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| 1 | Small bowel adenocarcinoma in Crohn's disease:A case report and review of literature显示文摘小肠腺癌为他们的稀有,困难的诊断和差的预后是显著的。这里,我们报导小肠的渗透性的腺癌在 Crohn 的疾病的 10 年的历史以后在被诊断的一个 33 岁的病人的一个不平常的案例。在最以前报导的案例中, Crohn 的疾病的察觉对小肠的癌的随后或包含的病人有疾病的甚至更长的历史。我们的文学评论建议小肠腺癌的风险比在全面人口在有 Crohn 的疾病的病人是更高的。我们传染病学以及这个稀罕疾病实体的临床、诊断的方面上的现在的细节。 | Irmgard E Kronberger Ivo W Graziadei Wolfgang Vogel | 2006 | World Journal of Gastroenterology2006，12，8： | 8 |
| 2 | Transjugular intrahepatic portosystemic shunt in liver transplant recipients显示文摘AIM:To evaluate the efficacy of transjugular intrahepatic portosystemic shunts (TIPSs) after liver transplantation (LT). METHODS: Between November 1996 and December 2005, 10 patients with severe recurrent hepatitis C virus infection (n=4), ductopenic rejection (n=5) or portal vein thrombosis (n=1) were included in this analysis. Eleven TIPSs (one patient underwent two TIPS procedures) were placed for management of therapy-refractory ascites (n=7), hydrothorax (n=2) or bleeding from colonic varices (n=1). The median time interval between LT and TIPS placement was 15 (4-158) mo. RESULTS: TIPS placement was successful in all patients. The mean portosystemic pressure gradient was reduced from 12.5 to 8.7 mmHg. Complete and partial remission could be achieved in 43% and 29% of patients with ascites. Both patients with hydrothorax did not respond to TIPS. No recurrent bleeding was seen in the patient with colonic varices. Nine of 10 patients died during the study period. Only one of two patients, who underwent retransplantation after the TIPS procedure, survived. The median survival period after TIPS placement was 3.3 (range 0.4-20) mo. The majority of patients died from sepsis with multiorgan failure.CONCLUSION: Indications for TIPS and technical performance in LT patients correspond to those in non-transplanted patients. At least partial control of therapy-refractory ascites and variceal bleeding could be achieved in most patients. Nevertheless, survival rates were disappointing, most probably because of the advanced stages of liver disease at the time of TIPS placement and the high risk of sepsis as a consequence of immunosuppression. | Armin Finkenstedt Ivo W Graziadei Karin Nachbaur Werner Jaschke Walter Mark Raimund Margreiter Wolfgang Vogel | 2009 | World Journal of Gastroenterology2009，15，16： | 8 |
| 3 | CD28/CTLA-4/B7 and CD40/CD40L costimulation and activation of regulatory T cells显示文摘Costimulatory signals are crucial for T cell activation. Attempts to block costimulatory pathways have been effective in preventing unwanted immune reactions. In particular, blocking the CD28/cytotoxic T lymphocyte antigen(CTLA)-4/B7 interaction(using CTLA-4Ig) and the CD40/CD40 L interaction(using anti-CD40 L antibodies) prevents T cell mediated autoimmune diseases, transplant rejection and graft vs host disease in experimental models. Moreover, CTLA-4Ig is in clinical use to treat rheumatoid arthritis(abatacept) and to prevent rejection of renal transplants(belatacept). Under certain experimental conditions, this treatment can even result in tolerance. Surprisingly, the underlying mechanisms of immune modulation are still not completely understood. We here discuss the evidence that costimulation blockade differentially affects effector T cells(Teff) and regulatory T cells(Treg). The latter are required to control inappropriate and unwanted immune responses, and their activity often contributes to tolerance induction and maintenance. Unfortunately, our knowledge on the costimulatory requirements of Treg cells is very limited. We therefore summarize the current understanding ofthe costimulatory requirements of Treg cells, and elaborate on the effect of anti-CD40 L antibody and CTLA-4Ig treatment on Treg cell activity. In this context, we point out that the outcome of a treatment aiming at blocking the CD28/CTLA-4/B7 costimulatory interaction can vary with dosing, timing and underlying immunopathology. | Isabel T Vogel Stefaan W Van Gool Jan L Ceuppens | 2014 | World Journal of Immunology2014，4，2： | 3 |
| 4 | Towards a structure-function analysis of bovine lactoferricin and related tryptophan and argini-necontaining peptides 显示文摘 | Vogel H J Schibli D J Jing W G | 2002 | Biochemistry and Cell Biology2002，80，1： | 1 |
| 5 | The discoindin domain receptor tyrosine kinases are activated by collagen 显示文摘 | Gish GD Alves F | 1997 | Mol Cell1997，1，1： | 1 |
| 6 | Experimental intracerebral hemorrhage:Description of a double injection model in rats显示文摘 | Deinsberger W Vogel J Kuschinsky W | 1996 | Neurol Res1996，18，5： | 1 |
| 7 | Cavitation bubble dynamics and acoustic transient generation in ocular surgery with pulsed Nd: YAG-lasers显示文摘 | Vogel A Lautterborn W | 1986 | Opthalmology1986，93，： | 1 |
| 8 | Experimental intracerebral hemorrhage:description of a double injection model in rats显示文摘 | Deinsberger W Vogel J Kuschinsky W | 1996 | Neurol Res1996，18，： | 1 |
| 9 | Circulating serum levels of interleukin 6 and C-reactive protein after liver transplantation显示文摘 | NORDBERG J VOGEL W | 1992 | Transplantation1992，54，： | 1 |
| 10 | Isotopic equilibrium between shells and their environment显示文摘 | Mook W G Vogel J C | 1968 | Science1968，159，： | 1 |
| 11 | Optical and acoustic investigations of the dynamics of laser-produced cavitation bubbles near a solid boundary显示文摘 | Vogel A Lautterborn W | 1989 | Journal of Fluid Mechanics1989，206，： | 1 |
| 12 | 显示文摘 | Vogel W | 2008 | The Journal of Physical Chemistry C2008，112，13： | 1 |
| 13 | Absence of Sry in species of the vole Ellobius显示文摘 | JUST W RAU W VOGEL W | 1995 | Nature genetics1995，11，2： | 1 |
| 14 | Earthwork Structures for New Railway Lines Slab Track-principles and Suggestions for Realization 显示文摘 | Vogel W | 1995 | Railway Technical Review1995，，1： | 1 |
| 15 | Discordin domain receptors:Structural relations and functional implications显示文摘 | Vogel W | 1999 | FASEB J1999，，： | 1 |
| 16 | Astrolabe: a robust and scalable technology for distributed systems monitoring, management, and data mining 显示文摘 | VAN RENESSE R BIRMAN K P VOGELS W | 2003 | ACM Transactions on Computing Systems2003，21，2： | 1 |
| 17 | Advances in Ceramics显示文摘 | Vogel W Holant W | 1982 | Amer Ceram Soc Inc1982，4，2： | 1 |
| 18 | Dynamics of initial subgingival colonization of pristine peri- implant pockets 显示文摘 | Quirynen M Vogels R Peeters W | 2006 | Clin Oral Implants Res2006，17，1： | 1 |
| 19 | Development of machinable bioactive glass-ceramics for medical uses显示文摘 | Vogel W Holand W Naumann K | 1986 | J Non-Cryst Solids1986，80，： | 1 |
| 20 | Discoidin domain receptor 1 is activated independently of β1 integrin 显示文摘 | Brakebusch C Fassler R | 2000 | J Biol Chem2000，275，8： | 1 |
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