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| 1 | sTREM-1 is a specific biomarker of TREM-1 pathway activation显示文摘TREM-1(triggering receptor expressed on myeloid cells-1)is a transmembrane receptor expressed by innate immune cells,including endothelial cells and platelets.TREM-1 is a crucial mediator of septic shock that acts by synergizing with Toll-like receptors(TLRs)to amplify the inflammatory responses to pathogens,thus promoting sepsis-induced immune dysregulation and organ dysfunction[1,2,3]. | Lucie Jolly Kévin Carrasco Margarita Salcedo-Magguilli Jean-Jacques Garaud Simon Lambden Tom van der Poll Alexandre Mebazaa Pierre-François Laterre Sebastien Gibot Amir Boufenzer Marc Derive | 2021 | Cellular & Molecular Immunology2021，18，8： | 8 |
| 2 | Mesenchymal stem cells as a therapeutic tool to treat sepsis显示文摘Sepsis is a clinical syndrome caused by a deregulated host response to an infection. Sepsis is the most frequent cause of death in hospitalized patients. Although knowledge of the pathogenesis of sepsis has increased substantially during the last decades, attempts to design effective and specific therapiestargeting components of the derailed host response have failed. Therefore, there is a dramatic need for new and mechanistically alternative therapies to treat this syndrome. Based on their immunomodulatory properties, adult mesenchymal stem or stromal cells(MSCs) can be a novel therapeutic tool to treat sepsis. Indeed, MSCs reduce mortality in experimental models of sepsis by modulating the deregulated inflammatory response against bacteria through the regulation of multiple inflammatory networks, the reprogramming of macrophages and neutrophils towards a more antiinflammatory phenotype and the release of antimicrobial peptides. This report will review the current knowledge on the effects of MSC treatment in preclinical experimental small animal models of sepsis. | Eleuterio Lombardo Tom van der Poll Olga Dela Rosa Wilfried Dalemans | 2015 | World Journal of Stem Cells2015，7，2： | 6 |
| 3 | Host–pathogen interactions in sepsis显示文摘 | Tom van der Poll Steven M Opal | 2008 | The Lancet Infectious Diseases2008，，1： | 2 |
| 4 | Bidirectional Relation Between Inflammation and Coagulation显示文摘 | Marcel Levi Tom van der Poll Harry R. Büller | 2004 | Circulation: Journal of the American Heart Association2004，，22： | 2 |
| 5 | ROLE OF TOLL-LIKE RECEPTORS 2 AND 4, AND THE RECEPTOR FOR ADVANCED GLYCATION END PRODUCTS IN HIGH-MOBILITY GROUP BOX 1-INDUCED INFLAMMATION IN VIVO显示文摘 | Marieke A.D. van Zoelen Huan Yang Sandrine Florquin Joost C.M. Meijers Shizuo Akira Bernd Arnold Peter P. Nawroth Angelika Bierhaus Kevin J. Tracey Tom van der Poll | 2009 | Shock2009，，3： | 2 |
| 6 | Bidirectional relation between inflammation and coagulation 显示文摘 | Levi M van der Poll T Bailer HR | 2004 | Circulation2004，109，22： | 1 |
| 7 | Rationale for restoration of physiological anticoagulant pathways in patients with sepsis and disseminated intravascular coagulation 显示文摘 | Levi M de Jonge E van der Poll T | 2001 | Crit Care Med2001，29，7： | 1 |
| 8 | Anticoagulant therapy for acute lung injury or pneumonia显示文摘 | Sehultz M J Levi M Van der Poll T | 2003 | Curr Drug Targets2003，4，4： | 1 |
| 9 | Effect of the factor V Leiden mutation on the incidence and outcome of severe infection and sepsis 显示文摘 | Marcel Schouten C Van't Veer T Van Der Poll | 2012 | Neth J Med2012，70，7： | 1 |
| 10 | Bidirectional relation between inflammation and coagulation显示文摘 | Levi M van der Poll T Buller HR | 2004 | Circulation2004，109，22： | 1 |
| 11 | Tissue factor in infection and severe inflammation显示文摘 | LEVI M VAN DER POLL T TEN CATE H | 2006 | Semin Thromb Hemost2006，32，： | 1 |
| 12 | Bidirectional relation between inflammation and coagulation显示文摘 | Marcel Levi Tom van der Poll Harry R | 2004 | Circulation2004，109，： | 1 |
| 13 | Severe sepsis and septic shock显示文摘 | ANGUS DC VAN DER POLL T | 2013 | The New England journal of medicine2013，369，21： | 1 |
| 14 | Interleukin-18gene-deficient mice show enhanced defense and reduced inflamma-tion during pneumococcal meningitis 显示文摘 | Zwijnenburg PJ van der Poll T Florquin S | 2003 | J Neuroimmunol2003，138，12： | 1 |
| 15 | Changes in endotoxin -induced cytokine production by whole blood after in vivo exposure of normal humans to endotoxin显示文摘 | Van Der Poll T Coyle S M Moldawer L L et 01 | 1996 | J Infect Dis1996，174，6： | 1 |
| 16 | Endothelial barrier dysfunction in septic shock显示文摘 | Opal SM Van Der Poll T | 2015 | J Intern Med2015，3，3： | 1 |
| 17 | The systemic pro-inflammatory response in sepsis显示文摘 | de Jong HK van der Poll T Wiersinga WJ | 2010 | J Innate Immun2010，2，5： | 1 |
| 18 | Tissue factor as an initiator of coagulation and inflammation in the lung显示文摘 | VAN DER POLL T | 2008 | Crit Care2008，12，6： | 1 |
| 19 | Amblyopia & Strabismus Questionnaire: design and initial validation显示文摘 | van de Graaf E S van der Sterre G W Polling J R | 2004 | Strabismus2004，12，3： | 1 |
| 20 | Novel approaches to the management of disseminated intravascular coagulation显示文摘 | Levi M de Jonge E van der Poll T | 2000 | Crit Care Med2000，28，9： | 1 |
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