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1Near-infrared fluorescence sentinel lymph node detection in gastric cancer: A pilot study显示文摘AIM: To investigate feasibility and accuracy of nearinfrared fluorescence imaging using indocyanine green: nanocolloid for sentinel lymph node(SLN) detection in gastric cancer.METHODS: A prospective, single-institution, phaseI feasibility trial was conducted. Patients suffering from gastric cancer and planned for gastrectomy were included. During surgery, a subserosal injection of 1.6 m L ICG:Nanocoll was administered around the tumor. NIR fluorescence imaging of the abdominal cavity was performed using the Mini-FLARE? NIR fluorescence imaging system. Lymphatic pathways and SLNs were visualized. Of every detected SLN, the corresponding lymph node station, signal-to-background ratio and histopathological diagnosis was determined. Patients underwent standard-of-care gastrectomy. Detected SLNs outside the standard dissection planes were also resected and evaluated.RESULTS: Twenty-six patients were enrolled. Four patients were excluded because distant metastases were found during surgery or due to technical failure of the injection. In 21 of the remaining 22 patients, at least 1 SLN was detected by NIR Fluorescence imaging(mean 3.1 SLNs; range 1-6). In 8 of the 21 patients, tumor-positive LNs were found. Overall accuracy of the technique was 90%(70%-99%; 95%CI), which decreased by higher p T-stage(100%, 100%, 100%, 90%, 0% for respectively Tx, T1, T2, T3, T4 tumors). All NIR-negative SLNs were completely effaced by tumor. Mean fluorescence signal-to-background ratio of SLNs was 4.4(range 1.4-19.8). In 8 of the 21 patients, SLNs outside the standard resection plane were identified, that contained malignant cells in 2 patients.CONCLUSION: This study shows successful use of ICG:Nanocoll as lymphatic tracer for SLN detection in gastric cancer. Moreover, tumor-containing LNs outside the standard dissection planes were identified.Quirijn RJG Tummers Leonora SF Boogerd Wobbe O de Steur Floris PR Verbeek Martin C Boonstra Henricus JM Handgraaf John V Frangioni Cornelis JH van de Velde Henk H Hartgrink Alexander L Vahrmeijer 2016World Journal of Gastroenterology2016,22,13:9
2Extended lymph node dissection for gastric cancer:who may benefit?Final results of the randomized Dutch gastric cancer group trial显示文摘Hartgrink HH van de Velde C J Putter H 0,,11:3
3An iterated dynasearch algorithm for the single-machine total weighted tardiness scheduling problem显示文摘Congram R K Potts C N van de Velde S 2002Informs Journal on Computing2002,14,:1
4Inflammatory signal transduction in Crohn's disease and novel therapeutic approaches显示文摘Van Montfrans C Peppelenbosch M Te Velde A A 2002Biochem Pharmacol2002,64,:1
5Late side eftects ot short-course preoperative radiotherapy combined with total mesorectal excision for rectal cancer: increased bowel dysfunction in irradiated patients-a Dutch colorectal cancer group study 显示文摘Pceters KC van de Velde C J Leer JW 2005J Clin Oncol2005,23,25:1
6BN1P3 heterodimeriz- es with Bcl-2/Bcl-X(L) and induces cell death independent of a Bcl-2 homology 3 (BH3) domain at both mitochondrial and nonmitochondrial sites 显示文摘Ray R Chen G Vande Velde C 2000J Biol Chem2000,275,2:1
7Announcement effect s of convertible bond loans and warrant bond loans:An empirical analysis for the Dutch market 显示文摘Roon F Veld C 1998Journal of Banking & Finance1998,,22:1
8Extended lymph node dissection for gastric cancer:who may benefit? Final results of the randomized Dutch gastric cancer group trial显示文摘Hartgrink HH van de Velde C J Putter H 2004J Clini On- col2004,22,11:1
9Preoperative chemotherapy in primary operable breast cancer: results from the European Organization for Research and Treat- ment of Cancer trial 10902 显示文摘van der HAGE J A van de VELDE C J H JULIEN J P 2001J Clin Oneol2001,19,22:1
10Association of estimated glomerular filtration rate and albuminuria with all cause and cardiovascular mortality in general population cohorts: a collaborative meta-analysis显示文摘Matsushita K van der Velde M Astor B C 2010Lancet2010,375,9731:1
11Classification of gastric carcinoma using the Goseki system provides prognostic information additional to TNM staging显示文摘Songun I van de Velde C J Arends J W 1999Cancer1999,85,10:1
12Optimal surgery for advanced gastric cancer显示文摘Songun I van de Velde C J 0,,12:1
13Micrometastasis and survival in stage Ⅱ colorectal cancer显示文摘Leifers G J Cleton Jansen A M Van de Velde C J H 1998N Engl J Med1998,339,4:1
14Adjuvant tamoxifen and ex- emcstane in early breast cancer (TEAM) : a randomised phase 3 trial 显示文摘Van De Velde C J Rea D Seynaeve C et at 2011Lancet2011,377,9762:1
15The effects of extreme water level fluctuations on the wetland vegetation of a nymphaeid-dominated oxbow lake in The Netberlands显示文摘BROCK T C M VELDE VAN DER G STEEG VAN DE H M 1987Arch Hydrobiologia1987,,27:1
16Expert opinion on management of gastric and gastro - oesophageal junction adenocarcinoma on behalf of the European organisation for research and treatment of cancer ( EORTC ) - gastrointestinal cancer group 显示文摘Van Cutsem E Van de Velde C Roth A 2008Eur J Cancer2008,44,:1
17Late side effects of short course preoperative radiotherapy combined with total mesoreetal excision for rectal cancer: increased bowel dysfunction in irradiated patients-a Dutch eolorectal cancer group study显示文摘Peeters KC van de Velde C J Leer JW 2005J Clin Oncol2005,23,25:1
18Occupational exposure to chemical substances and time to pregnancy:A systematic review显示文摘Snijder C A te Velde E Roeleveld N 0,,3:1
19Preoperative chemotherapy in primary operable breast cancer: results from the European Organization for Research and Treatment of Cancer trial 10902显示文摘van der Hage JA van de Velde C J Julien JP 2001J Clin Oncol2001,19,22:1
20Macroscopic evaluation of rectal cancer resection specimen: clinical significance of the pathologist in quality control 显示文摘Nagtegaal ID yen de Velde C J van de Worp E 2002J Clin Oncol2002,20,7:1
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