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| 1 | Comparative clinical trial of S-pantoprazole versus racemic pantoprazole in the treatment of gastro-esophageal reflux disease显示文摘AIM: To compare the effi cacy and tolerability of S-pan- toprazole (20 mg once a day) versus racemic Panto- prazole (40 mg once a day) in the treatment of gastro- esophageal reflux disease (GERD). METHODS: This multi-centre, randomized, double-blind clinical trial consisted of 369 patients of either sex suf- fering from GERD. Patients were randomly assigned to receive either one tablet (20 mg) of S-pantoprazole once a day (test group) or 40 mg racemic pantoprazole once a day (reference group) for 28 d. Patients were evaluated for reduction in baseline on d 0, GERD symptom score on d 14 and 28, occurrence of any adverse effect during the course of therapy. Gastrointestinal (GI) endoscopy was performed in 54 patients enrolled at one of the study centers at baseline and on d 28. RESULTS: Signifi cant reduction in the scores (mean and median) for heart burn (P < 0.0001), acid regurgitation (P < 0.0001), bloating (P < 0.0001), nausea (P < 0.0001) and dysphagia (P < 0.001) was achieved in both groups on d 14 with further reduction on continuing the therapy till 28 d. There was a statistically signifi cant difference in the proportion of patients showing improvement in acid regurgitation and bloating on d 14 and 28 (P = 0.004 for acid regurgitation; P = 0.03 for bloating) and heart burn on d 28 (P = 0.01) between the two groups, with a higher proportion in the test group than in the refer- ence group. Absolute risk reductions for heartburn/acid regurgitation/bloating were approximately 15% on d 14 and 10% on d 28. The relative risk reductions were 26%-33% on d 14 and 15% on d 28. GI endoscopy showed no signifi cant difference in healing of esophagitis (P = 1) and gastric erosions (P = 0.27) between the two groups. None of the patients in either group reported any adverse effect during the course of therapy.CONCLUSION: In GERD, S-pantoprazole (20 mg) is more effective than racemic pantoprazole (40 mg) in improving symptoms of heartburn, acid regurgitation, bloating and equally effective in healing esophagitis and gastric erosions. The relative risk reduction is 15%-33%. Both drugs are safe and well tolerated. | Vikas G Pai Nitin V Pai Hemant P Thacker Jaisingh K Shinde Vijay P Mandora Subhash S Erram | 2006 | World Journal of Gastroenterology2006，12，37： | 19 |
| 2 | The role and significance of Magnesium in modern day research-A review显示文摘Magnesium is one of the largely available elements in the earth’s crust. It has a low structural density with high specific strength. This unique material property has forced an increase in the use of magnesium and its alloys in various applications pertaining to industrial sector,automobiles, aerospace and biomedical. Since magnesium is a highly reactive metal, it is prone to higher rate of corrosion as compared to its counterparts. Thus, it is essential to analyze the corrosion behavior of magnesium and its alloys in its applications. An appropriate process is to be followed in the design and development of magnesium alloys which overcome the limitations of magnesium and enhance the desired material properties in accordance to their applications. This review paper summarizes the importance of magnesium and its material properties. The influence of various alloying elements on the mechanical properties of magnesium is reviewed. The broad classification of Mg alloys and their behavioral trends are detailed. The corrosion behavior of magnesium and the influence of corrosion products on the material characteristics of magnesium, in aqueous medium, are discussed. The manufacturing techniques of magnesium alloys along with the secondary techniques are also covered. The various applications and the limitations of magnesium in these applications are covered. A complete section is dedicated towards detailing the recent trends of magnesium(Mg) alloys, i.e., the biodegradable nature and applications of Mg alloys. The influence of biocorrosion on Mg alloys and techniques to overcome it have been deliberated. This paper provides a thorough review on recent developments of magnesium with respect to engineering applications. | S V Satya Prasad S B Prasad Kartikey Verma Raghvendra Kumar Mishra Vikas Kumar Subhash Singh | 2022 | Journal of Magnesium and Alloys2022，10，1： | 11 |
| 3 | Gamma Irradiation of Embryogenic Callus Cultures and In vitro Selection for Salt Tolerance in Sugarcane (Saccharum officinarum L.)显示文摘Radiation induced mutagenesis followed by in vitro selection was employed for salt tolerance in popular Indian sugarcane (Saccharum officinarum L.) cv. CoC-671. Embryogenic calli were gamma irradiated and exposed to different levels of NaCl (42.8,85.6,128.3,171.1,213.9,256.7,299.5,or 342.2 mM). The relative growth rate (RGR) decreased progressively with increasing salt stress and was the least with a salt stress of 256.7 mM (0.25 ± 0.009),almost 10 fold lesser than the control. The RGR was significantly lower in 85.6 mM and higher salt stressed calli than the control. The survival percent also decreased,with an increase in NaCl concentration. In case of 10 and 20 Gy irradiated calli,regeneration was observed up to 85.6 mM NaCl selection,medium,whereas,higher treatments (128.3 mM and beyond) exhibited browning initially. However,in the subsequent subcultures,regeneration was obtained in the case of 10 and 20 Gy irradiated calli on 128.3 and 171.1 mM NaCl selections. Higher dose of gamma irradiation (40 Gy) also showed regeneration,but only with 85.6 mM NaCl selection. The unirradiated calli regenerated the highest number of plantlets followed by 10 and 20 Gy irradiated calli on salt selection. A total of 147 plantlets were selected from different salt levels. The salt selected plants are being tested for their field performance. | Vikas Y Patade P Suprasanna V A Bapat | 2008 | Agricultural Sciences in China2008，7，9： | 6 |
| 4 | Predictors of spine deformity progression in adolescent idiopathic scoliosis: A systematic review with meta-analysis显示文摘AIM: To evaluate published data on the predictors of progressive adolescent idiopathic scoliosis(AIS) in order to evaluate their efficacy and level of evidence. METHODS: Selection criteria:(1) study design: randomized controlled clinical trials, prospective cohort studies and case series, retrospective comparative and none comparative studies;(2) participants: adolescents with AIS aged from 10 to 20 years; and(3) treatment: observation, bracing, and other. Search method: Ovid MEDLINE, Embase, the Cochrane Library, Pub Medand patent data bases. All years through August 2014 were included. Data were collected that showed an association between the studied characteristics and the progression of AIS or the severity of the spine deformity. Odds ratio(OR), sensitivity, specificity, positive and negative predictive values were also collected. A metaanalysis was performed to evaluate the pooled OR and predictive values, if more than 1 study presented a result. The GRADE approach was applied to evaluate the level of evidence.RESULTS: The review included 25 studies. All studies showed statistically significant or borderline association between severity or progression of AIS with the following characteristics:(1) An increase of the Cobb angle or axial rotation during brace treatment;(2) decrease of the rib-vertebral angle at the apical level of the convex side during brace treatment;(3) initial Cobb angle severity(> 25o);(4) osteopenia;(5) patient age < 13 years at diagnosis;(6) premenarche status;(7) skeletal immaturity;(8) thoracic deformity;(9) brain stem vestibular dysfunction; and(10) multiple indices combining radiographic, demographic, and physiologic characteristics. Single nucleotide polymorphisms of the following genes:(1) calmodulin 1;(2) estrogen receptor 1;(3) tryptophan hydroxylase 1;(3) insulin-like growth factor 1;(5) neurotrophin 3;(6) interleukin-17 receptor C;(7) melatonin receptor 1B, and(8) Scoli Score test. Other predictors included:(1) impairment of melatonin signaling in osteoblasts and peripheral blood mononuclear cells(PBMC);(2) G-protein signaling dysfunction in PBMC; and(3) the level of platelet calmodulin. However, predictive values of all these findings were limited, and the levels of evidence were low. The pooled result of brace treatment outcomes demonstrated that around 27% of patents with AIS experienced exacerbation of the spine deformity during or after brace treatment, and 15% required surgical correction. However, the level of evidence is also low due to the limitations of the included studies.CONCLUSION: This review did not reveal any methods for the prediction of progression in AIS that could be recommended for clinical use as diagnostic criteria. | Andriy Noshchenko Lilian Hoffecker Emily M Lindley Evalina L Burger Christopher MJ Cain Vikas V Patel Andrew P Bradford | 2015 | World Journal of Orthopedics2015，6，7： | 4 |
| 5 | Synthesis, Biological Activity and Molecular Modeling of 6-Benzyl?thioinosine Analogues as Subversive Substrates of Toxo?plasma Gondii Adenosine Kinase显示文摘 | VIKAS v CHUNG K C RE etal | 2004 | J Med Chern2004，47，8： | 1 |
| 6 | Management of non neoplastic renal hemorrhage by transarterial embolization 显示文摘 | Vikas J Arvind G Jigish V | 2009 | Urol2009，73，3： | 1 |
| 7 | 6-Benzylthio?inosine Analogues: Promising Anti-toxoplasmicagents as Inhibitors of the Mammalian Nucleoside Transporter ENTI (es)显示文摘 | AMOL G JOHN K B VIKAS v | 2005 | Biochem Pharrn2005，71，： | 1 |
| 8 | Management of non-neoplastic renal hemorrhage by transarterial embolization显示文摘 | Vikas J Arvind G Jigish V | 2009 | Urol2009，73，3： | 1 |
| 9 | Two-year clinical out- comes of a multicenter randomized controlled trial comparing two interspinous spacers for treatment of moderate lumbar spinal steno- sis显示文摘 | Vikas V P Peter G W Thomas R H | 2014 | BMC Musculoskeletal Disorders2014，15，： | 1 |
| 10 | Synthesis, characterization, and SANS studies of novel alkanediyl-α,ω-bis(hydroxy ethyl methyl hexadecyl ammonium bromide)cationic gemini surfactants显示文摘 | VIKAS S MAHENDRA B ASWAL V K | 2004 | Journal of Colloid and Interface Science2004，277，： | 1 |
| 11 | Management of nonneoplatie renal angiographic embollzation显示文摘 | Vikas J Arvind G Jigish V | 2008 | Urol- ogy2008，71，3： | 1 |
| 12 | Management of non-neoplastic renal hemorrhage by transarterial embolization显示文摘 | Vikas J Arvind G Jigish V | 2009 | Urology2009，74，3： | 1 |
| 13 | Growth of intermetallic layer at roll bonded IF-steel/aluminum interface 显示文摘 | Vikas Jindal Srivastava V C | 2007 | Materials Processing Technology2007，10，： | 1 |
| 14 | Liquid Phase Oxidation of P-cresol Over Cobalt Saponite显示文摘 | VIKAS S KSHIRSAGAR AJIT C GARADE CHAND-RASHEKAR V RODE | 2009 | Top Catal2009，52，67： | 1 |
| 15 | Oily sludge degration by bacteria from ankleshwar india显示文摘 | Shuchi V Renu B Vikas P | 2006 | International Biodeterioration and Biodegradation2006，57，： | 1 |
| 16 | Oily sludge degradation by bacteria from Ankleshwar,India显示文摘 | Shuchi V Renu B Vikas P | 2006 | Inter Biodeterior Biodegrad2006，57，4： | 1 |
| 17 | Oily sludge degradation by bacteria from Ankleshwar, India 显示文摘 | SHUCHI V RENU B VIKAS P | 2006 | International Biodeterioration ~ Biodegradation2006，57，4： | 1 |
| 18 | Validated high-performance thin-layer chromatography method for steviol glycosides in Stevia rebaudiana显示文摘 | Vikas Jaitak Gupta A P Kaul V K | 2008 | Journal of Pharmaceutical and Biomedical Analysis2008，，47： | 1 |
| 19 | Different types of mechanical complications after surgical correction of adult spine deformity with osteotomy显示文摘AIM To determine the incidence and risk factors for mechanical complications(MC) after surgical correction of adult spinal deformity(ASD) with osteotomy.METHODS A retrospective study was performed. Inclusion criteria: Surgical correction of ASD using osteotomy; male or female; > 20 years old; follow-up ≥ 24 mo or revision. The MC of spine and spinal instrumentation were studied separately. Risk analysis included assessment of the association between more than 50 different characteristics(demographic,clinical,radiographic,and instrumentation) with different types of MC.RESULTS The medical records of 94 operations in 88 subjects were analyzed: Female(68%),mean age 58.6(SD,12.7) years. Cumulative incidence of MC at 2 year follow-up was 43.6%. Of these,78% required revision(P < 0.001). The following characteristics had significant(P ≤ 0.05) association with MC:(1) Preoperative: osteoporosis,smoking,previous spinal operation,sagittal vertical axis(SVA) > 100 mm,lumbar lordosis(LL) < 34°;(2) postoperative: SVA > 75 mm; operative correction: SVA > 75 mm,LL > 30°,thoracic kyphosis > 25°,and pelvic tilt > 9°; a fall; pseudarthrosis; and(3) device and surgical technique: use of previously implanted instrumentation; use of domino and/or parallel connectors; type of osteotomy(PSO vs SPO) if preoperative SVA < 100 mm; lumbar osteotomy location; in-situ rod contouring > 60°; and fixation to sacrum/pelvis.CONCLUSION Risk of MC after surgical correction of ASD is substantial. To decrease this risk over-and/or insufficient correction of the sagittal imbalance should be avoided. | Cameron Barton Andriy Noshchenko Vikas V Patel Christopher M J Cain Christopher Kleck Evalina L Burger | 2017 | World Journal of Meta-Analysis2017，5，6： | 1 |
| 20 | Effect of head group polarity and spacer chain length on the aggre-gation properties of gemini surfactants in an aquatic environment显示文摘 | Borse Mahendra Sharma Vikas Aswal V K | 2005 | Journal of Colloid and Interface Science2005，284，1： | 1 |
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