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| 1 | Relationship between Th17 immune response and cancer显示文摘Cancer is the second leading cause of death worldwide and epidemiological projections predict growing cancer mortality rates in the next decades.Cancer has a close relationship with the immune system and,although Th17 cells are known to play roles in the immune response against microorganisms and in autoimmunity,studies have emphasized their roles in cancer pathogenesis.The Th17 immune response profile is involved in several types of cancer including urogenital,respiratory,gastrointestinal,and skin cancers.This type of immune response exerts pro and antitumor functions through several mechanisms,depending on the context of each tumor,including the protumor angiogenesis and exhaustion of T cells and the antitumor recruitment of T cells and neutrophils to the tumor microenvironment.Among other factors,the paradoxical behavior of Th17 cells in this setting has been attributed to its plasticity potential,which makes possible their conversion into other types of T cells such as Th17/Treg and Th17/Th1 cells.Interleukin(IL)-17 stands out among Th17-related cytokines since it modulates pathways and interacts with other cell profiles in the tumor microenvironment,which allow Th17 cells to prevail in tumors.Moreover,the IL-17 is able to mediate pro and antitumor processes that influence the development and progression of various cancers,being associated with variable clinical outcomes.The understanding of the relationship between the Th17 immune response and cancer as well as the singularities of carcinogenic processes in each type of tumor is crucial for the identification of new therapeutic targets. | Hanna Santos Marques Breno Bittencourt de Brito Filipe Antônio França da Silva Maria Luísa Cordeiro Santos Júlio César Braga de Souza Thiago Macêdo Lopes Correia Luana Weber Lopes Nayara Silva de Macêdo Neres Rafael Santos Dantas Miranda Dórea Anna Carolina Saúde Dantas Lorena Lôbo Brito Morbeck Iasmin Souza Lima Amanda Alves de Almeida Maiara Raulina de Jesus Dias Fabrício Freire de Melo | 2021 | World Journal of Clinical Oncology2021，12，10： | 5 |
| 2 | Late Cenozoic eolian deposition in the North Pacific: Asian drying, Tibetan uplift, and cooling of the northern hemisphere显示文摘 | Rea D K Snoeckx H Joseph L H | 1998 | Paleoceanography1998，3，： | 3 |
| 3 | Differential scanning calorimetry material studies:implications for the safety of lithium-ion cells显示文摘 | ZHANG Z FOUCHARD D REA J R | 1998 | J Power Sources1998，70，： | 1 |
| 4 | A direct link between the China loess and marine δ^18O records:Aeolian flux to the north Pacific显示文摘 | Hovan S A Rea D K PisiasN G | 1989 | Nature1989，340，： | 1 |
| 5 | Late Cenozoic eolian deposition in the North Pacific: Asian drying, Tibetan uplift and cooling of the Northern Hemisphere 显示文摘 | Rea D K Snoeckx H Joseph L H | 1998 | Paleoceanography1998，13，： | 1 |
| 6 | The paleoclimatic record provided by eolian deposi tion in the deep sea: the geologic history of wind 显示文摘 | Rea D K | 1994 | Reviews of Geophysics1994，32，2： | 1 |
| 7 | aTrom: Long-term effects of con- tinuing adjuvant tamoxifen to 10 years versus stopping at 5 years in 6, 953 women with early breast cancer显示文摘 | Gray RG Rea D Handley K | 2013 | J Clin 0ncol2013，31，18： | 1 |
| 8 | Improving Bystander Cardiopulmonary Resuscitation显示文摘 | Bradley S M Rea T D | 2011 | Curr Opin Crit Care2011，17，3： | 1 |
| 9 | Late Cenozoic eolian deposition in the North Pacific: Asian drying, Tibetan uplift, and cooling of the northern hemisphere 显示文摘 | Rea D K Snoeckx H Joseph L H | 1998 | Paleoceanography1998，13，3： | 1 |
| 10 | Geologic approach to the long term history of atmopsheric circulation 显示文摘 | Rea D K Leinen M Janecek T R | 1985 | Science1985，227，： | 1 |
| 11 | Differential scanning calor- imetry material studies: implications for the safety of lithium-ion cells显示文摘 | ZHANG Z FOUCHARD D REA J R | 1998 | Journal of Power Sources1998，700，： | 1 |
| 12 | Lung abnormalities after dasatinib treatment for chronic myeloid leukemia: a case series显示文摘 | Bergeron A Rea D Levy V | 2007 | Am J Respir Crit Care Med2007，176，8： | 1 |
| 13 | Coagulopathic complications in breast cancer显示文摘 | Caine GJ Stonelake PS Rea D | 2003 | Cancer2003，98，8： | 1 |
| 14 | Moving GLUT4: the biogenesis and trafficking of GLUT4 storage vesicles 显示文摘 | Rea S James D E | 1997 | Diabetes1997，46，： | 1 |
| 15 | Dissociation of oceanic methane hydrate as a cause of the carbon isotope ezcursion at the end of the Paleocene显示文摘 | Dickens G R O'Neil J R Rea D K | 1995 | Paleoceanography1995，10，： | 1 |
| 16 | Towards a conceptual understanding of entrepreneurial learning显示文摘 | Rea D and Carswell M | 2001 | Journal of Small Business and Enterprise Development2001，8，2： | 1 |
| 17 | Grain-size distribu-tion function of polymodal sediments in hydraulic and aeoli-an environments,and numerical partitioning of the sedimen-tary components显示文摘 | Sun D H Bloemendal J Rea D K | 2002 | Sedimentary Geology2002，152，34： | 1 |
| 18 | Late Pleistocene paleoclimatology of the central equatorial Pacific: a quantitative record of eolian and carbonate deposition显示文摘 | Chuey J M Rea D K Pisias N G | 1987 | Quatary Research1987，28，： | 1 |
| 19 | Cerebral arteriopathy in children with neurofibromatosis type 1 显示文摘 | Rea D Brandsema JF Armstrong D | 2009 | Pediatrics2009，124，： | 1 |
| 20 | Entrepreneurial leaning:A conceptual framework for technology-based enterprise显示文摘 | Rea D | 2006 | Technology Analysis &Strategic Management2006，18，1： | 1 |
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