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| 1 | Characterization of monocarboxylate transporter activity in hepatocellular carcinoma显示文摘AIM: To assess the immunoexpression of hypoxiarelated markers in samples from cirrhosis and primary and metastatic hepatocellular carcinoma(HCC).METHODS: From a total of 5836 autopsies performed at the Pathology Department- University of Sao Paulo School of Medicine Hospital- from 2003 to 2009, 188 presented primary liver tumors. Immunohistochemical reactivity for monocarboxylate transporters(MCTs)-1, 2 and 4, CD147 and glucose transporter-1(GLUT1)was assessed in necropsies from 80 cases of HCC. Data were stored and analyzed using the IBM SPSS statistical software(version 19, IBM Company, Armonk, NY). All comparisons were examined for statistical significance using Pearson's χ2 test and Fisher's exact test(when n < 5). The threshold for significant P values was established as P < 0.05.RESULTS: Plasma membrane expression of MCT4 and overall expression of GLUT1 showed progressively higher expression from non-neoplastic to primary HCC and to metastases. In contrast, overall expression of MCT2 was progressively decreased from non-neoplastic to primary HCC and to metastases. MCT1(overall and plasma membrane expression), MCT2 and CD147 plasma membrane expression were associated with absence of cirrhosis, while plasma membrane expression of CD147 was also associated with absence of HBV infection. MCT2 overall expression was associated with lower liver weight, absence of metastasis and absence of abdominal dissemination. Additionally, MCT4 plasma membrane positivity was strongly associated with Ki-67 expression. CONCLUSION: MCT4 and GLUT1 appear to play a role in HCC progression, while MCT2 is lost during progression and associated with better prognosis. | Venncio AF Alves Céline Pinheiro Filipa Morais-Santos Aloisio Felipe-Silva Adhemar Longatto-Filho Fátima Baltazar | 2014 | World Journal of Gastroenterology2014，20，33： | 11 |
| 2 | How to Make Capsules Containing Rejuvenators for Their Use in Asphalt Concrete显示文摘Rejuvenators are products designed to restore original properties to oxidized asphalt binders by restoring the original ratio of asphaltenes to maltenes. But,for a rejuvenator to be successful,it must penetrate the pavement surface. Besides,application of a rejuvenator will also reduce the skid resistance of the pavement. To solve this,these rejuvenators can be encapsulated and mixed in asphalt concrete. Once the stress in the capsules reaches a certain threshold,the particles break and the rejuvenator is released,giving back the original properties of the pavement. The objective of this paper is to show how these capsules behave and define the most appropriate testing methods to find their effect on asphalt concrete. For this,two different types of rejuvenators will be encapsulated and their effect on the properties of the capsules investigated. Besides,the release mechanisms of the capsules will be unravelled. | GARCIA A SCHLANGEN E VAN DE VEN M F C | 2010 | 武汉理工大学学报2010，32，17： | 7 |
| 3 | Durable Asphalt Pavements Are Self Healing显示文摘The traffic volume and the number of heavy vehicles are growing continuously. Considering the continuous traffic flow and the limited time available for road maintenance,it is very important to design a durable pavement system. Asphalt pavements with a healing capability are believed to be very useful since they can extend the pavement service life thanks to rest periods and hot summers. In order to design durable asphalt pavements,research in understanding and upgrading the self-healing capability of bituminous materials in time is of major importance. The self healing capability of bituminous mastic was evaluated in this research with a direct tension healing test. In the test program,different healing times,crack status and modifications were applied. The results indicate that elastic recovery and flow capacity are important factors for the self healing capability of bituminous materials at different crack phases as simulated with the direct tension test. | QIU J VAN DE VEN M F C WU S P YU J Y MOLENAAR A A A | 2010 | 武汉理工大学学报2010，32，17： | 2 |
| 4 | Sequential treatment ofGuillain-Barr6 syndrome with extracorporeal elimination and intravenous immunoglobulin 显示文摘 | Haupt WF Rosenow F van der Ven C | 1996 | J Neurol Sci1996，137，2： | 1 |
| 5 | Effects of simvastatin treatment on oxidant/ antioxidant state and ultrastructure of strepto-zotocin-diabetic rat lung显示文摘 | Ozansoy G Güven C Ceylan A | 2005 | Cell Biochem Funct2005，23，6： | 1 |
| 6 | Exposure to tetrabromobisphenol A (TBBPA) in Wistar rats: neurobehavioral effects in offspring from a one - generation reproduction study 显示文摘 | Lilienthal H Verwer C M Van der Ven T M | 2008 | Toxicology2008，246，1： | 1 |
| 7 | Charac- teristics of two-component epoxy modified bitumen 显示文摘 | Xiao Y van de Ven M F C Molenaar A A A | 2010 | Ma- ter Struct2010，44，： | 1 |
| 8 | The effect of calcium ions on the efficiency of polyethylene oxide-cofactor retention aid systems显示文摘 | Van de Ven T G M Qasaimeh M A Pigeon C | 2007 | Colloids Sur:2007，297，1： | 1 |
| 9 | Acute myocardial infarction and renal infarction in a bodybuilder using anabolic steroids显示文摘 | Ilhan E Demirci D G ven c TS | | 0，，： | 1 |
| 10 | Investiga- ting the self healing capability of bituminous binders 显示文摘 | Qiu J Van de Ven M F C Wu S | 2009 | Road Materials and Pavement Design2009，，： | 1 |
| 11 | Application of an ultrasonic assisted curing technique for improving the diffusion of sodium chloride in porcine meat显示文摘 | SIRO I VEN C BALLA C | 2009 | Journal of Food Engineering2009，91，2： | 1 |
| 12 | Hollow fi- ber dead-end ultrafiltration: influence of ionic environment on filtrationofalginates 显示文摘 | van de Ven W J C Sant van't K Pant I G M | 2008 | J Membr Sci2008，308，12： | 1 |
| 13 | Nonlinear dynamic modeling of gear shaft-disk-bearing systems using finite elements and describing functions显示文摘 | Maliha R Dogruer C U Ozgüven H N | 2004 | Journal of Mechanical Design2004，126，3： | 1 |
| 14 | A gene encoding an antigen recognized by cytolytic T lymphocytes on a human melanoma显示文摘 | Ven der Bruggen P Traversari C Chomez P | 1991 | Science1991，254，： | 1 |
| 15 | Observations on changes in ultrasonically treated waste-activated sludge 显示文摘 | Chu C P ven Chang Bea Liao G S | 2001 | Wat Res2001，35，4： | 1 |
| 16 | Jahn- Teller mediated ordering in layered LixMO2 compounds 显示文摘 | Dompablo M E A Marianetti C Ven A V D | 2001 | Phy Rev B2001，63，14： | 1 |
| 17 | A single stage posterior approach and rigid fixation for preventing kyphosis in the treatment of spinal tuberculosis显示文摘 | Güven O Kumano K Yal(c)in S | | 0，，1976： | 1 |
| 18 | Going dutch-managed- competition health insurance in the Netherlands 显示文摘 | Enthoven A C van de Ven W P | 2007 | New England Journal of Medicine2007，357，24： | 1 |
| 19 | Exposureto tetrabromobisphenol A(TBBPA)in Wistar rats:neurobehavioral effects inoffspring from a one-generation reproduction study显示文摘 | LILIENTHAL H VERWER C M VAN Der VEN L T | 2008 | Toxicology2008，246，1： | 1 |
| 20 | Cerclage retention versus removal following preterm premature rupture of mem- branes and association with amniotic fluid markers显示文摘 | Aguin E Van De Ven C Cordoba M | 2014 | Int J Gynaecol Obstet2014，125，1： | 1 |
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