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| 1 | Synergistic effect of multiple predisposing risk factors on the development of bezoars显示文摘AIM:To describe the clinical characteristics of patients with gastric or intestinal bezoars recently treated in our hospital.METHODS:In this study,a retrospective chart review of consecutive patients with gastrointestinal bezoars,who were treated at the Samsun Education and Research Hospital between January 2006 and March 2011,was conducted.Data on demographic characteristics,clinical presentation,history of risk factors,diagnostic procedures,localization of bezoars,treatment interventions,and postoperative morbidity and mortality rates were collected and evaluated.RESULTS:Forty-two patients [26 (61.9%) males and 16 (31.1%) females] with a mean±SD (range) age of 55.8±10.5 (37-74) years were enrolled in this study.Thirty-six patients (85.7%) had one or more predisposing risk factors for gastrointestinal bezoars.The most common predisposing risk factor was a history of previous gastric surgery which was identified in 18 patients (42.8%).Twenty three patients (54.8%) had multiple predisposing risk factors.Phytobezoars were identified in all patients except one who had a trichobezoar in the stomach.Non-operative endoscopic fragmentation was performed either initially or after unsuccessful medical treatment in 14 patients with gastric bezoars and was completely successful in 10 patients (71.5%).Surgery was the most frequent treatment method in our study,which was required in 28 patients (66.7%).Intestinal obstruction secondary to bezoars was the most common complication (n=18,42.8%) in our study.CONCLUSION:The presence of multiple predisposing factors may create a synergistic effect in the development of bezoars. | Metin Kement Nuraydin Ozlem Elif Colak Sadik Kesmer Cem Gezen Selahattin Vural | 2012 | World Journal of Gastroenterology2012，18，9： | 11 |
| 2 | Comparison of the effects of bevacizumab and ranibizumab injection on corneal angiogenesis in an alkali burn induced model显示文摘·AIM:To investigate the effects of bevacizumab and ranibizumab on corneal neovascularization in an alkali burn-induced model of corneal angiogenesis. ·METHODS:Fifteen Wistar-Albino rats were divided randomly into 3 groups after chemical cauterization of the cornea. The first group received a single dose of 0.1mL saline solution as a control group whereas second and third groups received a single dose of 2.5mg bevacizumab or 1mg ranibizumab by subconjunctival injection, respectively. After three weeks, the rat corneas were evaluated by biomicroscopy and corneal photographs were taken. The percentage of neovascularization area, length of the longest new vessel, corneal oedema and corneal opacity scores were assessed. ·RESULTS:The analysis of digital photographs showed that the percentage of neovascularization area to the total corneal area, the length of the longest new vessel, corneal oedema and opacity scores were significantly lower in both study groups compared to the control group (P <0.05). Additionally, the percentage of corneal neovascularization area, the length of the longest new vessel and corneal opacity score were less with bevacizumab than ranibizumab. ·CONCLUSION:Subconjunctival bevacizumab and ranibizumab treatments may be effective methods in reducing corneal neovascularization. Furthermore, bevacizumab is more effective than ranibizumab in the inhibition of corneal neovascularization. | Ayhan Dursun Mustafa Kemal Arici Feyza Dursun Ayse Vural Ozec Mustafa Ilker Toker Haydar Erdogan Aysen Topalkara | 2012 | International Journal of Ophthalmology(English edition)2012，5，4： | 10 |
| 3 | Pegylated interferon-alpha plus taurine in treatment of rat liver fibrosis显示文摘AIM: To investigate the antif ibrotic effects of peginterferon- alpha 2b and taurine on oxidative stress markers and hepatocellular apoptosis. METHODS: Sixty rats with CCl4-induced liver fibrosis were divided into 4 groups (n = 15). Group 1 was left for spontaneous recovery (SR). Groups 2-4 received peginterferon-alpha 2b, taurine, and their combination, respectively, for four weeks. Histological f ibrosis scores, histomorphometric analysis, tissue hydroxyproline, tissue MDA, GPx and SOD activities were determined. Activated stellate cells and hepatocellular apoptosis were also evaluated. RESULTS: The degree of f ibrosis decreased in all treatment groups compared to spontaneous recovery group. Taurine alone and in combination with peginterferon-alpha 2b reduced oxidative stress markers, but peginterferon-alpha 2b alone did not. Apoptotic hepatocytes and activated stellate cells were higher in groups 2-4 than in group 1. Combined taurine and peginterferon-alpha 2b further reduced fibrosis and increased activated stellate cell apoptosis, but could not improve oxidative stress more than taurine alone.CONCLUSION: Peginterferon-alpha 2b exerts anti- f ibrotic effects on rat liver fibrosis. It seems ineffective against oxidative stress in vivo. Peginterferon-alpha 2b in combination with taurine seems to be an antif ibrotic strategy. | Ilker Tasci Mehmet Refik Mas Sevil Atalay Vural Salih Deveci Bilgin Comert Gunay Alcigir Nuket Mas Cemal Akay Mithat Bozdayi Cihan Yurdaydin Hakan Bozkaya Ozden Uzunalimoglu Ahmet Turan Isik Harun M Said | 2007 | World Journal of Gastroenterology2007，13，23： | 7 |
| 4 | Comparison of intraperitoneal and intratesticular ozone therapy for the treatment of testicular ischemia-reperfusion injury in rats显示文摘我们在一个试验性的老鼠模型把 intratesticular 臭氧治疗的功效与 intraperitoneal 臭氧治疗作比较。为这个目的, 24 只老鼠加 intratesticular 臭氧(O 信息技术) 包括假冒操作, torsion/detorsion,加 intraperitoneal 臭氧(O-IP ) 的 torsion/detorsion,和 torsion/detorsion 被划分成四个组。O-IP 臭氧组收到了臭氧的 4 mg kg −1 intraperitoneal 注射,并且 O 信息技术组 epididymally 收到了一样的注射。在在 detorsion 以后的 4 h,老鼠被牺牲, orchiectomy 材料组织病理学说地被估计。在到 Sertoli 房间的生精的小管和损坏的精子发生组织病理学说地用 Johnsen 得分系统在睾丸被评估。我 -- 在睾丸织物的 NOS 和电子 NOS 活动也被评估。Torsion-detorsion 引起了一个减少的 Johnsen 分数并且增加了 spermatogonial 和 Sertoli 房间的 apoptosis。阻止的臭氧注射在 Johnsen 分数和 i 增加 -- NOS 水平。O-IP 组的电子 NOS 水平比 O-IP 组,和 i 的显著地低 --O 信息技术组的 NOS 水平比 O-IP 组的显著地低。本地臭氧治疗是比在改进 IRI 相关的阴囊的扭转的全身的臭氧治疗更有效的。我们的学习是第一证明臭氧治疗的 intratesticular 实现的功效比 intraperitoneal 臭氧治疗的高。 | Fatih Mete Huseyin Tarhan Orcun Celik Ilker Akarken Kamil Vural Rahmi Gokhan Ekin Isil Aydemir Yusuf Ozlem Ilbey | 2017 | Asian Journal of Andrology2017，19，1： | 5 |
| 5 | 规律月经周期但黄体功能不全女性卵巢、子宫及内膜血流的多普勒能量超声研究 | Dal J. Vural B. Caliskan E. 李跃萍 | 2005 | 世界核心医学期刊文摘(妇产科学分册)2005，0，12： | 3 |
| 6 | Evaluation of cardiovascular risk in patients with Parkinson disease under levodopa treatment显示文摘BackgroundLevodopa 是在有 Parkinson 疾病(PD ) 的病人的中间的治疗的不可缺少的选择。因为 L-dopa 治疗被显示增加浆液 homocysteine 层次,为心血管的混乱的一个著名风险因素,有在 L-dopa 治疗下面的 PD 的病人将在为未来的增加的风险心血管的事件。这研究的目的是在 levodopa treatment.MethodsThe 学习下面与 PD 在病人评估心血管的风险人口在 L-dopa 治疗下面与自发的 PD 由 65 个病人组成了。控制组包括了 32 年龄,性匹配没有认知衰落的个人。Echocardiographic 大小,浆液 homocysteine 层次和主动脉的有弹性的参数与 PD 和 controls.ResultsAs 在病人之间被作比较 L-dopa 治疗的一个期望的特征, Parkinson 组有显著地更高的 homocystein 层次(15.1 ±3.9 µ mol/L 对 11.5 ±3.2 µ mol/L, P = 0.02 ) 。当时,大动脉的膨胀性在有 PD 的病人是显著地更低的与控制相比(4.8 ±1.5 dyn/cm 2 对 6.2 ±1.9 dyn/cm 2, P = 0.016 ) 。另外,有 PD 的病人有更高大动脉的紧张和大动脉的僵硬索引(13.4%±6.4% 对 7.4%±3.6% , P <0.001 和 7.3 ±1.5 对 4.9 ±1.9, P <0.001 分别地) 。而且,浆液 homocysteine 层次被发现断然与大动脉的僵硬索引被相关,在浆液 homocysteine 的大动脉的膨胀性和层次之间有否定关联(r = 0.674, P <0.001;r =− 0.602, P <0.001,分别地) 有在 L-dopa 治疗下面的 PD 的 .ConclusionsThe 病人增加了大动脉的僵硬并且与健康个人相比损害了心脏舒张的功能。提高的浆液 homocysteine 层次可以是可能的 pathophysiological 机制。 | Zeki Yuksel Gunaydln Fahriye Feriha Ozer Ahmet Karagoz Osman Bektas Mehmet Baran Karatas Ash Vural Adil Bayramoglu Abdullah Celik Mehmet Yaman | 2016 | Journal of Geriatric Cardiology2016，13，1： | 3 |
| 7 | PPARγ配体罗格列酮及其激动剂GW9662对脂肪细胞因子表达的影响(英文)显示文摘目的:脂肪组织是一个内分泌器官已逐渐得到了肯定,它能分泌多种信号分子如:脂联素和抵抗素。过氧化物酶体增殖物激活受体(peroxisome pro-liferator activated receptorγ,PPARγ)在脂肪组织高水平表达,胰岛素增敏剂-噻唑烷二酮类药物是它的选择性激动剂,噻唑烷二酮类药物如罗格列酮的胰岛素增敏作用部分是通过激活PPARγ调节脂联素(胰岛素增敏分子)和抵抗素(涉及胰岛素抵抗)表达介导的。但现在不同研究发现PPARγ激动剂对抵抗素的表达调控方向存在矛盾,我们的问题是当抵抗素表达增加的情况下脂联素的表达还能否上调。方法:用3T3-L1细胞株作为研究模型,分别用溶媒对照、罗格列酮(10μmol/L)、GW9662(5μmol/L)或罗格列酮+GW9662作用细胞,然后检测脂联素和抵抗素 mRNA表达变化情况。结果:与对照组相比,罗格列酮分别增加脂联素和抵抗素 mRNA水平1.77和1.66倍,其差异具有统计学意义(P<0.05) ;重要的是GW9662也增加脂联素水平(1.57倍,P<0.05)但对抵抗素无影响。罗格列酮和GW9662两者合用时,仍上调adiponectin mRNA水平(对照组的1.87倍,P<0.05) ,抵抗素的增加与罗格列酮单用比弱下降(对照组的1.31倍,P<0.05)。结论:本研究为PPARγ激动剂(罗格列酮)和拮抗剂(GW9662)都上调脂联素的转录提供了新的证据,两者合用时GW9662不阻断罗格列酮诱导的脂联素上调作用。综合这些数据提示噻唑烷二酮类药上调脂联素的机制可能不依赖于PPARγ。并且, GW9662在增加脂联素水平的同时不上调抵抗素水平的特性进一步支持PPARγ拮抗剂用于临床治疗胰岛素抵抗的可能性。降低抵抗素表达可能不是罗格列酮胰岛素增敏作用的重要机制。我们的结果为将来研究噻唑烷二酮类药物对人脂肪细胞因子表达在剂量和时间上提供了一定的基础。 | LIU Ying-zi Vural Ozdemir OUYANG Dong-shengI LIU Zhao-qian LIU Jie LI Zhi WANG Dan ZENG Fei-yue TAN Zhi-rong HU Dong-li ZHOU Hong-hao | 2007 | 中国临床药理学与治疗学2007，12，10： | 3 |
| 8 | Contact lens impact on quality of life in keratoconus patients: rigid gas permeable versus soft siliconehydrogel keratoconus lenses显示文摘AIM: To determine the impact of rigid gas permeable(RGP) and silicone-hydrogel keratoconus lenses on the quality of life(Qo L) in keratoconus(KCN) patients using the self-reported results from the Contact Lens Impact on Quality of Life(CLIQ) Questionnaire.·METHODS: From January 2013 to April 2013, 27 consecutive KCN patients who wore RGP contact lenses(conflexair100 UV KE Zeiss-Whlk) or soft silicone-hydrogel contact lenses(SHCLs) for KCN(Kera Soft ICBausch&Lomb or Hydrocone Toris K-Swiss lens)completed the CLIQ questionnaire.·RESULTS: The mean age of 27 patients was 29.6±8.0y.Fifteen patients were RGP user. The groups were comparable with respect to the mean patient age, sex,and mean K values(P =0.1, P =0.8 and P =0.1, respectively).The mean CLIQperson measure was 42.8 ±5.5 in RGP group and 39.6 ±5.5 in SHCLs for KCN group(P =0.06).CLIQperson measure was positively correlated with steep K value(r =0.301, P =0.04). When eyes were stratified by visual acuity with contact lenses, the mean CLIQperson measure was 42. 01 ± 5. 6 in eyes with a visual acuity of20/20-20/25(n =44) and 38.4 ±5.26 in eyes with a visual acuity of 20/32 or less(n =10; P =0.097).·CONCLUSION: RGP lenses and SHCLs for KCN have similar impact on Qo L. | Elvin Hatice Yildiz Mesut Erdurmus Emine Savran Elibol Banu Acar Ece Turan Vural | 2015 | International Journal of Ophthalmology(English edition)2015，8，5： | 3 |
| 9 | Agenesis of the dorsal pancreas显示文摘Developmental anomalies of the pancreas have been reported but dorsal pancreatic agenesis is an extremely rare entity. We report an asymptomatic 62-year-old woman with complete agenesis of the dorsal pancreas. Abdominal computed tomography (CT) revealed a normal pancreatic head, but pancreatic body and tail were not visualized. Magnetic resonance imaging (MRI) findings were similar to CT. At magnetic resonance cholangiopancreatography (MRCP), the major pancreatic duct was short and the dorsal pancreatic duct was not visualized. The final diagnosis was dorsal pancreatic agenesis. | Lale Pasaoglu Murat Vural Hatice Gul Hatipoglu Gokce Tereklioglu Suha Koparal | 2008 | World Journal of Gastroenterology2008，14，18： | 3 |
| 10 | Total oxidative stress, paraoxonase and arylesterase levels at patients with pseudoexfoliation syndrome and pseudoexfoliative glaucoma显示文摘AIM: To investigate the oxidative stress status of the aqueous humor and serum of patients with pseudoexfoliation(PEX) syndrome and pseudoexfoliative glaucoma(PEG) and to measure paraoxonase(PON) and arylesterase(ARE) levels.·METHODS: A total of 78 patients were enrolled in the study, with 26 patients in each separate group. The patients were divided into three groups: the first group entailed PEX syndrome patients, while the second group consisted of patients with PEG and the third group involved patients with no additional systemic diseases,other than the diagnosis of cataract as control. Total oxidative stress(TOS), total antioxidant capacity(TAC),PON, and ARE levels in aqueous humor and serum were measured.·RESULTS: TAC, PON and arylesterase levels in aqueous humor and serum of the PEX syndrome and PEG patients were significantly decreased compared with control group(P <0.05). TOS values were higher in patients with PEX syndrome and PEG than controls(P <0.05). TAC, PON and ARE levels of aqueous humor did not differ significantly between the PEX syndrome and PEG groups·CONCLUSION: These findings are potentially of significance and add to the growing body of evidence for oxidative stress in PEX syndrome and PEG. Decreased antioxidant defense and increased oxidative stress system may play an important role in the pathogenesis of PEX syndrome and PEG. | Feyza Dursun Ayse Vural Ozec Huseyin Aydin Aysen Topalkara Ayhan Dursun Mustafa Ilker Toker Haydar Erdogan Mustafa Kemal Arici | 2015 | International Journal of Ophthalmology(English edition)2015，8，5： | 2 |
| 11 | Alterations of plasma magne- sium, copper, zinc, iron and selenium concentrations and some related erythrocyte antioxidant enzyme activities i patients with Alzheimer's disease 显示文摘 | Vural H Demirin H Kara Y | 2010 | Journal of Trace Elements in Medicine and Biology2010，24，3： | 1 |
| 12 | Nitric oxide/endothelin-1 in preeclampsia 显示文摘 | Vural P | 2002 | Clin Chim Acta2002，317，12： | 1 |
| 13 | Color Doppler sonographic analysis of uterine and ovarian artery blood flow in women polycystic ovary syndrome 显示文摘 | Ozkan S Vural B Caliskan E | 2007 | J Clin Ultrasound2007，35，6： | 1 |
| 14 | Color Doppler sono- graphic analysis of uterine and ovarian artery blood flow in women polycystic ovary syndrome显示文摘 | Ozkan S Vural B Caliskan E | 2007 | J Clin Ultrasound2007，35，6： | 1 |
| 15 | Simultaneous versus sequential one-stage combined anterior and posterior spinal surgery for spinal infections (outcomes and complications)显示文摘 | Ozturk C Aydinli U Vural R | 2007 | Int Orthop2007，31，3： | 1 |
| 16 | The scores of Hamilton depresion,anxiety,and panic agoraphobiarating scales in patients with acute coronary syndrome显示文摘 | Vural M Acer M Akbas B | 2008 | Anadolu Kardiyol Derg2008，8，1： | 1 |
| 17 | Performance evaluation of evolutionary algorithms for optimal filter design显示文摘 | Vural R A Yildirim T Kadioglu T | | 0，，01： | 1 |
| 18 | Effect of latanoprost/timolol and dorzolamide/tiomolol on intraocular pressure after phacoemulsification surgery显示文摘·AIM:To evalaute the effect of fixed-combination latanoprost 0.005%/timolol maleate 0.5% and dorzolamide hydrochloride 2%/timolol maleate 0.5% on postoperative intraocular pressure after phacoemulsification cataract surgery.·METHODS:This study is a prospective,randomized,double-masked and placebo-controlled.The study included 90 eyes of 90 patients which were scheduled to have phacoemulsification surgery.Patients were randomly assigned preoperatively to 1 of 3 groups (30 eyes of 30 patients).Two hour before surgery,the patients received one drop latanoprost/timolol (group 1),dorzolamide/timolol (group 2) and placebo (group 3,control group).The IOPs were measured at preoperative and postoperative 4,8,and 24 hours.·RESULTS:The preoperative mean intraocular pressure was not statistically significant between both drug groups and control group.In group 1 and 2,the postoperative mean IOP [group1:(14.03?à3.15)mmHg and group 2:(14.16?à4.43)mmHg] at 24 hours were significantly lower than the control group [(16.93?à3.70)mmHg,(P <0.05)].In addition,the postoperative mean IOP of group 1 [(14.90±3.69)mmHg] at 8 hours was significantly lower than the control group [(17.70?à3.89)mmHg,(P <0.05)],but there was no significant difference between group 2 [(16.16?à5.23)mmHg] and control group at 8 hours (P >0.05).·CONCLUSION:When compared with placebo,the use of preoperative fixed combination of latanoprost/timolol and dorzolamide/timolol is an effective method for preventing intraocular pressure elevation in 24 hours after phacoemulsification surgery,but did not completely prevent IOP spikes.· | Haydar Erdogan Ayse Vural Ozec Cengiz Caner Mustafa Ilker Toker Mustafa Kemal Arici Aysen Topalkara | 2011 | International Journal of Ophthalmology(English edition)2011，4，2： | 1 |
| 19 | The Vehicle Routing Problem:A Taxonomic Review显示文摘 | Eksioglu B Vural A V Reisman A | 2009 | Computers & Industrial Engineering2009，57，4： | 1 |
| 20 | Vaccination with recombinant oncosphere antigens reduces the susceptibility of sheep to infection with Taenia multiceps显示文摘 | Gauci C Vural G Oncel T | 2008 | Int J Parasitol2008，38，89： | 1 |
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