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| 1 | Experimental Podophyllotoxin (Bajiaolian) Poisoning:——Ⅰ. Effects on the Nervous System显示文摘Bajiaolian,one of the species in the Mayapple family(Podophyllum pelatum),has been widely used as t traditional Chinese herbal medicine for the remedies of snake bites,general weakness,poisons,condyloma accuminata,lymphadenopathy,and certain tumors in China.In Western medicine,Podophyllum was first used medically as a laxative in the early 19th century.Since 1940,the resin of podophyllum has also been used topically for various skin lesions such as warts and condyloma.Human poisonings have been reported.An animal model was established to investigate the neurotoxic effects of Bajiaolian,Podophyllotoxin,the major active ingredient in Podophyllum,was injected(ip)to young adult male rats at doses of ,0,5,10,or 15mg·kg^-1.b.w.The animalw were sacrificed 72h after injection.Neuronal changes were readily observable in animals treeated with 10 or 15mg·kg^-1 of the toxin,Edematous changes of the angerior horn motoneurons were observed in the spinal cord. No neuronal necrosis ws foun.The type of neuronal swelling is believed to be only a transient change and would probably subside with time if no further assaults coccr,More serious and perhaps longer term of changes were found in the dorsal ganglion neurons and the nerve fibers(axons)in the central and peripheral nervous system.Severe depletion of the Nissl substance(RNA/polyribosomes)was observed in the dorsal root ganglion neurons.Alterations in these sensory neurons would give rise to and correlate with the sensory disturbances experienced by th patients.Bodian staining also revealed a dose-related increase in the coarseness(thickness)of the nerve fibers(axons)in the cerebellum,cerebral cortex,brainstem,and spinal cord.This is the first scientific study showing the neurotoxicity of Bajiaolian,a commonly used Chinese herbal medicine.Toxiciities on other organ systems by this drug certainly exist.Caution should be exercised in the dispensing and usage of this medicine. | LOUIS W.CHANG C.M.YANG C.F.CHEN J.F.DENG | 1992 | Biomedical and Environmental Sciences1992，5，4： | 7 |
| 2 | 查看详情显示文摘 | W.J.Kim W.Chang S.B.Qadri H.D.Wu J.M.Pond S.W.Kirchoefer H.S.Newman D.B.Chrisey and J.S.Horwitz | | 0，，： | 1 |
| 3 | Safety and efficacy of two‐step peginterferon α‐2a treatment in patients of chronic hepatitis B with acute exacerbation显示文摘 | C.‐C.Chen P.‐C.Wang H.‐W.Chang C.‐F.Chen | 2012 | Journal of Viral Hepatitis2012，，3： | 1 |
| 4 | Introduction显示文摘Over the past 30 years ,there has been a general change of emphasis in toxicology from the traditional concerns with poisons and antidotes to understanding the chronic toxic effects associated with exposure to environmental agents.The major cause of this shift was a focusing of public interest on long-term health effects of man-made chemicals.This public awareness was motivated in part by the successes of public health sanitarians in controlling infectious diseases (with the recent exception of AIDS),which resulted in the lengthening oflife expectancy in the population(Hart and Turturro,1990).This change in emphasis has radically altered the scientific methods used in toxicology.There are basic differences in evaluating short-term and long-term consequences of toxic exposure.Interestingly,techniques similar to those used to understand the effects of long-term toxicity are also useful in understanding aging (Hart and Turturro,1998).Factors that contribute to these differences include the complexity of the endpoint being evaluated,the duration of the study,and economic considerations.Thus,questions that are most significant for human health and of current interest (e,g,the effects of long-term human response to low doses of an agent,quantitative assessment of human exposure,the effectiveness of control measures,etc)are only addressable by emerging techniques that emphasize the need to assess early events in one toxicological process. | RONALD W.HART LOUIS W.CHANG ANGELO TURTURRO FRED F.KADLUBAR | 1991 | Biomedical and Environmental Sciences1991，4，1： | 1 |
| 5 | Lethal cytomegalovirus ischemic colitis presenting with fever of unknown origin显示文摘 | C.‐J.Lee J.‐D.Lian S.‐W.Chang M.‐C.Chou Y.‐S.Tyan L.‐C.Wong H.‐R.Chang | 2004 | Transplant Infectious Disease2004，，3： | 1 |
| 6 | 要如何去那里?显示文摘找找看!
立陶小镇离这里有多远? | Linda W.Chang 吴国安(译) | 2011 | 空中英语教室(初级版.大家说英语)2011，，3： | 0 |
| 7 | 四处旅行显示文摘找找看!
琴恩在读什么? | Linda W.Chang 吴国安(译) | 2011 | 空中英语教室(初级版.大家说英语)2011，，3： | 0 |
| 8 | 搭乘大众交通工具显示文摘找找看!
杰克很希望什么事? | Linda W.Chang 吴国安(译) | 2011 | 空中英语教室(初级版.大家说英语)2011，，3： | 0 |
| 9 | Supraclavicular lymph node transplant:a focus on technique显示文摘Physiologic surgical options,including vascularized lymph node transplant and lymphovenous bypass are becoming increasingly popular interventions for the treatment of lymphedema of both the upper and lower extremities.Many different lymph node donor sites have been described,including submental,lateral thoracic,superficial groin,supraclavicular,and various intraabdominal sites.This paper describes a step-by-step approach to the harvest of vascularized lymph nodes from the supraclavicular area,which is the preferred donor site for most patients with both upper and lower extremity lymphedema. | Maureen Beederman David W.Chang | 2022 | Plastic and Aesthetic Research2022，9，1： | 0 |
| 10 | 圣诞节——准备过圣诞节显示文摘21
找找看!
艾玛的家人有哪些传统习俗? | Linda W.Chang 吴国安(译) | 2010 | 空中英语教室(初级版.大家说英语)2010，，12： | 0 |
| 11 | 新朋友显示文摘找找看!
汤姆是不是被他的新朋友吸引了呢?
会话A(杰克在丛林咖啡馆,汤姆走了进来。)
杰克:汤姆,你来了!
汤姆:抱歉,杰克,我碰到了珍妮丝。 | Linda W.Chang 陈信宏(译) | 2011 | 空中英语教室(初级版.大家说英语)2011，，9： | 0 |
| 12 | Biogenic Amines as Biomarkers for Neurotoxicity显示文摘There has been a surge of interest over the past several years in the use of neurochemical endpoints to contribute to our understanding of the mechanism of action of neurotoxicants. In our present presentation, two biogenic amine systems were selected as examples of biomarkers for neurotoxicity.To investigate these neurochemical endpoints ,two prototype neurotoxicants were evaluated in experimental animals.One agent,reserpine, was used to assess developmental neurotoxicity and administered prenatally ,while the other ,MDMA, was used in the adult animal.The neurochemical biomarkers measured were dopamine,serotonin,and their metabolite(DOPAC and 5-HIAA) concentrations by HPLC/EC and dopamine receptor binding by radioligand receptor techniques.A review of the background, experimental design,and results are presented in this article.Our findings indicate that components of the biogenic amine systems can be used as sensitive neurochemical biomarkers of neurotoxicity.These neurochemical biomarkers can be correlated with neuropathological and behavioral biomarkers to aid in the understanding of mechanisms of neurotoxicity. | SYED F.ALI LOUIS W.CHANG WILLIAM SLIKKER JR | 1991 | Biomedical and Environmental Sciences1991，4，1： | 0 |
| 13 | Effects of Adrenalectomy and Corticosterone on Hippocampal Lesions Induced by Trimethyltin显示文摘The effects of adrenalectomy and corticosterone supplementation on the neurotoxicity of trimethyltin (TMT) were tested. CD-1 mice with or without adrenalectomy were injected with TMT at a dose of 3.0mg/kg body wt. At 48h post-TMT administration, the animals were killed for pathological examination. It was found that the adrenalectomized animals developed even more severe lesions in the hippocampal formation (fascia dentata granule cells) than the intact animals. When animals were given a supplement of corticosterone pellets at doses of 0.15, 1.5, and 7.5mg, there was a reduction of lesion development. Total alleviation of pathology was seen at the two higher doses of supplementation. Our present investigation strongly indicates that there may be a close and important interrelationship between TMT-induced neurotoxicity and adrenal function. 1989 Academic Press, Inc. | LOUIS W.CHANG AUBREY J. HOUGH FRANK G. BIVINS DAVID COCKERILL | 1989 | Biomedical and Environmental Sciences1989，2，1： | 0 |
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