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| 1 | MicroRNAs as possible biomarkers for diagnosis and prognosis of hepatitis b- and c-related-hepatocellularcarcinoma显示文摘Aim of the present review is to summarize the current knowledge about the potential relationship between mi RNAs and hepatitis B virus(HBV)-hepatitis C virus(HCV) related liver diseases. A systematic computerbased search of published articles, according to the Preferred Reporting Items for Systematic reviews and Meta-Analysis Statement, was performed to identify relevant studies on usefulness of serum/plasma/urine mi RNAs, as noninvasive biomarkers for early detection of HBV and HCV-induced hepatocellular carcinoma(HCC) development, as well as for its prognostic evaluation. The used Medical Subject Headings terms and keywords were: 'HBV', 'HCV', 'hepatocellular carcinoma', 'micro RNAs', 'mi RNAs', 'diagnosis', 'prognosis', 'therapy', 'treatment'. Some serum/plasma mi RNAs, including mi R-21, mi R-122, mi-125a/b, mi R-199a/b, mi R-221, mi R-222, mi R-223, mi R-224 might serve as biomarkers for early diagnosis/prognosis of HCC, but, to date, not definitive results or well-defined panels of mi RNAs have been obtained. More well-designed studies, focusing on populations of different geographical areas and involving larger series of patients, should be carried out to improve our knowledge on the potential role of mi RNAs for HCC early detection and prognosis. | Sirio Fiorino Maria Letizia Bacchi-Reggiani Michela Visani Giorgia Acquaviva Adele Fornelli Michele Masetti Andrea Tura Fabio Grizzi Matteo Zanello Laura Mastrangelo Raffaele Lombardi Luca Di Tommaso Arrigo Bondi Sergio Sabbatani Andrea Domanico Carlo Fabbri Paolo Leandri Annalisa Pession Elio Jovine Dario de Biase | 2016 | World Journal of Gastroenterology2016，22，15： | 25 |
| 2 | role of microRNAs in the main molecular pathways of hepatocellular carcinoma显示文摘Hepatocellular carcinoma(HCC) is the most common primary liver malignant neoplasia. HCC is characterized by a poor prognosis. The need to find new molecular markers for its diagnosis and prognosis has led to a progressive increase in the number of scientific studies on this topic. MicroRNAs(miRNAs) are small noncoding RNA that play a role in almost all main cellular pathways. miRNAs are involved in the regulation of expression of the major tumor-related genes in carcinogenesis, acting as oncogenes or tumor suppressor genes. The aim of this review was to identify papers published in 2017 investigating the role of miRNAs in HCC tumorigenesis. miRNAs were classified according to their role in the main molecular pathways involved in HCC tumorigenesis:(1) m TOR;(2) Wnt;(3) JAK/STAT;(4) apoptosis; and(5) MAPK. The role of miRNAs in prognosis/response prediction was taken into consideration. Bearing in mind that the analysis of miRNAs in serum and other body fluids would be crucial for clinical management, the role of circulating miRNAs in HCC patients was also investigated. The most represented mi RNA-regulated pathway in HCC is m TOR, but apoptosis, Wnt, JAK/STAT or MAPK pathways are also influenced by mi RNA expression levels. These miRNAs could thus be used in clinical practice as diagnostic, prognostic or therapeutic targets for HCC treatment. | Francesco Vasuri Michela Visani Giorgia Acquaviva Thomas Brand Michelangelo Fiorentino Annalisa Pession Giovanni Tallini Antonia D’Errico Dario de Biase | 2018 | World Journal of Gastroenterology2018，24，25： | 16 |
| 3 | Aeute pulmonary em bolism: clinical outcomes in the international cooperalive ppulmo nary embolism registry显示文摘 | Goldhaber S Z Visani L Rosa M D | 1999 | Lancet1999，353，9162： | 1 |
| 4 | Acute pulmonary embolism: clinical outcomes in the International Cooperative Pulmonary Embolism Registry (ICOPER) 显示文摘 | Goldhaber SZ Visani L De Rosa M | 1999 | Lancet1999，353，9162： | 1 |
| 5 | Acute pulmonary embolism:clinical outcomes in the International Cooperative Pulmonary Embolism Registry (ICOPER)显示文摘 | Goldhaber SZ Visani L De Rosa M | | 0，，9162： | 1 |
| 6 | Language lateralizationin temporal lobe epilepsy:a comparison between fMRI andthe Wada Test显示文摘 | Benke T Koylu B Visani P | 2006 | Epilepsia2006，47，8： | 1 |
| 7 | Acute pulmonary embolism:clinical outcomes in the international cooperative pulmonary embolism registry(ICOPER)显示文摘 | Goldhaber S Z Visani L DeRosa M | 1999 | Lancet1999，353，9162： | 1 |
| 8 | Acute pulmonary em- bolismclinical outcomes in the international cooperative pulmo- nary embolism reqistry显示文摘 | Goldhaber S Z Visani L Rosa M D | 1999 | Lancet1999，353，9162： | 1 |
| 9 | Acute pulmonary embolism: clinical outcomes in the International Cooperative Pulmonary Embolism Registry (ICOPER)显示文摘 | Samuel Z Goldhaber Luigi Visani Marisa De Rosa | 1999 | The Lancet1999，，9162： | 1 |
| 10 | Acute pulmonary embolism: clinical outcomes in the International Cooperative Pulmonary Embolism Registry(ICOPER) 显示文摘 | Goldhaber SZ Visani L De Rosa M | 1999 | Lancet1999，353，9162： | 1 |
| 11 | Acute pulmonary embolism: clinical outcomes in the International Cooperative Pulmonary Embolism Registry(ICOPER) 显示文摘 | Coldhaber SZ Visani L De Rosa M | 1999 | Iancet1999，353，： | 1 |
| 12 | Fludarabin-containing regimens severely impair peripheral blood stem cells mobilization and collection in acute myeloid leukemia patients显示文摘 | Visani G Lemoli RM Tosi P | 1999 | Br J Haematol1999，105，3： | 1 |
| 13 | Language lateralization in temporal lobe epilepsy: a comparison belween fMRI and the Wada Test显示文摘 | Benke T Koylu B Visani P | 2006 | Epilepsia2006，47，： | 1 |
| 14 | Acute pulmonary embolism:clinical outcomes in the International Cooperative Pulmonary Embolism Registry (ICOPER)显示文摘 | Goldhaber SZ Visani L De Rosa M | 1999 | Lancet1999，353，9162： | 1 |
| 15 | Modifications of milk constituents during processing:A preliminary benchmarking study 显示文摘 | Fenaille F Parisod V Visani P | 2006 | International Dairy Journal2006，16，： | 1 |
| 16 | Acute pulmonary embolism: clinical outcomes in the international cooperative pulmonary embolism registry (ICOPER) 显示文摘 | Goldhaber SZ Visani L De Rosa M | 1999 | Lancet1999，353，： | 1 |
| 17 | Acute pulmonary embolism:Clinical outcomes in the Lnternational cooperative pulmonary embolism registry显示文摘 | Goldhaber S Visani Derosam | 1999 | Lancet1999，313，： | 1 |
| 18 | Photosensitive epilepsy: spectral and coherence analyses of EEG us- ing 14 Hz intermittent photic stimulation显示文摘 | Visani E Varotto G Binelli S | 2010 | Clinical Neurophysiology2010，121，3： | 1 |
| 19 | Acute pulmonary embolism: clinical outcomes in the International Cooperative Pulmonary Embolism Registry (ICOPER)显示文摘 | Goldhaber SZ Visani L De Rosa M | 1999 | Lancet1999，353，9162： | 1 |
| 20 | Fludarabine plus ARA-CTG- CSF- Cytotoxic effect and induction of apoptosis is on fresh acute myeloid - leukemia cells 显示文摘 | Tosi P Visani G Ottaviani E | 2004 | Leukemia2004，8，12： | 1 |
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