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| 1 | Efficacy of neoadjuvant therapy and surgical rescue for locally advanced hepatoblastomas:10 year single-center experience and literature review显示文摘AIM:To report our experience with long-term outcomes after multimodal management therapy.METHODS:An observational retrospective study was performed containing seven patients with hepatoblastoma(Hbl)treated in our institution,a tertiary referral center,from 2003 to 2011.Demographic,preoperative,surgical,and outcome variables were collected.A survival analysis and a review of the current literature related to combination neoadjuvant chemotherapy and surgical resection on Hbl were performed.RESULTS:The median age at surgery was 14.4 mo,with a male to female ratio of 4:3.Pretext staging at diagnosis was as follows:stageⅠ,4 cases;stageⅡ,2 patients;and stageⅢ,1 case.Mean pretreatment tumor volume was 735 cm3.Five out of seven patients received neoadjuvant chemotherapy according to SIOPEL-3 or SIOPEL-6 protocols.Tumor volume and alphafetoprotein levels significantly dropped after neoadjuvant therapy.Surgical procedures performed included hemihepatectomies,segmentectomies and atypical resection.All patients received chemotherapy after surgery.Median postoperative hospital stay was 8 d.All patients were alive and disease-free after a median follow-up period of 23 mo.With regards to the literature review,seventeen articles were found that were related to our search.CONCLUSION:Our series shows how multimodal management of Hbl,exhaustive control and a meticulous surgical approach leads to almost 100%complete resection with optimal postoperative results. | Dolores Ayllon Teran Oscar Gómez Beltran Rubén Ciria Bru Elena Mateos González María José Pea Rosa Antonio Luque Molina Pedro López Cillero Javier Briceo Delgado | 2014 | World Journal of Gastroenterology2014，20，29： | 12 |
| 2 | Conservative management of perforated duodenal diverticulum: A case report and review of the literature显示文摘Duodenal diverticula are a relatively common condition. They are asymptomatic, unless they become complicated, with perforation being the rarest but most severe complication. Surgical treatment is the most frequently performed approach. We report the case of a patient with a perforated duodenal diverticulum, which was diagnosed early and treated conservatively with antibiotics and percutaneous drainage of secondary retroperitoneal abscesses. We suggest this method could be an acceptable option for the management of similar cases, provided that the patient is in good general condition and without septic signs. | David Martínez-Cecilia Alvaro Arjona Sánchez Manuel Gómez álvarez Eva Torres Tordera Antonio Luque Molina Victor Valentí Azcárate Javier Briceo Delgado Francisco Javier Padillo Pedro López-Cillero Sebastián Rufián Pea | 2008 | World Journal of Gastroenterology2008，14，12： | 2 |
| 3 | Melatonin modifies SOX2^+ cell proliferation in dentate gyrus and modulates SIRT1 and MECP2 in long-term sleep deprivation显示文摘Melatonin is a pleiotropic molecule that,after a short-term sleep deprivation,promotes the proliferation of neural stem cells in the adult hippocampus.However,this effect has not been observed in long-term sleep deprivation.The precise mechanism exerted by melatonin on the modulation of neural stem cells is not entirely elucidated,but evidence indicates that epigenetic regulators may be involved in this process.In this study,we investigated the effect of melatonin treatment during a 96-hour sleep deprivation and analyzed the expression of epigenetic modulators predicted by computational text mining and keyword clusterization.Our results showed that the administration of melatonin under sleep-deprived conditions increased the MECP2 expression and reduced the SIRT1 expression in the dentate gyrus.We observed that let-7 b,mir-132,and mir-124 were highly expressed in the dentate gyrus after melatonin administration,but they were not modified by sleep deprivation.In addition,we found more Sox2^+/5-bromo-2’-deoxyuridine(BrdU)^+cells in the subgranular zone of the sleep-deprived group treated with melatonin than in the untreated group.These findings may support the notion that melatonin modifies the expression of epigenetic mediators that,in turn,regulate the proliferation of neural progenitor cells in the adult dentate gyrus under long-term sleep-deprived conditions.All procedures performed in this study were approved by the Animal Ethics Committee of the University of Guadalajara,Mexico(approval No.CI-16610)on January 2,2016. | Alan Hinojosa-Godínez Luis F. Jave-Suarez Mario Flores-Soto Alma Y. Gálvez-Contreras Sonia Luquín Edith Oregon-Romero Oscar González-Pérez Rocio E. González-Castaneda | 2019 | Neural Regeneration Research2019，14，10： | 2 |
| 4 | Effects of captopril related to increased levels of prostacyclin and angiotensin-(1 - 7) in essential hypertension显示文摘 | LUQUE M MARTIN P MARTELL N | 1996 | J Hypertension1996，14，： | 1 |
| 5 | Thrombospondin modules and angiogenesis显示文摘 | Iruela-Arispe ML Luque A Lee N | 2004 | Int J Biochem Cell Biol2004，36，6： | 1 |
| 6 | Effects of captopril related to increased levels of angiotensin-(1-7) in essential hypertension显示文摘 | Luque M Martin P Martell N | 1996 | Hypertension1996，14，： | 1 |
| 7 | Glucagon-like pep- tide-1 (GLP-1) and glucose metabolism in human myocytes显示文摘 | Luque M A Gonzalez N Marquez L | 2002 | Journal of Endocrinology2002，173，3： | 1 |
| 8 | Kisspeptin regulates gonadotroph and somatotroph function in nonhuman primate pituitary via common and distinct signaling mechanisms显示文摘 | Luque RM Córdoba-Chacón J Gahete MD | 2011 | Endocrinology2011，152，3： | 1 |
| 9 | Experimental analysis of the quasi-Fermi level split in quantum dot intermediate-band solar cells显示文摘 | LUQUE A MARTI A LOPEZ N | 2005 | Appl Phys Lett2005，87，8： | 1 |
| 10 | The complete sequence of the Cydia pomonella granulovirus genome 显示文摘 | Luque T Finch R Crook N | 2001 | J Gen Virol2001，82，： | 1 |
| 11 | Operation of the intermediate band solar cell under nonideal space charge re-gion conditions and half filling of the intermediate band显示文摘 | LUQUE A MARTI A LOPEZ N | 2006 | J appl Phys2006，99，9： | 1 |
| 12 | Glutamate N-methyl-D-aspartate receptor blockade prevents induction of GAP-43 after focal ischemia in rats显示文摘 | Luque JM Puig N Martinez JM | 2001 | Neurosci Lett2001，305，2： | 1 |
| 13 | pH control of the production of recombinant glucose oxidase in Aspergillus nidulans显示文摘 | Luque R Orejas M Perotti N I | 2004 | Appl Microbiol2004，97，： | 1 |
| 14 | Low-dose cinacalcet reduces serum calcium in patients with primary hy-perparathyroidism not eligible for surgery显示文摘 | Arranz Martín A Azcárate Villalón A Luque Ramírez M | 2011 | Endocrinol Nutr2011，58，1： | 1 |
| 15 | J Mol Struct显示文摘 | Castillo O Luque A Romān P | 2001 | 570:1812001，570，： | 1 |
| 16 | Thrombospondin modules and angiogenesis显示文摘 | Iruela-Arispe M L Luque A Lee N | 2004 | Int J Biochem Cell Biol2004，36，6： | 1 |
| 17 | Assessment of factors influencing health-related quality of life in HIV-infected patients显示文摘 | Briongos Figuerp LS Bachiller Luque P Palacios Martín T | | 0，，01： | 1 |
| 18 | The effect of grazing Lotus corniculatus during late summer-autumn on reproductive efficiency and wool production in ewes显示文摘 | Luque A Barry T N McNabb T N | 2000 | Aust J Agric Res2000，51，： | 1 |
| 19 | The effect of grazing Lotus corniculatus during late summer-autumn on reproductive efficiency and wool production in ewes显示文摘 | LUQUE A BARRY T N MCNABB T N | 2000 | Australian Journal of Agricultural Research2000，51，3： | 1 |
| 20 | Effects of captopril related to increased levels of prostacyclin and angiotensin-(1-7) in essential hypertension显示文摘 | Luque M Martin P Martell N | 1996 | J Hypertens1996，14，6： | 1 |
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