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| 1 | Should antibiotics be administered before arthroscopic knee surgery? A systematic review of the literature显示文摘AIM To explore the current evidence surrounding the administration of prophylactic antibiotics for arthroscopic knee surgery. METHODS Databases were searched from inception through May of 2018 for studies examining prophylactic antibiotic use and efficacy in knee arthroscopy. Studies with patient data were further assessed for types of arthroscopic procedures performed,number of patients in the study,use of antibiotics,and outcomes with the intention of performing a pooled analysis. Data pertaining to 'deep tissue infection' or 'septic arthritis' were included in our analysis. Reported data on superficial infection were not included in our data analysis. For the pooled analysis,a relative risk ratio was calculated and χ~2 tests were used to assess for statistical significance between rates of infection amongst the various patient groups. Post hoc power analyses were performed to compute the statistical power obtained from our sample sizes. Number needed to treat analyses were performed for statistically significant differences by dividing 1 by the difference between the infection rates of the antibiotic and no antibiotic groups. An alpha value of 0.05 was used for our analysis. Study heterogeneity was assessed by Cochrane's Q test as well as calculation of the I^2 value.RESULTS A total of 49682 patients who underwent knee ar-throscopy for a diverse set of procedures across 19 studies met inclusion critera for pooled analysis. For those not undergoing graft procedures,there were 27 cases of post-operative septic arthritis in 34487 patients(0.08%) who received prophylactic antibiotics and 16 cases in 10911(0.15%) who received none [risk ratio(RR) = 0.53,95% confidence interval(CI): 0.29-0.99,P = 0.05]. A sub-group analysis in which bony procedures were excluded was performed which found no significant difference in infection rates between patients that received prophylactic antibiotics and patients that did not(P > 0.05). All anterior cruciate ligament reconstruction studies used prophylactic antibiotics,but two studies investigating the effect of soaking the graft in vancomycin in addition to standard intravenous(IV) prophylaxis were combined for analysis. There were 19 cases in 1095 patients(1.74%) who received IV antibioitics alone and no infections in 2034 patients who received IV antibiotics and had a vancomycin soaked graft(RR = 0.01,95%CI: 0.001-0.229,P < 0.01).CONCLUSION Prophylactic antibiotics are effective in preventing septic arthritis following simple knee arthroscopy. In procedures involving graft implantation,graft soaking reduces the rate of infection. | John Carney Nathanael Heckmann Erik N Mayer Ram K Alluri Carleton Thomas Vangsness George F Hatch Ⅲ Alexander E Weber | 2018 | World Journal of Orthopedics2018，9，11： | 2 |
| 2 | Lasers and radiofreguency electromagnetic surgical devices in orthopaedics显示文摘 | Sherk HH Vangsness CT Thabit G | 2002 | J Bone Joint Surg2002，84，： | 1 |
| 3 | Lean blowout in a research combustor at simulated low pressures显示文摘 | Sturgess G J Heneghan S P Vangsness M D | 1996 | Journal of Engineer- ing for Gas Turbines and Power1996，118，4： | 1 |
| 4 | Recent advances in glucosamine and chondroitin supplementation 显示文摘 | Owens S Wagner P Vangsness CT Jr | 2004 | J Knee Surg2004，17，4： | 1 |
| 5 | Gamma irradiation : effects on biomechanical properties of human bone-patellar tendon- bone allografts 显示文摘 | Fideler BM Vangsness CT Jr Lu B | 1995 | Am J Sports Med1995，5，： | 1 |
| 6 | Adult human mesenchy- mal stem cells delivered via intra-articular injection to the knee fol- lowing partial medial meniscectomy:a randomized,double-blind,con- trolled study显示文摘 | Vangsness CT Jr Farr J 2nd Boyd J | 2014 | J Bone Joint Surg Am2014，96，2： | 1 |
| 7 | Arthroscopy of the subtalar joint:an experimental approach显示文摘 | Parision JS Vangsness T | 1985 | Arthroscopy1985，1，1： | 1 |
| 8 | Arthroscopy of meniscal injuries with tibial plateau fractures 显示文摘 | Vangsness CT Ghaderi B Hohl M | 1994 | Bone Joint J1994，76，3： | 1 |
| 9 | General quality of life in youth with type 1 diabetes显示文摘 | Laffel MB Connell A Vangsness L | 2003 | Diabetes Care2003，26，： | 1 |
| 10 | Gamma irradiation: effects on biomechanical properties of human bone - patellar tendon-bone allografts 显示文摘 | Fideler BM Vangsness CT Jr Lu B | 1995 | Am J Sports Med1995，5，： | 1 |
| 11 | Anterior cruciate lig-ament allograft surgery : underreporting of graft source,graft processing,and donor age 显示文摘 | Sikka R S Narvy S J Vangsness C T | 2011 | Am J Sports Med2011，39，3： | 1 |
| 12 | A Review of Evidence-Based Medicine for Glucosamine and Chondroitin Sulfate Use in Knee Osteoarthritis显示文摘 | C. Thomas Vangsness William Spiker Juliana Erickson | 2009 | Arthroscopy: The Journal of Arthroscopic and Related Surgery2009，，1： | 1 |
| 13 | Restoring articular cartilage in the knee显示文摘 | Vangsness CT Kurzweil PR Lieberman JR | 2004 | Am J Orthop2004，33，2： | 1 |
| 14 | Gamma irradiation: effects on biomechanical properties of human bone-patellar tendon-bone allografts显示文摘 | FIDELER B M VANGSNESS CT Jr LU B | 1995 | Am J Sports Med1995，23，： | 1 |
| 15 | Radiofrequency use on articular cartilage lesions显示文摘 | Vangsness CT Jr | | 0，，04： | 1 |
| 16 | An experimental and computational study of swirling hydrogen jet diffusion flame 显示文摘 | Anand M S Takahashi F Vangsness M D | 1997 | Journal of Engineering for Gas Turbines and Power1997，119，： | 1 |
| 17 | Electrosurgical methods for arthroscpic meniscectomy:a review of the literature显示文摘 | Polousky JD Hedman TP Vangsness CT Jr | | 0，，： | 1 |
| 18 | Collagen shortening:an experimental appmach with heat显示文摘 | Vangsness CT Jr Mitchell W 3rd Nimni M | | 0，，337： | 1 |
| 19 | Ipsilateral knee injury with femoral fracture:examination under anesthesia and arthroscopic evaluation显示文摘 | De Campos J Vangsness CTJ Merritt PO | 1994 | Clin Orthop1994，300，： | 1 |
| 20 | Impact of ambula- tory,family-focused teamwork intervention on glyeemic control in youth with type 1 diabetes显示文摘 | Laffel LMB Vangsness L Connell A | 2003 | J Pediatr2003，142，4： | 1 |
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