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| 1 | 钢渣沥青混合料应用现状显示文摘总结了钢渣的物理性质、化学成分及矿物相组成,分析了影响钢渣体积安定性的因素及其改善措施,探讨了钢渣沥青混合料的配合比设计方法,分析了钢渣沥青混合料的路用性能(高温稳定性、低温抗裂性、水稳定性、抗疲劳性、体积安定性、抗滑性)及其功能特性(导电性与微波加热),研究了钢渣沥青混合料的生态、社会及经济效益,介绍了国内外的工程应用。研究结果表明:钢渣可用于沥青混合料,且应为陈化半年以上的转炉钢渣或电炉钢渣,钢渣的物理力学性能优良,而化学成分及矿物相组成受炼钢工艺影响有所区别,钢渣体积安定性的不足可通过预处理或陈化处理得到较好的改善,钢渣沥青混合料的配合比设计要点包括钢渣替代传统集料的方式和比例、沥青混合料级配修正、有效相对密度测定以及最佳油石比的确定,钢渣沥青混合料的路用性能及功能特性优于天然集料沥青混合料,具有较好的环境影响性且综合经济效益更高,关于钢渣沥青混合料路用性能的研究较多,而作用机理方面相对缺乏,关键性的限制因素如密度较高、体积安定性不良、混合料沥青用量增加等仍未得到根本性解决,未来应重点研究钢渣沥青路面的长期性能及质量控制体系,并开展全寿命周期研究,以加快钢渣沥青路面的应用与推广。 | 何亮 詹程阳 吕松涛 GRENFELL James 高杰 KOWALSKI Karol J VALENTIN Jan 谢君 REKLidija 凌天清 | 2020 | 交通运输工程学报2020，20，2： | 68 |
| 2 | Antibacterial activity and characterization of secondary metabolites isolated from mangrove plant Avicennia officinalis显示文摘Objective:To explore antibacterial activity and characterization of secondary metabolites isolated from mangrove plant Avicennia officinalis(A.officinalis).Methods:In the present study the leaf extracts of A.officinalis were examined for its antibacterial potential using five different solvents against some reference strains of human pathogenic bacteria for the crude extract.Maximum activity was observed for ethyl acetate and hence different concentrations like 15μL,25μL,and 50μL of ethyl extracts was checked for its antibacterial activity.Partial purification of crude extract was carried by column chromatography and fractions were analyzed using gas chromatography-mass spectrometry(GC-MS) to identify compounds.Results:The crude ethyl acetate extracts of A.officinalis showed remarkable antibacterial activity with zones of inhibition of 13 mm against Eschericia coli(E.coli) and 11 mm against Staphylococcus aureus (S.aureus).Fraction 13(ethyl acetate:methanol= 8:2) as the most potent one against with the minimal inhibitory concentration of 30 mm against E.coli and 25 mm against S.aureus.The GCMS resultsof active column fraction(F13) revealed that the active principals were a mixture of hydroxy- 4 methoxybenzoic acid,diethyl phthalate,oleic acid.Conclusions:The leaf extracts with proven antibacterial effects can clearly be directed towards cancer treatment as to inhibiting cancer cell growth.The limited number of test organisms owes to a constraint of resource.So,the effect of strong bursts of leaf extracts on human pathogenic bacteria should further be tested on a wide range of test organisms. | Valentin Bhimba B J Meenupriya Elsa Lycias Joel D Edaya Naveena Suman kumar M Thangaraj | 2010 | Asian Pacific Journal of Tropical Medicine2010，3，7： | 13 |
| 3 | Serum biomarkers and risk of hepatocellular carcinoma recurrence after liver transplantation显示文摘Liver transplantation(LT) is the only potentially curative treatment for selected patients with cirrhosis and hepatocellular carcinoma(HCC) who are not candidates for resection. When the Milan criteria are strictly applied, 75% to85%of 3-to 4-year actuarial survival rates are achieved, but up to 20% of the patients experience HCC recurrence after transplantation. The Milan criteria are based on the preoperative tumor macromorphology, tumor size and number on computed tomography or magnetic resonance imaging that neither correlate well with posttransplant histological study of the liver explant nor accurately predict HCC recurrence after LT, since they do not include objective measures of tumor biology. Preoperative biological markers, including alpha-fetoprotein, desgamma-carboxiprothrombin or neutrophil-to-lymphocyte ratio and platelet-tolymphocyte ratio, can predict the risk for HCC recurrence after transplantation.These biomarkers have been proposed as surrogate markers of tumor differentiation and vascular invasion, with varied risk magnitudes depending on the defined cutoffs. Different studies have shown that the combination of one or several biomarkers integrated into prognostic models predict the risk of HCC recurrence after LT more accurately than Milan criteria alone. In this review, we focus on the potential utility of these serum biological markers to improve the performance of Milan criteria to identify patients at high risk of tumoral Published online: January 27, 2019 recurrence after LT.Liver transplantation(LT) is the only potentially curative treatment for selected patients with cirrhosis and hepatocellular carcinoma(HCC) who are not candidates for resection. When the Milan criteria are strictly applied, 75% to85%of 3-to 4-year actuarial survival rates are achieved, but up to 20% of the patients experience HCC recurrence after transplantation. The Milan criteria are based on the preoperative tumor macromorphology, tumor size and number on computed tomography or magnetic resonance imaging that neither correlate well with posttransplant histological study of the liver explant nor accurately predict HCC recurrence after LT, since they do not include objective measures of tumor biology. Preoperative biological markers, including alpha-fetoprotein, desgamma-carboxiprothrombin or neutrophil-to-lymphocyte ratio and platelet-tolymphocyte ratio, can predict the risk for HCC recurrence after transplantation.These biomarkers have been proposed as surrogate markers of tumor differentiation and vascular invasion, with varied risk magnitudes depending on the defined cutoffs. Different studies have shown that the combination of one or several biomarkers integrated into prognostic models predict the risk of HCC recurrence after LT more accurately than Milan criteria alone. In this review, we focus on the potential utility of these serum biological markers to improve the performance of Milan criteria to identify patients at high risk of tumoral recurrence after LT. | Maria J Citores Jose L Lucena Sara de la Fuente Valentin Cuervas-Mons | 2019 | World Journal of Hepatology2019，11，1： | 12 |
| 4 | 沥青体系的分子动力学研究进展及展望显示文摘随着我国道路工程的飞速发展,沥青混凝土在路面工程中有越来越广泛的应用。近年来,沥青材料的研究已不仅局限于宏观性能试验,还拓展到介观与微观层面对沥青材料进行多尺度研究。分子动力学方法属于微观研究方法的一种,它是通过积分算法模拟研究对象在不同条件下的分子运动轨迹与体系能量变化,并分析模拟数据得出结论。该方法已被广泛应用于分子尺度下路面沥青材料设计与微观机理研究,其优势在于从分子运动的角度解释沥青体系的各种现象与性质。因此,许多学者采用宏观试验和分子动力学模拟相结合的多尺度方法研究沥青体系,这将推动沥青材料的进一步发展。本文对沥青体系的分子动力学进行了全面的分析,构建了沥青体系分子动力学模型的一般平衡步骤,提出采用密度、玻璃态转变温度、黏度、溶解度参数等对沥青体系分子动力学模型的有效性进行验证。综合分析了分子动力学方法对沥青纳米聚集、自修复、改性、老化、界面黏附等行为机理的研究进展,提出采用耗散粒子动力学与粗粒化分子动力学对现阶段沥青体系分子动力学的研究尺度进行扩展。研究结果表明,沥青类材料的分子动力学方法还处于早期探索阶段,但其发展潜力极大,利用分子动力学方法研究沥青体系各组分分子的动力学行为,可揭示常规试验无法观察到的分子含时运动规律,预测沥青材料的宏观性能并针对沥青的分子结构提出其路用性能改善措施,从分子尺度上推动沥青路面多尺度试验仿真方法的发展与完善,为沥青材料基因组的开发研究奠定基础。 | 何亮 李冠男 郑雨丰 Alessio Alexiadis Jan Valentin Karol J Kowalski | 2020 | 材料导报2020，34，19： | 10 |
| 5 | 中美两家医院早产儿营养策略的对照研究显示文摘目的对比中美两家医院的早产儿营养支持数据,以期找到差距及改善方法。方法对2011年1月至2012年5月北京协和医院儿科NICU(PUMCH组)及2011年1月至2012年1月美国辛辛那提儿童医学中心辛辛那提大学医院NICU(CCHMC组)收治的胎龄<32周早产儿的肠内外营养数据进行回顾性对比研究。结果 PUMCH组74例、CCHMC组82例纳入研究。PUMCH组胎龄和出生体重均显著大于CCHMC组(P<0.01)。PUMCH组应用氨基酸和脂肪乳的总量均显著高于CCHMC组[分别为58±30 g/kg vs 24.0(19.6,32.8)g/kg,P<0.01;35±16 g/kg vs 14.0(11.0,22.5)g/kg,P<0.01],肠外营养时间显著长于CCHMC组[24±10 d vs 8.0(6.0,11.0)d,P<0.01]。PUMCH组母乳喂养率显著低于CCHMC组(10%vs 94%,P<0.01),达到足量喂养时间显著迟于CCHMC组[22±9 d vs 12.0(10.0,14.0)d,P<0.01]。CCHMC组坏死性小肠结肠炎发生率显著高于PUMCH组(13%vs 3%,P=0.018)。PUMCH组败血症发生率显著高于CCHMC组(32%vs 12%,P<0.01)。结论 PUMCH组较CCHMC组肠外营养时间延长、院内感染发生增加。需要推进强化母乳喂养、采取更积极的喂养方案以加快喂养进程。 | 李正红 董梅 王丹华 Cristina J Valentine | 2014 | 中国当代儿科杂志2014，16，7： | 4 |
| 6 | Influence of experimental soil disturbances on the diversity of plants in agricultural grasslands显示文摘Aims and Methods Disturbance is supposed to play an important role for biodiversity and ecosystem stability as described by the intermediate disturbance hypoth-esis(IDH),which predicts highest species richness at intermediate levels of disturbances.In this study,we tested the effects of artificial soil distur-bances on diversity of annual and perennial vascular plants and bryo-phytes in a field experiment in 86 agricultural grasslands differing in land use in two regions of Germany.On each grassland,we implemented four treatments:three treatments differing in application time of soil dis-turbances and one control.One year after experimental disturbance,we recorded vegetation and measured biomass productivity and bare ground.We analysed the disturbance response taking effects of region and land-use-accompanied disturbance regimes into account.Important Findings Region and land-use type strongly determined plant species rich-ness.Experimental disturbances had small positive effects on the species richness of annuals,but none on perennials or bryophytes.Bare ground was positively related to species richness of bryophytes.However,exceeding the creation of 12%bare ground further distur-bance had a detrimental effect on bryophyte species richness,which corresponds to the IDH.As biomass productivity was unaffected by disturbance our results indicate that the disturbance effect on spe-cies richness of annuals was not due to decreased overall produc-tivity,but rather due to short-term lowered inter-and intraspecific competition at the newly created microsites.Generally,our results highlight the importance of soil disturbances for species richness of annual plants and bryophytes in agricultural grasslands.However,most grasslands were disturbed naturally or by land-use practices and our additional experimental soil dis-turbances only had a small short-term effect.Overall,total plant diversity in grasslands seemed to be more limited by the availabil-ity of propagules rather than by suitable microsites for germination.Thus,nature conservation efforts to increase grassland diversity should focus on overcoming propagule limitation,for instance by additional sowing of seeds,while the creation of additional open patches by disturbance might only be appropriate where natural disturbances are scarce. | Jörg Müller Johannes Heinze Jasmin Joshi Steffen Boch Valentin H.Klaus Markus Fischer Daniel Prati | 2014 | Journal of Plant Ecology2014，7，6： | 3 |
| 7 | Role of perinatal long-chain omega-3 fatty acids in cortical circuit maturation:Mechanisms and implications for psychopathology显示文摘Accumulating translational evidence suggests that the long-chain omega-3 fatty acid docosahexaenoic acid(DHA) plays a role in the maturation and stability of cortical circuits that are impaired in different recurrent psychiatric disorders. Specifically, rodent and cell culture studies find that DHA preferentially accumulates in synaptic and growth cone membranes and promotes neurite outgrowth, dendritic spine stability, and synaptogenesis. Additional evidence suggests that DHA may play a role in microglia-mediated synaptic pruning, as well as myelin development and resilience. In nonhuman primates n-3 fatty acid insufficiency during perinatal development leads to widespread deficits in functional connectivity in adult frontal cortical networks compared to primates raised on DHA-fortified diet. Preterm delivery in non-human primates and humans is associated with early deficits in cortical DHA accrual. Human preterm birth is associated with longstanding deficits in myelin integrity and cortical circuit connectivity and increased risk for attention deficit/hyperactivity disorder(ADHD), mood, and psychotic disorders. In general, ADHD and mood and psychotic disorders initially emerge during rapid periods of cortical circuit maturation and are characterized by DHA deficits, myelin pathology, and impaired cortical circuit connectivity. Together these associations suggest that early and uncorrected deficits in fetal brain DHA accrual may represent a modifiable risk factor for cortical circuit maturation deficits in psychiatric disorders, and could therefore have significant implications for informing early intervention and prevention strategies. | Robert K McNamara Jennifer J Vannest Christina J Valentine | 2015 | World Journal of Psychiatry2015，5，1： | 2 |
| 8 | Alterations in the PITSLRE protein kinase gene complex on chromosome P36 in childhood neuroblastoma显示文摘 | Lahit JM Valentine M Xiang J | 1994 | Nat Genet1994，7，： | 2 |
| 9 | Expression ofa reflex of snapping/biting response to amino acids prior to the first exogenous feeding in salmonid alevins显示文摘 | Valentin(c)i(c) T B Lamb C F Caprio J | 1999 | Physiol Behav1999，67，4： | 1 |
| 10 | Digital PulseProcessor Using A Moving Average Technique显示文摘 | Valentin J | 1993 | IEEE Trans Nucl Sci1993，40，4： | 1 |
| 11 | CFD Evaluation of Waterwall Wastage in Coal-fired Utility Boilers 显示文摘 | VALENTINE J R SHIM H-S DAVIS K A | 2007 | Energy & Fuels2007，21，： | 1 |
| 12 | Three-dimensional optical metamaterial with a negative refractive index显示文摘 | VALENTINE J ZHANG S ZENTGRAF T | 2008 | Nature2008，455，7211： | 1 |
| 13 | Misfolded CuZnSOD and amyotrophic lateral sclerosis显示文摘 | Valentine J S Hart P J | 2003 | P Natl Acad Sci USA2003，100，7： | 1 |
| 14 | Receptor technology-cell binding to P-15:a new method of regenerating bone quickly and safely-preliminary histomorphometrical and mechanical results in sinus floor augmentations显示文摘 | VALENTIN A H WEBER J | 2004 | Keio J Med2004，53，3： | 1 |
| 15 | Long term 15N studies in a catena of the shortgrass steppe显示文摘 | Delgado J A Mosier A R Valentine D W Schimel D S Parton W J | 1996 | Biogeochemistry1996，32，： | 1 |
| 16 | The specific diversity indices for analysing phytoplankton succession: application to the Cabo Frio (RJ, Brazil)upwelling ecosystem显示文摘 | VALENTIN J L MACEDO - SAIDAH F E TENENBAUM D R | 1991 | Neritica1991，6，： | 1 |
| 17 | A kinetic model of N-nitrosodimethylamine(NDMA) formation during water chlorination /chloramination显示文摘 | Choi J Valentine R L | 2002 | Water Science and Technology2002，46，3： | 1 |
| 18 | Improving strate- gies for diagnosing ovarian cancer:a summary of the In- ternational Ovarian Tumor Analysis (IOTA)studies 显示文摘 | Kaijser J Bourne T Valentin L | 2013 | Ultrasound Obstct Gynecol2013，41，1： | 1 |
| 19 | Primary prevention of cardiovascular disease with atorvastatin in type 2 diabetes in the Collaborative Atorvastatin Diabetes Study (CARDS): multicentre randomised placebo-controlled trial显示文摘 | Helen M Colhoun D John Betteridge Paul N Durrington Graham A Hitman H Andrew W Neil Shona J Livingstone Margaret J Thomason Michael I Mackness Valentine Charlton-Menys John H Fuller | 2004 | The Lancet . 2004 (9435)2004，，9435： | 1 |
| 20 | Carbon monoxide poisoning:risk factors for cognitive sequelae and the role of hyperbaric oxygen显示文摘 | Weaver L K Valentine K J Hopkins R O | | 0，，05： | 1 |
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