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	题名	作者	年代	出处	被引量
1	Genetic diversity of the hepatitis C virus: Impact and issues inthe antiviral therapy显示文摘The hepatitis C Virus (HCV) presents a high degree of genetic variability which is explained by the combination of a lack of proof reading by the RNA dependant RNA polymerase and a high level of viral replication. The re- sulting genetic polymorphism defines a classification in clades, genotypes, subtypes, isolates and quasispecies. This diversity is known to reflect the range of responses to Interferon therapy. The genotype is one of the pre- dictive parameters currently used to define the antiviral treatment strategy and the chance of therapeutic suc- cess. Studies have also reported the potential impact of the viral genetic polymorphism in the outcome of antivi- ral therapy in patients infected by the same HCV geno- type. Both structural and non structural genomic regions of HCV have been suggested to be involved in the Inter- feron pathway and the resistance to antiviral therapy. In this review, we first detail the viral basis of HCV diversity. Then, the HCV genetic regions that may be implicated in resistance to therapy are described, with a focus on the structural region encoded by the E2 gene and the non- structural genes NS3, NS5A and NS5B. Both mechanisms of the Interferon resistance and of the new antiviral drugs are described in this review.	H Le Guillou-Guillemette S Vallet C Gaudy-Graffin C Payan A Pivert A Goudeau F Lunel-Fabiani	2007	World Journal of Gastroenterology2007，13，17：	6
2	Cell-surface Expression of the Channel Activating Protease xCAP-1 Is Required for Activation of ENaC in the Xenopus Oocyte显示文摘	Vallet V Pfister C Lolling J	2002	J Am Soc Nephrol (S1046 - 6673 )2002，13，3：	1
3	Real versus synthesized fractal surfaces: Contact mechanics and transport properties显示文摘	VALLET C LASSEUX D SAINSOT P	2009	Tribology International2009，42，2：	1
4	Size Effects in Single Grain Fragmentation显示文摘	Tsoungui O Vallet D Charmet J C	1999	Granular Matter1999，2，1：	1
5	Real versus synthesized fractal surfaces: Contact mechanics and transport properties 显示文摘	Vallet C Lasseux D Sainsot P	2009	Tribology International2009，，42：	1
6	Role of endothelial cells in restenosis after coronary angioplasty显示文摘	Vallet B Bauters C	1996	Fundam Clin Pharmacol1996，10，3：	1
7	Role of endothelial cells inrestenosis coronary angioplasty显示文摘	Meuice T Vallet B Bauters C	1996	Fundam Clin Pharmacal1996，10，3：	1
8	Reactive sputtering of titanium diboride or titanium disilicide显示文摘	Maya L Vallet C E Fiedor J N	1997	J Vac Sci Technol A1997，15，4：	1
9	NS3 protease polymorphism and natural resistance to protease inhibitors in French patients infected with HCV genotypes 1-5显示文摘	Vallet S Viron F Henquell C	2011	AntivirTher2011，16，7：	1
10	A coupled NMR and MS isotopie method for the authentication of natural vinegars 显示文摘	Guillou C Vallet C Martin G J	1992	Fresenius Journal Analytical Chemistry1992，342，：	1
11	Human bocavirus: a cause of severe asthma exacerbation in children 显示文摘	Vallet C Pons-Catalano C Mandelcwajg A	2009	J Pediatr2009，155，2：	1
12	Characterization of the human CD5 endogenous retrovirus-E in B lymphocytes显示文摘	Renaudineau Y Vallet S Le Dantec C	2005	Genes Immun2005，6，8：	1
13	Cell wall fractionation of alfalfa stem in relation to internode development:Biochemistry aspect显示文摘	Vallet C Lemaire G Monties B	1998	Agricultural and Food Chemistry1998，46，9：	1
14	Numerical model of crushing of grains inside two-dimensional granular materials显示文摘	Tsoungui O Vallet D Charmet J C	1999	Power Technology1999，105，：	1
15	Role of endotheliazation cells in restenosis after coronary angioplasty显示文摘	Meurice T Vallet B Cauters C	1996	Fundam Clin Pharmacol1996，10，3：	1
16	Complete remission of lupus nephritis with rituximab and steroids for induction and rituximab alone for maintenance therapy 显示文摘	Carnous L Melander C Vallet M	2008	Am J Kidney Dis2008，52，2：	1
17	NS3protease polymorphism and natural resistance to protease inhibitors in French patients in-fected with HCV genotypes1-5显示文摘	Vallet S Viron F Henquell C	2011	Antivir Ther2011，16，10：	1
18	Metabolic pathway to propionate of pectinatus fristugcnsis, a strictly anaerobic beer - spoilage bacterium显示文摘	THOLOZAN J L GREVIT J P VALLET C	1994	Arch Microbiol1994，162，：	1
19	Long-term oraladministration of Larginine reduce intimal thickening and enhances neo endo the lium-dependentacetvlcholine-induced rela-xation afer arterial injary显示文摘	Hamon M Vallet B Bauters C	1994	Circulation1994，90，3：	1
20	Long-termoral administration of L-arginine reduces intimal thickening and enhances neoedothelium-dependentacety choline-induced relaxation after arterial injury显示文摘	Hamon M Vallet B Banters C	1994	Circulation1994，90，：	1

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