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| 1 | Patients with primary biliary cirrhosis have increased serum total antioxidant capacity measured with the crocin bleaching assay显示文摘AIM: The balance between oxidants and antioxidants can play an important role in the initiation and development of liver diseases. Recently, we have described a new automated method for the determination of total antioxidant capacity (TAC) in human serum and plasma.METHODS: We measured TAC and corrected TAC (CTAC -abstraction of interactions due to endogenous uric acid,bilirubin and albumin) in 52 patients with chronic liver diseases (41 patients with primary biliary cirrhosis (PBC),10 patients with chronic hepatitis C and 13 patients with viral HCV cirrhosis) as well as in 10 healthy controls. In 23 PBC patients measurement were also done 6 mo after treatment with ursodeoxycholic acid (UDCA). The TAC assay was based on a modification of the crocin bleaching assay. The results were correlated with routine laboratory measurements and the histological stage of PBC.RESULTS: There were no significant differences in TAC between the various groups. However, CTAC was considerably increased in the PBC group compared to controls and cirrhotics. Analysis of these patients according to disease stages showed that this increase was an early phenomenon observed only in stages Ⅰ and Ⅱ compared to controls, cirrhotics and patients with chronic hepatitis C).After 6 mo of treatment with UDCA, levels of CTAC decreased to those similar to that of controls.CONCLUSION: Patients in the early stages of PBC present with high levels of corrected total antioxidant capacity and this maybe related to the pathophysiology of the disease. UDCA treatment restores the levels of CTAC to control levels. | George Notas Niki Miliaraki Marilena Kampa Fillipos Dimoulios Erminia Matrella Adam Hatzidakis Elias Castanas Elias Kouroumalis | 2005 | World Journal of Gastroenterology2005，11，27： | 13 |
| 2 | Peri-nuclear antibodies correlate with survival in Greek primary biliary cirrhosis patients显示文摘AIM:To investigate possible associations of anti-nuclear envelope antibody(ANEA)with disease severity and survival in Greek primary biliary cirrhosis(PBC)patients.METHODS:Serum samples were collected at diagnosis from 147 PBC patients(85%female),who were followed-up for a median 89.5 mo(range 1-240).ANEA were detected with indirect immunofluorescence on 1% formaldehyde fixed Hep2 cells,and anti-gp210 antibodies were detected using an enzyme linked immunosorbent assay.Findings were correlated with clinical data,histology,and survival.RESULTS:ANEA were detected in 69/147(46.9%) patients and 31/147(21%)were also anti-gp210 positive.The ANEA positive patients were at a more advanced histological stage(Ⅰ-Ⅱ/Ⅲ-Ⅳ56.5%/43.5% vs 74.4%/25.6%,P=0.005)compared to the ANEA negative ones.They had a higher antimitochondrial antibodies(AMA)titer(≤1:160/>1:160 50.7%/49.3%vs 71.8%/28.2%,P=0.001)and a lower survival time(91.7 ±50.7 mo vs 101.8±55 mo,P=0.043).Moreover,they had more advanced fibrosis,portal inflammation,interface hepatitis,and proliferation of bile ductules(P =0.008,P=0.008,P=0.019,and P=0.027,respectively).They also died more frequently of hepatic failure and/or hepatocellular carcinoma(P=0.016).ANEA positive,anti-gp210 positive patients had a difference in stage(Ⅰ-Ⅱ/Ⅲ-Ⅳ54.8%/45.2%vs 74.4%/25.6%,P= 0.006),AMA titer(≤1:160/>1:160 51.6%/48.4%vs 71.8%/28.2%,P=0.009),survival(91.1±52.9 mo vs 101.8±55 mo,P=0.009),and Mayo risk score(5.5 ±1.9 vs 5.04±1.3,P=0.04)compared to the ANEA negative patients.ANEA positive,anti-gp210 negative patients had a difference in AMA titer(≤1:160/>1:160 50%/50%vs 71.8%/28.2%,P=0.002),stage(Ⅰ-Ⅱ/Ⅲ -Ⅳ57.9%/42.1%vs 74.4%/25.6%,P=0.033),fibrosis(P=0.009),portal inflammation(P=0.018),interface hepatitis(P=0.032),and proliferation of bile ductules(P=0.031).Anti-gp210 positive patients had a worse Mayo risk score(5.5±1.9 vs 4.9±1.7,P=0.038)than the anti-gp210 negative ones.CONCLUSION:The presence of ANEA and anti-gp210 identifies a subgroup of PBC patients with advanced disease severity and poor prognosis. | Ourania Sfakianaki Meri Koulentaki Maria Tzardi Elena Tsangaridou Panayotis A Theodoropoulos Elias Castanas Elias A Kouroumalis | 2010 | World Journal of Gastroenterology2010，16，39： | 11 |
| 3 | Human health effects of air pollution显示文摘 | Marilena Kampa Elias Castanas | 2007 | Environmental Pollution2007，，2： | 2 |
| 4 | Human thyroid cancer:membrane thyrotropin binding and adenylate cyclase activity显示文摘 | Carayon P Thomas-Morvan C Castanas E | 1980 | J Clin Endocrinol Metab1980，51，： | 1 |
| 5 | The antiproliferative effect of opioid receptor agonists on the T47D human breast cancer cell line is partially mediated through opioid receptors显示文摘 | Hatzoglou A Bakogeorgou E Castanas E | 1996 | Eur J Pharmacol1996，296，2： | 1 |
| 6 | Features of somatosensory manifestations induced by intracranial electrical stimulations of the human insula显示文摘 | Pugnaghi M Meletti S Castana L | | 0，，： | 1 |
| 7 | Human health effects of air pollution显示文摘 | KAMPA M CASTANAS E | 2008 | Environmental Pollution2008，151，2： | 1 |
| 8 | Pharmacokinetic study of the relative bioavailability and bioequivalence after oral intensive or repeated short term treatment with two polyamino acid formulations显示文摘 | Matera M Castana R Insirello L | 1993 | Int J Clin Pharmacol Res1993，13，2： | 1 |
| 9 | Pharmacokinetic study of the relative bioavailability and bioequivalence after oral intensive or repeated short term treatment with two polyamino acid formulations显示文摘 | Matera M Castana R Insirello L | 1993 | Int J Clin Phaemacol Res1993，13，2： | 1 |
| 10 | Topical application of autologous adipose-derived mesenchymal stem cells ( MSCs ) for persistent sterile corneal epithelial defect 显示文摘 | Agorogiannis GI Alexaki VI Castana O | 2012 | Graefes Arch Clin Exp Ophthalmol2012，250，3： | 1 |
| 11 | Human health effects of air pollution显示文摘 | Kampa M Castanas E | 2008 | Environmental Pollution2008，151，2： | 1 |
| 12 | Opioid - somatostatin interactions in regulating cancer cell growth 显示文摘 | Hatzoglou A Kampa M Castanas E | 2005 | Front Biosci2005，，10： | 1 |
| 13 | Human thyroid cancer : membrane thyrotropin binding and adenylate cyclase activi- ty显示文摘 | Carayon P Thomas-Morvan C Castanas E | 1980 | J Clin Endocrinol Metab1980，51，4： | 1 |
| 14 | Stereoelectro- eneephalography in the presurgical evaluation of focal epilepsy: a retrospective analysis of 215 procedures 显示文摘 | Cossu M Cardinale F Castana L | 2005 | Neurosurgery2005，57，4： | 1 |
| 15 | Humanthyroid cancer:membrane thyrotropin binding and adeny-late cyclase activity显示文摘 | Carayon P Thomas-Morvan C Castanas E | 1980 | J Clin Endocrinol Metab1980，51，4： | 1 |
| 16 | Wireless electri- cal stimulation: an innovative powerful tool for the treatment of a complicated chronic ulcer 显示文摘 | Castana O Dimitrouli A Argyrakos T | 2013 | Int J Low Extrem Wounds2013，12，1： | 1 |
| 17 | Anti– saccharomyces cerevisiae mannan antibodies and antineutrophil cytoplasmic autoantibodies in Greek patients with inflammatory bowel disease显示文摘 | Ioannis E Koutroubakis Efthymia Petinaki Ioannis A Mouzas Ioannis G Vlachonikolis Evangelia Anagnostopoulou Elias Castanas Antonios N Maniatis Elias A Kouroumalis | 2001 | The American Journal of Gastroenterology2001，，2： | 1 |
| 18 | Features of so- matosensory manifestations induced by intracranial e- lectrical stimulations of the human insula显示文摘 | Pugnaghi M Metetti S Castana L | 2011 | Clinical Neurophysiology2011，122，： | 1 |
| 19 | The antiproliferative effect of opioid receptor agonists on the T47D human breast cancer cell line,is partially mediated through opioid receptors显示文摘 | HATZOGLOU A BAKOGEORGOU E CASTANAS E | 1996 | Eur J Pharmacol1996，296，2： | 1 |
| 20 | Human health effects of air pollution 显示文摘 | Kampaa M Castanas E | 2008 | Environ Pollut2008，151，2： | 1 |
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