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| 1 | Tumoral and immunologic response after vaccination of melanoma patients with an ALVAC virus encoding MAGE antigens recognized by T cells 显示文摘 | van Baren N Bonnet MC Dreno B | 2005 | J Clin Oncol2005，23，35： | 1 |
| 2 | Dichloroacetate pre vents and reverses pulmonary hypertension by inducing pulmonary artery smooth muscle cell apoptosis显示文摘 | Mc Murtry MS Bonnet S Wu X | 2004 | Circ Res2004，95，8： | 1 |
| 3 | Expression and function of neurotrophins and their receptors in human melanocytes显示文摘 | Marconi A1 Panza MC BonnetDuquennoy M | 2006 | Int J Cosmet Sci2006，28，4： | 1 |
| 4 | Tumoral and immunologic response after vaccination of melanoma patients with an ALVAC virus encoding MAGE antigens recognized by T cells显示文摘 | van Baren N Bonnet MC Dreno B | 2005 | J Clin Oncol2005，23，35： | 1 |
| 5 | Tumoral and immunologic response after vaccination of melanoma patients with an ALVAC virus encoding MAGE antigens recognized by T cells显示文摘 | Van Baren N Bonnet MC Dreno B | 2005 | J Clin Oncol2005，23，35： | 1 |
| 6 | PKR stimulates NF-kappaB irrespective of its kinase function by interacting with the IkappaB kinase complex显示文摘 | Bonnet MC Weil R Dam E | 2000 | Mol Cell Biol2000，20，13： | 1 |
| 7 | NF-κB in the regulation of epithelial homeostasis and inflammation显示文摘 | Wullaert A Bonnet MC Pasparakis M | 2011 | Cell Res2011，21，1： | 1 |
| 8 | Tumoral and immuno- logic response after ,Jaccination of melanoma patients with an AL-VAC virus encoding MAGE antigens recognized by T cells显示文摘 | Van Baren N Bonnet MC Dreno B | 2005 | J Clin Oncol2005，23，35： | 1 |
| 9 | Therapeutic vaccines against melanoma and colorectal cancer显示文摘 | Bonnet MC Berinstein N | 2001 | Vaccine2001，19，1719： | 1 |
| 10 | Tumoral and immunologic response after vaccination of melanoma patients with an ALVAC virus encoding MAGE antigens recognized by T cells显示文摘 | Van BN Bonnet MC Dreno B | | 0，，： | 1 |
| 11 | World wide experience with inactivated poliovirus vaccine 显示文摘 | Bonnet Mc DuttaA | 2008 | Vaccine2008，26，39： | 1 |
| 12 | NF - KB in the regulation of epi- thelial homeostasis and inflammation 显示文摘 | Wullaert A Bonnet MC Pasparakis M | 2011 | Cell Res2011，21，1： | 1 |
| 13 | Comparativeeffects of 10mg versus 80mg Atorvastatin on high-sen-sitivity C-reactive protein in patients with stable coro-nary artery disease:results of theCAP(comparativeatorvastatin pleiotropic effects)study显示文摘 | Bonnet J Mc Pherson R TedguiA | 2008 | ClinTher2008，30，12： | 1 |
| 14 | A colorimetric 96-well microtiter plate assay for the determination of urate oxidase activity and its kinetic parameters显示文摘 | Fraisse L Bonnet MC Agut C | 2002 | Anal Biochem2002，309，2： | 1 |
| 15 | Consumption of gluten with gluten-degrading enzyme by celiac patients: A pilot-study显示文摘AIM:To assesses the safety and efficacy of Aspergillus niger prolyl endoprotease(AN-PEP)to mitigate the im-munogenic effects of gluten in celiac patients.METHODS:Patients with initial diagnosis of celiac disease as confirmed by positive serology with subtotal or total villous atrophy on duodenal biopsies who adhere to a strict gluten-free diet(GFD)resulting in normalised antibodies and mucosal healing classified as Marsh 0 orⅠwere included.In a randomised double-blind placebo-controlled pilot study,patients consumed toast(approximately 7 g/d gluten)with AN-PEP for 2 wk(safety phase).After a 2-wk washout period with adherence of the usual GFD,14 patients were randomised to gluten intake with either AN-PEP or placebo for 2 wk(efficacy phase).Measurements at baseline included complaints,quality-of-life,serum antibodies,immunophenotyping of T-cells and duodenal mucosa immunohistology.Furthermore,serum and quality of life questionnaires were collected during and after the safety,washout and efficacy phase.Duodenal biopsies were collected after the safety phase and after the efficacy phase.A change in histological evaluation according to the modified Marsh classification was the primary endpoint.RESULTS:In total,16 adults were enrolled in the study.No serious adverse events occurred during the trial and no patients withdrew during the trial.The mean score for the gastrointestinal subcategory of the celiac disease quality(CDQ)was relatively high throughout the study,indicating that AN-PEP was well tolerated.In the efficacy phase,the CDQ scores of patients consuming gluten with placebo or gluten with AN-PEP did not significantly deteriorate and moreover no differences between the groups were observed.During the efficacy phase,neither the placebo nor the AN-PEP group developed significant antibody titers.The IgA-EM concentrations remained negative in both groups.Two patients were excluded from entering the efficacy phase as their mucosa showed an increase oftwo Marsh steps after the safety phase,yet with undetectable serum antibodies,while 14 patients were considered histologically stable on gluten with AN-PEP.Also after the efficacy phase,no significant deterioration was observed regarding immunohistological and flow cytometric evaluation in the group consuming placebo compared to the group receiving AN-PEP.Furthermore,IgA-tTG deposit staining increased after 2 wk of gluten compared to baseline in four out of seven patients on placebo.In the seven patients receiving AN-PEP,one patient showed increased and one showed decreased IgA-tTG deposits.CONCLUSION:AN-PEP appears to be well tolerated.However,the primary endpoint was not met due to lack of clinical deterioration upon placebo,impeding an effect of AN-PEP. | Greetje J Tack Jolanda MW van de Water Maaike J Bruins Engelina MC Kooy-Winkelaar Jeroen van Bergen Petra Bonnet Anita CE Vreugdenhil Ilma Korponay-Szabo Luppo Edens B Mary E von Blomberg Marco WJ Schreurs Chris J Mulder Frits Koning | 2013 | World Journal of Gastroenterology2013，19，35： | 1 |
| 16 | Dichloroacetate prevents and reverses puhnonary hypertension by inducing puhnonary artery smooth muscle cell apoptosis 显示文摘 | Mc Murtry MS Bonnet S Wu X | 2004 | Circ Res2004，95，8： | 1 |
| 17 | World wide experience with inactivated poliovirus vaccine 显示文摘 | Bonnet MC Dutta A | 2008 | Vaccine2008，26，39： | 1 |
| 18 | Tumoral and immunologic response after vaccination of melanoma patients with an ALVAC virus encoding MAGE antigens recognized by T Cells 显示文摘 | Baren NV Bonnet MC Dreno B | 2005 | J Clin Oncoh2005，23，35： | 1 |
| 19 | PKR stimulates NF - kappa B irrespective of its kinase function by interacting with the I kappa B kinase complex 显示文摘 | Bonnet MC Weil R Dam E | 2000 | Mol Cell Biol2000，20，13： | 1 |
| 20 | Recombinant viruses as a tool for therapeutic vaccination against human cancers 显示文摘 | Bonnet MC Tartaglia J Verdier F | 2000 | Immunol Lett2000，74，1： | 1 |
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