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| 1 | Prophylaxis with ketotifen in rats with portal hypertension:involvement of mast cell and eicosanoids显示文摘BACKGROUND:Since we have previously shown an increase of mast cells in the small bowel and in the mesenteric lymph nodes in the rats with prehepatic portal hypertension,it can be hypothesized that this essential inflammatory cell would be involved in the pathogeny of the splanchnic changes related to portal hypertension. METHODS:To verify this hypothesis,we first studied mast cell infiltration in the ileum and in the mesenteric lymph nodes in sham-operated male Wistar rats(n=12) and in short-term prehepatic portal hypertensive rats (n=12),and the serum levels of rat mast cell protease Ⅱ(RMCP-Ⅱ)by ELISA.In a second set of experiments ketotifen,a mast cell stabilizer drug,was administered to sham-operated(n=10)and portal hypertensive(n=12) rats 24 hours before the intervention and prostanoids (PGE2,PGI2,TXB2)and leukotrienes(LTC4,LTB4)were assayed by RIA,mast cell infiltration in the ileum and in the mesenteric lymph nodes and the serum levels of RMCP-Ⅱwere also studied,to show its effectiveness to prevent the mesenteric alterations produced by the inflammatory mediators released by the mast cell. RESULTS:Forty-eight hours after the intervention RMCP-Ⅱ (P<0.05),PGE2(P<0.001)and LTC4 serum levels decreased and mast cell number and RMCP-Ⅱlevels increased in mesenteric lymph nodes in portal hypertensive rats.Prophylactic administration of ketotifen reduced portal pressure(P<0.001),serum levels of PGE2(P<0.001)and RMCP-Ⅱ(P<0.001)in mesenteric lymph nodes. CONCLUSIONS:In acute portal hypertension in the rat,the mast cell translocation from intestinal mucosa to mesenteric lymph nodes,where they are activated and degranulates,would represent a defence mechanism to avoid the activation of an acute and massive inflammatory response in this location.Prophylactic administration of ketotifen is able to reduce the splanchnic inflammatory changes related to acute portal hypertension in the rat. | Fernando Sánchez-Patán Raquel Anchuelo Elena Vara Cruz García Yolanoa Saavedra Patri Vergara Carmen Cuellar Marta Rodero Maria-Angeles Aller Jaime Arias | 2008 | Hepatobiliary & Pancreatic Diseases International2008，7，4： | 2 |
| 2 | Hepatic lipid metabolism changes in short-and long-term prehepatic portal hypertensive rats显示文摘AIM: To verify the impairment of the hepatic lipid metabolism in prehepatic portal hypertension. METHODS: The concentrations of free fatty acids, diacylglycerol, triglycerides, and phospholipids were assayed by using D-[U-14C] glucose incorporation in the different lipid fractions and thin-layer chromatography and cholesterol was measured by spectrophotometry, in liver samples of Wistar rats with partial portal vein ligation at short- (1 mo) and long-term (1 year) (i.e. portal hypertensive rats) and the control rats. RESULTS: In the portal hypertensive rats, liver phospholipid synthesis significantly decreased (7.42 ± 0.50 vs 4.70 ± 0.44 nCi/g protein; P < 0.01) and was associated with an increased synthesis of free fatty acids (2.08 ± 0.14 vs 3.36 ± 0.33 nCi/g protein; P < 0.05), diacylglycerol (1.93 ± 0.2 vs 2.26 ± 0.28 nCi/g protein), triglycerides (2.40 ± 0.30 vs 4.49 ± 0.15 nCi/g protein) and cholesterol (24.28 ± 2.12 vs 57.66 ± 3.26 mg/g protein; P < 0.01). CONCLUSION: Prehepatic portal hypertension in rats impairs the liver lipid metabolism. This impairment consists in an increase in lipid deposits (triglycerides,diacylglycerol and cholesterol) in the liver, accompanied by a decrease in phospholipid synthesis. | Maria-Angeles Aller Elena Vara Cruz García Maria-Paz Nava Alejandra Angulo Fernando Sánchez-Patán Ana Calderón Patri Vergara Jaime Arias | 2006 | World Journal of Gastroenterology2006，12，42： | 2 |
| 3 | Hedghog singalingregulates differentiation from double-negative to doublepositive thymocyte显示文摘 | Outram SV Varas A Pepiceli CV | 2001 | Immunity2001，13，6： | 2 |
| 4 | Stromal cell-derived factor 1/CXCR4 signaling is eritieal for early human T-cell development显示文摘 | Hernandez-Lopez C Varas A Sacedon R | 2002 | Blood2002，99，2： | 1 |
| 5 | Leukaemia presenting with fulminant hepatic failure in a child显示文摘 | Kader A Vara R Egberongbe Y | 2006 | Pediatr Blood Cancer2006，47，： | 1 |
| 6 | Cellular automaton model for evacuation process with obstacles 显示文摘 | VARAS A CORNEJO M D MAINEMER M | 2007 | Physica A2007，382，2： | 1 |
| 7 | Pancreatic endocrine tu-mors or apudomas显示文摘 | Varas M Gornals J Ponseti JM AlastruèA Durán C Llevaria C Ballesta C Díez Caballero A Artigas V | 2011 | Rev Esp Enferm Dig2011，103，： | 1 |
| 8 | Effect of chronic treatments with GH, melatonin, estrogens, and phytoestrogens on oxidative stress parameters in liver from aged female rats 显示文摘 | Kireev R A Tresguerres A F Vara E | 2007 | Biogerontology2007，8，5： | 1 |
| 9 | Cellular automaton model for evacuation process with obstacles显示文摘 | Varas A Cornejo M D Mainemer D | 2007 | Physica A: Statistical Mechanics and its Applications2007，382，2： | 1 |
| 10 | Cellular automaton model for evacuation process with obstacles显示文摘 | Varas A Cornejo M D Mainemer D | 2007 | Physica A2007，382，： | 1 |
| 11 | Appearance and development of lymphoid cells in the chicken (Gallus gallus) caecal tonsil显示文摘 | Gomez D M Fonfria J Varas A | 1998 | Anat Rec1998，250，2： | 1 |
| 12 | Appearance and development of lymphoid cellsin the chicken (Gallus gallus) caecal tonsil 显示文摘 | Gomez M M Fonfria J Varas A | 1998 | Anat Rec1998，250，： | 1 |
| 13 | Cloning and expression of a puromycin N-acetyl transferase gene from Streptomyces alboniger in Streptomyces lividans and Escherichia coli显示文摘 | Vara J Malpartida F Hopwood D A | 1985 | Gene1985，33，2： | 1 |
| 14 | Cellular automaton model for evacuation process with obstacles显示文摘 | VARAS A CORN MAINEMER D | 2007 | Physica A2007，382，： | 1 |
| 15 | Molecular analysis of the pac gene encoding a puromycin N-acetyl transferase from Streptomyces alboniger显示文摘 | Lacalle R A Pulido D Vara J | 1989 | Gene1989，79，2： | 1 |
| 16 | Cellular automaton model for evacuation process with obstacles 显示文摘 | Varas A Cornejo M D Mainemer D | 2007 | Physica A2007，382，2： | 1 |
| 17 | The CXCL12/CXCR4 pair in aged human thymus显示文摘 | Hemandez-Lopez C Varas A Sacedon R | 2010 | Neuroimmunomodulation2010，17，3： | 1 |
| 18 | Cellular automaton model for evacuation process with obstacles 显示文摘 | VARAS A CORNEJO M D MAINEMER D | 2007 | Physica A2007，382，2： | 1 |
| 19 | Age-dependent alterations of long-term synaptic plasticity in thyroid-deficient rats 显示文摘 | Vara H Munoz-Cuevas J Colino A | 2003 | Hippocampus2003，13，7： | 1 |
| 20 | Influence of nickel content on the electrochemical behavior of Finemet type amorphous and nanocrystalline alloys显示文摘 | VARA G PIERNA A R JIMENEZ J A | 2007 | Journal of Non-Crystalline Solids2007，353，： | 1 |
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