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| 1 | Epithelial ovarian cancer:An overview显示文摘Ovarian cancer is the second most common gyneco-logical cancer and the leading cause of death in the United States. In this article we review the diagnosis and current management of epithelial ovarian cancer which accounts for over 95 percent of the ovarian malignancies. We will present various theories about the potential origin of ovarian malignancies. We will discuss the genetic anomalies and syndromes that may cause ovarian cancers with emphasis on Breast cancer type 1/2 mutations. The pathology and pathogenesis of ovarian carcinoma will also be presented. Lastly, we provide a comprehensive overview of treatment strategies and staging of ovarian cancer, conclusions and future directions. | Arpita Desai Jingyao Xu Kartik Aysola Yunlong Qin Chika Okoli Ravipati Hariprasad Ugorji Chinemerem Candace Gates Avinash Reddy Omar Danner Geary Franklin Anachebe Ngozi Guilherme Cantuaria Karan Singh William Grizzle Charles Landen Edward E Partridge Valerie Montgomery Rice E Shyam P Reddy Veena N Rao | 2014 | World Journal of Translational Medicine2014，3，1： | 10 |
| 2 | Advances in small animal mesentery models for in vivo flow cytometry,dynamic microscopy,and drug screening显示文摘Using animal mesentery with intravital optical microscopy is a well-established experimental model for studying blood and lymph microcirculation in vivo. Recent advances in cell biology and optical techniques provide the basis for extending this model for new applications, which should generate significantly improved experimental data. This review summarizes the achievements in this specific area, including in vivo label-free blood and lymph photothermal flow cytometry, super-sensitive fluorescence image cytometry, light scattering and speckle flow cytometry, microvessel dynamic microscopy, infrared (IR) angiography, and high-speed imaging of individual cells in fast flow. The capabilities of these techniques, using the rat mesentery model, were demonstrated in various studies; e.g., real-time quantitative detection of circulating and migrating individual blood and cancer cells, studies on vascular dynamics with a focus on lymphatics under normal conditions and under different interventions (e.g. lasers, drugs, nicotine), assessment of lymphatic disturbances from experimental lymphedema, monitoring cell traffic between blood and lymph systems, and high-speed imaging of cell transient deformability in flow. In particular, the obtained results demonstrated that individual cell transportation in living organisms depends on cell type (e.g., normal blood or leukemic cells), the cell’s functional state (e.g., live, apoptotic, or necrotic), and the functional status of the organism. Possible future applications, including in vivo early diagnosis and prevention of disease, monitoring immune response and apoptosis, chemo- and radio-sensitivity tests, and drug screening, are also discussed. | Ekaterina I Galanzha Valery V Tuchin Vladimir P Zharov | 2007 | World Journal of Gastroenterology2007，13，2： | 2 |
| 3 | Metabolomic and elemental profiling of blood serum in bladder cancer显示文摘Bladder cancer(BC)is one of the most frequently diagnosed types of urinary cancer.Despite advances in treatment methods,no specific biomarkers are currently in use.Targeted and untargeted profiling of metabolites and elements of human blood serum from 100 BC patients and the same number of normal controls(NCs),with external validation,was attempted using three analytical methods,i.e.,nuclear magnetic resonance,gold and silver-109 nanoparticle-based laser desorption/ionization mass spectrometry(LDI-MS),and inductively coupled plasma optical emission spectrometry(ICP-OES).All results were subjected to multivariate statistical analysis.Four potential serum biomarkers of BC,namely,isobutyrate,pyroglutamate,choline,and acetate,were quantified with proton nuclear magnetic resonance,which had excellent predictive ability as judged by the area under the curve(AUC)value of 0.999.Two elements,Li and Fe,were also found to distinguish between cancer and control samples,as judged from ICP-OES data and AUC of 0.807(in validation set).Twenty-five putatively identified compounds,mostly related to glycans and lipids,differentiated BC from NCs,as detected using LDI-MS.Five serum metabolites were found to discriminate between tumor grades and nine metabolites between tumor stages.The results from three different analytical platforms demonstrate that the identified distinct serum metabolites and metal elements have potential to be used for noninvasive detection,staging,and grading of BC. | Krzysztof Ossolinski Tomasz Ruman Valerie Copie Brian P.Tripet Leonardo B.Nogueira Katiane O.P.C.Nogueira Artur Kołodziej Aneta Płaza-Altamer Anna Ossolinska Tadeusz Ossolinski Joanna Nizioł | 2022 | Journal of Pharmaceutical Analysis2022，12，6： | 2 |
| 4 | Modulation of mismatch repair and genomic stability by miR-155显示文摘 | Valeri N Gasparini P Fabbri M | 2010 | Proc Natl Acad Sci U S A2010，107，15： | 1 |
| 5 | Modulation of mismatch repair and genomic stability by miR-155显示文摘 | Valeri N Gasparini P Fabbri M | 2010 | Proc Natl Acad Sci U S A2010，107，15： | 1 |
| 6 | Automationof the glycerolization of red blood cells with the high-separation bowl in the Haemonetics ACP215instrument显示文摘 | Valeri CR Ragno G Van Houten P | 2005 | Transfusion2005，45，10： | 1 |
| 7 | MieroRNA-135b promotes cancer progression by acting as a downstream effector of oneogenic pathways in colon cancer显示文摘 | Valeri N Braeoni C Gasparini P | 2014 | Cancer Cell2014，25，4： | 1 |
| 8 | Fiber sensor for simultaneous mesurement of voltage and temperature显示文摘 | Valery N Filippov Andrey N Starodumov Vladimir P Minkovich | 2000 | IEEE Photonics Technology Letters2000，12，11： | 1 |
| 9 | Phage display显示文摘 | George P Valery A P | 1997 | Chem Rev1997，97，： | 1 |
| 10 | Bioactive terpenoids from caribbean marine algae of the genera Penicillus and Udotea (Chlorophyta)显示文摘 | Valerie J P | 1984 | Tetrahedron1984，40，： | 1 |
| 11 | Wholesale pricing under mild and privately known concerns for fairness显示文摘 | Katok E Tava O Valery P | 2012 | Prodution and Operation Management Society2012，1，10： | 1 |
| 12 | A pulse system for spectrum analysis of magnetoelastic biosensors显示文摘 | SHEN W LESLIE C M VALERY A P | 2010 | Applied Physics Letters2010，96，16： | 1 |
| 13 | High-pressure as a tool to study some protein' s properties:conformational,modification,activity and oligomeric dissociation显示文摘 | Valerie L P Claude B | | 0，，2： | 1 |
| 14 | Phage display 显示文摘 | GEORGE P S VALERY A P | 1997 | Chem Rev1997，97，： | 1 |
| 15 | MicroRNA-135b promotes cancer progression by acting as a downstream effector of oncogenic pathways in colon cancer显示文摘 | Valeri N Braconi C Gasparini P | 2014 | Cancer Cell2014，25，4： | 1 |
| 16 | The chemistry of lysozyme andits use as a food preservative and a phamaceutical显示文摘 | VALERIE A P CUNNINGHAM F E | 1988 | Food Science andNutrition1988，26，4： | 1 |
| 17 | Monte-Carlo simulation of light propagation in a multi-layered biological tissue with optical clearing显示文摘 | EUGENHY P SAVCHENKO VALERY V | 2000 | SPIE2000，4162，： | 1 |
| 18 | Modifiable Factors Associated With Improved Cardiac Arrest Survival in a Multicenter Basic Life Support/Defibrillation System: OPALS Study Phase I Results显示文摘 | Ian G Stiell George A Wells Valerie J DeMaio Daniel W Spaite Brian J Field Douglas P Munkley Marion B Lyver Lorraine G Luinstra Roxanne Ward | 1999 | Annals of Emergency Medicine1999，，： | 1 |
| 19 | Dmitriyev, Mechanical analogies for the Lorentz gauge,particles and antipartieles显示文摘 | Valery P | 2000 | APEIRON2000，7，34： | 1 |
| 20 | Cardiac-specific Overexpression of RhoA Results in Sinus and Atrioventricular Nodal Dysfunction and Contractile Failure显示文摘 | VALERIE P SAH SUSUMU MINAMISAWA | 1999 | Clin Invest1999，103，12： | 1 |
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