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| 1 | 硫胺素与甘草酸二铵治疗慢性乙型肝炎的临床疗效分析显示文摘观察硫胺素与甘草酸二铵治疗慢性乙型肝炎的临床疗效。在美国加州及大连分别对慢性乙型肝炎患者应用硫胺素和甘草酸二铵。甘草酸二铵组与甘草酸二铵 +硫胺素组肝功复常率两组间有显著差异 ;硫铵素组与上述两组比较肝功复常率明显降低 ,差异显著。硫铵素组连续用药 4 8周后 ,肝功复常率、血清HBVDNA、HBeAg阴转率与治疗第八周结束时各治疗组比较有显著差异。硫铵素可降低乙肝病毒含量 ,稳定肝脏内环境 。 | 李永新 高庆伟 Diana M Luan Amy E. Wallace 王英兰 | 2003 | 临床肝胆病杂志2003，19，4： | 12 |
| 2 | Software for automated classification of probe-based confocal laser endomicroscopy videos of colorectal polyps显示文摘AIM:To support probe-based confocal laser endomi-croscopy (pCLE) diagnosis by designing software for the automated classification of colonic polyps. METHODS:Intravenous fluorescein pCLE imaging of colorectal lesions was performed on patients under-going screening and surveillance colonoscopies, followed by polypectomies. All resected specimens were reviewed by a reference gastrointestinal pathologist blinded to pCLE information. Histopathology was used as the criterion standard for the differentiation between neoplastic and non-neoplastic lesions. The pCLE video sequences, recorded for each polyp, were analyzed off-line by 2 expert endoscopists who were blinded to the endoscopic characteristics and histopathology. These pCLE videos, along with their histopathology diagnosis, were used to train the automated classification software which is a content-based image retrieval technique followed by k-nearest neighbor classification. The performance of the off-line diagnosis of pCLE videos established by the 2 expert endoscopists was compared with that of automated pCLE software classification. All evaluations were performed using leave-one-patient- out cross-validation to avoid bias. RESULTS:Colorectal lesions (135) were imaged in 71 patients. Based on histopathology, 93 of these 135 lesions were neoplastic and 42 were non-neoplastic. The study found no statistical significance for the difference between the performance of automated pCLE software classification (accuracy 89.6%, sensitivity 92.5%, specificity 83.3%, using leave-one-patient-out cross-validation) and the performance of the off-line diagnosis of pCLE videos established by the 2 expert endoscopists (accuracy 89.6%, sensitivity 91.4%, specificity 85.7%). There was very low power (< 6%) to detect the observed differences. The 95% confidence intervals for equivalence testing were:-0.073 to 0.073 for accuracy, -0.068 to 0.089 for sensitivity and -0.18 to 0.13 for specificity. The classification software proposed in this study is not a 'black box' but an informative tool based on the query by example model that produces, as intermediate results, visually similar annotated videos that are directly interpretable by the endoscopist. CONCLUSION:The proposed software for automated classification of pCLE videos of colonic polyps achieves high performance, comparable to that of off-line diagnosis of pCLE videos established by expert endoscopists. | Barbara André Tom Vercauteren Anna M Buchner Murli Krishna Nicholas Ayache Michael B Wallace | 2012 | World Journal of Gastroenterology2012，18，39： | 5 |
| 3 | Total pancreatectomy: Short- and long-term outcomes at a high-volume pancreas center显示文摘AIM To identify the current indications and outcomes of total pancreatectomy at a high-volume center. METHODS A single institutional retrospective study of patients undergoing total pancreatectomy from 1995 to 2014 was performed.RESULTS One hundred and three patients underwent totalpancreatectomy for indications including: Pancreatic ductal adenocarcinoma(n = 42, 40.8%), intraductal papillary mucinous neoplasms(n = 40, 38.8%), chronic pancreatitis(n = 8, 7.8%), pancreatic neuroendocrine tumors(n = 7, 6.8%), and miscellaneous(n = 6, 5.8%). The mean age was 66.2 years, and 59(57.3%) were female. Twenty-four patients(23.3%) underwent a laparoscopic total pancreatectomy. Splenic preservation and portal vein resection and reconstruction were performed in 24(23.3%) and 18 patients(17.5%), respectively. The 90 d major complications, readmission, and mortality rates were 32%, 17.5%, and 6.8% respectively. The 1-, 3-, 5-, and 7-year survival for patients with benign indications were 84%, 82%, 79.5%, and 75.9%, and for malignant indications were 64%, 40.4%, 34.7% and 30.9%, respectively.CONCLUSION Total pancreatectomy, including laparoscopic total pancreatectomy, appears to be an appropriate option for selected patients when treated at a high-volume pancreatic center and through a multispecialty approach. | Hazem M Zakaria John A Stauffer Massimo Raimondo Timothy A Woodward Michael B Wallace Horacio J Asbun | 2016 | World Journal of Gastrointestinal Surgery2016，8，9： | 3 |
| 4 | Singular value decomposition of wintertimes sea surface temperature and 500-mb height anomalies 显示文摘 | Wallace J M Smith C Bretherton C S | 1992 | J Climate1992，5，3： | 2 |
| 5 | 显示文摘 | Wilk G D Wallace R M Anthony J M | 2001 | Journal of Applied Physics2001，89，10： | 2 |
| 6 | Superior mesenteric artery pseudoaneurysm following pancreaticoduodenectomy:management by endovascular stent-graft placement and transhiminal thromhin injection显示文摘 | Wallace M Choi E McRae S | 2007 | Cardiovasc Intervent Radiol2007，30，： | 1 |
| 7 | A thermodynamic bench-mark for assessing an emergency drinking water device based on forward osmosis显示文摘 | Wallace M Cui Z Hankins N | 2008 | Desalination2008，227，13： | 1 |
| 8 | Dimeric inhibins in amniotic fluid, maternal serum, and fetal serum in human pregnancy显示文摘 | Riley SC Crossley JA Ritoe SC Horne A Shade M Ellis PM Aitken DA Groome NP | 1997 | J Clin Endocrinol Metab1997，82，1： | 1 |
| 9 | Origin and evolution of a submarine large igneous province: The Kerguelen plateau and Broken ridge, southem Indian ocean显示文摘 | Frey F A Coffin M F Wallace P J | 2000 | Earth and Planetary Science Letters2000，176，： | 1 |
| 10 | Role of angiography following aneurysm surgery显示文摘 | MACDONALD R L WALLACE M C KESTLE J R | 1993 | J Neurosurg1993，79，： | 1 |
| 11 | Nosocomial bloodstream infections in United States hospitals: a three-year analysis显示文摘 | EDMOND M B WALLACE S E MCCLISH D K | 1999 | Clin Infect1999，29，23： | 1 |
| 12 | Board-invited review:intrauterine growth retardation:implications for the animalsciences显示文摘 | Wu G Bazer F W Wallace J M | 2006 | J Anim Sci2006，84，9： | 1 |
| 13 | Hypoxia-induc- ible factor-l-dependent regulation of the multidrug resistance ( MDR1 ) gene显示文摘 | Comerford K M Wallace T J Karhausen J | 2002 | Cancer Res2002，1562，12： | 1 |
| 14 | Regional climate impacts of the Northern Hemisphere annular mode显示文摘 | Thompson D W J Wallace J M | 2001 | Science2001，29，3： | 1 |
| 15 | Mitochondrial mutations in cancer显示文摘 | Brandon M Baldi P Wallace DC | 2006 | Oncogene2006，25，34： | 1 |
| 16 | Invasive mediastinal staging of lung cancer: ACCP evidence-based clinical practice guidelines (2rid edition) 显示文摘 | Detterbeck FC Jantz MA Wallace M | 2007 | Chest2007，132，3： | 1 |
| 17 | Enhanced detection of nanostructures by scanning electron microscopy using insulating materials显示文摘 | O'Shea A Wallace J Hummel M | 2013 | Micron2013，5253，8： | 1 |
| 18 | Mitochondrially mediated synergistic cell killing by bile acids显示文摘 | Anabela P Rolo Carlos M Palmeira Kendall B Wallace | 2002 | BBA - Molecular Basis of Disease2002，，1： | 1 |
| 19 | How software project risk affects project performance: An investigation of the di- mensions of risk and an exploratory model显示文摘 | Wallace L Keil M Rai A | 2004 | Decision Sciences2004，35，2： | 1 |
| 20 | Hydrogen sulfide-based therapeutics and gastrointestinal diseases : translating physiology to treatments显示文摘 | Chan M V Wallace J L | 2013 | Am J Physial Gastrointest Liver Physiol2013，305，7： | 1 |
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