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| 1 | Surgical treatment of anal stenosis显示文摘Anal stenosis is a rare but serious complication of anorectal surgery, most commonly seen after hemorrhoidectomy. Anal stenosis represents a technical challenge in terms of surgical management. A Medline search of studies relevant to the management of anal stenosis was undertaken. The etiology, pathophysiology and classifi cation of anal stenosis were reviewed. An overview of surgical and non-surgical therapeutic options was developed. Ninety percent of anal stenosis is caused by overzealous hemorrhoidectomy. Treatment, both medical and surgical, should be modulated based on stenosis severity. Mild stenosis can be managed conservatively with stool softeners or fiber supplements. Sphincterotomy may be quite adequate for a patient with a mild degree of narrowing. For more severe stenosis, a formal anoplasty should be performed to treat the loss of anal canal tissue. Anal stenosis may be anatomic or functional. Anal stricture is most often a preventable complication. Many techniques have been used for the treatment of anal stenosis with variable healing rates. It is extremely diffi cult to interpret the results of the various anaplastic procedures de in the literature as prospective trials have not been performed. However, almost any approach will at least improve patient symptoms. | Giuseppe Brisinda Serafino Vanella Federica Cadeddu Gaia Marniga Pasquale Mazzeo Francesco Brandara Giorgio Maria | 2009 | World Journal of Gastroenterology2009，15，16： | 22 |
| 2 | Botulinum toxin for chronic anal fissure after biliopancreatic diversion for morbid obesity显示文摘AIM: To study the effect of botulinum toxin in patients with chronic anal fissure after biliopancreatic diversion (BPD) for severe obesity. METHODS: Fifty-nine symptomatic adults with chronic anal fissure developed after BPD were enrolled in an open label study. The outcome was evaluated clinically and by comparing the pressure of the anal sphincters before and after treatment. All data were analyzed in univariate and multivariate analysis. RESULTS: Two months after treatment, 65.4% of the patients had a healing scar. Only one patient had mild incontinence to flatus that lasted 3 wk after treatment, but this disappeared spontaneously. In the multivariate analysis of the data, two registered months after the treatment, sex (P = 0.01), baseline resting anal pressure (P = 0.02) and resting anal pressure 2 mo after treatment (P < 0.0001) were significantly related to healing rate.CONCLUSION: Botulinum toxin, despite worse results than in non-obese individuals, appears the best alternative to surgery for this group of patients with a high risk of incontinence. | Serafino Vanella Giuseppe Brisinda Gaia Marniga Anna Crocco Giuseppe Bianco Giorgio Maria | 2012 | World Journal of Gastroenterology2012，18，10： | 4 |
| 3 | Increased heme- ojtygenase 1 expression in mesenchymal stem cell-derived adipocytes decreases differentiation and lipid accumulation via upregulation of the canonical Wnt signaling cascade显示文摘 | Vanella L Sodhi K Kim DH | 2013 | Stem Cell Res Ther2013，4，2： | 1 |
| 4 | Epoxyeicosatrienoic acids and heme oxygenase-1 interaction attenuates diabetes and metabolic syn- drome complications显示文摘 | Burgess A Vanella L Bellner L | 2012 | Prostaglandins Other Lipid Mediat2012，97，12： | 1 |
| 5 | Heine oxygenase (HO-1) rescue of adipocyte dysfunction in HO-2 deficient mice via recruit- ment of epoxyeicosatrienoic acids (EETs) and adiponectin 显示文摘 | Burgess A P Vanella L Bellner L | 2012 | Cell Physiol Biochem2012，29，12： | 1 |
| 6 | Severe acute pan-creatitis:advances and insights in assessment of severityand management显示文摘 | Brisinda G Vanella S Crocco A et a1 | 2011 | Eur JGastroenterol Hepatol2011，23，7： | 1 |
| 7 | Adipocytc heine oxygenase-I induction attenuates metabolic syndrome in both male and female obes mice显示文摘 | Burgess A Li M Vanella L | 2010 | Hypertension2010，56，6： | 1 |
| 8 | ApoAl: mimetic peptide reverses aclipocyte dysfunction in vivo and in vitro via an increase in heme oxygonase (HO-1) and Wnt10b显示文摘 | Vanella L Li M Kim D | 2012 | Cell Cycle2012，11，4： | 1 |
| 9 | Bone marrow stem cell transplant into intra-bone cavity prevent Type 2 diabetes:role of hemeoxygenase and CO显示文摘 | Abraham N Li M Vanella L | 2008 | J Autoimmunity2008，30，3： | 1 |
| 10 | Overexpression of heine oxygenase-I inereases human osteoblast stem cell differentiation显示文摘 | Barbagallo 1 Vanella AP eterson SJ Kim DH | 2010 | J Bone Miner Metab2010，28，3： | 1 |
| 11 | Severe acute pancreatitis:advances and insights in assessment of severity andmanagement显示文摘 | Brisinda G Vanella S Crocco A | 2011 | Eur J Gastroenterol Hepatol2011，23，7： | 1 |
| 12 | Correlation between lipid profile and heme oxygenase system in patients with benign prostatic hyperplasia显示文摘 | VANELLA L RUSSO GI CIMINO S | 2014 | Urology2014，83，6： | 1 |
| 13 | End-to-end versus end-to-side stapled anastomoses after anterior resection for rectal cancer显示文摘 | Brisinda G1 Vanella S Cadeddu F | 2009 | J Surg Oncol2009，99，1： | 1 |
| 14 | dinical and pathological response to primary chemotherapy in patients with locally advanced breast cancer grouped according to hormonal receptors,Her2 status,grading and Ki67 proliferation index显示文摘 | Miglietta L Vanella P Canobbio L | 2009 | Anticancer Res2009，29，5： | 1 |
| 15 | L-propionyl-carnitine as superoxide scavenger,antioxidant,and DNA cleavage protector显示文摘 | Vanella A Russo A Acquaviva R | | 0，，02： | 1 |
| 16 | Recent isolations of encephalomyocarditis virus显示文摘 | Kissling R E Vanella J M Schaeffer M | 1956 | Proc Soc Exp Biol Med1956，91，： | 1 |
| 17 | L-propionyl-carnitine as superoxide scavenger, antioxidant, and DNA cleavage protector显示文摘 | Vanella A Russo A Acquaviva R | 2000 | Cell Biol Toxicol2000，16，2： | 1 |
| 18 | Antioxidant activity of propolis:role of caffeic acid phenethyl ester and galangin显示文摘 | A Russo R Longo A Vanella | 2002 | Fitoterapia2002，73，1： | 1 |
| 19 | Oxidative Stress and Heme Oxygenase-1 Regulated Human Mesenchymal Stem Cells Differentiation显示文摘 | Luca Vanella Christopher Sanford Dong Hyun Kim Nader G. Abraham Nabil Ebraheim David E. Stec | 2012 | International Journal of Hypertension2012，，： | 1 |
| 20 | Recent isolations of encephalomyocarditis virus显示文摘 | Kissling RE Vanella JM Schaeffer M | 1956 | Proc Soc Exp Biol Med1956，91，1： | 1 |
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