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| 1 | Intensified intensity-modulated radiotherapy in anal cancer with prevalent HPV p16 positivity显示文摘AIM: To investigate the toxicity and response of intensity-modulated radiotherapy schedule intensified with a simultaneous integrated boost in anal canal cancer.METHODS: From March 2009 to March 2014, we retrospectively analyzed 41 consecutive patients treated with intensity-modulated radiotherapy(IMRT) and concurrent chemotherapy for anal canal squamous cell carcinoma at our center. Radiotherapy was delivered via simultaneous integrated boost(SIB) technique by helical tomotherapy, and doses were adapted to two clinical target volumes according to the tumor-nodemetastasis(TNM) stage: 50.6 Gy and 41.4 Gy in 23 fractions in T1N0, 52.8 Gy and 43.2 Gy in 24 fractionsin T2N0, and 55 Gy and 45 Gy in 25 fractions in all patients with N positive and/or ≥ T3, respectively, to planning target volumes 1 and 2. The most common chemotherapy regimen was 5-fluorouracil and mitomycin-based. Human papilloma virus(HPV) p16 expression was performed by immunohistochemistry and evaluated in the majority of patients. Acute and late toxicity was scored according to CTCAe v 3.0 and RTOG scales.RESULTS: The median follow-up was 30 mo(range:12-71). Median age was 63 years(range 32-84). The stage of disease was: stage Ⅰ in 2 patients, stage Ⅱin 13 patients, stage ⅢA in 12 patients, and stage ⅢB in 14 patients, respectively. Two patients were known to be HIV positive(4.9%). HPV p16 expression status was positive in 29/34(85.3%) patients. The 4-year progression-free survival and overall survival in HPVpositive patients were 78% and 92%, respectively.Acute grade 3 skin and gastrointestinal toxicities were reported in 5% and 7.3% of patients, respectively;patients' compliance to the treatment was good due to a low occurrence of severe acute toxicity, although treatment interruptions due to toxicity were required in 7.3% of patients. At 6 mo from end of treatment,36/40(90%) patients obtained complete response;during follow-up, 5(13.8%) patients presented with disease progression(local or systemic).CONCLUSION: In our experience, intensified SIBIMRT with chemotherapy is very feasible in clinical practice, with excellent results in terms of overall survival and local control. | Liliana Belgioia Stefano Vagge Dario Agnese Stefania Garelli Roberto Murialdo Giuseppe Fornarini Silvana Chiara Fabio Gallo Almalina Bacigalupo Renzo Corvò | 2015 | World Journal of Gastroenterology2015，21，37： | 2 |
| 2 | The pattern of inflammatory/anti-inflammatory cytokines and chemokines in type 1 diabetic patients over time显示文摘 | Antonios Chatzigeorgiou Vaggelis Harokopos Christina Mylona-Karagianni Emmanouil Tsouvalas Vassilis Aidinis Elli Kamper | 2010 | Annals of Medicine2010，，6： | 1 |
| 3 | Magnesium and milk fever显示文摘 | Sansom B F Manston R Vagg M J | 1983 | Vet Rec1983，112，19： | 1 |
| 4 | The relationship of self-efficacy expectancies to relapse among alcohol dependent men and women: a prospective study显示文摘 | Greenfield SF Hufford MR Vagge LM | 2000 | J Stud Alcohol2000，61，2： | 1 |
| 5 | Synthesis of Novel Bis (amides) by Means of Triphenyl Phosphite Intermediates 显示文摘 | Barnes D J Chapman R L Vagg R S | 1978 | J Chem Eng Data1978，23，4： | 1 |
| 6 | Taxanes for adjuvant treatment of early breast cancer显示文摘 | Ferguson T Wilcken N Vagg R | 2007 | Cochrane Database of Systematic Reviews2007，4，： | 1 |
| 7 | Bosutinib : a review of preclinieal and clinical studies in chronic myelogenous leukemia 显示文摘 | RUSCONI F PIAZZA R VAGGE E | 2014 | Expert Opin Pharmacother2014，15，5： | 1 |
| 8 | Comparative Expression Profiling in Pulmonary Fibrosis Suggests a Role of Hypoxia- inducible Factor-I in Disease Pathogenesis显示文摘 | Argyris T Vaggelis H Triantafillos P | 2007 | Respir Crit Care Med2007，176，8： | 1 |
| 9 | Taxanes for adjuvant treat- ment of early breast cancer显示文摘 | Ferguson T Wilcken N Vagg R | 2007 | Cochrane Database of Systematic Reviews2007，，4： | 1 |
| 10 | Suppliers' behavioronthepost-adoptionstageofbusiness-to-businesse-reverseauctions: Anempiricalstudy显示文摘 | Vaggelis S | 2013 | Telem- atics and Informatics2013，30，2： | 1 |
| 11 | Epidemiology, aetiology and outcomes of acute pancreatitis: A retrospective cohort study显示文摘 | Maryam Nesvaderani Guy D. Eslick Daniel Vagg Shadi Faraj Michael R. Cox | 2015 | International Journal of Surgery2015，，： | 1 |
| 12 | Taxanes for adjuvant treatmerit of early breast cancer显示文摘 | Ferguson T Wilcken N Vagg R | 2007 | Cochrane Database Syst Rev2007，，00： | 1 |
| 13 | Occupational stress: measuring job pressure and organizational support in the workplace 显示文摘 | VAGG PR SPIELBERGER CD | 1998 | JOccu- pHealth Psychol1998，3，4： | 1 |
| 14 | Use of the field vole (Microtus agrestis) for monitoring potentially harmful elements in the environment显示文摘 | Beardsley A Vagg M J Beckett P H T | 1978 | Environmental Pollution1978，16，1： | 1 |
| 15 | Interleukin-1-receptor antagonist in type 2 diabetes mellitus显示文摘 | Claus M Larsen Mirijam Faulenbach Allan Vagg | 2007 | N Engl J Med2007，356，： | 1 |
| 16 | Bosutinib : a review of preclinical and clinical studies in chronic myelogenous leukemia 显示文摘 | Rusconi F Piazza R Vagge E | 2014 | Expert Opin Pharmacother2014，15，5： | 1 |
| 17 | Polyelectrolyte-stabilized biosensors based on macroporous carbon electrode 显示文摘 | Vaggelis T | 2002 | Analytica Chimica Acta2002，467，： | 1 |
| 18 | Test anxiety: A transactional process 显示文摘 | Spietberger C D Vagg P R | 1987 | Advances in Test Anxiety Research1987，5，： | 1 |
| 19 | Thyroid Dysfunction and Autoantibodies in Early Pregnancy Are Associated with Increased Risk of Gestational Diabetes and Adverse Birth Outcomes显示文摘 | Polyxeni Karakosta Dimitris Alegakis Vaggelis Georgiou Theano Roumeliotaki Eleni Fthenou Maria Vassilaki Dimitrios Boumpas Elias Castanas Manolis Kogevinas Leda Chatzi | 2012 | The Journal of Clinical Endocrinology & Metabolism2012，，12： | 1 |
| 20 | Benthic diatom community response to metal contamination from an abandoned Cu mine:Case study of the Gromolo Torrent(Italy)显示文摘Environmental contamination has become a global problem of increasing intensity due to the exponential growth of industrialization. One main debated issue is the metal contamination of rivers receiving Acid Mine Drainage(AMD) from active/abandoned mines. In order to assess the quality of lotic systems, diatoms are commonly used, as their assemblage modifies on the basis of changes in environmental parameters. Benthic diatom changes were analyzed along the metal-impacted Gromolo Torrent(Liguria, NW Italy) with the aim of understanding the effects of input from the abandoned Libiola Cu mine. The results support the hypothesis that metals from AMD lead to massive changes in diatoms, resulting in low biological diversity and in a shift of dominance, passing from the genera Cymbella and Cocconeis to more tolerant and opportunistic species, such as Achnanthidium minutissimum and Fragilaria rumpens. The high concentrations of labile metals, measured through Diffusion Gradients in Thin-films(DGT) immediately downstream of the two AMD inputs in the torrent, corresponded to a sudden decrease in the presence of diatoms, indicating the possible reaching of acute toxic levels. In particular,A. minutissimum dominated the mining area and was positively correlated with Cu and Zn;whereas F. rumpens bloomed downstream of this area, where the metal content was diluted,and was positively correlated with As and Pb. Finally, an important abundance of Nitzschia palea and teratological forms of A. minutissimum and F. rumpens were observed downstream from the mine, indicating that metals may have an important impact on diatoms up to the torrent mouth. | Raffaella Tolotti Sirio Consani Cristina Carbone Greta Vagge Marco Capello Laura Cutroneo | 2019 | Journal of Environmental Sciences2019，31，1： | 1 |
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