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1篇 您的检索式：作者名="W.Brian DALTON"

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		题名	作者	年代	出处	被引量
	1	Krüppel-like factors 4 and 5:the yin and yang regulators of cellular proliferation显示文摘Krüppel-like factors (KLFs) are evolutionarily conserved zinc finger-containing transcription factors with diverseregulatory functions in cell growth, proliferation, differentiation, and embryogenesis. KLF4 and KLF5 are two closelyrelated members of the KLF family that have a similar tissue distribution in embryos and adults. However, the two KLFsoften exhibit opposite effects on regulation of gene transcription, despite binding to similar, if not identical, cis-actingDNA sequences. In addition, KLF4 and 5 exert contrasting effects on cell proliferation in many instances; while KLF4is an inhibitor of cell growth, KLF5 stimulates proliferation. Here we review the biological properties and biochemicalmechanisms of action of the two KLFs in the context of growth regulation.	Amr M.GHALEB Mandayam O.NANDAN Sengthong CHANCHEVALAP W.Brian DALTON Irfan M.HISAMUDDIN Vincent W.YANG	2005	Cell Research2005，15，2：	21

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