|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | L-carnitine supplementation improves hematological pattern in patients affected by HCV treated with Peg interferon-α 2b plus ribavirin显示文摘AIM:To evaluate the efficacy of L-carnitine on alleviating anemia,thrombocytopenia and leukopenia,and minimizing dose reductions in patients with chronic hepatitis C virus(HCV)in treatment with Interferonα(IFN-α)plus ribavirin.METHODS:Sixty-nine patients with chronic hepatitis C were enrolled in the study and divided into two groups.group A(n=35)received Peg-IFN-α2b plus ribavirin plus L-carnitine,and group B(n=34)received Peg-IFN-αand ribavirin for 12 mo.All patients underwent laboratory investigations including:red cell count,he-moglobin,white cell count,platelets,bilirubin,alanine aminotransferase(ALT),aspartate aminotransferase(AST),and viremia.RESULTS:After 12 mo in group A compared to group B we observed significant differences in AST 108.8 vs 76.8(IU/L;P<0.001),ALT 137.vs 112.3(IU/L;P 0.001),viremia 4.04 vs 2.36(106 copies/mL;P< 0.001),Hb 1 vs 3.5(g/dL;P<0.05),red blood cells 0.3 vs 1.1(X1012/L;P0.001),white blood cells 1.5 vs 3(10/L;Pn0.001)and platelets 86 vs 85(×10/L;P0.001).The end treatment responders were 18 vs 12(60%vs>44%)and the non responders were 12 vs 15(40%vs<50%)[odds ratio(OR)1.65,n5%CI =0.65-5.37,P<0.05?.In group A compared to group B there was a significant improvement of sustained vi-rological response in 15 vs 7 patients(50%vs>25%),while the relapsers were 3 vs 5(10%vs<18%)(OR>3.57,n5%CI=0.65-1n.3,Pn0.001).CONCLUSION:L-carnitine supplementations modulate erythropoiesis,leucopoiesis and thrombocytopoiesis,and may be useful in patients treated for HCV.L-carni-tine treatment offers the possibility of achieving a sustained virological response while preventing overtreatment. | Michele Malaguarnera Marco Vacante Maria Giordano Massimo Motta Gaetano Bertino Manuela Pennisi Sergio Neri Mariano Malaguarnera Giovanni Li Volti Fabio Galvano | 2011 | World Journal of Gastroenterology2011，17，39： | 4 |
| 2 | Bifidobacterium longum with Fructo-Oligosaccharides in Patients with Non Alcoholic Steatohepatitis显示文摘 | Michele Malaguarnera Marco Vacante Tijana Antic Maria Giordano Giuseppe Chisari Rosaria Acquaviva Silvana Mastrojeni Giulia Malaguarnera Antonio Mistretta Giovanni Volti Fabio Galvano | 2012 | Digestive Diseases and Sciences2012，，2： | 2 |
| 3 | Moro orange juice prevents fatty liver in mice显示文摘AIM:To establish if the juice of Moro,an anthocyaninrich orange,may improve liver damage in mice with diet-induced obesity.METHODS:Eight-week-old mice were fed a high-fat diet(HFD) and were administrated water or Moro juice for 12 wk.Liver morphology,gene expression of lipid transcription factors,and metabolic enzymes were assessed.RESULTS:Mice fed HFD displayed increased body weight,insulin resistance and dyslipidemia.Moro juice administration limited body weight gain,enhanced insulin sensitivity,and decreased serum triglycerides and total cholesterol.Mice fed HFD showed liver steatosis associated with ballooning.Dietary Moro juice markedly improved liver steatosis by inducing the expression of peroxisome proliferator-activated receptor-α and its target gene acylCoA-oxidase,a key enzyme of lipid oxidation.Consistently,Moro juice consumption suppressed the expression of liver X receptor-α and its target gene fatty acid synthase,and restored liver glycerol-3-phosphate acyltransferase 1 activity.CONCLUSION:Moro juice counteracts liver steatogenesis in mice with diet-induced obesity and thus may represent a promising dietary option for the prevention of fatty liver. | Federico Salamone Giovanni Li Volti Lucilla Titta Lidia Puzzo Ignazio Barbagallo Francesco La Delia Shira Zelber-Sagi Michele Malaguarnera Pier Giuseppe Pelicci Marco Giorgio Fabio Galvano | 2012 | World Journal of Gastroenterology2012，18，29： | 2 |
| 4 | Natural heme oxygenase-1 inducers in hepatobiliary function显示文摘Many physiological effects of natural antioxidants,their extracts or their major active components,have been reported in recent decades.Most of these compounds are characterized by a phenolic structure,similar to that of α-tocopherol,and present antioxidant proper-ties that have been demonstrated both in vitro and in vivo.Polyphenols may increase the capacity of en-dogenous antioxidant defences and modulate the cellu-lar redox state.Changes in the cellular redox state may have wide-ranging consequences for cellular growth and differentiation.The majority of in vitro and in vivo studies conducted so far have attributed the protective effect of bioactive polyphenols to their chemical reac-tivity toward free radicals and their capacity to prevent the oxidation of important intracellular components.However,in recent years a possible novel aspect in the mode of action of these compounds has been sug-gested; that is,the ultimate stimulation of the heme oxygenase-1 (HO-1) pathway is likely to account for the established and powerful antioxidant/anti-inflam-matory properties of these polyphenols.The products of the HO-catalyzed reaction,particularly carbon mon-oxide (CO) and biliverdin/bilirubin have been shown to exert protective effects in several organs against oxidative and other noxious stimuli.In this context,it is interesting to note that induction of HO-1 expression by means of natural compounds contributes to protec-tion against liver damage in various experimental mod-els.The focus of this review is on the significance of targeted induction of HO-1 as a potential therapeutic strategy to protect the liver against various stressors in several pathological conditions. | Giovanni Li Volti David Sacerdoti Claudia Di Giacomo Maria Luisa Barcellona Antonio Scacco Paolo Murabito Antonio Biondi Francesco Basile Diego Gazzolo Raul Abella Alessandro Frigiola Fabio Galvano | 2008 | World Journal of Gastroenterology2008，14，40： | 2 |
| 5 | Carbon monoxide signaling in promoting angiogenesis in human mierovessel endothelial cells 显示文摘 | Volti GL Sacerdoti D Sangras B | 2005 | Antioxid Redox Signal2005，7，6： | 1 |
| 6 | Differential effect of heme oxygenase-1 in endothelial and smooth muscle cell cycle progression 显示文摘 | Li Volti G Wang Jishi Abraham NG | 2002 | Biochem Biophys Res Commun2002，296，5： | 1 |
| 7 | Differential effect of heme oxygenase- 1 in endothelial and smooth muscle cell cycle progression显示文摘 | LI VOLTI G WANG J TRAGANOS F | 2002 | Biochem Biophys Res Commun2002，296，5： | 1 |
| 8 | Schisandrin B stimulates a cytoprotective response in rat liver exposed to mercuric chloride 显示文摘 | Stacehiotti A Li Volti G Lavazza A | 2009 | Food Chem Toxicol2009，47，： | 1 |
| 9 | Pharmacological induction of heme oxygenase - 1 inhibits iNOS and oxidative stress in renal ischemia - reperfusion injury 显示文摘 | Li Volti G Sorrenti V Murabito P | 2007 | Transplant Proc2007，39，10： | 1 |
| 10 | Immune status and the immune response to hepatitis B virus vaccine in thalassemic patients after allgeneicer bone marrow transplantation显示文摘 | Li Volti S Di Gregorio F Romeo M A | | 0，，： | 1 |
| 11 | Differential effect ofheme oxygenase1 in endot helial and smooth muscle cell cycle progression显示文摘 | Li Volti G Wang J Traganos F | 2002 | Biochem Biophys Res Commun2002，9，296： | 1 |
| 12 | Carbon monoxide signaling in promoting angiogenesis in human mierovessel endothelial cells显示文摘 | Volti GL Sacerdoti D Sangras B | 2005 | Antioxid Redox Signal2005，7，6： | 1 |
| 13 | Different role of schisandrin B on mercury-induced renal damage in vivo and in vitro显示文摘 | Stacchiotti A Volti G L Lavazza A | 2011 | Toxicology2011，286，1： | 1 |
| 14 | Carbon monoxide signaling in promoting angiogenesis in human microvessel endothelial cells显示文摘 | Volti GL Sacerdoti D Sangras B | | 0，，56： | 1 |
| 15 | Metal fume fever显示文摘 | Michele Malaguarnera Filippo Drago Giulia Malaguarnera Giovanni Li Volti Salvatore Salomone Filippo Caraci Fabio Galvano Marco Vacante Claudio Bucolo Mariano Malaguarnera | 2013 | The Lancet . 2013 (9885)2013，，9885： | 1 |
| 16 | The role of neutrophils in comeal wound healing inHO-2 null mice显示文摘 | Marrazzo G Bellner L Halilovic A Li Volti G Drago F DunnMW | 2011 | PLoS One2011，6，21： | 1 |
| 17 | Persistent high plasma levels of interleukins 18 and 4 in children with recurrent infections of the upper respiratory tract显示文摘 | Volti G Malaponte G Bevelacqua V | 2003 | Transplant Proc2003，35，8： | 1 |
| 18 | Persistent high plasma levels of interleukins 18 and 4 in children with recurrent infections of the upper respiratory tract显示文摘 | Li Volti G Malaponte G Bevelacqua V | 2003 | Transplant Proc2003，35，8： | 1 |
| 19 | Potential immunoregula-tory role of heme oxygenase-1 in human milk: a combined biochemical and molecular modeling approach 显示文摘 | Li Volti G Galvano F Frigiola A | 2010 | J Nutr Biochem2010，21，9： | 1 |
| 20 | Immunocytochemical localization and expression ofheme oxygenase-1 in primary astroglial cell cultures during differentiation: effect of glutamate显示文摘 | Li Volti G Ientile R Abraham NG | 2004 | Biochem Biophys Res Commun2004，315，2： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员