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| 1 | Endoscopic management of biliary disorders during pregnancy显示文摘BACKGROUND:Biliary interventions during pregnancy are associated with risks to both the pregnancy and developing fetus.In this report we summarize our experience with endoscopic interventions including endoscopic ultrasound (EUS)in the management of biliary disorders during pregnancy. METHODS:Endoscopic retrograde cholangiopancreatographies (ERCPs)performed between May 2003 through January 2010(n=607)were identified from our database,and cases of interventions during pregnancy were reviewed.All procedures were done using conscious sedation and lead shielding. RESULTS:Nine ERCPs(1.5%)were performed in 8 pregnant patients.Their median gestational period was 22 weeks (range,<2-36 weeks).Two,5 and 2 patients were in their first,second and third trimester,respectively.Indications for ERCP included obstructive jaundice(6 patients)cholangitis (2),and acute pancreatitis/obstructive jaundice(1).Two patients underwent EUS before ERCP.Fluoroscopy was used in 5 ERCPs(median 12 seconds;range 2-20 seconds),and the overall time for a ERCP ranged from 5 to 25 minutes. During ERCP endoscopic sphincterotomy was performed in 5 patients,stenting in 6,and balloon clearance in 3.One procedure caused complication in induction of labor.During pregnancy,there were 4 non-procedure related complications including acute cholecystitis(1),HELLP syndrome resulting in spontaneous abortion(1)and stent migrations(2).Five pregnancies had uncomplicated term deliveries,whereas 2 required urgent caesarian sections(one for fetal distress and 1 for cholangitis secondary to stent migration).One patient was well in her second trimester during follow-up.Seven babies were well at birth with median APGAR scores of 9,and 10 at 5 and 10 minutes,respectively.One baby died of sudden death syndrome at age of 40 days. CONCLUSIONS:ERCP is a safe procedure for pregnant women.It can be conducted for biliary stenting and subsequent clearance after deliveries.EUS has a complementary role. Different strategies can be applied according to the conditions or expertise of endoscopists. | Vui Heng Chong Anand Jalihal | 2010 | Hepatobiliary & Pancreatic Diseases International2010，9，2： | 18 |
| 2 | Clinical significance of heterotopic gastric mucosal patch of the proximal esophagus显示文摘Heterotopic gastric mucosa of the proximal esophagus (HGMPE),also referred to as'inlet patch'or'cervical inlet patch',is a salmon colored patch that is usually located just distal to the upper esophageal sphincter. HGMPE is uncommon with endoscopic studies reporting a prevalence ranging from less than one percent to 18%.Most HGMPE are asymptomatic and are detected incidentally during endoscopy for evaluations of other gastrointestinal complaints.Most consider HGMPE as clinically irrelevant entity.The clinical significance of HGMPE is mainly acid related or neoplastic transformation.The reported prevalence of laryngopharyngeal reflux symptoms varies from less than 20%to as high as 73.1%.However,most of these symptoms are mild. Clinically significant acid related complications such as bleeding,ulcerations,structure and fistulization have been reported.Although rare,dysplastic changes and malignancies in association with HGMPE have also been reported.Associations with Barrett's esophagus have also been reported but the findings so far have been conflicting.There are still many areas that are unknown or not well understood and these include the natural history of HGMPE,risk factors for complications,role of Helicobacter pylori infection and factors associated with malignant transformations.Follow-up may need to be considered for patients with complications of HGMPE and surveillance if biopsies show intestinal metaplasia or dysplastic changes.Despite the overall low incidence of clinically relevant manifestations reported in the literature,HGMPE is a clinically significant entity but further researches are required to better understand its clinical significance. | Vui Heng Chong | 2013 | World Journal of Gastroenterology2013，19，3： | 18 |
| 3 | Spontaneous gallbladder perforation,pericholecystic abscess and cholecystoduodenal fistula as the first manifestations of gallstone disease显示文摘BACKGROUND:Gallstone disease is common,and complications that are frequently encountered include acute cholecystitis and acute pancreatitis,but rarely gallbladder perforation. METHOD:Data were retrospectively collected from clinical case notes and a literature review is presented. RESULTS:A 72-year-old lady presented with spontaneous gallbladder perforation,pericholecystic abscess and cholecystoduodenal fistula as the first manifestations of gallstone disease.She was previously well and had no abdominal complaints.Her condition was successfully managed with initial antibiotic therapy followed by interval cholecystectomy and fistula repair. CONCLUSIONS:Our case highlighted some uncommon but severe complications which occurred simultaneously as the first manifestations of previously asymptomatic gallstone disease.Such complications need to be considered in patients suspected of intra-abdominal sepsis,even when there are no characteristic symptoms. | Vui Heng Chong Kian Soon Lim Varkey Vallickad Mathew | 2009 | Hepatobiliary & Pancreatic Diseases International2009，8，2： | 4 |
| 4 | Prevalence and risk factors of methotrexate hepatoxicity in Asian patients with psoriasis显示文摘AIM: To establish the prevalence of liver fibrosis and to evaluate the possible risk factors for fibrosis and progression in Asian with psoriasis treated with methotrexate (MTX) based on liver histology. METHODS: Patients with psoriasis treated with MTX referred to the Department of Gastroenterology, Tan Tock Seng Hospital for liver biopsy were identified and retrospectively studied. Patient case notes and electronic records were retrieved from the hospital database and relevant data collated. Histological changes of liver biopsies were staged according to Roengik score. The factors assessed were age, gender, ethnicity, cumulative dose of MTX, presence of comorbid conditions such as diabetes, hypertension, hyperlipidemia, and ethanol use. We also assessed the histological change in those with multiple liver biopsies. Statistical analysis was performed using Stata V.9.2. RESULTS: There were altogether 59 patients (median age 50 years old, range 22-81 years old, male, 88%) with 98 biopsies liver biopsies; 6 normal [median cumulative dose (MCD), 2285 mg]; 62 gradeⅠ (MCD 2885 mg), 23 grade Ⅱ (MCD 1800 mg) and 7 grade Ⅲ (MCD 1500 mg). There was no grade Ⅳ or cirrhosis. The prevalence of liver fibrosis (grade Ⅲ) was 12%. Of the factors assessed, diabetes (P=0.001) and hypertension (P=0.003) were significant for fibrosis on univariate analysis but not on multivariate analysis. Of the 26 patients who had more than one biopsy (median 2, range 2-6), 57.7% (n=15) were stable, 34.6% (n=9) had progression and 7.7% (n=2) had regression of histological grades. On univariate analysis, nonChinese ethnicity (P=0.031), diabetes (P=0.018), and hyperlipidemia (P=0.011) were predictive of progression of grades, but these were not significant on multivariate analysis. CONCLUSION: Liver fibrosis in Asian psoriatic population on MTX is comparable to the West. Cumulative dose was not associated with liver fibrosis. Metabolic syndrome is important factors. | Chong Meng Yeo Vui Heng Chong Arul Earnest Wei Lyn Yang | 2013 | World Journal of Hepatology2013，5，5： | 3 |
| 5 | Profiles of autoimmune hepatitis in Brunei Darussalam显示文摘BACKGROUND:Autoimmune hepatitis(AIH)is a chronic inflammatory disease of the liver.Data on the disease remain scarce in the Southeast Asia region.This study was undertaken to assess the profiles of AIH in Brunei Darussalam.METHODS:Nineteen patients with AIH treated at the hepatology clinic,RIPAS Hospital(up until December 2008)were reviewed.Demographic,laboratory,histologic,clinical,and therapeutic data of the patients were collected.RESULTS:The median age of the 19 patients at diagnosis was 52 years(range 33-70)with a male to female ratio of 1:3.75.All patients were diagnosed with typeⅠAIH.The prevalence rate of the disease was 5.61/100 000 and was higher in the Chinese than in Malays and Indigenous people.Commonly seen presentations were abnormal liver function(52.6%),icteric hepatitis(36.8%),and decompensated liver disease(10.5%).Histologically advanced fibrosis was found in 47.4%and cirrhosis in 21.1%of the patients.Immune-mediated diseases were present in 36.8%.In a follow-up for 31 months(range 0.25-102),three patients died,2 had progressive liver failure and 1 had lymphoma.Complete biochemical response was seen in 75%of the patients,partial response in 12.5%,and no response in 12.5%.HLA DRB1*03(DR3) was detected in 18.2%of the patients and DRB1*04(DR4) in 45.5%.There were significant associations between HLA Cw7(P=0.038)and DQB1*04(P=0.007).CONCLUSIONS:The data of the 19 patients were comparable to those reported in the literature.Most of the patients were found to have abnormal biochemistry.There were significant associations between HLA Cw7 and DQB104,but not between DRB103(DR3)and DRB104(DR4). | Anand Jalihal Pemasari Upali Telisinghe Vui Heng Chong | 2009 | Hepatobiliary & Pancreatic Diseases International2009，8，6： | 3 |
| 6 | Factors Determining Diagnostic Yield of Endoscopic Ultrasound Guided Fine-Needle Aspiration for Pancreatic Cystic Lesions: A Multicentre Asian Study显示文摘 | Lee Guan Lim Sandeep Lakhtakia Tiing Leong Ang Charles K. F. Vu Frederick Dy Vui Heng Chong Christopher J. L. Khor Wee Chian Lim Bhavesh Kishor Doshi Shyam Varadarajulu Kenjiro Yasuda Jennie Y. Y. Wong Yiong Huak Chan Min En Nga Khek Yu Ho | 2013 | Digestive Diseases and Sciences2013，，6： | 2 |
| 7 | Pyogenic liver abscess as the first manifestation of hepatobiliary malignancy显示文摘BACKGROUND:Pyogenic liver abscess(PLA)is commonly seen in patients in the Far East.Similarly,hepatobiliary neoplasms are also common.PLA as the initial manifestation of hepatobiliary neoplasms is extremely rare. METHOD:Three patients with PLA were identified from the ward registion files and were retrospectively reviewed. RESULTS:These patients(two men aged 74 and 80 years, and one woman aged 35 years)were treated(in the right lobe in two patients and in the left lobe in one)and subsequently followed up for 11-22 months.Two patients were diagnosed with hepatocellular carcinoma and one with metastatic cholangiocarcinoma.Two patients were subjected to biopsies showing features of inflammatory pseudotumor before a diagnosis of hepatocellular carcinoma.One patient underwent hepatic resection with good results.In the other two patients who declined any further interventions,one died a few weeks after diagnosis and the other is still alive on conservative treatment. CONCLUSIONS:This series of cases highlights the importance of considering underlying hepatobiliary malignancies in patients with PLA and a close follow-up necessary for non-resolving hepatic lesions. | Vui Heng Chong Kian Soon Lim | 2009 | Hepatobiliary & Pancreatic Diseases International2009，8，5： | 2 |
| 8 | Primary biliary cirrhosis in Brunei Darussalam显示文摘BACKGROUND:Primary biliary cirrhosis(PBC)is an uncommon autoimmune cholestatic disease that predominantly affects women.Certain human leukocyte antigens(HLAs) have been reported to be associated with susceptibility for PBC.We describe the profiles of PBC in Brunei Darussalam. METHODS:All patients with PBC(n=10)were identified from our prospective databases.The HLA profiles(n=9,PBC)were compared to controls(n=65)and patients with autoimmune hepatitis(n=13,AIH). RESULTS:All patients were women with a median age of 51 years(27-83)at diagnosis.The prevalence rate of the disease was 25.6/million-population and the estimated incidence rate varied from 0 to 10.3/million-population per year.Chinese (41.15/million)and the indigenous(42.74/million)groups had higher prevalence rates compared to Malays(22.62/ million).The prevalence among female population was 54.6/ million-population.All patients were referred for abnormal liver profiles.Five patients had symptoms at presentations: jaundice(20%),fatigue(20%),arthralgia(30%)and pruritus (20%).Serum anti-mitochondrial antibody was positive in 80%of the patients.Overlap with AIH was seen in 30%.Liver biopsies(n=8)showed stage I(n=2),II(n=4)and III(n=2) fibrosis.There were no significant differences in the HLA profiles between PBC and AIH.Compared to the controls,PBC patients had significantly more HLA class I alleles specifically B7(P=0.003),Cw7(P=0.002)and Cw12(P=0.007)but not the class II alleles.At a median follow-up of 23.5 months(2 to 108), all patients were alive without evidence of disease progression. CONCLUSIONS:PBC is also a predominant female disorder in our local setting and most had mild disease.The HLA profiles of our patients were different to what have been reported. | Vui Heng Chong Pemasiri Upali Telisinghe Anand Jalihal | 2010 | Hepatobiliary & Pancreatic Diseases International2010，9，6： | 2 |
| 9 | Piglet Diarrhea and Technology Transfers to Prevent E. coli Infection at Small-Holder Pig Farms in Binh Dinh, Vietnam显示文摘 | Nguyen Quang Linh Hoang Nghia Duyet Tran Quang Vui Du Thanh Hang | 2014 | Journal of Agricultural Science and Technology(A)2014，4，8： | 2 |
| 10 | The in vitro inhibition of Gram-negative patho- genic bacteria by bifidobacteria is caused by the production of organic: acids 显示文摘 | Makras L Vuys L D | 2006 | International Dairy Journal2006，16，： | 1 |
| 11 | Role of biomarkers for early detection of intra-abdominal sepsis: a clinician's perspective显示文摘Infection remains an universal important cause of morbidity and mortality,with the highest mortality rate for bloodstream infections(20%-70%).[1,2]Fortunately,most community acquired infections。 | Vui Heng Chong | 2015 | Hepatobiliary & Pancreatic Diseases International2015，14，5： | 1 |
| 12 | Heteropolysaccharides from lactic acid bacteria显示文摘 | De Vuys L Degeest B | 1999 | J FEMS Microbiol Rev1999，23，： | 1 |
| 13 | Heterotopic gastric mucosal patch of the esophagus is associated with higher prevalence of laryngopharyngeal reflux symptoms显示文摘 | Vui Heng Chong Anand Jalihal | 2010 | European Archives of Oto - Rhino - Laryngology2010，，11： | 1 |
| 14 | Temperature and leaf wetness duration-hazed model for prediction of gray leaf spot of perennial ryegrass turf显示文摘 | UDDIN W SERLEMITSOS K VUI G A | 2003 | Phytopathology2003，93，3： | 1 |
| 15 | Human immunodeficiency virus and endoscopy:Experience of a general hospital in singapore显示文摘 | Vui heng cheng Chee china lira | 2005 | Journal of Gastroenterology and Hepatology2005，20，5： | 1 |
| 16 | Prevalence of gastrointestinal and psychosomatic symptoms among A sian patients undergoing regular hemodialysis显示文摘 | Vui Heng Chong Jackson Tan | 2013 | Nephrology2013，，2： | 1 |
| 17 | Complete genome characterizationof porcine epidemic diarrhea virus in Vietnam 显示文摘 | Vui D T Thanh T L Tung N | 2015 | Archives ofVirology2015，160，8： | 1 |
| 18 | Genome of a thermophilic bacterium Geobacillus sp. TFV3 from Deception Island, Antarctica显示文摘Thermophilic microorganisms have always been an important part of the ecosystem,particularly in a hot environment,as they play a key role in nutrient recycling at high temperatures where most microorganisms cannot cope.While most of the thermophiles are archaea,thermophiles can also be found among some species of bacteria.These bacteria are very useful in the fundamental study of heat adaptation,and they are also important as potential sources of thermostable enzymes and metabolites.Recently,we have isolated a Gram-positive thermophilic bacterium,Geobacillus sp.TFV3 from a volcanic soil sample from Deception Island,Antarctica.This project was undertaken to analyze the genes of this thermophilic Antarctic bacterium and to determine the presence of thermal-stress adaptation proteins in its genome.The genome of Geobacillus sp.TFV3 was first purified,sequenced,assembled,and annotated.The complete genome was found to harbor genes encoding for useful thermal-stress adaptation proteins.The majority of these proteins were categorized under the family of molecular chaperone and heat shock protein.This genomic information could eventually provide insights on how the bacterium adapts itself towards high growth temperatures. | Xin Jie CHING Chui Peng TEOH Dexter J.H.LEE Marcelo GONZáLEZ-ARAVENA Nazalan NAJIMUDIN Yoke Kqueen CHEAH Paris LAVIN Clemente Michael Vui Ling WONG | 2020 | Advances in Polar Science2020，31，2： | 1 |
| 19 | Complete genome sequence of porcine epidemic diarrhea virus in Vietnam显示文摘 | VUI D T TUNG N INUI K | 2014 | Genome Announ2014，2，00： | 1 |
| 20 | Shewanella putrefaciens,a rare cause of splenic abscess显示文摘 | Norwani Basir Alice Moi Ling Yong Vui Heng Chong | | 0，，： | 1 |
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