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| 1 | Krüppel-like factors 4 and 5:the yin and yang regulators of cellular proliferation显示文摘Krüppel-like factors (KLFs) are evolutionarily conserved zinc finger-containing transcription factors with diverseregulatory functions in cell growth, proliferation, differentiation, and embryogenesis. KLF4 and KLF5 are two closelyrelated members of the KLF family that have a similar tissue distribution in embryos and adults. However, the two KLFsoften exhibit opposite effects on regulation of gene transcription, despite binding to similar, if not identical, cis-actingDNA sequences. In addition, KLF4 and 5 exert contrasting effects on cell proliferation in many instances; while KLF4is an inhibitor of cell growth, KLF5 stimulates proliferation. Here we review the biological properties and biochemicalmechanisms of action of the two KLFs in the context of growth regulation. | Amr M.GHALEB Mandayam O.NANDAN Sengthong CHANCHEVALAP W.Brian DALTON Irfan M.HISAMUDDIN Vincent W.YANG | 2005 | Cell Research2005，15，2： | 21 |
| 2 | Effect of Y content and equal channel angular pressing on the microstructure, texture and mechanical property of extruded Mg-Y alloys显示文摘The microstructure, texture and mechanical property evolution of the extruded Mg-x Y(x = 1, 5 wt.%) alloys during equal channel angular pressing(ECAP) were systematically investigated using an optical microscope, electron backscatter diffraction(EBSD) and uniaxial tensile test. The Mg-Y alloys exhibited a weakened basal texture before the ECAP, and the texture was further weakened with the max basal poles dispersed along ~45° between the extrusion direction and the transverse direction after the ECAP. The Mg-5 Y alloys always exhibited a finer grain size comparing to that of Mg-1 Y for the same ECAP process. With a proper ECAP process, both the strength and elongation of Mg-5 Y alloy could be improved simultaneously after the ECAP, i.e., the yield strength(273.9 ± 1.2 MPa), ultimate strength(306.4 ± 3.0 MPa),and elongation(23.9 ± 1.0%) were increased by 10%, 6%, and 72%, respectively, comparing to that before the ECAP. This was considered to be arose from the combined effects of grain refinement, significant improved microstructure homogeneity and solid solution hardening.In addition, it was found that Mg-Y alloy with better comprehensive properties could be obtained by the decreasing-temperature ECAP processes. The yield strength-grain size relationship could be well described by the Hall-Petch relation for all the ECAPed Mg-Y alloys,which was consistent with that the texture changes did not significantly affect the average Schmid factors of basal, prismatic and pyramidal slips for both Mg-Y alloys. | W.Yang G.F.Quan B.Ji Y.F.Wan H.Zhou J.Zheng D.D.Yin | 2022 | Journal of Magnesium and Alloys2022，10，1： | 6 |
| 3 | Effects of Y content and temperature on the damping capacity of extruded Mg-Y sheets显示文摘The damping behavior of extruded Mg-xY(x=0.5,1.0,3.0 wt.%)sheets were investigated in detail concerning the effects of Y addition and temperature,and the relationship between damping capacity and yield strength was discussed.At room temperature(RT),with Y content increasing from 0.5%to 3.0%,the damping capacity(Q-1)significantly decreased from 0.037 to 0.015.For all the studied sheets,the relationship between strain amplitude and Q-1 fitted well with the Granato and Liicke(G-L)dislocation damping model.With temperature increased,the G-L plots deviated from linearity indicating that the dislocation damping was not the only dominate mechanism,and the grain boundary sliding(GBS)could contribute to damping capacity.Consequently,the Q-1 increased remarkably above the critical temperature,and the critical temperature increased significantly from 50℃ to 290℃ with increasing Y contents from 0 to 3.0wt.%.This result implied that the segregation of Y solutes at grain boundary could depress the GBS,which was consistent with the recent finding of segregation tendency for rare-earth solutes.The extruded Mg-IY sheet exhibited slightly higher yield strength(Rp0.2)and Q-1 comparing with high-damping Mg-0.6Zr at RT.At an elevated temperature of 325℃,the Mg-IY sheet had similar Q-1 but over 3 times larger Rp0.2 than that of the pure Mg.The present study indicated that the extruded Mg-Y based alloys exhibited promising potential for developing high-performance damping alloys,especially for the elevated-temperature application. | Y.T.Tang C.Zhang L.B.Ren W.Yang D.D.Yin G.H.Huang H.Zhou Y.B.Zhang | 2019 | Journal of Magnesium and Alloys2019，7，3： | 5 |
| 4 | Dynamics of hairpin vortices generated by a mixing tab in a channel flow显示文摘 | W.Yang H.Meng J.Sheng | | 0，，： | 1 |
| 5 | The structure of SiC‐reinforced Mg casting alloys显示文摘 | W.Yang G. C.Weatherly D. W.McComb D. J.Lloyd | 2003 | Journal of Microscopy2003，，2： | 1 |
| 6 | Efficient Synthesis of 2-Aryl-6-chloronicotinamides via PXPd2-Catalyzed Regioselective Suzuki Coupling显示文摘 | W.Yang Y.Wang J.R.Corte | | 0，，17： | 1 |
| 7 | Single‐Crystal SiC Nanowires with a Thin Carbon Coating for Stronger and Tougher Ceramic Composites显示文摘 | W.Yang H.Araki C.Tang S.Thaveethavorn A.Kohyama H.Suzuki T.Noda | 2005 | Adv. Mater2005，，12： | 1 |
| 8 | Multiple time step molecular dynamics simulation for interaction between dislocations and grain boundaries显示文摘A multiple time step algorithm, called reversible reference system propagator algorithm, is introduced for thelong time molecular dynamics simulation. In contrast to the conventional algorithms, the multiple time method has better convergence, stability and efficiency. The method is validated by simulating free relaxation and the hypervelocity impact of nano-clusters. The time efficiency of the multiple time step method enables us to investigate the long time interaction between lattice dislocations and low-angle grain boundaries. | X.Y.Li W.Yang Department of Engineering Mechanics,Tsinghua University,Beijing 100084.China | 2005 | Acta Mechanica Sinica2005，21，4： | 1 |
| 9 | Mammalian krüppel-like factors in health and diseases显示文摘 | Beth B.McConnell Vincent W.Yang | | 0，，04： | 1 |
| 10 | The development of bladder tumors and contralateral upper urinary tract tumors after primary transitional cell carcinoma of the upper urinary tract显示文摘 | Chih‐HsiungKang Tsan‐JungYu Hwei‐HoHsieh Joseph W.Yang KennethShu Chao‐ChengHuang Po‐HuangChiang Yow‐LingShiue | 2003 | Cancer2003，，： | 1 |
| 11 | Characterization of rumen bacterial diversity and fermentation parameters in concentrate fed cattle with and without forage显示文摘 | R.M.Petri R.J.Forster W.Yang J.J.McKinnon T.A.McAllister | 2012 | Journal of Applied Microbiology2012，，6： | 1 |
| 12 | Phase fragility and mechatronic reliability for Pb(Mg_(1/3)Nb_(2/3))O_(3)-PbTiO_(3) ferroelectric single crystals-A review显示文摘Single crystals of(1x) Pb(Mg_(1/3)Nb_(2/3))O_(3)-PbTiO_(3)(PMN-xPT)near their morphotropic phase boundaries(MPBs)are under extensive investigations for their extraordinary high dielectric and piezoelectric behavior.Applications of those single crystals facilitated the breakthrough in ultrasonic transducer materials and devices.Ferroelectric materials are known to be fragile which often leads to various reliability failures in applications involving electric loadings.In a mechanical sense,the failure modes concern the fracture under an intensive electric field,and the fatigue crack propagation under an alternating electric field.In an electrical sense,the failure is exhibited by degenerated hysteresis loop by shrinking the remnant polarization and expanding the coercive field.All these modes degrade the performance for ferroelectric devices.As a departure from the tetragonal TÞferroelectric materials,exemplified by BaTiO_(3) and Pb(ZrTi)O_(3),the domain structures of PMN-PT around the MPB are versatile and intricate,depending sensitively on the composition variation,orientation and previous loading history.In this review,the attention is mainly focused on three aspects.First,the phase fragility and multiphase coexistence are presented for both[100]-and[101]-oriented PMN-PT single crystals.Second,investigations on electric field-induced fatigue crack propagation are described,along with the orientation effect on the crack propagation behavior.Third,the inverse effects of the phase transition and fatigue crack growth on the polarization behavior,or the interaction between the mechanical and electrical degradations will be elucidated.The review aims for better understanding the underlying mechanism for the ultrahigh performance of the PMN-PT single crystals,to bridge the studies of ferroelectric materials from the mechanical and electrical senses,as well as to evaluate the reliability of PMN-PT single crystals under device applications. | F.Fang W.Yang | 2014 | Journal of Advanced Dielectrics2014，4，1： | 0 |
| 13 | The inositol metabolism pathway as a target for neuroprotective strategies显示文摘Neurodegeneration is characterized by the progressive and permanent loss of neurons.Degeneration typically results in a debilitating loss of function in an otherwise healthy person.Neurodegenerative diseases have enormous direct health care costs,with some estimates for diseases,such as Alzheimer’s disease exceeding$36。 | Arne M.Nystuen Andy W.Yang | 2015 | Neural Regeneration Research2015，10，12： | 0 |
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