|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Clinicopathological and prognostic implications of endoglin (CD105) expression in hepatocellular carcinoma and its adjacent non-tumorous liver显示文摘AIM: The expression pattern of endoglin (CD105) in hepatocellular carcinoma (HCC) has not been reported so far. We hypothesized that CD105 could differentially highlight a subset of microvessels in HCC, and intratumoral microvessel density (IMVD) by CD105 immunostaining (IMVD-CD105) could provide better prognostic information than IMVD by CD34 immunostaining (IMVD-CD34).METHODS: Paraffin blocks of tumor and adjacent nontumorous liver tissues from 86 patients who underwent curative resection of HCC were used for this study. Serial sections were stained for CD105 and CD34, respectively,to highlight the microvessels. IMVD was counted according to a standard protocol.RESULTS: In the HCC tissues, CD105 was either negatively or positively stained only in a subset of microvessels. In contrast, CD34 showed positive and more extensive microvessel staining in all cases examined. However, in the adjacent non-tumorous liver sections, CD105 showed a diffuse pattern of microvessel staining in 20 of 86 cases,while CD34 showed negative or only focal staining of the sinusoids around portal area. Correlation with clinicopathological data demonstrated that lower scores of IMVD-CD105 were found in larger sized tumors [mean 41.4/0.74 mm2 (>5 cm tumor) vs 65.9/0.74 mm2(≤ 5 cm tumor), P = 0.043] and more aggressive tumors,as indicated by venous infiltration [36.8/0.74 mm2 (present)vs 64.2/0.74 mm2 (absent), P = 0.020], microsatellite nodules [35.1/0.74 mm2 (present) vs 65.9/0.74 mm2(absent), P = 0.012], and advanced TNM tumor stage [38.8/0.74 mm2 (stage 3 or 4) vs 68.3/0.74 mm2 (stage 1or 2), P = 0.014]. No prognostic significance was observed when median values were used as cut-off points using either IMVD-CD105 or IMVD-CD34. However, the presence of the diffuse pattern of CD105 expression in the adjacent non-tumorous liver tissues predicted a poorer disease-free survival (median 8.6 vs 21.5 mo, P = 0.026).CONCLUSION: Our data demonstrate that a lower IMVDCD105 is associated with larger and more aggressive tumors. In this study, IMVD-CD105 did not provide significant prognostic information. However, active angiogenesis as highlighted by diffuse CD105 staining of the microvessels in the adjacent non-tumorous liver tissues is predictive of early recurrence. | Joanna W.Ho Ronnie T.Poon Chris K.Sun Sheung-Tat Fan | 2005 | World Journal of Gastroenterology2005，11，2： | 16 |
| 2 | Dynamic idle mode procedures for femtocells显示文摘 | HolgerClaussen ImranAshraf Lester T. W.Ho | 2010 | Bell Labs Tech J2010，，2： | 1 |
| 3 | Prevalence and predictors of renal artery stenosis in Chinese patients with coronary artery disease显示文摘 | Y.Wang D. S. W.Ho W. H.Chen Y. Q.Wang W. F.Lam Z. J.Shen C. Z.Lu M.Chui | 2003 | Internal Medicine Journal2003，，7： | 1 |
| 4 | Phylogeographical analyses of domestic and wild yaks based on mitochondrial DNA: new data and reappraisal显示文摘 | ZhaofengWang XinShen BinLiu JianpingSu TakahiroYonezawa YunYu SongchangGuo Simon Y. W.Ho CarlesVilà MasamiHasegawa JianquanLiu | 2010 | Journal of Biogeography2010，，12： | 1 |
| 5 | Phylogeographical analyses of domestic and wild yaks based on mitochondrial DNA: new data and reappraisal显示文摘 | ZhaofengWang XinShen BinLiu JianpingSu TakahiroYonezawa YunYu SongchangGuo Simon Y. W.Ho CarlesVilà MasamiHasegawa JianquanLiu | 2010 | Journal of Biogeography2010，，12： | 1 |
| 6 | 出租车:不仅仅是一部电影显示文摘《出租车》是伊朗导演贾法·帕纳西在2015年执导并主演的一部电影。这部电影记录了一辆黄色出租车行驶在德黑兰大街上,各种各样乘客上车下车的遭遇以及与司机的谈话,这个司机就是贾法·帕纳西本人。这个电影是导演前几部作品的连接和延续,也是媒介传播层面再创造的一部电影。所有在媒介层面的传播和对它进行的新一轮的创造,最终又回到了诞生这个电影的地方——伊朗, | 刘伟伟 Elaine W.Ho | 2016 | 艺术界2016，0，4： | 0 |
| 7 | 香港水墨:浮动身份的探索显示文摘随着水墨艺术在中外艺坛备受瞩目,有关水墨的论述通过艺评、展览、市场等平台渐渐建构了相关的概念和定义。综观现有的论述,往往以水墨象征中国性,并设20世纪80年代为当代水墨艺术的开端,地理上着眼于中国大陆,而对于香港及台湾艺坛在水墨领域的贡献,着墨甚少1。香港的文化定位常常被形容为“浮动的身份”,交织在殖民主义、民族主义及资本主义之中。本文意图追索当代水墨艺术在香港的发展,探索水墨与香港文化身份之间微妙的关系,从而了解香港水墨在水墨论述中应占有的重要位置。 | 陈蓓 Elaine W.Ho | 2016 | 艺术界2016，0，5： | 0 |
| 8 | Roles of macrophages in tumor development: a spatiotemporalperspective显示文摘Macrophages are critical regulators of tissue homeostasis but are also abundant in the tumor microenvironment (TME). In bothprimary tumors and metastases, such tumor-associated macrophages (TAMs) seem to support tumor development. While we knowthat TAMs are the dominant immune cells in the TME, their vast heterogeneity and associated functions are only just beingunraveled. In this review, we outline the various known TAM populations found thus far and delineate their specialized rolesassociated with the main stages of cancer progression. We discuss how macrophages may prime the premetastatic niche to enablethe growth of a metastasis and then how subsequent metastasis-associated macrophages can support secondary tumor growth.Finally, we speculate on the challenges that remain to be overcome in TAM research. | Mathilde Bied William W.Ho Florent Ginhoux Camille Blériot | 2023 | Cellular & Molecular Immunology2023，20，9： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员