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| 1 | Influences of Ivabradine treatment on serum levels of cardiac biomarkers sST2, GDF-15, suPAR and H-FABP in patients with chronic heart failure显示文摘长期的心失败(CHF ) 代表住院和死亡的一个主要原因。最近的证据表演那新奇 biomarkers 象 tumorigenicity (sST2 ) 的可溶的抑制那样,生长区别 factor-15 (GDF-15 ) ,可溶的尿激 plasminogen 使活跃之物受体(suPAR ) 和心类型丰满的酸绑定蛋白质(H-FABP ) 被相关与煽动性并且在 CHF 病人的 ischemic 回答。在这研究,我们检验了禁止了 激活hyperpolarization 的周期的核苷酸门隧道的 Ivabradine 的效果( HCN 隧道,也叫的滑稽电流我 从而导致选择心率减小的 f ),和改进的心肌的氧在心脏的 biomarkers sST2 上供应, GDF-15 ,在在 Jena 的大学医院的 50 个 CHF 病人的 suPAR 和 H-FABP 。病人们基于 CHF 的病原学被划分成三个组:扩大心肌症(DCM, n=20 ) , ischemic 心肌症(ICM, n=20 ) 并且高血压的心肌症(HCM, n=10 ) 。病人是管理 Ivabradine (5 mg,为 3 个月的出价,和 7.5 mg 期望推进 3 个月) 。心血管的 biomarkers 的分析在基线以及在 3 月、 6 月的后续被执行。在 6 月的后续, GDF-15 层次显著地与基线层次(P=0.0215 ) 相比被减少,显示在心脏的改变的进步的减小。H-FABP 集中在与 ICM (1.89 对 3.24 g/mL ) 和 HCM 病人(1.89 对 3.80 g/mL ) 相比的 DCM 病人是显著地更低的,并且在 6 月的后续(P=0.0151 ) 上减少了。中部的层次仍然是的 suPAR 提高了,暗示主要进行中的煽动性的过程。是在 GDF-15 和 H-FABP 由重要减少证明层次,在室的改变的减小和无临床症状的局部缺血能被假定。然而,血液动力学的应力(sST2 ) 的标记和发炎(suPAR ) 没在 CHF 病人在 6 月 Ivabradine 治疗以后显示出变化或前进。进一步的研究是必要的验证这些新奇心血管的 biomarkers 的临床的适用性。 | Peter JIRAK Dzeneta FEJZIC Vera PAAR Bernhard WERNLY Rudin PISTULLI Ilonka ROHM Christian JUNG Uta C HOPPE P Christian SCHULZE Michael LICHTENAUER Atilla YILMAZ Daniel KRETZSCHMAR | 2018 | Acta Pharmacologica Sinica2018，39，7： | 31 |
| 2 | Spatial organization of bacterial flora in normal and inflamed intestine: A fluorescence in situ hybridization study in mice显示文摘AIM: To studythe role of intestinal flora in inflammatory bowel disease (IBD).METHODS: The spatial organization of intestinal flora was investigated in normal mice and in two models of murine colitis using fluorescence in situ hybridization.RESULTS: The murine small intestine was nearly bacteriafree. The normal colonic flora was organized in three distinct compartments (crypt, interlaced, and fecal), each with different bacterial compositions. Crypt bacteria were present in the cecum and proximal colon. The fecal compartment was composed of homogeneously mixed bacterial groups that directly contacted the colonic wall in the cecum but were separated from the proximal colonic wall by a dense interlaced layer. Beginning in the middle colon, a mucus gap of growing thickness physically separated all intestinal bacteria from contact with the epithelium. Colonic inflammation was accompanied with a depletion of bacteria within the fecal compartment, a reduced surface area in which feces had direct contact with the colonic wall, increased thickness and spread of the mucus gap, and massive increases of bacterial concentrations in the crypt and interlaced compartments. Adhesive and infiltrative bacteria were observed in inflamed colon only, with dominant Bacteroides species.CONCLUSION: The proximal and distal colons are functionally different organs with respect to the intestinal flora, representing a bioreactor and a Segregation device.The highly organized structure of the colonic flora, its specific arrangement in different colonic segments, and its specialized response to inflammatory stimuli indicate that the intestinal flora is an innate part of host immunity that is under complex control. | Alexander Swidsinski Vera Loening-Baucke Herbert Lochs Laura P.Hale | 2005 | World Journal of Gastroenterology2005，11，8： | 27 |
| 3 | 附睾炎:基于临床和基础研究的总结启示显示文摘急性附睾炎在泌尿外科门诊的病人中有共同的临床表现。大多数情况下,性传播疾病或者泌尿系的感染都会引起病原菌的感染,并通过泌尿生殖道逆行引发急性附睾炎。虽然保守治疗可能对大多数患者有效并能根除病原菌,但有研究表明这类患者中少精子症甚至无精子症患者升高至40%。为了探讨引起这种现象和随后对精子功能损伤的潜在原因,我们建立了附睾炎的动物模型。研究数据表明附睾管里聚集着异常表达的免疫细胞、免疫调节基因以及病原菌敏感分子。我们推测在附睾头部存在一个耐药微环境,而炎症反应常发生在附睾尾部。这与附睾在不需要降低自身抵抗上行感染能力的前提下,当精子从睾丸中射出后,保护其不受新产生的抗精子抗体损害的观点相一致。然而,严重的炎症反应,特别是在附睾尾部,也可能迁延引发附睾结构和功能的损害。通过对动物模型临床观察研究,我们更好地理解附睾的免疫微环境,附睾炎的易感因素以及合理的治疗,在此基础上减轻附睾炎对附睾的损害,降低这类人群不育的发生率。 | Vera Michel Adrian Pilatz Mark P Hedger Andreas Meinhardt | 2015 | Asian Journal of Andrology2015，17，5： | 16 |
| 4 | Prognostic angiogenic markers(endoglin, VEGF, CD31) and tumor cell proliferation(Ki67) for gastrointestinal stromal tumors显示文摘AIM: To evaluate the correlation between the immunoexpression of angiogenic markers [CD31, CD105 and vascular endothelial growth factor(VEGF)], proliferative index(Ki67), and prognosis of patients with gastrointestinal stromal tumors(GIST).METHODS: This is a retrospective study of 54 GIST cases. Medical records were searched to obtain the GIST patients' demographic and clinical data, and paraffin-embedded blocks of tumor samples were retrieved from the hospital archives to conduct a new immunohistochemical evaluation. The tumor samples of GIST patients were subject to immunohistochemical evaluation for endoglin(CD105), CD31, VEGF, and Ki67 expression. The CD105 and CD31 intratumoral microvascular density(IMVD) was measured using automated analysis. We determined the correlation between the immunoexpression of CD105, CD31, VEGF,Ki67 and prognosis. In addition, we conducted a cutoff analysis using the receiver-operating characteristic curve. VEGF positivity was classified as either null/weak or strong. Ki67 was evaluated using a cutoff of 5%positive cells. The prognosis was classified as good(patient alive without recurrence) or poor(patient with recurrence/death).RESULTS: The distribution of tumor sites among the54 analyzed samples was as follows: 27(50%) in the stomach, 20(37.1%) in the small intestine, 6(11.1%)in the colon, and 1(1.8%) in the esophagus. The size of the tumors ranged from 2 to 33 cm(median: 8cm); in 12 cases(22.2%), the tumor was below 5 cm at the largest diameter, but in 42 cases(77.7%), the tumor was larger than 5 cm. The means of CD105 and CD31 were significantly higher in the group with poor prognosis(P < 0.001). The cut-off values of CD105(>1.2%) and CD31(> 2.5%) in the receiver-operating characteristic curve were related to a poorer prognosis.Cases with a better prognosis showed significantly null/weak staining for VEGF(P < 0.001). Ki-67 expression of≥ 5% was strongly correlated with a worse prognosis(P< 0.001). In the multivariate analysis, CD105 was the variable that most strongly correlated with prognosis.CONCLUSION: The IMVD cutoff values for the angiogenic markers CD105 and CD31, may be prognostic factors for GIST, in addition to VEGF and Ki67. | Rodrigo Panno Basilio-de-Oliveira Vera Lucia Nunes Pannain | 2015 | World Journal of Gastroenterology2015，21，22： | 15 |
| 5 | Capecitabine and cisplatin with or without cetuximab for patients with previously untreated advanced gastric cancer (EXPAND): a randomised, open-label phase 3 trial显示文摘 | Florian Lordick Yoon-Koo Kang Hyun-Cheol Chung Pamela Salman Sang Cheul Oh Gy?rgy Bodoky Galina Kurteva Constantin Volovat Vladimir M Moiseyenko Vera Gorbunova Joon Oh Park Akira Sawaki Ilhan Celik Heiko G?tte Helena Melezínková Markus Moehler | 2013 | Lancet Oncology2013，，6： | 14 |
| 6 | B-cell-targeted therapies in systemic lupus erythematosus显示文摘Autoreactive B 房间是在全身的豺狼座 erythematosus (SLE ) 的致病被含有的关键有免疫力的房间之一。除了有害自身抗体(auto-Abs ) 的生产, B 房间作为介绍抗原的房间告知 autoreactive T 房间并且分泌大量支持 inflammatory cytokines 有 autocrine 和 paracrine 效果。调制 B 房间的代理人可能因此具有潜在的治疗学的价值。当前的策略包括指向 B 房间表面抗原, cytokines 支持 B 房间生长和功能,和 B 房间和 T 房间相互作用。在这篇文章,我们在动物和人的研究在 SLE 考察 B 细胞的角色,并且我们检验为这个条件的处理作为有希望的策略支持 B 房间调整的以前的报告。另外,我们在场评估了在人的 SLE 反对 CD20, CD22 和 B 淋巴细胞激发器(BLyS ) 的代理人的治疗学的功效和安全的临床的试用上的更改。当这些研究的许多的结果仍然保持不确定时, belimumab,对 BLyS 的人的 monoclonal 抗体,显示出诺言并且最近被 US 食物药品管理局为病人作为显示的治疗同意了与对中等 SLE 温和。无疑,在 B 房间免疫学的进展将继续带我们到 SLE 致病的更好的理解和指向 B 房间的新奇特定的治疗的发展。 | Vera Sau-Fong Chan Helen Hoi-Lun Tsang Rachel Chun-Yee Tam Liwei Lu Chak-Sing Lau | 2013 | Cellular & Molecular Immunology2013，10，2： | 12 |
| 7 | Signaling pathways for germ cell death in adult cynomolgus monkeys(Macaca fascicularis) induced by mild testicular hyperthermia and exol enous testosterone treatment显示文摘 | Jia, Y. Hikim, A.P.S. Lue,Y.H. Swerdloff, R.S. Vera,Y. Zhang,X. S. Hu, Z. Y. Li, Y. C. Liu, Y. X. Wang, C | 2007 | 南京医科大学学报(自然科学版)2007，27，10： | 10 |
| 8 | Use of butyrate or glutamine in enema solution reduces inflammation and fibrosis in experimental diversion colitis显示文摘AIM:To investigate whether butyrate or glutamine enemas could diminish inflammation in experimental diversion colitis.METHODS:Wistar specific pathogen-free rats were submitted to a Hartmann's end colostomy and treated with enemas containing glutamine,butyrate,or saline.Enemas were administered twice a week in the excluded segment of the colon from 4 to 12 wk after the surgical procedure.Follow-up colonoscopy was performed every 4 wk for 12 wk.The effect of treatment was evaluated using video-endoscopic and histologic scores and measuring interleukin-1β,tumor necrosis factor-alpha,and transforming growth factor beta production in organ cultures by enzyme linked immunosorbent assay.RESULTS:Colonoscopies of the diverted segment showed mucosa with hyperemia,increased number of vessels,bleeding and mucus discharge.Treatment with either glutamine or butyrate induced significant reductions in both colonoscopic(P < 0.02) and histological scores(P < 0.01) and restored the densities of collagen fibers in tissue(P = 0.015;P = 0.001),the number of goblet cells(P = 0.021;P = 0.029),and the rate of apoptosis within the epithelium(P = 0.043;P = 0.011) to normal values.The high levels of cytokines in colon explants from rats with diversion colitis significantly decreased to normal values after treatment with butyrate or glutamine.CONCLUSION:The improvement of experimental diversion colitis following glutamine or butyrate enemas highlights the importance of specific luminal nutrients in the homeostasis of the colonic mucosa and supports their utilization for the treatment of human diversion colitis. | Rodrigo Goulart Pacheco Christiano Costa Esposito Lucas CM Müller Morgana TL Castelo-Branco Leonardo Pereira Quintella Vera Lucia A Chagas Heitor Siffert P de Souza Alberto Schanaider | 2012 | World Journal of Gastroenterology2012，18，32： | 9 |
| 9 | Role of Osteoprotegerin and Receptor Activator of Nuclear Factor-kB Ligand in Bone Loss Related to Advanced Chronic Obstructive Pulmonary Disease显示文摘 | Ludmila Ugay Evgenia Kochetkova Vera Nevzorova Yuliya Maistrovskaia | 2016 | Chinese Medical Journal2016，，14： | 9 |
| 10 | 应用多聚酶链扩增技术鉴别混合感染轮状病毒VP7的血清型别显示文摘1991年秋冬季收集了北京等我国四个地区婴幼儿腹泻患儿粪便标本,通过聚丙烯酰胺凝胶电泳(PAGE)发现一些标本中有不同轮状病毒的混合感染。应用套式多聚酶链反应(套式PCR),确定了7例混合感染轮状病毒的VP7血清型别,并用Northern印迹杂交法证实。该方法用于鉴别混合感染毒株的血清型别,不仅敏感、特异,而且节省时间和材料。 | 熊朝晖 钱渊 袁丽娟 张又 刘军 关德华 刘长青 张振华 赵慧欣 王之梁 Vera Gouvea | 1995 | 中华微生物学和免疫学杂志1995，15，2： | 9 |
| 11 | Expression of cyclooxygenase-2 is associated with p53 accumulation in premalignant and malignant gallbladder lesions显示文摘瞄准:在胆囊癌和它的先锋损害在表示和 p53 累积上检验在 cyclooxygenase-2 (COX-2 ) 之间的关系。方法:包括正常胆量 blader 上皮,发育异常(11 低档 dyplasia 和 16 高级发育异常) 的 27 个盒子和 27 腺癌的 14 个盒子的 68 件胆囊织物样品被免疫组织化学为 COX-2 表示和 p53 累积评估。在 COX-2 表示, p53 累积和 clinicopathological 特征之中的关系被分析。结果:COX-2 被表示在 14.3% 正常胆囊上皮, 70.3% 发育异常的 epite hlium,和 59.2% 腺癌。当划分了成低档和高级发育异常时, COX-2 在 5 是积极的(45.4%) 低档的盒子并且 14 (87.5%) 高级发育异常(P = 0.019 ) 。p53 的累积在 5 被检测(31.2%) 癌的高级发育异常并且在 13 的盒子(48.1%) 。没有 p53 累积在正常上皮或低档发育异常被发现。在表示上的 COX-2 在 18 中的 17 个被观察(94.4%) 有从没有 p53 累积的 50 个盒子的与 20 比较的 p53 累积(40.0%) 的盒子(P <
0.001 ) 。结论:在在正常上皮,低档发育异常和高级发育异常之中的 COX-2 表示的有效差量建议在 COX-2 的表示上,酶是在胆囊 carcinogenensis 的一个早事件。自从有 COX-2 表示的 p53 相互关联的累积,而且,在表示上的 COX-2 在高级发育异常和癌可能是的胆囊观察了部分由于 p53 的机能障碍。 | Mateja Legan Bo(s|ˇ)tjan Luzar Vera Ferlan Marolt Andrej C(o|¨)r | 2006 | World Journal of Gastroenterology2006，12，21： | 7 |
| 12 | Collagen/hyaluronan based hydrogels releasing sulfated hyaluronan improve dermal wound healing in diabetic mice via reducing inflammatory macrophage activity显示文摘Sustained inflammation associated with dysregulated macrophage activation prevents tissue formation and healing of chronic wounds.Control of inflammation and immune cell functions thus represents a promising approach in the development of advanced therapeutic strategies.Here we describe immunomodulatory hyaluronan/collagen(HA-AC/coll)-based hydrogels containing high-sulfated hyaluronan(sHA)as immunoregulatory component for the modulation of inflammatory macrophage activities in disturbed wound healing.Solute sHA downregulates inflammatory activities of bone marrow-derived and tissue-resident macrophages in vitro.This further affects macrophage-mediated pro-inflammatory activation of skin cells as shown in skin ex-vivo cultures.In a mouse model of acute skin inflammation,intradermal injection of sHA downregulates the inflammatory processes in the skin.This is associated with the promotion of an anti-inflammatory gene signature in skin macrophages indicating a shift of their activation profile.For in vivo translation,we designed HA-AC/coll hydrogels allowing delivery of sHA into wounds over a period of at least one week.Their immunoregulatory capacity was analyzed in a translational experimental approach in skin wounds of diabetic db/db mice,an established model for disturbed wound healing.The sHA-releasing hydrogels improved defective tissue repair with reduced inflammation,augmented pro-regenerative macrophage activation,increased vascularization,and accelerated new tissue formation and wound closure. | Sophia Hauck Paula Zager Norbert Halfter Elke Wandel Marta Torregrossa Ainur Kakpenova Sandra Rother Michelle Ordieres Susann Räthel Albrecht Berg Stephanie Möller Matthias Schnabelrauch Jan C.Simon Vera Hintze Sandra Franz | 2021 | Bioactive Materials2021，6，12： | 7 |
| 13 | Engineering the Smart Factory显示文摘The fourth industrial revolution promises to create what has been called the smart factory. The vision is that within such modular structured smart factories, cyber-physical systems monitor physical processes, create a virtual copy of the physical world and make decentralised decisions. This paper provides a view of this initiative from an automation systems perspective. In this context it considers how future automation systems might be effectively configured and supported through their lifecycles and how integration,application modelling, visualisation and reuse of such systems might be best achieved. The paper briefly describes limitations in current engineering methods, and new emerging approaches including the cyber physical systems(CPS) engineering tools being developed by the automation systems group(ASG) at Warwick Manufacturing Group, University of Warwick, UK. | HARRISON Robert VERA Daniel AHMAD Bilal | 2016 | Chinese Journal of Mechanical Engineering2016，29，6： | 7 |
| 14 | Institutional experience of PTH evaluation on fine-needle washing after aspiration biopsy to locate hyperfunctioning parathyroid tissue显示文摘Assaying parathyroid hormone(PTH) in the washing liquid after fine-needle aspiration biopsy(FNAB) seems to be a valid approach to locate parathyroid tissue.PTH-FNAB was evaluated in 47 patients with a clinical picture of primary hyper-parathyroidism(PHP) and ultrasonography(US) suggestive of parathyroid lesion.The patients were subdivided into two groups on the basis of the absence or presence of US thyroid alterations.The result of PTH-FNAB was compared with those of cytology,scintigraphy and,in 24 patients,surgical outcome.PTH-FNAB samples with a value higher than that recorded in the serum and higher than our institutional cut-off were deemed to be probable samples of parathyroid tissue.Cytology proved diagnostic for benign thyroid lesions,non-diagnostic for thyroid lesions,hyperplastic parathyroid tissue,undetermined or malignant thyroid lesions and other lesions in 45%,30%,17%,4%,and 4% of cases,respectively.In 47% of cases,PTH-FNAB indicated that the sample had been taken in parathyroid tissue.In patients without US alterations,the diagnostic accuracy of PTH-FNAB was greater than that of scintigraphy.After surgery,comparison between the results of PTH-FNAB and scintigraphy,in terms of positive predictive value(PPV),revealed the superiority of PTH-FNAB;PPV was 94% for FNAB and 71% for scintigraphy,while sensitivity was 83% and 69%,respectively.PTH-FNAB evaluation after FNAB appears to be more diagnostic than cytology and scintigraphy.Of all the procedures used,PTH-FNAB appears to be the method of choice when the target is US suggestive and reachable.PTH-FNAB appears to be a useful method of guiding surgical intervention. | Massimo GIUSTI Mara DOLCINO Lara VERA Carla GHIARA Francesca MASSARO Laura FAZZUOLI Diego FERONE Michele MUSSAP Francesco MINUTO | 2009 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2009，10，5： | 6 |
| 15 | Quantitative genetic analysis of chlorophyll a fluorescence parameters in maize in the field environments显示文摘Chlorophyll fluorescence transient from initial to maximum fluorescence('P' step) throughout two intermediate steps('J' and 'I')(JIP‐test) is considered a reliable early quantitative indicator of stress in plants. The JIP‐test is particularly useful for crop plants when applied in variable field environments. The aim of the present study was to conduct a quantitative trait loci(QTL) analysis for nine JIP‐test parameters in maize during flowering in four field environments differing in weather conditions. QTL analysis and identification of putative candidate genes might help to explain the genetic relationship between photosynthesis and different field scenarios in maize plants. The JIP‐test parameters were analyzed in the intermated B73 Mo17(IBM) maize population of 205 recombinant inbred lines. A set of 2,178 molecular markers across the whole maize genome was used for QTL analysis revealing 10 significant QTLs for seven JIP‐test parameters, of which five were co‐localized when combinedover the four environments indicating polygenic inheritance and pleiotropy. Our results demonstrate that QTL analysis of chlorophyll fluorescence parameters was capable of detecting one pleiotropic locus on chromosome 7, coinciding with the gene gst23 that may be associated with efficient photosynthesis under different field scenarios. | Domagoj ?imi? Hrvoje Lepedu? Vlatka Jurkovi? Jasenka Antunovi? Vera Cesar | 2014 | Journal of Integrative Plant Biology2014，56，7： | 6 |
| 16 | Induction of the AOX1D Isoform of Alternative Oxidase in A. thaliana T-DNA Insertion Lines Lacking Isoform AOX1A Is Insufficient to Optimize Photosynthesis when Treated with Antimycin A显示文摘植物呼吸被二条小径为电子转移描绘到 O2,也就是被连接到 ATP 生产的细胞色素小径(CP ) ,和其他的小径(AP ) ,没有伴随物 ATP,从 ubiquinol 的电子在哪儿,直接经由其他的 oxidase (AOX ) 转到 O2 生产。这条后者小径很好被适合在光过量电子处理,导致优化光合的性能。我们描绘了不表示主要 isoform 的 Arabidopsis thaliana 的 T-DNA-insertion 变异的线, AOX1A。处于标准生长条件,这些植物没由抗霉素 A 通过 CP 显示出电子流动的任何显型,而是限制,它导致 AOX1A 表示在野类型,在 aox1a 大美人异种的叶子导致了 AOX1D 的增加的表情。尽管有在异种的 AOX1D isoform 的增加的存在,抗霉素 A 引起了光合作用的抑制,增加了 ROS,并且当时,最终导致了放大的膜漏和坏死与相比野类型,它被禁止者仅仅在边际地影响。经由 CP 的电子流动什么时候被限制,因此出现 AOX1D 是不能的充分补偿 AOX1A 的损失。抑制的联合学习,联合了到代谢物介绍并且指向了 glycine decarboxylase 建筑群(GDC ) 的 P 蛋白质的表示分析,建议 aox1a 异种试图为 photorespiration 增加他们的能力。然而,给他们的缺乏,在当与抗霉素 A 对待时,任何一个 AOX1D 都不能充分补偿让 AOX1A 的缺乏优化光合作用的表示增加,是吸引人的。我们建议 aox1a 异种能进一步被用来有关对光合的性能和基因表示的 mitochondrial 氧化还原作用的影响证实当前的模型。 | Inga Strodtkotter Kollipara Padmasree Challabathula Dinakar Birgit Speth Pamela S. Niazi Joanna Wojtera Ingo Voss Phuc Thi Do Adriano Nunes-Nesi Alisdair R. Fernie Vera Linke Agepati S. Raghavendra Renate Scheibe | 2009 | Molecular Plant2009，2，2： | 5 |
| 17 | 性别和年龄对中国人冠状动脉旁路移植术后住院病死率的影响显示文摘目的确定中国人冠状动脉旁路移植术后住院病死率是否存在性别差异以及该差异是否与年龄相关.方法回顾性分析1997年1月1日至2001年12月31日阜外心血管病医院外科全部接受冠状动脉旁路移植术的患者共2682例(男性2316例,女性366例).按照性别和年龄分组调查它们之间的围手术期并发症及手术后住院病死率的差异.结果女性术前合并主要疾病的比例比男性高,术后并发症多,但她们术前的左心室射血分数较男性好,且冠状动脉病变数量少.然而,女性患者的术后住院病死率是男性的3倍(女性3.01%,男性1.12%,P=0.001),病死率的性别差异在低龄组更有统计学意义(女性2.6%,男性0.5%,P=0.001,ORs:4.844,95%可信区间:1.549~15.142),在老年患者中则无统计学意义(女性3.7%,男性2.4%,P=0.383).结论中国女性冠状动脉旁路移植术的住院病死率高于男性,特别是低龄女性.低龄组女性是住院病死率的独立危险因素.死亡率的性别差异随年龄增加而减少.需要进一步的研究来阐明病死率的性别差异在低龄组更显著的原因. | 宫路佳 Elke Lehmkuhl 胡盛寿 Friederike Kendel Stein Kandle Yong Du 章晏 杜茗 吴清玉 许建屏 孙立忠 朱晓东 Vera Regitz-Zagrosek | 2006 | 中华心血管病杂志2006，34，5： | 5 |
| 18 | Monoclonal immunoscintigraphy for detection of metastasis and recurrence of colorectal cancer显示文摘AIM:To assess the clinical role of monoclonal immunoscintigraphy for the detection of metastasis and recurrence of colorectal cancer.METHODS:Monoclonal immunoscintigraphy was performed in patients operated on for colorectal adenocar-cinoma suspected of local recurrence and metastatic disease.The results were compared with conventional diagnostics.RESULTS:Immunoscintigraphic investigation was done in 53 patients.Tumor recurrence occurred in 38 patients,and was confirmed by other diagnostic modalities in 35.In 15 patients,immunoscintigraphic findings were negative,and confirmed in 14 with other diagnostic methods.Comparative analysis confirmed good correlation of immunoscintigraphic findings and the results of conventional diagnostics and the level of tumor marker carcinoembryonic antigen.Statistical analysis of parameters of radiopharmaceutical groups imacis,indimacis and oncoscint presented homogenous characteristics all of three radiopharmaceuticals.The analysis of immunoscintigraphic target focus was clearly improved using tomography.CONCLUSION:Immunoscintigraphy is highly specific and has a good predictive value in local recurrence of colorectal cancer. | Vera Artiko Ana Koljevic Markovi Dragana obi-aranovi Milorad Petrovi Andrija Anti Mirjana Stojkovi Marinko Zuvela Djordjije aranovi Milica Stojkovi Neboja Radovanovi Danijel Galun Aleksandar Milovanovi Jovica Milovanovi Anica Bobi-Radovanovi Zoran Krivokapic Vladimir Obradovi | 2011 | World Journal of Gastroenterology2011，17，19： | 4 |
| 19 | Cerium dioxide as a new reactive sorbent for fast degradation of parathion methyl and some other organophosphates显示文摘Cerium dioxide was used for the first time as reactive sorbent for the degradation of the organophosphate pesticides parathion methyl,chlorpyrifos,dichlofenthion,fenchlorphos,and prothiofos,as well as of some chemical warfare agents—nerve gases soman and O-ethyl S-[2-(diisopropylamino) ethyl] methylphosphonothioate(VX).CeO2 specimens were prepared by calcination of basic cerous carbonate obtained by precipitation from an aqueous solution.The CeO2 samples containing certain amounts(1 wt.%–5 wt.%) of the neighboring lanthanides(La,Pr,Nd) were prepared in a similar way from pure lanthanide salts.It was shown that ceria accelerated markedly the decomposition of parathion methyl causing the cleavage of the P-O-aryl bond in the pesticide molecule.A similar reaction mechanism was proposed for the degradation of other organophosphate pesticides and nerve agents.The degradation times(reaction half-times) were in an order of minutes in the presence of CeO2,compared to hours or days under common environmental conditions.The reaction in suitable organic solvents allowed conversions of about 90% for parathion methyl loading of 20 mg pesticide/g CeO2 within 2 h with a reactant half-life in the order of 0.1 min.The key parameter governing the degradation efficiency of CeO2 was the temperature during calcination.At optimum calcination temperature(about 773.15 K),the produced ceria retained a sufficiently high surface area,and attained an optimum degree of crystallinity(related to a number of crystal defects,and thus potential reactive sites).The presence of other lanthanides somewhat decreased the reaction rate,but this effect was not detrimental and permitted the possible use of chemically impure ceria as a reactive sorbent.A fast organophosphate degradation was demonstrated not only in non-polar solvents(such as heptane),but also in polar aprotic solvents(acetonitrile,acetone) that are miscible with water.This opens new possibilities for designing more versatile decontamination strategies.The cleavage of phosphate ester bonds is of a great importance not only for the degradation of dangerous chemicals(chemical weapons,pesticides),but also for interactions of ceria(especially the nano-sized one) in biologically relevant systems. | Pavel Janos Pavel Kuran Martin Kormunda Vaclav Stengl Tomas Matys Grygar Marek Dosek Martin Stastny Jakub Ederer Vera Pilarova Lubos Vrtoch | 2014 | Journal of Rare Earths2014，32，4： | 4 |
| 20 | Characteristics of the active-layer under the China-Russia Crude Oil pipeline显示文摘Active layer is a key component for permafrost environment studies as many subsurface biological,biogeochemical,ecological,and pedogenic activities prevail in this layer.This study focuses on active layer temperature monitoring in an area with sporadic permafrost at two adjacent sites along China-Russia Crude Oil Pipeline(CRCOP),NorthEast China.Site T1 is located in disturbed ground on the right-of-way(on-ROW)2 m away from the center of the oil pipeline.T2 is located in a natural and undisturbed site,around 16.6 m off-ROW.Our objective was to study seasonal variability of the active layer depth and thermal regime from October 2017 to September 2018.The monitoring sites consist of soil temperature probes arranged in a vertical array at different depths at both sites.The following parameters were computed:number of isothermal days(ID),freezing days(FD),thawing days(TD),freezing degree days(FDD),thawing degree days(TDD),number of freeze-thaw days(FTD).The mean air temperature in the monitoring period reached-3.2℃.The temperature profile indicates that the maximum active layer thickness observed during the study period was 10 m at T1 and 2 m at T2.The majority of the soil temperatures were above or close to 0℃,resulting in great values of TDD,especially in the first 4 m depth.TDD for T1 were predominant and ranged between 600-1160℃·days(0-4 m depth)reflecting the influence of oil temperature from the pipeline.In T2 borehole FDD were predominant for all the soil layer depths resulting in less permafrost degradation.This comparison emphasizes the significant influence of vegetation removal and the dispersed heat from the pipeline on the active layer thickness. | SERBAN Mihaela LI Guo-yu SERBAN Raul-David WANG Fei FEDOROV Alexander VERA Samsonova CAO Ya-peng CHEN Peng-chao WANG Wei | 2021 | Journal of Mountain Science2021，18，2： | 4 |
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