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| 1 | Assessing the quality of studies in meta-analyses: Advantages and limitations of the Newcastle Ottawa Scale显示文摘One of the most important points in the meta-analyses is certainly represented by the assessment of the quality of the studies included in such research. The meta-analyses are considered the highest level of evidence in science. Also for this reason, the quality of the studies included should be accurately evaluated by standardized tools. The overall results of the metaanalysis depend indeed also on a rigorous evaluation of the studies quality. Among all the possible tools for this complex evaluation, the Newcastle Ottawa Scale(NOS) is one of the most used worldwide, above all for observational studies. In this review, we will discuss the strengths and limitation of the NOS, also on the basis of the branch of science in which it has been applied. | Claudio Luchini Brendon Stubbs Marco Solmi Nicola Veronese | 2017 | World Journal of Meta-Analysis2017，5，4： | 35 |
| 2 | Prevention of vertical transmission of hepatitis B virus infection显示文摘Hepatitis B virus(HBV)is the leading cause of chronic viral hepatitis.Annually,almost two million children younger than 5 years acquire the infection,mostly through vertical or horizontal transmission in early life.Vertical transmission of HBV is a high efficacy phenomenon ranging,in the absence of any preventive interventions,from 70%to 90%for hepatitis e antigen positive mothers and from 10%to 40%for hepatitis e antigen-negative mothers.Maternal viraemia is a preeminent risk factor for vertical transmission of HBV.Maternal screening is the first step to prevent vertical transmission of HBV.Hepatitis B passive and active immunoprophylaxis at birth together with antiviral treatment of highly viraemic mothers are the key strategies for global elimination of HBV infection.Strategies are needed to promote implementation of birth-dose vaccination and hepatitis B immunoglobulins in low-and middle-income countries where the prevalence of the infection is at the highest. | Piero Veronese Icilio Dodi Susanna Esposito Giuseppe Indolfi | 2021 | World Journal of Gastroenterology2021，27，26： | 10 |
| 3 | Personalized surgical management of colorectal cancer in elderly population显示文摘Colorectal cancer(CRC)in the elderly is extremely common but only a few clinicians are familiar with the complexity of issues which present in the geriatric population.In this phase of the life cycle,treatment is frequently suboptimal.Despite the fact that,nowadays,older people tend to be healthier than in previous generations,surgical undertreatment is frequently encountered.On the other hand,surgical overtreatment in the vulnerable or frail patient can lead to unacceptable postoperative outcomes with high mortality or persistent disability.Unfortunately,due to the geriatric patient being traditionally excluded from randomized controlled trials for a variety of factors(heterogeneity,frailty,etc.),there is a dearth of evidence-based clinical guidelines for the management of these patients.The objective of this review was to summarize the most relevant clinical studies available in order to assist clinicians in the management of CRC in the elderly.More than in any other patient group,both surgical and non-surgical management strategies should be carefully individualized in the elderly population affected by CRC.Although cure and sphincter preservation are the primary goals,many other variables need to be taken into account,such as maintenance of cognitive status,independence,life expectancy and quality of life. | Giampaolo Ugolini Federico Ghignone Davide Zattoni Giacomo Veronese Isacco Montroni | 2014 | World Journal of Gastroenterology2014，20，14： | 5 |
| 4 | Handgrip strength and health outcomes: Umbrella review of systematic reviews with meta-analyses of observational studies显示文摘Purpose:The aim of the present study was to assess both the credibility and strength of evidence arising from systematic reviews with meta-analyses of observational studies on handgrip strength and health outcomes.Methods:An umbrella review of systematic reviews with meta-analyses of observational studies was conducted.We assessed meta-analyses of observational studies based on random-effect summary effect sizes and their p values,95%prediction intervals,heterogeneity,small-study effects,and excess significance.We graded the evidence from convincing(Class I)to weak(Class IV).Results:From 504 articles returned in a search of the literature,8 systematic reviews were included in our review,with a total of 11 outcomes.Overall,nine of the 11 of the outcomes reported nominally significant summary results(p<0.05),with 4 associations surviving the application of the more stringent p value(p<106).No outcome presented convincing evidence.Three associations showed Class II evidence(i.e.,highly suggestive):(1)higher handgrip values at baseline were associated with a minor reduction in mortality risk in the general population(n=34 studies;sample size=1,855,817;relative risk=0.72,95%confidence interval(95%CI):0.670.78),(2)cardiovascular death risk in mixed populations(n=15 studies;relative risk=0.84,95%CI:0.780.91),and(3)incidence of disability(n=7 studies;relative risk=0.76,95%CI:0.660.87).Conclusion:The present results show that handgrip strength is a useful indicator for general health status and specifically for early all-cause and cardiovascular mortality,as well as disability.To further inform intervention strategies,future research is now required to fully understand mechanisms linking handgrip strength scores to these health outcomes. | Pinar Soysal Christopher Hurst Jacopo Demurtas Joseph Firth Reuben Howden Lin Yang Mark A.Tully Ai Koyanagi Petre Cristian Ilie Guillermo F.Lopez-Sanchez Lukas Schwingshackl Nicola Veronese Lee Smith | 2021 | Journal of Sport and Health Science2021，10，3： | 5 |
| 5 | Associations between cardiac arrhythmia,incident disability in activities of daily living and physical performance:the ILSA study显示文摘Background Cardiac arrhythmias are common conditions in older people.Unfortunately,there is limited literature on associations between cardiac arrhythmias and physical performance or disability.We therefore aimed to prospectively investigate associations between cardiac arrhythmias and changes in disability and physical performance during 8 years of follow-up,using data from the Italian Longitudinal Study on Aging(ILSA).Methods Cardiac arrhythmias diagnosis was posed through a screening phase,confirmed by a physician.The onset of disability in activities of daily living(ADL)and the changes in several physical performance tests during follow-up were considered as outcomes.Fully-adjusted and propensity-score Cox Proportional Hazard models and mixed models were used for exploring associations between cardiac arrhythmia and the outcomes of interest.Results The prevalence of cardiac arrhythmia at baseline was 23.3%.People reporting cardiac arrhythmia at the baseline were significantly older,more frequently male,smokers and reported a higher presence of all medical conditions investigated(hypertension,heart failure,angina,myocardial infarction,diabetes,stroke),but no difference in dementia,Parkinsonism,cognitive or mood disorder.Cardiac arrhythmia at baseline was significantly associated with the incidence of disability in ADL(HR=1.23;95%:CI:1.01–1.50;P=0.0478 in propensity score analyses;HR=1.28;95%CI:1.01–1.61;P=0.0401 in fully adjusted models).Cardiac arrhythmia at baseline was also associated with a significant worsening in balance test(P=0.0436).Conclusions The presence of cardiac arrhythmia at baseline was associated with a significant higher risk of disability and of worsening in some physical performance tests,particularly those relating to balance.Screening and frequently assessing physical performance in older people affected by cardiac arrhythmia can be important to prevent a loss of physical performance,with further,potential,complications of medical management. | Marianna Noale Nicola Veronese Lee Smith Andrea Ungar Stefano Fumagalli Stefania Maggi the Italian Longitudinal Study on Aging Working Group | 2020 | Journal of Geriatric Cardiology2020，17，3： | 3 |
| 6 | State of the art in PEGylation: The great versatility achieved after forty years of research显示文摘 | Gianfranco Pasut Francesco M. Veronese | 2011 | Journal of Controlled Release2011，，2： | 2 |
| 7 | MicroRNA-135b promotes cancer progression by acting as a downstream effector of oncogenic pathways in colon cancer显示文摘 | Nicola Valeri Chiara Braconi Pierluigi Gasparini Claudio Murgia Andrea Lampis Viola Paulus-Hock Jonathan R. Hart Lynn Ueno Sergei I. Grivennikov Francesca Lovat Alessio Paone Luciano Cascione Khlea M. Sumani Angelo Veronese Muller Fabbri Stefania Carasi H | 2014 | Cancer Cell2014，，： | 2 |
| 8 | The impact of PEGylation on biologi- cal therapies显示文摘 | Veronese F M Mero A | 2008 | BioDrugs2008，22，5： | 1 |
| 9 | Gene copy num- ber for epidermal growth factor receptor(EGFR)and clin- ical response to anti-EGFR treatment in colorectal cancer:a cohort study显示文摘 | Moroni M Veronese S Benvenuti S | 2005 | Lancet Oncol2005，6，5： | 1 |
| 10 | Peptide and protein PEGylation: a review of problems and solutions显示文摘 | Veronese FM | 2001 | Biomateriols2001，22，： | 1 |
| 11 | baximmunohistochemicalexpressioninbreastcarcinoma:astudywithlongtermfollow-up显示文摘 | VeroneseS MauriFA CaffoO etal | 1998 | IntJCancer1998，79，1： | 1 |
| 12 | A comparative study of enzymatic, structural, and pharmacokinetic properties of superoxide dismutase isolated from tow sources and modified by monomethoxypolyethylene glycol using different methods of coupling显示文摘 | Veronese FM Sartore L Schiavon O | 1990 | Ann N Y Acad Sci1990，613，4： | 1 |
| 13 | PEGylation, successful approach to drug delivery显示文摘 | Veronese F M Pasut G | 2005 | Drug Discovery Today2005，10，21： | 1 |
| 14 | Anti-cancer PEG-enzymes: 30 years old, but still a current approach 显示文摘 | Pasut G Sergi M Veronese FM | 2008 | Adv Drug Deliv Rev2008，60，1： | 1 |
| 15 | miR - 181b is a biomarker of disease progression in chronic lymphocytic leukemia 显示文摘 | Visone R Veronese A Rassenti LZ | 2011 | Blood2011，118，11： | 1 |
| 16 | Pharmacokinetic and biodistribution properties of poly (ethylene glycol)-protein conjugates 显示文摘 | Caliceti P Veronese F M | 2003 | Adv Dru Deiv Rev2003，55，10： | 1 |
| 17 | Polyphosphazene Membranes and Beresin Periodontal Diseases and Implant Surgery 显示文摘 | Veronese F Me Marsilio F | 1999 | Biomaterials1999，20，1： | 1 |
| 18 | Monoclonal antibodies in the treatment of colorectal cancer 显示文摘 | Veronese M L O'Dwyer P J | 2004 | Eur J Cancer2004，40，9： | 1 |
| 19 | Quantitative analyses of kidney injury molecule -1messenger RNA in kidney transplant recipients with graft dysfunc-tion显示文摘 | Nogare A L Joelsons G Pedroso J A Veronese F J Gonalves L F Manfro R C | 2010 | Transplant Proc2010，42，： | 1 |
| 20 | Peptide and protein PEGylation: a review of problems and solutions 显示文摘 | Veronese FM | 2001 | Biomaterials2001，22，5： | 1 |
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