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| 1 | MicroRNA-451 regulates LKB1/AMPK signaling and allows adaptation to metabolic stress in glioma cells显示文摘 | Godlewski J Nowicki MO Bronisz A Nuovo G Palatini J De Lay M Van Brocklyn J Ostrowskl MC Chlocca EA Lawler SE. | 2010 | 中国神经肿瘤杂志2010，8，1： | 37 |
| 2 | Delayed gastric emptying following pancreaticoduodenectomy:Incidence,risk factors,and healthcare utilization显示文摘AIM To characterize incidence and risk factors for delayed gastric emptying(DGE) following pancreaticoduodenectomy and examine its implications on healthcare utilization. METHODS A prospectively-maintained database was reviewed. DGE was classified using International Study Group of Pancreatic Surgery criteria. Patients who developed DGE and those who did not were compared. RESULTS Two hundred and seventy-six patients underwent pancreaticoduodenectomy(PD)(> 80% pyloruspreserving, antecolic-reconstruction). DGE developed in 49 patients(17.8%): 5.1% grade B, 3.6% grade C. Demographic, clinical, and operative variables were similar between patients with DGE and those without. DGE patients were more likely to present multiplecomplications(32.6% vs 4.4%, ≥ 3 complications, P < 0.001), including postoperative pancreatic fistula(POPF)(42.9% vs 18.9%, P = 0.001) and intra-abdominal abscess(IAA)(16.3% vs 4.0%, P = 0.012). Patients with DGE had longer hospital stay(median, 12 d vs 7 d, P < 0.001) and were more likely to require transitional care upon discharge(24.5% vs 6.6%, P < 0.001). On multivariate analysis, predictors for DGE included POPF [OR = 3.39(1.35-8.52), P = 0.009] and IAA [OR = 1.51(1.03-2.22), P = 0.035].CONCLUSION Although DGE occurred in < 20% of patients after PD, it was associated with increased healthcare utilization. Patients with POPF and IAA were at risk for DGE. Anticipating DGE can help individualize care and allocate resources to high-risk patients. | Somala Mohammed George Van Buren II Amy Mc Elhany Eric J Silberfein William E Fisher | 2017 | World Journal of Gastrointestinal Surgery2017，9，3： | 13 |
| 3 | 25-羟维生素D和甲状旁腺激素与高血压的相关性显示文摘有研究证实,维生素D缺乏和甲状旁腺激素(PTH)过高与高血压的发生密切相关。维生素D缺乏不仅可以影响肾素血管紧张素系统及PTH水平,而且可以直接参与血管炎性反应,影响高血压的发生发展。PTH可以通过促进血管炎性反应及血管钙化等参与高血压的进展。目前还没有前瞻性研究同时评估维生素D和PTH水平与高血压发病的关系。该研究分析多民族动脉粥样硬化研究的前瞻性数据,发现低水平25羟维生素D[25(OH)D]和高水平PTH与高血压发病相关,特别是在肥胖人群中。但在校正混杂因素后,25(OH)D水平与高血压发病的相关性无统计学意义,而PTH水平与高血压发病仍然相关。鉴于维生素D缺乏和PTH过量在人群中是普遍现象,该研究对于更好地了解高血压发病机制,在人群中开展高血压预防工作有重要意义。 | van Ballegooijen AJ Kestenbaum B Sachs MC de Boer IH Siscovick DS Hoofnagle AN Ix JH Visser M Brouwer IA 练桂丽 叶鹏 | 2014 | 中华高血压杂志2014，22，6： | 10 |
| 4 | Pancreatic endometrial cyst mimics mucinous cystic neoplasm of the pancreas显示文摘Pancreatic cysts include a variety of benign, premalignant, and malignant lesions. Endometrial cysts in the pancreas are exceedingly rare lesions that are difficult to diagnose pre-operatively. This report describes the findings in a 43-year-old patient with a recent episode of acute pancreatitis who presented with a large cyst in the tail of the pancreas. Imaging demonstrated a loculated pancreatic cyst, and cyst fluid aspiration revealed an elevated amylase and carcinoembryonic antigen. The patient experienced an interval worsening of abdominal pain, fatigue, diarrhea, and a 15-pound weight loss 3 mo after the initial episode of pancreatitis. With concern for a possible pre-malignant lesion, the patient underwent a laparoscopic distal pancreatectomy with splenectomy, which revealed a 16cm×12cm×4cm lesion. Final histopathology was consistent with an intra-pancreatic endometrial cyst. Here we discuss the overlapping imaging and laboratory features of pancreatic endometrial cysts and mucinous cystic neoplasms of the pancreas. | Michael A Mederos Nicole Villafane Sadhna Dhingra Carlos Farinas Amy Mc Elhany William E Fisher George Van Buren II | 2017 | World Journal of Gastroenterology2017，23，6： | 7 |
| 5 | Preventive chemotherapy for HIV-associated TB in Uganda: an operational assessment at a voluntary counseling and testing center显示文摘 | Raviglione MC Van Prang E | 1995 | AIDS1995，9，3： | 1 |
| 6 | An RBP4 promoter polymorphism increases risk of type 2 diabetes显示文摘 | van Hoek M Dehghan A Zillikens MC | 2008 | Diabetologia2008，51，8： | 1 |
| 7 | Randomized, clinical trial comparison of trisodium citrate 30% and heparin as catheter-locking solution in hemodialysis patients 显示文摘 | Weijmer MC van den Dorpel MA Van de Ven PJ | 2005 | J Am Soc Nephrol2005，16，9： | 1 |
| 8 | Iodine-induced thyroid inhibition and cell necrosis:two consequences of the same free-radical mediated mechanism显示文摘 | DENEF JF MANY MC VAN DEN HOVE MF | 1996 | Mol Cel Endocrinology1996，121，1： | 1 |
| 9 | The cytomegalovirus antigenemia assay:a plea for standardization显示文摘 | The TH van den Berg AP Harmsen MC | 1995 | Scand J Infect Dis Suppl1995，99，： | 1 |
| 10 | Effects of high dose Ⅳ pamidronate on disease activity and bone metabolism in patients with active RA : a randomized, double - blind, placebo - controlled trial 显示文摘 | Lodder MC Van Pelt PA Lems WF | 2003 | J Rheumatol2003，30，： | 1 |
| 11 | Bacterial load in relation to vacuum-assisted closure wound therapy: a prospective randomized trial 显示文摘 | Moues CM Vos MC van den Bemd GJ | 2004 | Wound Repair Regen2004，12，1： | 1 |
| 12 | Heliox re- duces respiratory system resistance in respiratory syncyti- al virus induced respiratory failure显示文摘 | Kneyber MC van Heerde M Twisk JW | 2009 | Critical care Med2009，13，3： | 1 |
| 13 | The incidence of endometrial hypcrplasia and cancer in 1031 patients with a gran- ulosa cell tumor of the ovary :long - term follow - up in a population - based cohort study 显示文摘 | van Meurs HS Bleeker MC van der Velden J | 2013 | Int J Gynecol Cancer2013，23，8： | 1 |
| 14 | Genetic determinants of von Willebrand factor levels and activity in relation to the risk of cardiovascular disease:a review显示文摘 | van Schie MC van Loon JE de Maat MP | | 0，，05： | 1 |
| 15 | Plasma proprotein convertase subtilisin kexin type 9 is not altered in subjects with impaired glucose metabolism and type 2 diabetes mellitus, but its relationship with non-HDL cholesterol and apolipoprotein B may be modified by type 2 diabetes mellitus: The CODAM study 显示文摘 | Brouwers MC Troutt JS van Greevenbroek MM | 2011 | Atherosclerosis2011，217，1： | 1 |
| 16 | Preoperative chemoradiotherapy for esophageal or junctional cancer显示文摘 | van Hagen P Hulshof MC van Lanschot J J | 2012 | N Engl J Med2012，366，22： | 1 |
| 17 | Short-term esophageal stenting in the management of benign perforations显示文摘 | van Heel NC Haringsma J Spaander MC | 2010 | Am J Gastroenterol2010，105，7： | 1 |
| 18 | Severe adverse reactions after the use of sulphur hexafluoride (SonoVue) as an ultrasonographic contrast agent 显示文摘 | de Groot MC van Zwieten-Boot BJ van Grootheest AC | 2004 | Ned Tijdschr Geneeskd2004，148，38： | 1 |
| 19 | RNA silencing in viral infections:in- sights from poliovirus显示文摘 | Saleh MC Van Rij RP Andino R | 2004 | Virus Res2004，102，1： | 1 |
| 20 | Tumoral and immunologic response after vaccination of melanoma patients with an ALVAC virus encoding MAGE antigens recognized by T cells 显示文摘 | van Baren N Bonnet MC Dreno B | 2005 | J Clin Oncol2005，23，35： | 1 |
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