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| 1 | Factors associated with incomplete small bowel capsule endoscopy studies显示文摘AIM:To identify patient risk factors associated with incomplete small bowel capsule endoscopy(CE) studies.METHODS:Data from all CE procedures performed at St.Paul's Hospital in Vancouver,British Columbia,Canada,between December 2001 and June 2008 were collected and analyzed on a retrospective basis.Data collection for complete and incomplete CE study groups included patient demographics as well as a number of potential risk factors for incomplete CE including indication for the procedure,hospitalization,diabetes mellitus with or without end organ damage,limitations in mobility,renal insufficiency,past history of bowel obstruction,abdominal surgery,abdominal radiation therapy and opiate use.Risk factors were analyzed using a univariable and multivariable logistic regression model.RESULTS:From a total of 535 CE procedures performed,158 were incomplete(29.5%).The univariable analysis showed that CE procedures performed for overt gastrointestinal bleeding(P = 0.002),and for patients with a prior history of abdominal surgery(P = 0.023) or bowel obstruction(P = 0.023) were significantly associated with incomplete CE studies.Patients on opiate medications(P = 0.094) as well as hospitalized patients(P = 0.054) were not statistically significant,but did show a trend towards incomplete CE.The multivariable analysis showed that independent risk factors for an incomplete CE procedure include prior history of bowel obstruction [odds ratios(OR) 2.77,P = 0.02,95% confidence intervals(CI):1.17-6.56] and procedures performed for gastrointestinal bleeding(Occult OR 2.04,P = 0.037,95% CI:1.04-4.02 and Overt OR 2.69,P = 0.002,95% CI:1.44-5.05).Patients with a prior history of abdominal surgery(OR 1.46,P = 0.068,95% CI:0.97-2.19),those taking opiate medications(OR 1.54,P = 0.15,95% CI:0.86-2.76) and hospitalized patients(OR 1.82,P = 0.124,95% CI:0.85-3.93) showed a trend towards statistical significance.CONCLUSION:We have identified a number of risk factors for incomplete CE procedures that can be used to risk-stratify patients and guide interventions to improve completion rates. | Mitchell M Lee Andrew Jacques Eric Lam Ricky Kwok Pardis Lakzadeh Ajit Sandhar Brandon Segal Sigrid Svarta Joanna Law Robert Enns | 2010 | World Journal of Gastroenterology2010，16，42： | 10 |
| 2 | Immunity Genes and Susceptibility to Otitis Media:A Comprehensive Review显示文摘Otitis media(OM) is a middle ear infection associated with inflammation and pain.This disease frequently afflicts humans and is the major cause of hearing loss worldwide.OM continues to be one of the most challenging diseases in the medical field due to its diverse host targets and wide range of clinical manifestations.Substantial morbidity associated with OM is further exacerbated by high frequency of recurrent infections leading to chronic suppurative otitis media(CSOM).Children have greater susceptibility to,and thus,suffer most frequently from OM,which can cause significant deterioration in quality of life.Genetic factors have been demonstrated,in large part by twin and family studies,to be key determinants of OM susceptibility.In this review,we summarize the current knowledge on immunity genes and selected variants that have been associated with predisposition to OM.In particular,polymorphisms in innate immunity and cytokine genes have been strongly linked with the risk of developing OM.Future studies employing state-of-the-art technologies,including next-generation sequencing(NGS),will aid in the identification of novel genes associated with susceptibility to OM.This,in turn,will open up avenues for identifying high-risk individuals and designing novel therapeutic strategies based on precise targeting of these genes. | Rahul Mittal Giannina Robalino Robert Gerring Brandon Chan Denise Yan M'hamed Grati Xue-Zhong Liu | 2014 | Journal of Genetics and Genomics2014，41，11： | 5 |
| 3 | Clinical classification of symptomatic heterotopic pancreas of the stomach and duodenum:A case series and systematic literature review显示文摘BACKGROUND Heterotopic pancreas(HP)is an aberrant anatomic malformation that occurs most commonly in the upper gastrointestinal tract.While the majority of heterotopic pancreatic lesions are asymptomatic,many manifest severe clinical symptoms which require surgical or endoscopic intervention.Understanding of the clinical manifestations and symptoms of HP is limited due to the lack of large volume studies in the literature.The purpose of this study is to review symptomatic cases at a single center and compare these to a systematic review of the literature in order to characterize common clinical manifestations and treatment of this disease.AIM To classify the common clinical manifestations of heterotopic pancreas.METHODS A retrospective review was conducted of pathologic samples containing heterotopic pancreas from 2000-2018.Review was limited to HP of the upper gastrointestinal tract due to the frequency of presentation in this location.Symptomatic patients were identified from review of the medical records and clinical symptoms were tabulated.These were compared to a systematic review of the literature utilizing Pub Med and Embase searches for papers pertaining to heterotopic pancreas.Publications describing symptomatic presentation of HP were selected for review.Information including demographics,symptoms,presentation and treatment were compiled and analyzed.RESULTS Twenty-nine patient were identified with HP at a single center,with six of these identified has having clinical symptoms.Clinical manifestations included,gastrointestinal bleeding,gastric ulceration with/without perforation,pancreatitis,and gastric outlet obstruction.Systemic review of the literature yielded 232 publications detailing symptomatic cases with only 20 studies describing ten or more patients.Single and multi-patient studies were combined to form a cohort of 934 symptomatic patients.The majority of patients presented with abdominal pain(67%)combined with one of the following clinical categories:(1)Dyspepsia,(n=445,48%);(2)Pancreatitis(n=260,28%);(3)Gastrointestinal bleeding(n=80,9%);and(4)Gastric outlet obstruction(n=80,9%).The majority of cases(n=832,90%)underwent surgical or endoscopic resection with 85%reporting resolution or improvement in their symptoms.CONCLUSION Heterotopic pancreas can cause significant clinical symptoms in the upper gastrointestinal tract.Better understanding and classification of this disease may result in more accurate identification and treatment of this malformation. | Michael T Le Compte Brandon Mason Keenan J Robbins Motoyo Yano Deyali Chatterjee Ryan C Fields Steven M Strasberg William G Hawkins | 2022 | World Journal of Gastroenterology2022，28，14： | 3 |
| 4 | SOFC technology development at Rolls-Royce显示文摘 | Gardner F J Day M J Brandon N P | 2000 | J Power Sources2000，86，： | 2 |
| 5 | Hydrocompression settlement of deep fills 显示文摘 | Brandon T L Duncan J M Gardner W S | 1990 | ASCE Journal of Geotech Eng1990，116，10： | 1 |
| 6 | Re-Os isotopic systematics of primitive lavas from the Lassen region of the Cascade Arc,California显示文摘 | Brandon A D Clynne M A | 2000 | Earth and Planetary Science Letters2000，177，34： | 1 |
| 7 | The Impact of Auditor Tenure on Initial Bond Ratings 显示文摘 | Aaron D Crabtree Duane M Brandon John J Maher | 2006 | Advances in Accounting2006，22，6： | 1 |
| 8 | A neural networks of carrot tip classification显示文摘 | Brandon J R Howarth M S Searcy S W | 1990 | Trans of the ASAE1990，，： | 1 |
| 9 | Probability Density Plot for Fission-Track Gra-in Age Samples显示文摘 | Brandon M T | 1996 | Radiation Measurements1996，26，5： | 1 |
| 10 | 显示文摘 | Hart N Brandon N Day M | 2002 | J Power Sources2002，106，： | 1 |
| 11 | Mitochondrial mutations in cancer显示文摘 | Brandon M Baldi P Wallace DC | 2006 | Oncogene2006，25，34： | 1 |
| 12 | Consumer product in vitro digestion model: Bioaccessibility of contaminants and its application in risk assessment显示文摘 | BRANDON E F A OOMEN A G ROMPELBERG C J M | 2006 | Regulatory Toxicology and Pharmacology2006，44，： | 1 |
| 13 | Striatal delivery of neurturin by CERE-120, an AAV2 vector for the treatment of dopaminergic neuron degeneration in Parkinson's disease 显示文摘 | Gasmi M Herzog CD Brandon EP | 2007 | Mol Ther2007，15，1： | 1 |
| 14 | On steady states in mountain belts 显示文摘 | Willett S D Brandon M T | 2002 | Geology2002，30，2： | 1 |
| 15 | The direct electro- winning of gold from dilute cyanide leach liquors 显示文摘 | Brandon N P Mahmood M N Page P W | 1987 | Hydrometal- lurgy1987，18，3： | 1 |
| 16 | Leucocyte distribution in the uterus during the preimplantation period of pregancy and phagocyte recruitment to sites of blasto cyst attachment in mice 显示文摘 | | 1993 | J Reprod Fertil1993，98，2： | 1 |
| 17 | Com- bining trail with PI3 kinase or HSP90 inhibitors enhances apoptosis in colorectal cancer ceils via suppression of sur- vival signaling 显示文摘 | Saturno G Valenti M De Haven Brandon A | 2013 | Oncotarget2013，4，8： | 1 |
| 18 | Spartacas: automating component reuse and adaptation显示文摘 | BRANDON M PERRY A | 2004 | IEEE Trans on Software Engineering2004，30，9： | 1 |
| 19 | Antimalarial quinolines and artemisinin inhibit endocytosis in plasmodium falciparum显示文摘 | Heinrich C Donelly A Ursula M Sandra A Joanne E Brandon W | 2004 | Antimicro Agents Chemother2004，48，： | 1 |
| 20 | Preterm infants born at less than 31 weeks' gestation have improved growth in cycled light compared with continuous near darkness 显示文摘 | Brandon D H Holditch D D Belyea M | 2002 | J Pediatr2002，140，： | 1 |
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