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| 1 | Genome-wide MicroRNA Expression Profiles in COPD: Early Predictors for Cancer Development显示文摘Chronic obstructive pulmonary disease(COPD) significantly increases the risk of developing cancer. Biomarker studies frequently follow a case-control set-up in which patients diagnosed with a disease are compared to controls. Longitudinal cohort studies such as the COPD-centered German COPD and SYstemic consequences-COmorbidities NETwork(COSYCONET) study provide the patient and biomaterial base for discovering predictive molecular markers. We asked whether microRNA(miRNA) profiles in blood collected from COPD patients prior to a tumor diagnosis could support an early diagnosis of tumor development independent of the tumor type. From 2741 participants of COSYCONET diagnosed with COPD, we selected 534 individuals including 33 patients who developed cancer during the follow-up period of 54 months and 501 patients who did not develop cancer, but had similar age, gender and smoking history. Genome-wide miRNA profiles were generated and evaluated using machine learning techniques. For patients developing cancer we identified nine miRNAs with significantly decreased abundance(two-tailed unpaired t-test adjusted for multiple testing P < 0.05), including members of the miR-320 family. The identified mi RNAs regulate different cancer-related pathways including the MAPK pathway(P = 2.3 x 10^(-5)). We also observed the impact of confounding factors on the generated miRNA profiles, underlining the value of our matched analysis. For selected miRNAs, qRT-PCR analysis was applied to validate the results. In conclusion, we identified several miRNAs in blood of COPD patients, which could serve as candidates for biomarkers to help identify COPD patients at risk of developing cancer. | Andreas Keller Tobias Fehlmann Nicole Ludwig Mustafa Kahraman Thomas Laufer Christina Backes Claus Vogelmeier Caroline Diener Frank Biertz Christian Herr Rudolf A. Jorres Hans-Peter Lenhof Eckart Meese Robert Bals | 2018 | Genomics, Proteomics & Bioinformatics2018，16，3： | 9 |
| 2 | Tiotropium versus Salmeterol for the Prevention of Exacerbations of COPD显示文摘 | Vogelmeier C Hederer B Glaab T | 2011 | N Eng J Med2011，364，12： | 1 |
| 3 | Budesonide/formoterol maintenance and reliever therapy:an effective asthma treatment option?显示文摘 | C Vogelmeier R Pauwels J M Merino | 2005 | European Respiratory Journal2005，26，： | 1 |
| 4 | Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summary显示文摘 | Vestbo J Hurd SS Agusti AG Jones PW Vogelmeier C Anzueto A | 2013 | Respir Crit Care Med2013，187，： | 1 |
| 5 | A retrospective database study comparing treatment outcomes and cost associated with choice of fixed-dose inhaled corticosteroid/long-acting β 2 agonists for asthma maintenance treatment in Germany显示文摘 | S Aballea S Cure C Vogelmeier | 2008 | International Journal of Clinical Practice2008，62，12： | 1 |
| 6 | Patient understanding,detection,and experience of COPD exacerbations:an observational,interview-based study显示文摘 | Kessler R Stahl E Vogelmeier C | 2006 | Chest2006，130，1： | 1 |
| 7 | Inhibition of NF-kappa B mediated inflammation by si RNA expressed by recombinant adeno-associated virus显示文摘 | Pinkenburg O Platz J Beisswenger C Vogelmeier C Bals R | 2004 | J Virol Methods2004，120，1： | 1 |
| 8 | ESPEN Guidelines on Enteral Nutrition: Cardiology and Pulmonology显示文摘 | S.D. Anker M. John P.U. Pedersen C. Raguso M. Cicoira E. Dardai A. Laviano P. Ponikowski A.M.W.J. Schols H.F. Becker M. B?hm F.M. Brunkhorst C. Vogelmeier | 2006 | Clinical Nutrition2006，，2： | 1 |
| 9 | Chronic obstructive pulmonary disease(COPD) as a systemic disease显示文摘 | Greulich T Koczulla R Vogelmeier C | 2009 | Dtsch Med Wochenschr2009，134，23： | 1 |
| 10 | Tiotropium versus salmeterol for the prevention of exacerbations of COPD 显示文摘 | Vogelmeier C Hederer B Glaab T | 2011 | N Engl J Med2011，364，12： | 1 |
| 11 | Anti-neutrophil elastase defense of the normal human respiratory epithelial surface provided by the secretory leukoprotease inhibitor显示文摘 | Vogelmeier C Hubbard RC Fells GA | 1991 | J Clin Invest1991，87，2： | 1 |
| 12 | Tiotropium versus salmeterol for the prevention of exacerbations of COPD 显示文摘 | Vogelmeier C Hederer B Glaab T | 2011 | N Engl J Med2011，364，12： | 1 |
| 13 | Patient understanding, detection, and experience of COPD exacerbations: an observa- tional, interview-based study 显示文摘 | Kessler R Stahl E Vogelmeier C | 2006 | Chest2006，130，1： | 1 |
| 14 | Exacerba- tions of COPD: quantifying the patient's perspective using dis- crete choice modeling 显示文摘 | Haughney J Partridge MR Vogelmeier C | 2005 | Eur Respir2005，26，4： | 1 |
| 15 | Efficacy and safetyof ciclesonide in the treatment of 24,037 asthmatic patients inroutine medical care显示文摘 | Vogelmeier CF Hering F Lewin R | 2011 | Respir Med2011，105，2： | 1 |
| 16 | Totropium versus Salmeterol for the prevention of exacerbations of COPD显示文摘 | Vogelmeier C Hederer B Glaab T | 2011 | N Engl J Med2011，364，12： | 1 |
| 17 | Excess Costs of Comorbidities in Chronic Obstructive Pulmonary Disease: A Systematic Review显示文摘 | Huber MB Waekcr ME Vogelmeier CF | 2015 | PLoS One2015，10，01： | 1 |
| 18 | Exacerbations of COPD: quantifying the patient's perspective using discrete choice modelling 显示文摘 | Haughney J Partridge MR Vogelmeier C | 2005 | Eur Respir J2005，26，4： | 1 |
| 19 | Budesonide/formoterol as effective as predisolone plus formoterol in acute exacerbations of COPD : a double-blind, randomised, non-inferiority, parallel-group, muhicentre study显示文摘 | Stallberg B Selroos O Vogelmeier C | 2009 | Respir Res2009，10，1： | 1 |
| 20 | Formoterol mono- and combination therapy with tiotropium in patients with COPD: A 6-month study显示文摘 | Vogelmeier C Kardos P Harari S | 2008 | Respir Med2008，102，11： | 1 |
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