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| 1 | Chronic antiepileptic drug use and functional network efficiency: A functional magnetic resonance imaging study显示文摘AIM To increase our insight in the neuronal mechanisms underlying cognitive side-effects of antiepileptic drug(AED) treatment.METHODS The relation between functional magnetic resonance-acquired brain network measures, AED use, and cognitive function was investigated. Three groups of patients with epilepsy with a different risk profile for developing cognitive side effects were included: A 'low risk' category(lamotrigine or levetiracetam, n=16), an 'intermediate risk' category(carbamazepine, oxcarbazepine, phenytoin, or valproate, n=34) and a 'high risk' category(topiramate, n=5). Brain connectivity was assessed using resting state functional magnetic resonance imaging and graph theoretical network analysis. The Computerized Visual Searching Task was used to measure central information processing speed, a common cognitive side effect of AED treatment. RESULTS Central information processing speed was lower in patients taking AEDs from the intermediate and high risk categories, compared with patients from the low risk category. The effect of risk category on global efficiency was significant(P < 0.05, ANCOVA), with a significantly higher global efficiency for patient from the low category compared with the high risk category(P < 0.05, post-hoc test). Risk category had no significant effect on the clustering coefficient(ANCOVA, P > 0.2). Also no significant associations between information processing speed and global efficiency or the clustering coefficient(linear regression analysis, P > 0.15) were observed. CONCLUSION Only the four patients taking topiramate show aberrant network measures, suggesting that alterations in functional brain network organization may be only subtle and measureable in patients with more severe cognitive side effects. | Tamar M van Veenendaal Dominique M IJff Albert P Aldenkamp Richard H C Lazeron Paul A M Hofman Anton J A de Louw Walter H Backes Jacobus F A Jansen | 2017 | World Journal of Radiology2017，9，6： | 2 |
| 2 | Acute surgical emergencies in inflammatory bowel disease显示文摘 | Dale F Berg Anil M Bahadursingh Donald L Kaminski Walter E Longo | 2002 | The American Journal of Surgery2002，，： | 2 |
| 3 | Estimating Basin-wide Hydraulic Parameters of a Semi-arid Mountainous Watershed by Recessionflow Analysis显示文摘 | Mendoza G F Steenhuis T S Walter M T | 2003 | Journal of Hydrology2003，279，： | 1 |
| 4 | Numerical study of detonation stabilization by finite length wedges显示文摘 | WALTER M A T FIGUEIRA L F | 2006 | A1AA Journal2006，44，2： | 1 |
| 5 | Hydrolofically sensitive areas:variable source area hydrology implications for water quality risk assessment显示文摘 | Walter M T Walter M F Brooks E S | 2000 | J Soil and Water Conservation2000，55，3： | 1 |
| 6 | Conservation of methylation reprogramming in mammalian development:aberrant reprogramming in cloned embryos显示文摘 | Dean W Santos F Stojkovic M Zakhartchenko V Walter J Wolf E Reik W | 2001 | Proceedings of the National Academy of Sciences2001，98，13： | 1 |
| 7 | Evidence for a Second Crystal Form of Polypropylene显示文摘 | Keith H D Padden F J Walter N M | 1959 | J Appl Phys1959，30，10： | 1 |
| 8 | Machining of ring shaped workpiece 显示文摘 | Walter M F SLahl J E | 1995 | Journal of Materials Processing Technology1995，48，4： | 1 |
| 9 | Scanning laser tomography of full thickness idiopathic macular holes显示文摘 | Bishop F Walters G Geall M | 2005 | Eye (Lond)2005，19，2： | 1 |
| 10 | Evaluation of hybrid RANS/LES models for prediction of flow around surface com-batant and Suboff geometries显示文摘 | Bhushan S Alam M F Walters D K | 2013 | Computers & Fluids2013，88，： | 1 |
| 11 | Alloys of iron manganese and carbon-part XV 显示文摘 | WALTERS F M WELLS A C | 1936 | Transactions of the American Society of Metals1936，24，2： | 1 |
| 12 | Special injection moulding processes in practical application显示文摘 | Oliver P Andreas F | 2000 | Kunststoffe Plast Europe2000，90，10： | 1 |
| 13 | Closed form solution for pesticide loss in runoff water显示文摘 | Steenhuis T S Walter M F | 1980 | Transactions of American Society Agriculture Engineering1980，23，3： | 1 |
| 14 | Hydrogen sensors and switches from electrodeposited palladium mesowire arrays显示文摘 | Favier F Walter E C Zach M P | 2001 | Science2001，293，5338： | 1 |
| 15 | Strueture-aetivity relationships in NH3-SCR over Cu-SSZ-13 as probed by reaction kinetics and EPR studies显示文摘 | Gao F Walter E D Karp E M | 2013 | Journal of Catalysis2013，300，0： | 1 |
| 16 | The mode of action of the Bacillus thuringiensis vegetative insecticidal protein Vip3A differs from that of Cry1Ab delta-endotoxin显示文摘 | Lee M K Walters F S Hart H | 2003 | Applied and Environmental Microbiology2003，69，46： | 1 |
| 17 | Evidence for a second crystal form of polypropylene显示文摘 | Keith H D Padden F J Jr Walter N M | 1959 | Appl Phys1959，30，： | 1 |
| 18 | Palladium mesowire arrays for fas hydrogen sensors and hydrogenactuated witches显示文摘 | Walter E C Favier F Penner R M | 2002 | Anal Chem2002，74，7： | 1 |
| 19 | Closed form solution for pesticide loss in runoff water显示文摘 | STEENHUIS T S WALTER M F | 1980 | Transactions of American Society Agriculture Engineering1980，23，3： | 1 |
| 20 | Listeners' cognitive and affective reactions to English speakers with standard American English and Asian accents 显示文摘 | Hosoda M Stone-Romero E F & Walter J N | 2007 | Perceptual and Motor Skills2007，104，1： | 1 |
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