|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Retrospective study on mixed neuroendocrine non-neuroendocrine neoplasms from five European centres显示文摘BACKGROUND Mixed neuroendocrine non-neuroendocrine neoplasm(MiNEN)is a rare diagnosis,mainly encountered in the gastro-entero-pancreatic tract.There is limited knowledge of its epidemiology,prognosis and biology,and the best management for affected patients is still to be defined.AIM To investigate clinical-pathological characteristics,treatment modalities and survival outcomes of a retrospective cohort of patients with a diagnosis of MiNEN.METHODS Consecutive patients with a histologically proven diagnosis of MiNEN were identified at 5 European centres.Patient data were retrospectively collected from medical records.Pathological samples were reviewed to ascertain compliance with the 2017 World Health Organisation definition of MiNEN.Tumour responses to systemic treatment were assessed according to the Response Evaluation Criteria in Solid Tumours 1.1.Kaplan-Meier analysis was applied to estimate survival outcomes.Associations between clinical-pathological characteristics and survival outcomes were explored using Log-rank test for equality of survivors functions(univariate)and Cox-regression analysis(multivariable).RESULTS Sixty-nine consecutive patients identified;Median age at diagnosis:64 years.Males:63.8%.Localised disease(curable):53.6%.Commonest sites of origin:colon-rectum(43.5%)and oesophagus/oesophagogastric junction(15.9%).The neuroendocrine component was;predominant in 58.6%,poorly differentiated in 86.3%,and large cell in 81.25%,of cases analysed.Most distant metastases analysed(73.4%)were occupied only by a poorly differentiated neuroendocrine component.Ninety-four percent of patients with localised disease underwent curative surgery;53%also received perioperative treatment,most often in line with protocols for adenocarcinomas from the same sites of origin.Chemotherapy was offered to most patients(68.1%)with advanced disease,and followed protocols for pure neuroendocrine carcinomas or adenocarcinomas in equal proportion.In localised cases,median recurrence free survival(RFS);14.0 months(95%CI:9.2-24.4),and median overall survival(OS):28.6 months(95%CI:18.3-41.1).On univariate analysis,receipt of perioperative treatment(vs surgery alone)did not improve RFS(P=0.375),or OS(P=0.240).In advanced cases,median progression free survival(PFS);5.6 months(95%CI:4.4-7.4),and median OS;9.0 months(95%CI:5.2-13.4).On univariate analysis,receipt of palliative active treatment(vs best supportive care)prolonged PFS and OS(both,P<0.001).CONCLUSION MiNEN is most commonly driven by a poorly differentiated neuroendocrine component,and has poor prognosis.Advances in its biological understanding are needed to identify effective treatments and improve patient outcomes. | Melissa Frizziero Xin Wang Bipasha Chakrabarty Alexa Childs Tu V Luong Thomas Walter Mohid S Khan Meleri Morgan Adam Christian Mona Elshafie Tahir Shah Annamaria Minicozzi Wasat Mansoor Tim Meyer Angela Lamarca Richard A Hubner Juan W Valle Mairéad G McNamara | 2019 | World Journal of Gastroenterology2019，25，39： | 13 |
| 2 | Clinical significance of NOD2/CARD15 and Toll-like receptor 4 gene single nucleotide polymorphisms in inflammatory bowel disease显示文摘AIM: To evaluate the role of genetic factors in the pathogenesis of Crohn's disease (CD) and ulcerative colitis (UC), we investigated the single nucleotide poly- morphisms (SNPs) of NOD2/CARD15 (R702W, G908R and L1007fi nsC), and Toll-like receptor 4 (TLR4) genes (D299G and T399I) in a selected inflammatory bowel disease (IBD) population coming from Southern Italy. METHODS: Allele and genotype frequencies of NOD2/ CARD15 (R702W, G908R and L1007finsC) and TLR4 (D299G and T399I) SNPs were examined in 133 CD pa-tients, in 45 UC patients, and in 103 healthy controls. A genotype-phenotype correlation was performed. RESULTS: NOD2/CARD15 R702W mutation was sig-nificantly more frequent in CD (9.8%) than in controls (2.4%, P = 0.001) and in UC (2.3%, P = 0.03). No sig-nificant difference was found between UC patients and control group (P > 0.05). In CD and UC patients, no signifi cant association with G908R variant was found. L1007f insC SNP showed an association with CD (9.8%) compared with controls (2.9%, P = 0.002) and UC patients (2.3%, P = 0.01). Moreover, in CD patients, G908R and L1007finsC mutations were significantly associated with different phenotypes compared to CD wild-type patients. No association of IBD with the TLR4 SNPs was found in either cohort (allele frequencies: D299G-controls 3.9%, CD 3.7%, UC 3.4%, P > 0.05; T399I-controls 2.9%, CD 3.0%, UC 3.4%, P > 0.05). CONCLUSION: These findings confirm that, in our IBD patients selected from Southern Italy, the NOD2/ CARD15, but not TLR4 SNPs, are associated with in-creased risk of CD. | Luciana Rigoli Claudio Romano Rosario Alberto Caruso Maria A Lo Presti Chiara Di Bella Vincenzo Procopio Giuseppina Lo Giudice Maria Amorini Giuseppe Costantino Maria D Sergi Caterina Cuppari Giovanna Elisa Calabrò Romina Gallizzi Carmelo Damiano Salpietro Walter Fries | 2008 | World Journal of Gastroenterology2008，14，28： | 8 |
| 3 | Multi-element determination of Cu, Fe, Ni and Zn content in vegetable oils samples by high-resolution continuum source atomic absorption spectrometry and microemulsion sample preparation显示文摘 | Luana S. Nunes José T.P. Barbosa Andréa P. Fernandes Valfredo A. Lemos Walter N.L. dos Santos Maria Gra?as A. Korn Leonardo S.G. Teixeira | 2011 | Food Chemistry2011，，2： | 4 |
| 4 | 靶向uPAR的免疫毒素对人胶质母细胞瘤及其血管生成的影响(英文)显示文摘目的:观察靶向尿激酶型纤溶酶原激活物受体(uPAR)的免疫毒素DTAT和DTATEGF对人胶质母细胞瘤体外和祼小鼠脑内生长的影响。方法:MTT法检测靶向毒素DTAT,DTATEGF对体外培养的人胶质瘤U87-luc细胞系及人脐静脉细胞系(HUVEC)的增殖影响。建立祼小鼠脑内荧光素酶标记的人胶质母细胞瘤模型。加强对流给药(CED)方式瘤内泵入1μg的DTAT,DTATEGF或对照液,生物荧光显像(BLI)检测肿瘤生物荧光信号强度变化,免疫组织化学检测肿瘤微血管密度(MVD)。结果:体外实验显示DTAT和DTATEG高效抑制uPAR表达阳性的U87-luc和HUVEC细胞系增殖,DTATEGF和DTAT抑制U87-luc的IC50值分别<0.01 nmol/L和<1 nmol/L。裸小鼠肿瘤荧光信号检测显示两治疗组的信号强度较对照组增长缓慢,差异有统计学意义(P<0.05);DTATEGF和DTAT组肿瘤标本的MVD分别为(25.1±6.5)/mm2和(31.6±5.2)/mm2,明显少于对照组(51.3±7.4)/mm2(P<0.01)。结论:靶向uPAR的DTAT和DTATEGF能明显抑制胶质瘤U87-luc肿瘤细胞增殖,抑制祼小鼠脑内胶质瘤生长及其新生血管的形成。 | 黄军 袁盾 刘定阳 李坚 李岩 Walter A Hall 李波 | 2014 | 中南大学学报(医学版)2014，39，1： | 4 |
| 5 | 渗透泵强化对流释放给药治疗恶性脑胶质瘤的裸小鼠模型显示文摘目的探寻渗透泵强化对流释放给药治疗脑肿瘤的祼小鼠模型,为新药的临床前期应用提供良好的实验动物模型。方法 14只祼小鼠基底节区种植4×105个人胶质瘤U87细胞,并安置渗透泵强化对流释放给药系统。裸小鼠按体重和活体荧光信号强度分为二组:治疗组(n=7)的泵内注入100μl(1μg)的DTATEGF,对照组(n=7)泵内注入100μl(1μg)的无关毒素DT。观察动物的生长特征,Kaplan-Meier生存曲线分析和脑内肿瘤的病理学特征。结果实验动物没有与渗透泵及外科手术相关的病残和病死发生。动物对渗透泵给药系统耐受好,无抓搔及渗透泵脱位,伤口无感染及裂开等情况。Kaplan-Meier生存曲线显示治疗组动物的中位生存期较对照组明显延长,差异有显著性。(治疗组126天vs.对照组68天,P=0.0002)。治疗组中有两只小鼠生存期超过180天。病理学检测祼小鼠脑内种植生长的肿瘤与人类胶质母细胞瘤的病理特征极为相似。结论该祼小鼠实验动物模型简便、实用、可靠,适用于新的药物包括单克隆抗体、靶向小分子、肿瘤疫苗等通过强化对流投递治疗脑内恶性肿瘤的临床前期应用。 | 黄军 龙小艳 李波 Yan Michael Li Walter A Hall 刘定阳 刘庆 王君宇 袁贤瑞 | 2012 | 国际神经病学神经外科学杂志2012，39，4： | 3 |
| 6 | Recent development of process simulation for industrial application显示文摘 | Walters J Wu W T Arvind A | 2000 | Journal of Materials Processing Technology2000，98，： | 2 |
| 7 | CD4+ T cells and natural killer cells: Biomarkers for hepatic fibrosis in human immunodeficiency virus/hepatitis C virus-coinfected patients显示文摘AIM To characterize peripheral blood natural killer(NK) cells phenotypes by flow cytometry as potential biomarker of liver fibrosis in human immunodeficiency virus(HIV)/hepatitis C virus(HCV) coinfected patients.METHODS Peripheral mononuclear cells from 24 HIV/HCV(HBVnegative) coinfected and 5 HIV/HCV/HBV seronegative individuals were evaluated. HIV/HCV coinfected patients were divided in to groups: G1, patients with METAVIR F0-F2 and G2, patients with METAVIR F3-F4. NK surface cell staining was performed with: AntiCD3(APC/Cy7), anti-CD56(PE/Cy5), anti-CD57(APC), anti-CD25(PE), anti-CD69(FITC), anti-NKp30(PE), antiNKp46(PE/Cy7), anti-NKG2D(APC), anti-DNAM(FITC); anti-CD62L(PE/Cy7), anti-CCR7(PE), anti-TRAIL(PE), anti-Fas L(PE), anti CD94(FITC). Flow cytometry data acquisition was performed on BD FACSCanto, analyzed using Flow Jo software. Frequency of fluorescence was analyzed for all single markers. Clinical records were reviewed, and epidemiological and clinical data were obtained.RESULTS Samples from 11 patients were included in G1 and from 13 in G2. All patients were on ARV, with undetectable HIV viral load. Liver fibrosis was evaluated by transient elastography in 90% of the patients and with biopsy in 10% of the patients. Mean HCV viral load was(6.18 ± 0.7 log10). Even though, no major significant differences were observed between G1 and G2 regarding NK surface markers, it was found that patients with higher liver fibrosis presented statistically lower percentage of NK cells than individual with low to mild fibrosis and healthy controls(G2: 5.4% ± 2.3%, G1: 12.6% ± 8.2%, P = 0.002 and healthy controls 12.2% ± 2.7%, P = 0.008). It was also found that individuals with higher liver fibrosis presented lower CD4 LT count than those from G1(G2: 521 ± 312 cells/μL, G1: 770 ± 205 cells/μL; P = 0.035).CONCLUSION Higher levels of liver fibrosis were associated with lower percentage of NK cells and LTCD4+ count; and they may serve as noninvasive biomarkers of liver damage. | Natalia Laufer Diego Ojeda María Laura Polo Ana Martinez Héctor Pérez Gabriela Turk Pedro Cahn Norberto Walter Zwirner Jorge Quarleri | 2017 | World Journal of Hepatology2017，9，25： | 2 |
| 8 | Chronic antiepileptic drug use and functional network efficiency: A functional magnetic resonance imaging study显示文摘AIM To increase our insight in the neuronal mechanisms underlying cognitive side-effects of antiepileptic drug(AED) treatment.METHODS The relation between functional magnetic resonance-acquired brain network measures, AED use, and cognitive function was investigated. Three groups of patients with epilepsy with a different risk profile for developing cognitive side effects were included: A 'low risk' category(lamotrigine or levetiracetam, n=16), an 'intermediate risk' category(carbamazepine, oxcarbazepine, phenytoin, or valproate, n=34) and a 'high risk' category(topiramate, n=5). Brain connectivity was assessed using resting state functional magnetic resonance imaging and graph theoretical network analysis. The Computerized Visual Searching Task was used to measure central information processing speed, a common cognitive side effect of AED treatment. RESULTS Central information processing speed was lower in patients taking AEDs from the intermediate and high risk categories, compared with patients from the low risk category. The effect of risk category on global efficiency was significant(P < 0.05, ANCOVA), with a significantly higher global efficiency for patient from the low category compared with the high risk category(P < 0.05, post-hoc test). Risk category had no significant effect on the clustering coefficient(ANCOVA, P > 0.2). Also no significant associations between information processing speed and global efficiency or the clustering coefficient(linear regression analysis, P > 0.15) were observed. CONCLUSION Only the four patients taking topiramate show aberrant network measures, suggesting that alterations in functional brain network organization may be only subtle and measureable in patients with more severe cognitive side effects. | Tamar M van Veenendaal Dominique M IJff Albert P Aldenkamp Richard H C Lazeron Paul A M Hofman Anton J A de Louw Walter H Backes Jacobus F A Jansen | 2017 | World Journal of Radiology2017，9，6： | 2 |
| 9 | 脑肿瘤靶向毒素治疗的现状和展望显示文摘靶向毒素,亦称为免疫毒素或细胞毒素,是一种肿瘤细胞表面特异性抗原或受体相结合的细胞分子。如与EG-FR、IL-13受体等相结合的细胞分子,其毒素成份可杀死肿瘤细胞。目前研究的毒素多为以白喉毒素、假单胞杆菌外毒素等为母基合成的毒素。双重特异性靶向毒素能同时靶向肿瘤细胞和/或其新生血管上的两个过表达受体的毒素,如DTAT13靶向uPAR和IL-13受体,DTATEGF靶向EGFR和uPAR,其较单一靶向毒素具有更高的特异性和更强的毒性,同时免疫源性亦大为降低。寻找特异性的肿瘤细胞表面标志物、降低毒素的免疫源性及研究实体肿瘤毒素的投递方式是靶向毒素治疗脑肿瘤的研究方向。 | 黄军 Yan Michael Li Walter A Hall | 2011 | 国际神经病学神经外科学杂志2011，38，5： | 2 |
| 10 | Imaging of renal lesions: evaluation of fast MRI and helical CT显示文摘 | Walter C Kruessell M Gindele A | 2003 | Br J Radiol2003，76，910： | 2 |
| 11 | Prolactin production from proliferative phase leiomyoma显示文摘 | DALY D C WALTERS C A PRIOR J C | 1984 | Am J Obstet Gynecol1984，148，8： | 2 |
| 12 | Aberrant p53 protein expression is associated with an increased risk of neoplastic progression in patients with Barrett’s oesophagus显示文摘 | Florine Kastelein Katharina Biermann Ewout W Steyerberg Joanne Verheij Marit Kalisvaart Leendert H J Looijenga Hans A Stoop Laurens Walter Ernst J Kuipers Manon C W Spaander Marco J Bruno | 2013 | Gut2013，，12： | 2 |
| 13 | Solar cells based on CuIn(Se,S)2显示文摘 | WALTER T CONTENT A VELTHAUS K O | 1992 | Solar Energy Materials and Solar Cells1992，26，： | 1 |
| 14 | Childhood Allergic Rhinitis Predicts Asthma Incidence and Persistence to Middle Age: A Longitudinal Study显示文摘 | Burgess J A Walters E H Byrnes G B | 2007 | J Allergy Clin Immunol2007，120，4： | 1 |
| 15 | Association between glycemic state and lung function显示文摘 | Walter RE Beiser A Givelber RJ | 2003 | Am Respir Crit Care Med2003，167，： | 1 |
| 16 | Mercury speciation in fluorescent lamps by thermal release analysis显示文摘 | CLAUDIO R CLAUDIO C WALTER A D J | 2003 | Waste Management2003，23，10： | 1 |
| 17 | Interleukin- 6 in theinjured patient 显示文摘 | Emest E Frederick A | 1996 | AnnSurg1996，224，： | 1 |
| 18 | Nonlinear normal modes of buckled beams: three-to-one and one-to-one International resonance显示文摘 | Nayfeh A H Walter Lacarbonara Char-ming Chin | 1999 | Nonlinear Dynamics1999，18，： | 1 |
| 19 | Dynamic stress concentrations for an axially loaded strut at discontinuities due to an elliptical hole or double circular notches显示文摘 | WILLIAM A NADER Z WALTER N | 2004 | International Journal of Impact Engineering2004，30，3： | 1 |
| 20 | Fundamental photoelectrocatalytic and eleetrophoretic mobility studies of TiO2 and V-doped TiO2 thin- film electrode materials显示文摘 | Jeosadaque J S Walter A Z Marc A A | 2003 | Journal of Physical Chemistry B2003，107，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员