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| 1 | Contribution of the IL-17/IL-23 axis to the pathogenesis of inflammatory bowel disease显示文摘Inflammatory bowel diseases(IBDs) are chronic disorders of modern society, requiring management strategies aimed at prolonging an active life and establishing the exact etiology and pathogenesis.These idiopathic diseases have environmental, genetic,immunologic, inflammatory, and oxidative stress components. On the one hand, recent advances have shown that abnormal immune reactions against the microorganisms of the intestinal flora are responsible for the inflammation in genetically susceptible individuals. On the other hand, in addition to T helper cell-type(Th) 1 and Th2 immune responses,other subsets of T cells, namely regulatory T cells and Th17 maintained by IL-23 are likely to develop IBD. IL-23 acts on innate immune system members and also facilitates the expansion and maintenance of Th17 cells. The IL-17/IL-23 axis is relevant in IBD pathogenesis both in human and experimental studies. Novel biomarkers of IBD could be calprotectin,microRNAs, and serum proinflammatory cytokines.An efficient strategy for IBD therapy is represented by the combination of IL-17 A and IL-17 F in acute IL-17 A knockout TNBS-induced colitis, and also definite decrease of the inflammatory process in IL-17 F knockout, DSS-induced colitis have been observed.Studying the correlation between innate and adaptive immune systems, we hope to obtain a focused reviewin order to facilitate future approaches aimed at elucidating the immunological mechanisms that control gut inflammation. | Cristina-Sorina Cǎanǎ Ioana Berindan Neagoe Vasile Cozma Cristian Magdas Flaviu Tǎbǎan Dan Lucian Dumitrasu | 2015 | World Journal of Gastroenterology2015，21，19： | 37 |
| 2 | 毛皮鞣制中不同铝鞣剂的对比研究显示文摘通过对比试验研究了三甲酸铝和明矾鞣制毛皮的优缺点。试验证明,采用三甲酸铝为鞣剂,成品革在面积得革率、单位面积重量。 | Vasil kovac Dr. H. Francke | 1999 | 中国皮革1999，28，19： | 7 |
| 3 | Mastitis Pathogens Isolated from Samples of Milk in Dairy Cows and Their Resistance against Antimicrobial Agents显示文摘The objective of this study was to evaluate the effectiveness of different antibiotics against mastitis causing microorganisms during first phase of lactation in herd of 320 Holstein cows in east of Slovakia. Milk samples from quarters were cultured and identified bacteria were subjected to antimicrobial susceptibility test by disc diffusion method to a large number of antibiotics. The results revealed higher sensitivity against tetradelta (100% of Strep. Agalactiae and Strep. uberis, Coagulase Negative Staphylococci), (94.4% of Stap. aureus) with highest number of bacterial isolates, followed by cefalexin + kanamycin amoxicillin plus clavulanat acid and ceftiotur (100% of Strep. agalactiae and Strep. uberis). Resistance was observed against penicillin (22.2% of Stap. aureus) amoxicillin (22.2% of Stap. aureus and 10.5% of Strep. uberis) and streptomycin (22.2% of Stap. aureus and 52.7% of Strep. uberis). | Frantiek Zigo Milan Vasil Juraj Elecko Martina Zigová Zuzana Farkasova | 2017 | Journal of Food Science and Engineering2017，7，2： | 4 |
| 4 | FOLFIRINOX and translational studies: Towards personalized therapy in pancreatic cancer显示文摘Pancreatic cancer is an extremely aggressive disease; although progress has been made in the last few years, the prognosis of these patients remains dismal. FOLFIRINOX is now considered a standard treatment in first-line setting, since it demonstrated an improved overall and progression-free survival vs gemcitabine alone. However, the enthusiasm over the benefit of this three-drug regimen is tempered by the associated increased toxicity profile, and many efforts have been made to improve the feasibility of this schedule. After a more recent phase Ⅲ trial showing an improved outcome over gemcitabine, the combination of gemcitabine/nab-paclitaxel emerged as another standard first-line treatment. However, this treatment is also associated with more side effects. In addition, despite initial promising data on the predictive role of SPARClevels, recent studies showed that these levels are not associated with nab-paclitaxel efficacy. The choice to use this treatment over FOLFIRINOX is therefore a topic of debate, also because no validated biomarkers to guide FOLFIRINOX treatment are available. In the era of actionable mutations and target agents it would be desirable to identify molecular factors or biomarkers to predict response to therapy in order to maximize the efficacy of treatment and avoid useless toxic effects for non-responding patients. However, until today the milestone of treatment for pancreatic cancer remains chemotherapy combinations, without predictive or monitoring tools existing to optimize therapy. This review analyzes the state-of-the-art treatments, promises and limitations of targeted therapies, ongoing trials and future perspectives, including potential role of microR NAs as predictive biomarkers. | Chiara Caparello Laura L Meijer Ingrid Garajova Alfredo Falcone Tessa Y Le Large Niccola Funel Geert Kazemier Godefridus J Peters Enrico Vasile Elisa Giovannetti | 2016 | World Journal of Gastroenterology2016，22，31： | 4 |
| 5 | Sol-gel synthesis, surface and magnetic properties of nanocrystalline SmAlO_3显示文摘Nanocrystals of single-phase samarium monoaluminate (SmAlO3) were synthesized and studied for the first time. Malic acid was employed as a new complexing agent in the sol-gel process. The material was characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM), energy-dispersive X-ray analysis (EDS), specific surface area and density. The lowest size of the nanoparticles was about 50–60 nm and some of them formed agglomerates. The binding energies of core-level electrons of Sm (3d, 4d, 4f, 5p, 5s), Al (2s, 2p) and O (1s, 2s) in nanocrystalline SmAlO3 were obtained by X-ray photoelectron spectroscopy (XPS) and found shifted in respect to the correspond- ing values for the same elements. The temperature dependence of the AC magnetic susceptibility of the substance was determined between 2.5 and 250 K. The experimental molar magnetic susceptibility was compared with the theoretical one of Sm3+ ions. The nanomaterial was found paramagnetic in the specified temperature range with Curie-type paramagnetism below 12 K. | Dimitar Petrov Bogdan Angelov Vasil Lovchinov | 2010 | Journal of Rare Earths2010，28，4： | 3 |
| 6 | Split-dose or hybrid nonsteroidal anti-inflammatory drugs and Nacetylcysteine therapy for prevention of post-retrograde cholangiopancreatography pancreatitis显示文摘BACKGROUND Despite significant technical and training improvements, the incidence of postendoscopic retrograde cholangiopancreatography(ERCP) pancreatitis(PEP) has not significantly dropped. Although many studies have evaluated the efficacy of various agents, e.g. nonsteroidal anti-inflammatory drugs, octreotide,antioxidants, administered via various dosages, routes(oral, intrarectal or parenteral), and schedules(before or after the procedure), the results have been conflicting.AIM To evaluate efficacy of three pharmacologic prophylactic methods for prevention of PEP.METHODS In this prospective, single-center randomized trial, patients who underwent firsttime ERCP for choledocholithiasis were randomly assigned to three groups. The first group received 600 mg N-acetylcysteine 15 min prior to ERCP, and perrectum administration of 50 mg indomethacin both prior to and after completion of the ERCP. The second group was administered only the 50 mg indomethacin per-rectum both prior to and after the ERCP. The third group was administeredper-rectum 100 mg indomethacin only after the ERCP, representing the control group given the guideline-recommended regimen. The primary end-point was PEP prevention.RESULTS Among the total 211 patients evaluated during the study, 186 fulfilled the inclusion criteria and completed the protocol. The percentages of patients who developed PEP in each of the three groups were not significantly different(χ2 =2.793, P = 0.247). Among the acute PEP cases, for all groups, 14 patients developed mild pancreatitis(77.77%) and 4 moderate. No severe cases of PEP occurred, and in all PEP cases the resolution was favorable. No adverse events related to the medications(digestive hemorrhage, rectal irritation, or allergies)occurred.CONCLUSION The efficacies of split-dose indomethacin and combined administration(Nacetylcysteine with indomethacin) for preventing PEP were similar to that of the standard regimen. | Laura Pavel Gheorghe Gh Balan Alexandra Nicorescu Georgiana Emmanuela Gilca-Blanariu Catalin Sfarti Stefan Chiriac Smaranda Diaconescu Vasile Liviu Drug Gheorghe Balan Gabriela Stefanescu | 2019 | World Journal of Clinical Cases2019，7，3： | 3 |
| 7 | Evaluation on the corrosion resistance, antibacterial property and osteogenic activity of biodegradable Mg-Ca and Mg-Ca-Zn-Ag alloys显示文摘The rapid degradation of magnesium(Mg)-based implants in physiological environment limits its clinical applications, and alloying treatment is an effective way to regulate the degradation rate of Mg-based materials. In the present study, three Mg alloys, including Mg-0.8Ca(denoted as ZQ), Mg-0.8Ca-5Zn-1.5Ag(denoted as ZQ71) and Mg-0.8Ca-5Zn-2.5Ag(denoted as ZQ63), were fabricated by alloying with calcium(Ca), zinc(Zn) and silver(Ag). The results obtained from electrochemical corrosion tests and in vitro degradation evaluation demonstrated that the three Mg alloys exhibited distinct corrosion resistance, and ZQ71 exhibited the lowest degradation rate in vitro among them. After addition of Zn and Ag, the antibacterial potential of Mg alloys was also enhanced. The in vitro cell experiments showed that all the three Mg alloys had good biocompatibility. After implantation in a rat femoral defect, ZQ71 showed significantly higher osteogenic activity and bone substitution rate than ZQ63 and ZQ, due to its higher corrosion resistance as well as the stimulatory effects of the released metallic ions. In addition, the average daily degradation rate of each Mg alloy in vivo was significantly higher than that in vitro, as could be due to the implantation site located in the highly vascularized trabecular region. Importantly, the correlations between the in vitro and in vivo degradation parameters of the Mg alloys were systematically analyzed to find out the potential predictors of the in vivo degradation performance of the materials. The current work not only evaluated the clinical potential of the three biodegradable Mg alloys as bone grafts but also provided a feasible approach for predicting the in vivo degradation behavior of biodegradable materials. | Hewei Chen Bo Yuan Rui Zhao Xiao Yang Zhanwen Xiao Antoniac Aurora Bita Ana Iulia Xiangdong Zhu Antoniac Vasile Iulian Xingdong Zhang | 2022 | Journal of Magnesium and Alloys2022，10，12： | 3 |
| 8 | Characterization and remediation of soils contaminated with uranium显示文摘 | Maria Gavrilescu Lucian Vasile Pavel Igor Cretescu | 2008 | Journal of Hazardous Materials2008，，2： | 3 |
| 9 | Degradation of pharmaceutical compound pentoxifylline in water by non-thermal plasma treatment显示文摘 | Monica Magureanu Daniela Piroi Nicolae Bogdan Mandache Victor David Andrei Medvedovici Vasile I. Parvulescu | 2010 | Water Research2010，，11： | 2 |
| 10 | Herbicide resistant fertile transgenic wheat plant obtained by microprojectile bombardment of regenerable embryogenic callus显示文摘 | Vasil V Castillo A M Fromm M E Vasil I K | 1992 | Bio/Tech1992，10，： | 2 |
| 11 | Construction of a magnesium hydroxide/graphene oxide/hydroxyapatite composite coating on Mg-Ca-Zn-Ag alloy to inhibit bacterial infection and promote bone regeneration显示文摘The improved corrosion resistance, osteogenic activity, and antibacterial ability are the key factors for promoting the large-scale clinical application of magnesium (Mg)-based implants. In the present study, a novel nanocomposite coating composed of inner magnesium hydroxide, middle graphene oxide, and outer hydroxyapatite (Mg(OH)_(2)/GO/HA) is constructed on the surface of Mg-0.8Ca-5Zn-1.5Ag by a combined strategy of hydrothermal treatment, electrophoretic deposition, and electrochemical deposition. The results of material characterization and electrochemical corrosion test showed that all the three coatings have high bonding strength, hydrophilicity and corrosion resistance. In vitro studies show that Mg(OH)2 indeed improves the antibacterial activity of the substrate. The next GO and GO/HA coating procedures both promote the osteogenic differentiation of MC3T3-E1 cells and show no harm to the antibacterial activity of Mg(OH)2 coating, but the latter exhibits the best promoting effect. In vivo studies demonstrate that the Mg alloy with the composite coating not only ameliorates osteolysis induced by bacterial invasion but also promotes bone regeneration under both normal and infected conditions. The current study provides a promising surface modification strategy for developing multifunctional Mg-based implants with good corrosion resistance, antibacterial ability and osteogenic activity to enlarge their biomedical applications. | Bo Yuan Hewei Chen Rui Zhao Xuangeng Deng Guo Chen Xiao Yang Zhanwen Xiao Antoniac Aurora Bita Ana Iulia Kai Zhang Xiangdong Zhu Antoniac Vasile Iulian Shen Hai Xingdong Zhang | 2022 | Bioactive Materials2022，7，12： | 2 |
| 12 | The effect of annealing on the photoluminescent and optical properties of porous anodic alumina films formed in sulfamic acid显示文摘 | S. Stojadinovic Z. Nedic I. Belca R. Vasilic B. Kasalica M. Petkovic Lj. Zekovic | 2009 | Applied Surface Science2009，，3： | 2 |
| 13 | Fullscale evaluation of biological nitrogen removal in the stepfeed activated sludge process 显示文摘 | John Fillos Vasil Diyamandoglu Luis A Carrio | 1996 | Water Environ Res1996，68，2： | 2 |
| 14 | 不同株行距和树形对高密度栽植樱桃产量的影响显示文摘优质樱桃的生产取决于品种、砧木、栽植密度、树形、树势、树龄、果实着生位置、果树负载量、农药和生长调节剂的使用等环境因素和农业技术管理措施。在樱桃的栽培管理中,应选择正确的授粉品种结合适合的砧木、树形和栽培密度。摩尔多瓦共和国的气候条件非常适合樱桃高密度栽培,但现在很多樱桃果园仍然是传统栽培模式。摩尔多瓦共和国政府为建立现代樱桃园的果农提供有吸引力的补贴,鼓励选择适宜的品种、砧木和树形,以实现果园现代化生产。 | Igor IVANOV Valerian BALAN Ananie PE?TEANU Sergiu VAMA?ESCU Petru BALAN Vasile ?ARBN 赵慧 | 2019 | 烟台果树2019，0，3： | 2 |
| 15 | Determination of 3H and 14C in Organic Sample after Separation through Combustion Method显示文摘 | Simona Popoaca Cristina Bucur Vasile Simionov | 2014 | Journal of Energy and Power Engineering2014，8，10： | 2 |
| 16 | Integration and exprssion of the high molecular-weight glutenin subunit 1 A×1 gene into wheat显示文摘 | Altpeter F Vasil V Srivastava V Vasil I K | 1996 | Nat Biotechnol1996，14，11： | 2 |
| 17 | 谷类植物原生质体研究的重要进展显示文摘自1986年以来,已从所有重要的谷类植物,包括小麦、水稻、玉米和大麦,以及多种禾本科植物例如甘蔗的原生质体再生得到了完整的再生植株。此外,在一些实验室中已得到了谷类植物的体细胞杂种或胞质杂种以及一些带有引入的有用农艺性状的转基因植株。在过去的十年期间。 | Indra K.Vasil Vimla Vasil 黄健秋 | 1993 | 细胞生物学杂志1993，15，3： | 1 |
| 18 | Herbicide resistance fertile transgenic wheat plants obtained by microprojectile bombardment of regenerable emhryogenic callus 显示文摘 | Vasil V AM Castillo ME Fromm | 1992 | Bio/Technology1992，10，： | 1 |
| 19 | Modern methods for diagnosis of Gardnerella infection显示文摘 | Makarova L N Kravtsov E G Vasil E A | 2000 | Bull Exp Biol Med2000，130，8： | 1 |
| 20 | MicroRNA-21 in pancreatic cancer:correlation with clinical outcome and pharmacologic aspects underlying its role in the modulation of gemcitabine activity显示文摘 | Giovannetti E Funel N Peters G J Del Chiaro M Erozenci LA Vasile E | | 0，，： | 1 |
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