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| 1 | Experimental Podophyllotoxin (Bajiaolian) Poisoning:——Ⅰ. Effects on the Nervous System显示文摘Bajiaolian,one of the species in the Mayapple family(Podophyllum pelatum),has been widely used as t traditional Chinese herbal medicine for the remedies of snake bites,general weakness,poisons,condyloma accuminata,lymphadenopathy,and certain tumors in China.In Western medicine,Podophyllum was first used medically as a laxative in the early 19th century.Since 1940,the resin of podophyllum has also been used topically for various skin lesions such as warts and condyloma.Human poisonings have been reported.An animal model was established to investigate the neurotoxic effects of Bajiaolian,Podophyllotoxin,the major active ingredient in Podophyllum,was injected(ip)to young adult male rats at doses of ,0,5,10,or 15mg·kg^-1.b.w.The animalw were sacrificed 72h after injection.Neuronal changes were readily observable in animals treeated with 10 or 15mg·kg^-1 of the toxin,Edematous changes of the angerior horn motoneurons were observed in the spinal cord. No neuronal necrosis ws foun.The type of neuronal swelling is believed to be only a transient change and would probably subside with time if no further assaults coccr,More serious and perhaps longer term of changes were found in the dorsal ganglion neurons and the nerve fibers(axons)in the central and peripheral nervous system.Severe depletion of the Nissl substance(RNA/polyribosomes)was observed in the dorsal root ganglion neurons.Alterations in these sensory neurons would give rise to and correlate with the sensory disturbances experienced by th patients.Bodian staining also revealed a dose-related increase in the coarseness(thickness)of the nerve fibers(axons)in the cerebellum,cerebral cortex,brainstem,and spinal cord.This is the first scientific study showing the neurotoxicity of Bajiaolian,a commonly used Chinese herbal medicine.Toxiciities on other organ systems by this drug certainly exist.Caution should be exercised in the dispensing and usage of this medicine. | LOUIS W.CHANG C.M.YANG C.F.CHEN J.F.DENG | 1992 | Biomedical and Environmental Sciences1992，5，4： | 7 |
| 2 | Experimental Podophyllotoxin (Bajiaolian) Poisoning:——Ⅱ. Effects on the Liver, Intestine, Kidney, Pancreas and Testis显示文摘Young male rats were orally intubated with podophyllotoxin:Grou I,control animals,orally fed with vehicle only;Group Ⅱ.few with an initial dose of 5mg·kg^-1 b.w., followed by a daily dose of 1.67mg·kg^-1 b.w.for 7d.GroupⅢ.fed with an initial dose of 15mg·kg^-1 b.w., followed by a daily dose of 5mg·kg^-1 b.w.for 7d.All animals were sacrificed 72h after the last dosing.Histopathologcal examination revealed dose-related fatty change of the liver,atrophy and degenerative changes of the intestinal epithelial linings and testiculas seminiferous tubules.Depletion of the pancreatic acinar cell granules was also apparent in the GroupⅢ animals,No pathology,however,was observed in the kidneys.The present study demonstrated for the first time degenerative changes in the liver,intestine,testis,and pancreas of animals ingested podophyllotoxin.These pathological changes correlate well with the clinical signs/symptoms of abnormal liver function,abdominal pain and diarrhea,and reduced serum amylase in humans poisonded by podophyllum.Inhibition of protein synthesis and mitosis(disruption of microtubules)are believed to be the underlying mechanisms of these changes observed in the animals intoxicated by podophyllotoxin. | LOUISW.CHANG C.M.YANG C.F.CHEN J.F.DENG | 1992 | Biomedical and Environmental Sciences1992，5，4： | 2 |
| 3 | A miniaturized net-type microstrip bandpass filter using/8resonators显示文摘 | C.F.Chen T.Y.Huang R.B.Wu | | 0，，07： | 1 |
| 4 | Pharmacology and modernization of traditional Chinese medicine显示文摘Traditional TCM does not need modernization. What needs modernization are the commercial TCM products which have become the prevailing form of TCM. Traditional TCM treats patients individually and different practitioners prescribe their individual formulations. There is no way to modernize such a fine-tuned traditional approach. Commercial TCM is a marketable product for the treatment of the mass population. These are two different forms of medical practice. This form of TCM | PeterK.T.PANG G.Z.LIU C.F.CHEN J.X.YANG J.P.SO | 2004 | Acta Pharmacologica Sinica2004，25，11： | 0 |
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