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| 1 | Clinical observation of salvianolic acid B in treatment of liver fibrosis in chronic hepatitis B显示文摘AIM: To evaluate the clinical efficacy of salvianolic acidB (SA-B) on liver fibrosis in chronic hepatitis B.METHODS: Sixty patients with definite diagnosis of liverfibrosis with hepatitis B were included in the trial.Interferon-γ (IFN-γ) was used as control drug. Thepatients took orally SA-B tablets or received muscularinjection of IFN-γ in the double blind randomized test,The complete course lasted 6 months. The histologicalchanges of liver biopsy specimen before and after thetreatment were the main evidence in evaluation, incombination with the results of contents of serum HA,LN, Ⅳ-C, P-Ⅲ-P, liver ultrasound imaging, andsymptoms and signs.RESULTS: Reverse rate of fibrotic stage was 36.67 % inSA-B group and 30.0 % in IFN-γgroup. Inflammatoryalleviating rate was 40.0 % in SA-B group and 36.67 %in IFN-γ group. The average content of HA and Ⅳ-Cwas significantly lower than that before treatment. Theabnormal rate also decreased remarkably. Overallanalysis of 4 serological fibrotic markers showedsignificant improvement in SA-B group as comparedwith the IFN-γgroup. Score of liver ultrasound imagingwas lower in SA-B group than in IFN-γgroup (HA 36.7 %vs80 %,Ⅳ-C 3.3 % vs23.2 %). Before the treatment,ALT AST activity and total bilirubin content of patientswho had regression of fibrosis after oral administrationof SA-B, were significantly lower than those of patientswho had aggravation of fibrosis after oraladministration of SA-B. IFN-γ showed certain sideeffects (fever and transient decrease of leukocytes,occurrence rates were 50 % and 3.23 %), but SA-Bshowed no side effects.CONCLUSION: SA-B could effectively reverse liverfibrosis in chronic hepatitis B. SA-B was better than IFN-γ in reduction of serum HA content, overall decrease of4 serum fibrotic markers, and decrease of ultrasoundimaging score. Liver fibrosis in chronic hepatitis B withslight liver injury was more suitable to SA-B in anti-fibrotic treatment. SA-B showed no obvious side effects. | Ping Liu Yi-Yang Hu Cheng Liu Hui-Ming Xue Zhi-Qiang Xu Lie-Ming Xu Cheng-Hai Liu Hong-Tu Gu Shanghai University of Traditional Chinese Medicine,Shanghai 200032,China Da-Yuan Zhu Shanghai Institute of Metaria Medica,Chinese Academy of Sciences,Shanghai 200031,China Zhi-Qing Zhang the 4~(th) Hualyin City Hospital,Hualan City,223000,JiangSu Province,China | 2002 | World Journal of Gastroenterology2002，8，4： | 85 |
| 2 | Relationship Between Soil Properties and Different Fractions of Soil Hg显示文摘Correlation and path analysis methods were used to study the relationship between soil properties and the distribution of different soil Hg fractions with nine representative soils from Chongqing, China. Results showed that clay (< 2 m) could increase water-soluble Hg (r = 0.700*). Soil organic matter (OM) could enhance the increase of elemental Hg (r = 0.674*). The higher the base saturation percentage (BSP), the more the residual Hg (T = 0.684*). Organic Hg, the sum of acid-soluble organic Hg and alkali-soluble Hg, was positively affected by silt (2-20 μm) but negatively affected by pH, with the direct path coefficients amounting to 1.0487 and 0.5121, respectively. The positive effect of OM and negative effect of BSP on organic Hg were the most significant, with the direct path coefficients being 0.7614 and -0.8527, respectively. The indirect effect of clay (< 2 μm) via BSP (path coefficient = 0.4186) was the highest, showing that the real influencing factor in the effect of clay (< 2 μm) on acid-soluble organic Hg was BSP. Since the available Hg fraction, water-soluble Hg, was positively affected by soil clay content, and the quite immobile and not bioavailable residual Hg by soil BSP, suitable reduction of clay content and increase of BSP would be of much help to reduce the Hg availability and Hg activity in Hg-contaminated soils. | WU HONGTAO YU GUIFEN QING CHANGLE and CHEN TONGBIN Southwest Agricultural University, Chongqing 400716 (China) Institute of Geographic Sciences and Natural Resources, the Chinese Academy of Sciences, Beijing 100101 (China) Institute of Soil Science, th | 2001 | Pedosphere2001，11，3： | 2 |
| 3 | The cytomegalovirus antigenemia assay:a plea for standardization显示文摘 | The TH van den Berg AP Harmsen MC | 1995 | Scand J Infect Dis Suppl1995，99，： | 1 |
| 4 | The immunobiological effects of interleukin-2 in vivo显示文摘 | Janssen RAJ Mulder NH The TH | 1994 | Cancer Immunol Immunother1994，39，： | 1 |
| 5 | Procalcitonin behaves as a fast responding acute phase protein in vivo and in vitro 显示文摘 | Nijsten MW Olinga P The TH | 2000 | Crit Care Med2000，28，2： | 1 |
| 6 | Viral chemokinemodulatory proteins: tools and targets 显示文摘 | Boomker JM de Leij LF The TH | 2005 | Cytokine Growth Factor Rev2005，16，1： | 1 |
| 7 | 地磁场的空间相关性及其在地震预报中的应用显示文摘 | THE 10 TH SECTION OF THE INSTITUTE OF GEOPHYSICS ACADEMIA SINICA | 1977 | 地球物理学报1977，，03： | 1 |
| 8 | Guiddines Subcomminttee显示文摘 | 1999 World Heal th Organization- Internation Society of Hypertension Guidelines for the Managemnet of Hypertemion | 1999 | J Hypentens1999，17，： | 1 |
| 9 | Procalcitonin behaves as a fast responding acute phase protein in vivo and in vitro显示文摘 | Nijsten MW Olinga P The TH | 2000 | Crit Care Med2000，28，2： | 1 |
| 10 | Investigation of the Influence of the Reheating Temperature on Size and Composition of Precipitates in Microalloyed HSLA Steels by Analytical Electron Microscopy显示文摘 | Güth A Kaun L Koüthe A | 1987 | Scripta Metall1987，21，： | 1 |
| 11 | Procalcitonin behaves as a fast responding acute phase protein in vivo and in vitro 显示文摘 | Nijsten MW 01inga P The TH | 2000 | Crit Care Med2000，28，2： | 1 |
| 12 | Procalcitonin behaves as a fast responding acute phase protein in vivo and in vitro 显示文摘 | Nijsten MW Clinqa P The TH | 2000 | Crit Care Med2000，28，2： | 1 |
| 13 | Procalcitonin behaves as a fast responding acute phase protein in vivo and in vitro显示文摘 | Nijsten MW Olinga P The TH | 2000 | Crit Care Med2000，28，2： | 1 |
| 14 | Procalcitonin behaves as a fast responding acute phase protein in vivo and in vitro 显示文摘 | Nijsten MW Olinga P The TH | 2000 | Crit Care Med2000，28，2： | 1 |
| 15 | Guideline for the diagnosis and optimal man- agement of asthma in children 显示文摘 | The Subspecialty Group of Respiratory Desease th Society of Pe- diatrics Chinese Medical Association the Editoral Board Chi- nese J of Pediatrics | 2008 | Chin J Pediatric2008，10，46： | 1 |
| 16 | Procalcitonin behaves as a fast responding acute phase protein in vivo and in vitro显示文摘 | Nijsten MW Olinga P The TH | | 0，，2： | 1 |
| 17 | Procalcitonin behaves as a fast responding acute phase protein in vivo and in vitro 显示文摘 | Nijsten MW Olinga P The TH | 2000 | Crit Care Med2000，28，2： | 1 |
| 18 | Proca1citonin behaves as a fast responding acute phase protein in vivo and in vitro显示文摘 | Nijsten MW Ollinga P The TH | 2000 | Crit Care Med2000，28，2： | 1 |
| 19 | The cytomegalovirus antigenmia assey:a plea for standardization显示文摘 | The TH van den berg AP Harmsen MC | 1995 | Scand J Infect Dis Suppl1995，99，： | 1 |
| 20 | Direct detection of cytomegalovirus in peripheral blood leukocytes-a review of the antigenemia assay and polymerase chain reaction显示文摘 | VAN DER PLOEG M VAN DEN BERG AP | 1992 | Transplantation1992，54，2： | 1 |
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