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您的检索式：作者名="SYED F.ALI"
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| 1 | Peroxynitrite plays a role in methamphetamine‐induced dopaminergic neurotoxicity: evidence from mice lacking neuronal nitric oxide synthase gene or overexpressing copper–zinc superoxide dismutase显示文摘 | Syed Z.Imam Glenn D.Newport YossefItzhak Jean L.Cadet FakhrulIslam WilliamSlikker Syed F.Ali | 2008 | Journal of Neurochemistry2008，，3： | 1 |
| 2 | Biogenic Amines as Biomarkers for Neurotoxicity显示文摘There has been a surge of interest over the past several years in the use of neurochemical endpoints to contribute to our understanding of the mechanism of action of neurotoxicants. In our present presentation, two biogenic amine systems were selected as examples of biomarkers for neurotoxicity.To investigate these neurochemical endpoints ,two prototype neurotoxicants were evaluated in experimental animals.One agent,reserpine, was used to assess developmental neurotoxicity and administered prenatally ,while the other ,MDMA, was used in the adult animal.The neurochemical biomarkers measured were dopamine,serotonin,and their metabolite(DOPAC and 5-HIAA) concentrations by HPLC/EC and dopamine receptor binding by radioligand receptor techniques.A review of the background, experimental design,and results are presented in this article.Our findings indicate that components of the biogenic amine systems can be used as sensitive neurochemical biomarkers of neurotoxicity.These neurochemical biomarkers can be correlated with neuropathological and behavioral biomarkers to aid in the understanding of mechanisms of neurotoxicity. | SYED F.ALI LOUIS W.CHANG WILLIAM SLIKKER JR | 1991 | Biomedical and Environmental Sciences1991，4，1： | 0 |
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