impetiginosus,Colubrina glandulosa)and three exotic species(Acacia mangium,Casuarina equisetifolia,Eucalyptus urophylla)plus a non-forested agricultural area were evaluated for organic carbon contents,and microbial and chemical soil properties.The levels of soil organic carbon were highest in A.colubrina and C.equisetifolia plantations.Low basal soil respiration was observed but the microbial biomass was particularly low in the non-forested area.In the C.equisetifolia,E.urophylla,and H.impetiginosus plantations,elevated soil metabolic quotients were found.The A.colubrina and H.impetiginosus plantations had the highest levels of easily extracted-glomalin related soil protein.Tree species affect concentrations of essential nutrients and the biological quality of the soil in different ways.They can also improve the biological and chemical properties of the soil in the coastal plains of tropical regions. | Olmar Baller Weber Maria Catia Barroso da Silva Cristiane Figueira da Silva Joao Alencar de Sousa Carlos Alberto Kenji Taniguch Deborah dos Santos Garruti Ricardo Espindola Romero | 2020 | Journal of Forestry Research2020，31，5： | 1 |
| 13 | Specific consumption of liquid l:iofuels in gasoline fuelled engines 显示文摘 | Renato Catalufia Rosangela da Silva Eliana Weber de Menezes | 2008 | Fuel2008，87，1516： | 1 |
| 14 | Clinical performance of a newly developed spectrophotometric system on toothcolor reproduction显示文摘 | Da SJD Park SE Weber HP | 2008 | J Prosthet Dent2008，99，5： | 1 |
| 15 | Clinical performance of a newly developed spectrophotometric system on tooth color repro-duction显示文摘 | Da Silva JD Park SE Weber HP | 2008 | J Prosthet Dent2008，99，5： | 1 |
| 16 | Acute dis- continuation syndrome from dexmedetomidine after pro- tracted use in a pediatric patient显示文摘 | Weber MD Thammasitboon S and Rosen DA | 2008 | Paediatr Anaesth2008，18，1： | 1 |
| 17 | Phase IIII study of ipi1imumab for patients with metastatic melanoma显示文摘 | WEBER IS O'DA Y S URBA W | 2008 | J Clin Oncol2008，26，36： | 1 |
| 18 | Clinical perform- ance of a newly developed speetrophotometric system on tooth color reproduction显示文摘 | Da Silva JD Park SE Weber HP | 2008 | J Prosthet Dent2008，99，5： | 1 |
| 19 | Maternal drug histories and central nervous system Anomalies显示文摘 | Winship KA Cahal DA Weber JC | 1984 | Arch Dis Child1984，59，11： | 1 |
| 20 | Long term compliance with California' s smoke-free workplace law among bars and restaurants in Los Angeles county 显示文摘 | Weber MD Bagwell DA Fielding JE | 2003 | Tob Control2003，12，3： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员