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| 1 | Preventive effect of a pectic polysaccharide of the common cranberry Vaccinium oxycoccos L. on acetic acid-induced colitis in mice显示文摘AIM: To study isolation and chemical characterization of pectin derived from the common cranberry Vaccinium oxycoccos L. (oxycoccusan OP) and the testing of its preventive effect on experimental colitis.METHODS: Mice were administrated orally with OP two days prior to a rectal injection of 5% acetic acid and examined for colonic damage 24 h later. Colonic inflammation was characterized by macroscopical injury and enhanced levels of myeloperoxidase activity measured spectrophotometrically with o-phenylene diamine as the substrate. The mucus contents of the colon were determined by the Alcian blue dye binding method. Vascular permeability was estimated using 4% Evans blue passage after i.p. injection of 0.05 mol/L acetic acid. RESULTS: In the mice treated with OP, colonic macroscopic scores (1.1 ± 0.4 vs 2.7, P < 0.01) and the total square area of damage (10 ± 2 vs 21 ± 7, P < 0.01) were significantly reduced when compared with the vehicle-treated colitis group. OP was shown to decrease the tissue myeloperoxidase activity in colons (42 ± 11 vs 112 ± 40, P < 0.01) and enhance the amount of mucus of colitis mice (0.9 ± 0.1 vs 0.4 ± 0.1, P < 0.01). The level of colonic malondialdehyde was noted to decrease in OP-pretreated mice (3.6 ± 0.7 vs 5.1 ± 0.8, P < 0.01). OP was found to decrease the inflammatory status of mice as was determined by reduction of vascular permeability (161 ± 34 vs 241 ± 21, P < 0.01). Adhesionof peritoneal neutrophils and macrophages was also shown to decrease after administration of OP (141 ± 50 vs 235 ± 37, P < 0.05).CONCLUSION: Thus, a preventive effect of pectin from the common cranberry, namely oxycoccusan OP, on acetic acid-induced colitis in mice was detected. A reduction of neutrophil infiltration and antioxidant action may be implicated in the protective effect of oxycoccusan. | Sergey V Popov Pavel A Markov Ida R Nikitina Sergey Petrishev Vasily Smirnov Yury S Ovodov | 2006 | World Journal of Gastroenterology2006，12，41： | 9 |
| 2 | Emotion recognition through facial expression analysis based on a neurofuzzy network显示文摘 | Spiros V Ioannou Amaryllis T RaouzAiou Vasilis A Tzouvaras Theofilos P MAilis Kostas C Karpouzis Stefanos D Kollias | 2005 | Neural Networks2005，，： | 1 |
| 3 | Analysis of the glutathione S-transferase (GST) gene family 显示文摘 | Nebert DW Vasiliou V | 2004 | Hum Genomics2004，1，6： | 1 |
| 4 | Morphology of the minute larva of Ptinella, with special reference to effects of miniaturisation and the systematic position of ptiliidae ( Coleoptera: Staphylinoidea ) 显示文摘 | VASILY V G ROLF G B | 2002 | Arthropod Structure and Deveolpment2002，31，2： | 1 |
| 5 | The role of hyperosmotic stress in inflammation and disease显示文摘 | Brocker C Thompson D C Vasiliou V | 2012 | Biomol Concepts2012，3，4： | 1 |
| 6 | Aldehyde dehydrogenase gene superfamily: the 2002 update显示文摘 | Sophos NA Vasiliou V | 2003 | Chemico-Biological Interactions2003，14，1： | 1 |
| 7 | Aldehyde dehydrogenase gene superfamily : the 2002 update 显示文摘 | Sophos N A Vasiliou V | 2003 | Chem B iol Interact2003，14，： | 1 |
| 8 | Giant resonant light forces in microspherical photonics显示文摘Resonant light pressure effects can open new degrees of freedom in optical manipulation with microparticles,but they have been traditionally considered as relatively subtle effects.Using a simplified two-dimensional model of surface electromagnetic waves evanescently coupled to whispering gallery modes(WGMs)in transparent circular cavities,we show that under resonant conditions the peaks of the optical forces can approach theoretical limits imposed by the momentum conservation law on totally absorbing particles.Experimentally,we proved the existence of strong peaks of the optical forces by studying the optical propulsion of dielectric microspheres along tapered microfibers.We observed giant optical propelling velocities,0.45 mm s21 for some of the 15-20 mm polystyrene microspheres in water for guided powers limited at,43 mW.Such velocities exceed previous observations by more than an order of magnitude,thereby providing evidence for the strongly enhanced resonant optical forces.We analyzed the statistical properties of the velocity distribution function measured for slightly disordered(,1%size variations)ensembles of microspheres with mean diameters varying from 3 to 20 mm.These results demonstrate a principal possibility of optical sorting of microspheres with the positions of WGM resonances overlapped at the wavelength of the laser source.They can be used as building blocks of the lossless coupled resonator optical waveguides and various integrated optoelectronics devices. | Yangcheng Li Oleksiy V Svitelskiy Alexey V Maslov David Carnegie Edik Rafailov Vasily N Astratov | 2013 | Light(Science & Applications)2013，2，1： | 1 |
| 9 | Advanced computer aided design simulation of gear hobbing by means of three-dimensional kinematics modeling显示文摘 | Vasilis D Nectarios V Aristomenis A | 2007 | Journal of Manufacturing Science and Engineering2007，129，5： | 1 |
| 10 | The genotypic and phenotypicspectrum of pyridoxine-dependent epilepsy due to mutations in ALDH7A1显示文摘 | Scharer G Brocker C Vasiliou V | | 0，，05： | 1 |
| 11 | A quantum-theoretical approach to the phenomenon of directed mutations in bacteria(hypothesis)显示文摘 | Ogryzko Vasily V | 1997 | BioSystems1997，43，： | 1 |
| 12 | Panel flutter at low supersonic speeds 显示文摘 | Vasily V Vedeneev | 2012 | Journal of fluids and structures2012，29，： | 1 |
| 13 | Interaction between particles in a nonwetting liquid显示文摘 | Vladimir S Yushchenko Vasily V Yaminsky Eugenie D Shchukin | 1983 | Journal of Colloid and Interface Science1983，96，： | 1 |
| 14 | Analysis and update of the human aldehyde dehydrogenase (ALDH) gene family显示文摘 | Vasiliou V Nebert Daniel W | 2005 | Human Genomics2005，2，2： | 1 |
| 15 | Assessment of cortisol and ACTH responses to the desmopressin test in patients with Cushing’s syndrome and simple obesity显示文摘 | Tsagarakis S Vasiliou V Kokkoris P | 1999 | Clin Endocrinol (Oxf)1999，51，4： | 1 |
| 16 | Analysis and update of the human aldehyde dehydrogenase (ALDH) gene family显示文摘 | Vasiliou V Nebert D W | | 0，，02： | 1 |
| 17 | Aldehyde dehydrogenase gene superfamily:the 2000 update显示文摘 | Sophos N A Pappa A Ziegler T L Vasiliou V | | 0，，： | 1 |
| 18 | Analysis and update of the human aldehyde dehydro-genase (ALDH) gene family显示文摘 | Vasiliou V Nebert DW | 2005 | Hum Genomics2005，2，2： | 1 |
| 19 | Aldehyde dehydrogenase gene su- perfamily: the 2002 update 显示文摘 | SOPHOS N A VASILIOU V | 2003 | Chem Biol Interact2003，14，： | 1 |
| 20 | Role of aldehyde dehydrogenases in endogenous and xenobiotic metabolism显示文摘 | Vasilis V Aglaia P Dennis R P | | 0，，： | 1 |
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