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| 1 | INMA-Sabadell队列中孕期双酚A及邻苯二甲酸酯暴露与胎儿发育的超声测量(续完)显示文摘暴露于ΣMWPm与任何胎儿大小或胎儿发育结局(见补充材料,表8)及所评估的出生结局(表2及补充材料表S7)都没有显著相关性。代谢物MnBP与12-20孕周HC增长降低有显著相关性(-4.88%;95%CI:-8.36,-1.36),且与EFW增长减低也有显著相关性(-4.32%;95%CI:-8.33,-0.27)(图3及补充材料表S8)。 | Maribel Casas Damaskini Valvi Ana Ballesteros-Gomez Mireia Gascon Mariana F.Fernández Raquel Garcia-Esteban Carmen I?iguez David Martínez Mario Murcia Nuria Monfort Noelia Luque Soledad Rubio Rosa Ventura Jordi Sunyer Martine Vrijheid 袁亚群(翻译) 金泰廙(审校) | 2016 | 环境与职业医学2016，33，9： | 3 |
| 2 | Variability and predictors of urinary phthalate metabolites in Spanish pregnant women显示文摘 | Valvi D Monfort N Ventura R Casas M Casas L Sunyer J | 2015 | Int J Hyg Environ Health2015，218，2： | 1 |
| 3 | Granulomatous eheilitis associated with exa-cerbations of Crohn's disease: a case report 显示文摘 | Triantafilidis JK Valvi FZ Merikas E | 2008 | J Medical Case Reports2008，2，： | 1 |
| 4 | Fibrinogen, COPD and mortality in a nationally representative US cohort 显示文摘 | Mannino D M Valvi D Mullerova H | 2012 | COPD: Journal of Chronic Obstructive Pulmonary Disease2012，9，4： | 1 |
| 5 | Fibrinogen, chronic obstructive pulmonary disease (COPD) and outcomes in two United States cohorts显示文摘 | D M Mannino Tal-Singer Muellerova Valvi | 2012 | International Journal of Chronic Obstructive Pulmonary Disease . 2012 (defa)2012，，： | 1 |
| 6 | Fibrinogen,chronic obstructive pulmonary disease (COPD)and outcomes in two United States cohorts显示文摘 | Deepa Valvi David M5Mannino | 2012 | International Journal of Chronic Obstructive Pulmonary Disease2012，7，2： | 1 |
| 7 | Fibrinogen,chronic obstructive pulmonary disease (COPD) and outcomes in two United States cohorts interna- tional显示文摘 | Deepa Valvi | 2012 | Journal of COPD2012，，7： | 1 |
| 8 | Deficit of vita- min D in pregnancy and growth and overweight in the offspring 显示文摘 | Morales E Rodriguez A Valvi D | 2015 | International Journal of Obesity2015，39，1： | 1 |
| 9 | Exposure to bisphenol A during pregnancy and child neuropsychological development in the INMA-Sabadell cohort显示文摘 | Maribel Casas Joan Forns David Martínez Claudia Avella-García Damaskini Valvi Ana Ballesteros-Gómez Noelia Luque Soledad Rubio Jordi Julvez Jordi Sunyer Martine Vrijheid | 2015 | Environmental Research2015，，： | 1 |
| 10 | INMA-Sabadell队列中孕期双酚A及邻苯二甲酸酯暴露与胎儿发育的超声测量(待续)显示文摘[背景]产前暴露于双酚A(BPA)及邻苯二甲酸酯会影响胎儿发育;然而该类研究很少,且得出的结果不一致。[目的]对一个西班牙出生队列中488对母婴进行研究,评估产前暴露于BPA及邻苯二甲酸酯是否与胎儿发育相关。[方法]检测第一和第三孕期两次尿液样本中BPA及8种邻苯二甲酸酯[4种邻苯二甲酸二(2-乙基己基)酯代谢物(DEHPm),邻苯二甲酸单卞酯(MBzP)以及3种低分子量邻苯二甲酸酯代谢物(LMWPm)]。另外,估计股骨长度(FL)、头围(HC)、腹围(AC)、双顶径(BPD)的生长曲线,估计孕期(12—20周,20~34周)的胎儿体重,并测量出生体重、出生长度、出生头围以及胎盘重量。[结果]总体上,结果并不支持孕期暴露于BPA或DEHPm与胎儿发育参数相关。产前MBzP暴露与20~34孕周的FL呈正相关,MBzP浓度每增加一倍,平均FL增加3.7%(95%CI:0.75,6.63%)。MBzP与男婴出生体重呈正相关(48g;95%CI:6,90),但在女婴中没有相关性(-27g;95%CI:-79,25)(交互作用P=0.04)。LMWPm邻苯二甲酸单丁酯(MnBP)与12—20孕周的HC呈负相关[平均HC降低了4.88%(95%CI:-8.36,-1.36%)]。[结论]本研究首次将暴露生物标志重复测量值与胎儿期多种发育参数相结合,发现暴露于BPA或邻苯二甲酸酯与胎儿发育不相关。邻苯二甲酸酯代谢物MBzP与MnBP与部分胎儿发育参数相关,但这些结果还需要重复验证。 | Maribel Casas Damaskini Valvi Ana Ballesteros-Gomez Mireia Gascon Mariana F.Fernández Raquel Garcia-Esteban Carmen I?iguez David Martínez Mario Murcia Nuria Monfort Noelia Luque Soledad Rubio Rosa Ventura Jordi Sunyer Martine Vrijheid 袁亚群 金泰廙 | 2016 | 环境与职业医学2016，33，8： | 1 |
| 11 | Prenatal bisphenol A urine concentrations and early rapid growth and overweight risk in the offspring显示文摘 | Valvi D Casas M Mendez MA BallesterosGómez A Luque N Rubio S | 2013 | Epidemiology2013，24，6： | 1 |
| 12 | Fibrinogen, chronic obstructive pulmonary disease (COPD) and outcomes in two United States cohorts显示文摘 | Valvi D Mannino DM Mtillerova H | 2012 | Int J Chron Obstruct Pulmon Dis2012，7，： | 1 |
| 13 | Circulating microRNA expression and nonalcoholic fatty liver disease in adolescents with severe obesity显示文摘BACKGROUND Nonalcoholic fatty liver disease(NAFLD)is one of the most common chronic liver diseases in children and adolescents.NAFLD ranges in severity from isolated hepatic steatosis to nonalcoholic steatohepatitis(NASH),wherein hepatocellular inflammation and/or fibrosis coexist with steatosis.Circulating microRNA(miRNA)levels have been suggested to be altered in NAFLD,but the extent to which miRNA are related to NAFLD features remains unknown.This analysis tested the hypothesis that plasma miRNAs are significantly associated with histological features of NAFLD in adolescents.AIM To investigate the relationship between plasma miRNA expression and NAFLD features among adolescents with NAFLD.METHODS This study included 81 adolescents diagnosed with NAFLD and 54 adolescents without NAFLD from the Teen-Longitudinal Assessment of Bariatric Surgery study.Intra-operative core liver biopsies were collected from participants and used to characterize histological features of NAFLD.Plasma samples were collected during surgery for miRNA profiling.A total of 843 plasma miRNAs were profiled using the HTG EdgeSeq platform.We examined associations of plasma miRNAs and NAFLD features using logistic regression after adjusting for age,sex,race,and other key covariates.Ingenuity Pathways Analysis was used to identify biological functions of miRNAs that were associated with multiple histological features of NAFLD.RESULTS We identified 16 upregulated plasma miRNAs,including miR-193a-5p and miR-193b-5p,and 22 downregulated plasma miRNAs,including miR-1282 and miR-6734-5p,in adolescents with NAFLD.Moreover,52,16,15,and 9 plasma miRNAs were associated with NASH,fibrosis,ballooning degeneration,and lobular inflammation,respectively.Collectively,16 miRNAs were associated with two or more histological features of NAFLD.Among those miRNAs,miR-411-5p was downregulated in NASH,ballooning,and fibrosis,while miR-122-5p,miR-1343-5p,miR-193a-5p,miR-193b-5p,and miR-7845-5p were consistently and positively associated with all histological features of NAFLD.Pathway analysis revealed that most common pathways of miRNAs associated with multiple NAFLD features have been associated with tumor progression,while we also identified linkages between miR-122-5p and hepatitis C virus and between miR-199b-5p and chronic hepatitis B.CONCLUSION Plasma miRNAs were associated with NAFLD features in adolescent with severe obesity.Larger studies with more heterogeneous NAFLD phenotypes are needed to evaluate miRNAs as potential biomarkers of NAFLD. | Yi-Jie Li Brittney O Baumert Nikos Stratakis Jesse A Goodrich Hao-Tian Wu Jing-Xuan He Yin-Qi Zhao Max T Aung Hong-Xu Wang Sandrah P Eckel Douglas I Walker Damaskini Valvi Michele A La Merrill Justin R Ryder Thomas H Inge Todd Jenkins Stephanie Sisley Rohit Kohli Stavra A Xanthakos Andrea A Baccarelli Rob McConnell David V Conti Lida Chatzi | 2024 | World Journal of Gastroenterology2024，30，4： | 0 |
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