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| 1 | In vivo magnetic resonance spectroscopy of liver tumors and metastases显示文摘Primary liver cancer is the fifth most common malignancy in men and the eighth in women worldwide. The liver is also the second most common site for metastatic spread of cancer. To assist in the diagnosis of these liver lesions non-invasive advanced imaging techniques are desirable. Magnetic resonance (MR) is commonly used to identify anatomical lesions, but it is a very versatile technique and also can provide specific information on tumor pathophysiology and metabolism, in particular with the application of MR spectroscopy (MRS). This may include data on the type, grade and stage of tumors, and thus assist in further management of the disease. The purpose of this review is to summarize and discuss the available literature on proton, phosphorus and carbon-13-MRS as performed on primary liver tumors and metastases, with human applications as the main perspective. Upcoming MRSapproaches with potential applications to liver tumors are also included. Since knowledge of some technical background is indispensable to understand the results, a basic introduction of MRS and some technical issues of MRS as applied to tumors and metastases in the liver are described as well. In vivo MR spectroscopy of tumors in a metabolically active organ such as the liver has been demonstrated to provide important information on tumor metabolism, but it also is challenging as compared to applications on some other tissues, in particular in humans, mostly because of its abdominal location where movement may be a disturbing factor. | EGW ter Voert L Heijmen HWM van Laarhoven A Heerschap | 2011 | World Journal of Gastroenterology2011，17，47： | 7 |
| 2 | 结直肠癌肝转移的MR扩散加权成像:可重复性及生物学验证显示文摘 | L.Heijmen E.E.G.W.ter Voert I.D.Nagtegaal P.Span J.Bussink C.J.A.Punt 徐后云 | 2013 | 国际医学放射学杂志2013，，03： | 1 |
| 3 | Tumour res-ponse prediction by diffusion-weighted MR imaging: ready for clinical use? 显示文摘 | Heijmen L Verstappen MC Ter Voert EE | 2012 | Crit Rev Oncol Hematol2012，83，： | 1 |
| 4 | Turnout response prediction by diffusion-weighted MR imaging: ready for clinical use显示文摘 | Heijmen L Verstappen M C Ter Voert E E | 2012 | Crit Rev Oneol Hematol2012，83，2： | 1 |
| 5 | Functional MRI tech- niques demonstrate early vascular changes in renal cell cancer pa- tients treated with sunitinib: a pilot study 显示文摘 | Desar IM ter Voert EG Hambrock T | 2012 | Cancer Imaging2012，11，1： | 1 |
| 6 | Diffusion-weighted MR imaging in liver metastases of colorectal cancer: reproducibility and biological validation显示文摘 | Linda Heijmen Edwin E. G. W. Voert Iris D. Nagtegaal Paul Span Johan Bussink Cornelis J. A. Punt Johannes H. W. Wilt Fred C. G. J. Sweep Arend Heerschap Hanneke W. M. Laarhoven | 2013 | European Radiology2013，，3： | 1 |
| 7 | Compar- ison of liver SUV using unenhanced CT versus contrast- enhanced CT for attenuation correction in ~SF-FDG PET/ CT 显示文摘 | Ter Voert EE Van Laarhoven HW Kok PJ | 2014 | Nuclear Medicine Communications2014，35，5： | 1 |
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