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| 1 | Inflammatory bowel disease serology in Asia and the West显示文摘AIM:To study serological antibodies in Caucasians and Asians,in health and inflammatory bowel disease(IBD),in Australia and Hong Kong(HK).METHODS:Anti-glycan antibodies[anti-chitobioside(ACCA),anti-laminaribioside(ALCA)],and anti-mannobioside(AMCA),anti-Saccharomyces cervisiae(gASCA);and atypical perinuclear anti-neutrophil cytoplasmic antibody(pANCA)were tested in IBD patients,their unaffected relatives,and healthy controls in Australia and HK(China).Antibody status(positive or negative)and titre was compared between subjects of different geography,ethnicity and disease state.RESULTS:Ninety subjects were evaluated:21 Crohn’s disease(CD),32 ulcerative colitis(UC),29 healthy controls,and 8 IBD patient relatives.Forty eight subjects were Australian(29 Caucasian and 19 ethnic Han Chinese)and 42 were from HK(all Han Chinese).Caucasian CD patients had a significantly higher antibody prevalence of gASCA(67%vs 3%,P<0.001),ALCA(44%vs 6%,P=0.005),and AMCA(67%vs 15%,P=0.002),whereas HK CD patients had a higher prevalence of only AMCA(58%vs 25%,P=0.035),when compared with UC and healthy subjects in both countries.Caucasian CD had significantly higher gASCA prevalence(67%vs 0%,P<0.001)and titre(median59 vs 9,P=0.002)than HK CD patients.Prevalence and titres of ALCA,ACCA and AMCA did not differ between CD in the two countries.Presence of at least one antibody was higher in Caucasian than HK CD patients(100%vs 58%,P=0.045).pANCA did not differ between countries or ethnicity.CONCLUSION:Serologic CD responses differ between HK Asian and Australian Caucasian patients.Different genetic,environmental or disease pathogenic factors may account for these differences. | Lani Prideaux Michael A Kamm Peter De Cruz Daniel R van Langenberg Siew C Ng Iris Dotan | 2013 | World Journal of Gastroenterology2013，19，37： | 10 |
| 2 | Anterograde and Retrograde Regulation of Nuclear Genes Encoding Mitochondrial Proteins during Growth, Development, and Stress显示文摘在植物的 Mitochondrial 生物的续生说和功能要求编码 mitochondrial 蛋白质(NGEMP ) 的超过 1000 原子基因的表示。这些基因的表达式被织物特定、发展、内部、外部的刺激 thatresult 在涉及的一个动态细胞器调整新陈代谢并且许多发信号的进程。尽管线粒体的新陈代谢的 andbiosynthetic 机械很好相对被理解,调整这些过程和 varioussignaling 小径的因素仅仅在分子的水平正在识别包含。anterograde 的分子的部件(对 mitochondrial 原子) 并且后退(mitochondrial 到原子) 与叶绿体调整 NGEMPsinteract 的表示的发信号的小径 -- ,生长 -- ,并且在在许多层次的房间的发信号压力的小径,与在这些信号的传播和执行的普通 componentsinvolved。这作为在 thecell,不是仅仅在 mitochondrial 功能本身的直接发信号,而且在察觉到或集成许多 otherinternal 和外部信号发信号的重要中心放线粒体。这与精力新陈代谢和压力回答集成并且优化生长,哪个在光合、非光合的 cells.Key 词的 isrequired: | Sophia Ng Inge De Clercqc Olivier Van Akena Simon R. Lawd Aneta Ivanovad Patrick Willems Estelle Giraud Frank Van Breusegem James Wheland | 2014 | Molecular Plant2014，7，7： | 8 |
| 3 | Gastroenterologist perceptions of faecal microbiota transplantation显示文摘AIM: To explore gastroenterologist perceptions towards and experience with faecal microbiota transplantation(FMT).METHODS: A questionnaire survey consisting of 17 questions was created to assess gastroenterologists' attitude towards and experience with FMT. This was anonymously distributed in hard copy format amongst attendees at gastroenterology meetings in Australia between October 2013 and April 2014. Basic descriptive statistical analyses were performed.RESULTS: Fifty-two clinicians participated. Twenty one percent had previously referred patients for FMT,8% more than once. Ninety percent would refer patients with Clostridium difficile infection(CDI) for FMT if easily available,37% for ulcerative colitis,13% for Crohn's disease and 6% for irritable bowel syndrome. Six percent would not refer any indication,including recurrent CDI. Eighty-six percent would enroll patients in FMT clinical trials. Thirty-seven percent considered the optimal mode of FMT administration transcolonoscopic,17% nasoduodenal,13% enema and 8% oral capsule. The greatest concerns regarding FMT were: 42% lack of evidence,12% infection risk,10% non infectious adverse effects/lack of safety data,10% aesthetic,10% lack of efficacy,4% disease exacerbation,and 2% inappropriate use; 6% had no concerns. Seventy seven percent believed there is a lack of accessibility while 52% had an interest in learning how to provide FMT. Only 6% offered FMT at their institution.CONCLUSION: Despite general enthusiasm,most gastroenterologists have limited experience with,or access to,FMT. The greatest concerns were lack of supportive evidence and safety issues. However a significant proportion would refer indications other than CDI for FMT despite insufficient evidence. These data provide guidance on where education and training are required. | Sudarshan Paramsothy Alissa J Walsh Thomas Borody Douglas Samuel Johan van den Bogaerde Rupert WL Leong Susan Connor Watson Ng Hazel M Mitchell Nadeem O Kaakoush Michael A Kamm | 2015 | World Journal of Gastroenterology2015，21，38： | 5 |
| 4 | 血压难以控制的高血压患者临时停用降压药的安全性分析显示文摘血压控制成功依赖于有效鉴别出继发性病因和发现高血压的发病因素。由于抗高血压药物可能会干扰诊断调查,在一些研究中可能会要求患者临时停药。然而,对于血压难以控制的高血压患者,临时停用抗高血压药物的安全性令人担忧。 | 刘莉 叶鹏 Beeftink MM van der Sande NG Bots ML Doevendans PA Blankestijn PJ Visseren FL Voskuil M Spiering W | 2017 | 中华高血压杂志2017，25，4： | 2 |
| 5 | Reduced accumulation of specific microRNAs in colorectal neo?plasia显示文摘 | MICHAEL MZ SM OC VAN HOLST PELLEKAAN NG | 2003 | Mol Cancer Res2003，1，： | 1 |
| 6 | Reduced accumulation of specific microRNAs in colorectal neoplasia显示文摘 | Michael MZ O'Connor SM van Holst Pellekaan NG | | 0，，12： | 1 |
| 7 | Comparison of aortic root dimensions and geometries before and after transcatheter aortic valve implantation by 2-and 3-dimensional transesophageal echocardiography and multislice computed tomography显示文摘 | Ng AC Delgado V Van der Kley F | | 0，，01： | 1 |
| 8 | Genotype and phenotype in patients with dihydropyfimidine dehydrogenase deficiency 显示文摘 | Van Kuilenburg AB Vreken P Abeling NG | 1999 | Hum Genet1999，104，： | 1 |
| 9 | Re- duced accumulation of specific microRNAs in colorectal neoplasia 显示文摘 | Michael MZ O'Connor SM van Holst Pellekaan NG | 2003 | nol Cancer Res2003，1，12： | 1 |
| 10 | Numerical changes in the various peripheral white blood cells in children as a result of antineoplastic therapy 显示文摘 | Cranendonk E Van Gennip AH Abeling NG | 1984 | Acta Haematol1984，72，5： | 1 |
| 11 | Gallstone disease: pri- mary and secondary prevention显示文摘 | Venneman NG van Erpecum KJ | 2006 | Best Pract Res Clin Gastroenterol2006，20，6： | 1 |
| 12 | Gallstone disease:primary and secondary prevention 显示文摘 | Venneman NG van Erpecum KJ | 2006 | Best Praet Res Clin Gastroenterol2006，20，6： | 1 |
| 13 | Reduced accumulation of specific microRNAs in colorectal neoplasia显示文摘 | Michael MZ O′Connor SM van Holst Pellekaan NG | 2003 | Mol Cancer Res2003，1，12： | 1 |
| 14 | Individualism-Collectiv- ism as a Boundary Condition for Effectiveness of Mi- nority Influence in Decision Making显示文摘 | NG K Y VAN DYNE L | 2001 | Organiza- tional Behavior and Human Decision Processes2001，84，2： | 1 |
| 15 | Geographic distribution of vacA allelic types of Helicobacter pylori显示文摘 | Leen–Jan Van Doorn Céu Figueiredo Francis Mégraud Salvador Pena Peter Midolo Dulciene Maria De Magalh?es Queiroz Fátima Carneiro Bart Vanderborght Maria Da Glória F. Pegado Ricardo Sanna Wink De Boer Peter M. Schneeberger Pelayo Correa Enders K.W. Ng John | 1999 | Gastroenterology1999，，4： | 1 |
| 16 | Two cases of keratoconus diagnosed after pregnancy显示文摘 | Soeters N Tahzib NG Bakker L Van der Lelij A | | 0，，01： | 1 |
| 17 | MF59 adjuvant enhances the immunogenicity of influenza vaccine in both young and old mice显示文摘 | Higgins DA Carlson JR Van NG | 1996 | Vaccine1996，14，： | 1 |
| 18 | Re- duced accumulation of specific microRNAs in colorectal neoplasia 显示文摘 | Michael MZ O'Connor SM van Hoist Pellekaan NG | 2003 | Mol Cancer Res2003，1，12： | 1 |
| 19 | Centrifuge modeling of loose fill embankment subjected to uni-axial and bi-axial earthquakes显示文摘 | Ng C W W Li Xiang-Song Van Laak P A | 2004 | Soil Dynamics & Earthquake Engineering2004，，24： | 1 |
| 20 | Antecedents and performance consequences of helping behavior in work groups显示文摘 | Ng K Y Van Dyne L | | 0，，05： | 1 |
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