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| 1 | Spatial cloud computing: how can the geospatial sciences use and help shape cloud computing?显示文摘The geospatial sciences face grand information technology(IT)challenges in the twenty-first century:data intensity,computing intensity,concurrent access intensity and spatiotemporal intensity.These challenges require the readiness of a computing infrastructure that can:(1)better support discovery,access and utilization of data and data processing so as to relieve scientists and engineers of IT tasks and focus on scientific discoveries;(2)provide real-time IT resources to enable real-time applications,such as emergency response;(3)deal with access spikes;and(4)provide more reliable and scalable service for massive numbers of concurrent users to advance public knowledge.The emergence of cloud computing provides a potential solution with an elastic,on-demand computing platform to integrateobservation systems,parameter extracting algorithms,phenomena simulations,analytical visualization and decision support,and to provide social impact and user feedbackthe essential elements of the geospatial sciences.We discuss the utilization of cloud computing to support the intensities of geospatial sciences by reporting from our investigations on how cloud computing could enable the geospatial sciences and how spatiotemporal principles,the kernel of the geospatial sciences,could be utilized to ensure the benefits of cloud computing.Four research examples are presented to analyze how to:(1)search,access and utilize geospatial data;(2)configure computing infrastructure to enable the computability of intensive simulation models;(3)disseminate and utilize research results for massive numbers of concurrent users;and(4)adopt spatiotemporal principles to support spatiotemporal intensive applications.The paper concludes with a discussion of opportunities and challenges for spatial cloud computing(SCC). | Chaowei Yang Michael Goodchild Qunying Huang Doug Nebert Robert Raskin Yan Xu Myra Bambacus Daniel Fay | 2011 | International Journal of Digital Earth2011，4，4： | 55 |
| 2 | Clinical importance of the cytochromes P450显示文摘 | Daniel W Nebert David W Russell | 2002 | The Lancet . 2002 (9340)2002，，： | 2 |
| 3 | Redefining the possibility of digital Earth and geosciences with spatial cloud computing显示文摘Global challenges(such as economy and natural hazards)and technology advancements have triggered international leaders and organizations to rethink geosciences and Digital Earth in the new decade.The next generation visions pose grand challenges for infrastructure,especially computing infrastructure.The gradual establishment of cloud computing as a primary infrastructure provides new capabilities to meet the challenges.This paper reviews research conducted using cloud computing to address geoscience and Digital Earth needs within the context of an integrated Earth system.We also introduce the five papers selected through a rigorous review process as exemplar research in using cloud capabilities to address the challenges.The literature and research demonstrate that spatial cloud computing provides unprecedented new capabilities to enable Digital Earth and geosciences in the twenty-first century in several aspects:(1)virtually unlimited computing power for addressing big data storage,sharing,processing,and knowledge discovering challenges,(2)elastic,flexible,and easy-to-use computing infrastructure to facilitate the building of the next generation geospatial cyberin-frastructure,CyberGIS,CloudGIS,and Digital Earth,(3)seamless integration environment that enables mashing up observation,data,models,problems,and citizens,(4)research opportunities triggered by global challenges that may lead to breakthroughs in relevant fields including infrastructure building,GIScience,computer science,and geosciences,and(5)collaboration supported by cloud computing and across science domains,agencies,countries to collectively address global challenges from policy,management,system engineering,acquisition,and operation aspects. | Chaowei Yang Yan Xu Douglas Nebert | 2013 | International Journal of Digital Earth2013，6，4： | 2 |
| 4 | Analysis of the glutathione S-transferase (GST) gene family 显示文摘 | Nebert DW Vasiliou V | 2004 | Hum Genomics2004，1，6： | 1 |
| 5 | An internet based GIS data access system显示文摘 | PENG Z R NEBERT D | 1997 | Journal of Urban and Regional Information Systems1997，9，1： | 1 |
| 6 | 显示文摘 | Nebert D W Russell D W | 2002 | Lancet2002，360，： | 1 |
| 7 | Human P450 genes:e-volution,regulation and possible role in carcinogenesis显示文摘 | Nebert DW Jaiswal AK Meyer UA | 1987 | Bio-chem Soc Trans1987，15，4： | 1 |
| 8 | Pharmacogenomics and 'individualized drug therapy':high expectations and disappointing achievements显示文摘 | Nebert DW Jorge-Nebert L Vesell ES | | 0，，06： | 1 |
| 9 | Update of human and mouse forkhead box (FOX) gene families显示文摘 | Jackson BC Carpenter C Nebert DW | | 0，，： | 1 |
| 10 | From human genetics and genomics to pharmacogenetics and pharmacogenomics:past lessons,future directions显示文摘 | Nebert DW Zhang G Vesell ES | | 0，，02： | 1 |
| 11 | CYP450gene: structure, evolution, and regulation 显示文摘 | Nebert DW Alcasaka S Guengerich FP | 1987 | Ann Rev Biochem1987，56，： | 1 |
| 12 | Pharmacogenomics and ''individualized drug therapy'': high expectations and disappointing achievements显示文摘 | Nebert DW Jorge- Nebert L Vesell ES | 2003 | Am J Pharmacogenomics2003，3，6： | 1 |
| 13 | Pharm acgenetics in clinical Pharm acolory and toxicology显示文摘 | Inaba T Nebert DW Burchell B | 1995 | Can J Pharm acol1995，73，： | 1 |
| 14 | Human dioxin-inducible cytochrome P1-450: complementary DNA and amino acid sequence显示文摘 | Jaiswal AK Gonzalez F J Nebert DW | 1985 | Science1985，228，4695： | 1 |
| 15 | Update of human and mouse forkhead box (FOX) gene families 显示文摘 | JACKSON BC CHRISTOPHER C NEBERT DW | 2010 | Human Genomics2010，4，5： | 1 |
| 16 | Role of aryl hydrocarbon receptor-mediated induction of the CYP1 enzymes in environmental toxicity and cancer显示文摘 | Nebert DW Dalton TP Okey AB | 2004 | J Biol Chem2004，279，23： | 1 |
| 17 | Clinical importance of the cytochromes P450显示文摘 | Nebert DW Russell DW | 2002 | Lancet2002，360，9340： | 1 |
| 18 | Role of the aromatic hydrocarbonreceptor and gene battery in the oxidative stress response, cell cycle control and apoptosis 显示文摘 | Nebert DW Roe AL Dieter MZ | 2000 | Biochem Pharmacol2000，59，65： | 1 |
| 19 | Clinical importance of the cyto- chromes P450显示文摘 | Nebert DW Russell DW | 2002 | Lancet2002，360，9340： | 1 |
| 20 | Analysis and update of the human aldehyde dehydrogenase (ALDH) gene family显示文摘 | Vasiliou V Nebert Daniel W | 2005 | Human Genomics2005，2，2： | 1 |
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