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| 1 | 帕博利珠单抗治疗伴脑转移NSCLC患者的一项非随机、开放Ⅱ期试验的长期随访结果和生物标志物分析显示文摘背景与目的我们开展了一项帕博利珠单抗用于伴未治疗脑转移的非小细胞肺癌(non-small cell lung cancer,NSCLC)或黑色素瘤患者的疗效和安全性的II期试验,旨在评估程序性死亡受体1(programmed cell death 1,PD-1)抑制剂在中枢神经系统(central nervous system,CNS)中的疗效。中期结果已发表,现报道对NSCLC队列的更新分析结果。方法这是一项开放性、单中心、II期试验。纳入标准:年龄≥18岁,诊断为晚期NSCLC并伴有≥1个5 mm-20 mm脑转移病灶,既往从未治疗或之前放疗后进展,无神经系统症状,不需要激素治疗且美国东部肿瘤协作组(Eastern Cooperative Oncology Group,ECOG)<2分。患者每2周接受一次帕博利珠单抗(10 mg/kg)治疗。队列1为程序性死亡配体1(programmed cell death ligand 1,PD-L1)≥1%的患者,队列2为PD-L1<1%或未评估的患者。主要终点是脑转移患者缓解比例。所有经治患者均纳入疗效与安全性终点的分析。该研究已结束入组,并于Clinicaltrials.gov登记注册,注册号为NCT02085070。结果2014年3月31日-2018年5月21日,共42例患者接受治疗。中位随访时间为8.3个月(IQR:4.5个月-26.2个月)。队列1的37例患者中11例有脑转移缓解[29.7%(95%CI:15.9%-47.0%)]。队列2未观察到缓解。治疗相关的3级-4级不良事件(adverse events,AEs)包括2例肺炎、1例全身症状、1例结肠炎、1例肾上腺皮质功能不全、1例高血糖症和1例低钾血症。6例(14%)患者发生了治疗相关的严重不良事件,包括肺炎、急性肾损伤、低钾血症和肾上腺皮质功能不全。没有观察到治疗相关死亡病例。结论帕博利珠单抗治疗PD-L1≥1%的NSCLC伴脑转移患者有效,且对所有纳入的未经治疗的脑转移患者安全。需要进一步探索免疫治疗用于NSCLC合并CNS转移。 | Sarah B GOLDBERG Kurt A SCHALPER Scott N GETTINGER Amit MAHAJAN Roy S HERBST Anne C CHANG Rogerio LILENBAUM Frederick H WILSON Sacit Bulent OMAY James B YU Lucia JILAVEANU Thuy TRAN Kira PAVLIK Elin ROWEN Heather GERRSH Annette KOMLO Richa GUPTA Hailey WYATT Matthew RIBEIRO Yuval KLUGER Geyu ZHOU Wei WEI Veronica L CHANG Harriet M KLUGER 董晓荣(翻译/校对) | 2021 | 中国肺癌杂志2021，24，9： | 34 |
| 2 | Treatments affecting maturation and germination of American chestnut somatic embryos显示文摘 | Rodney L R Veronica C L Scott A M | | 0，，： | 1 |
| 3 | Sandra streukens comfort your online customer: quality, trust and loyalty on the internet 显示文摘 | DINA R ALLARD C V VERONICA L | 2004 | Managing Service Quality2004，14，6： | 1 |
| 4 | Development and characterization of composite materials for production of composite risers by filament winding 显示文摘 | Ledjane L S Veronica M A C Femando L B | 2011 | Materials Research2011，14，30： | 1 |
| 5 | Functional analysis of the promoter of the rice sucrose phosphate synthase gene (sps1)显示文摘 | Miguel M T Tztzqui C B Veronica L B | | 0，，01： | 1 |
| 6 | Two classes of plant eDNA clones differentially complement yeast calcineurin mutants and increase salt tolerance of wild-type yeast 显示文摘 | Veronica L Martha S C Charles S G | 1996 | J Bio Chem1996，271，12： | 1 |
| 7 | Diameter growth models using Minnesota Forest inventory and analysis data显示文摘 | Veronica C L Ronald E M Margaret R H | 2001 | Forest Science2001，47，3： | 1 |
| 8 | The relationship between the structure and biological actions of green teacatechins显示文摘 | CORNELIA B MICHAEL R L VERONICA S C | 2013 | Food Chemistry2013，141，3： | 1 |
| 9 | Functional analysis of the 5′ untranslated region of the sucrose phosphate synthase rice gene (spsl)显示文摘 | MIGUEL M T VERONICA L B TZTZQUI C B | 2003 | Plant Science2003，165，： | 1 |
| 10 | Functional analysis of the promoter of the rice sucrose phosphate synthase gene (spsl) 显示文摘 | Miguel M T Tztzqui C B Veronica L B | 2004 | Plant Science2004，166，： | 1 |
| 11 | Diameter growth models using Minnesota forest inventory and analysis data显示文摘 | VERONICA C L RONALD E M MARGARET R H | 2001 | Forest Science2001，47，3： | 1 |
| 12 | Educational, psychosocial, and clinical impact of SARS-CoV-2 (COVID-19) pandemic on medical students in the United States显示文摘BACKGROUND The coronavirus disease 2019(COVID-19)pandemic altered education,exams,and residency applications for United States medical students.AIM To determine the specific impact of the pandemic on US medical students and its correlation to their anxiety levels.METHODS An 81-question survey was distributed via email,Facebook and social media groups using REDCapTM.To investigate risk factors associated with elevated anxiety level,we dichotomized the 1-10 anxiety score into low(≤5)and high(≥6).This cut point represents the 25th percentile.There were 90(29%)shown as low anxiety and 219(71%)as high anxiety.For descriptive analyses,we used contingency tables by anxiety categories for categorical measurements with chi square test,or mean±STD for continuous measurements followed by t-test or Wilcoxson rank sum test depending on data normality.Least Absolute Shrinkage and Selection Operator was used to select important predictors for the final multivariate model.Hierarchical Poisson regression model was used to fit the final multivariate model by considering the nested data structure of students clustered within State.RESULTS 397 medical students from 29 states were analyzed.Approximately half of respondents reported feeling depressed since the pandemic onset.62%of participants rated 7 or higher out of 10 when asked about anxiety levels.Stressors correlated with higher anxiety scores included“concern about being unable to complete exams or rotations if contracting COVID-19”(RR 1.34;95%CI:1.05-1.72,P=0.02)and the use of mental health services such as a“psychiatrist”(RR 1.18;95%CI:1.01-1.3,P=0.04).However,those students living in cities that limited restaurant operations to exclusively takeout or delivery as the only measure of implementing social distancing(RR 0.64;95%CI:0.49-0.82,P<0.01)and those who selected“does not apply”for financial assistance available if needed(RR 0.83;95%CI:0.66-0.98,P=0.03)were less likely to have a high anxiety.CONCLUSION COVID-19 significantly impacted medical students in numerous ways.Medical student education and clinical readiness were reduced,and anxiety levels increased.It is vital that medical students receive support as they become physicians.Further research should be conducted on training medical students in telemedicine to better prepare students in the future for pandemic planning and virtual healthcare. | Veronica Frank Anjali Doshi Natalie L Demirjian Brandon K K Fields Catherine Song Xiaomeng Lei Sravanthi Reddy Bhushan Desai Drayton C Harvey Steven Cen Ali Gholamrezanezhad | 2022 | World Journal of Virology2022，11，3： | 0 |
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