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| 1 | Retrospective study on mixed neuroendocrine non-neuroendocrine neoplasms from five European centres显示文摘BACKGROUND Mixed neuroendocrine non-neuroendocrine neoplasm(MiNEN)is a rare diagnosis,mainly encountered in the gastro-entero-pancreatic tract.There is limited knowledge of its epidemiology,prognosis and biology,and the best management for affected patients is still to be defined.AIM To investigate clinical-pathological characteristics,treatment modalities and survival outcomes of a retrospective cohort of patients with a diagnosis of MiNEN.METHODS Consecutive patients with a histologically proven diagnosis of MiNEN were identified at 5 European centres.Patient data were retrospectively collected from medical records.Pathological samples were reviewed to ascertain compliance with the 2017 World Health Organisation definition of MiNEN.Tumour responses to systemic treatment were assessed according to the Response Evaluation Criteria in Solid Tumours 1.1.Kaplan-Meier analysis was applied to estimate survival outcomes.Associations between clinical-pathological characteristics and survival outcomes were explored using Log-rank test for equality of survivors functions(univariate)and Cox-regression analysis(multivariable).RESULTS Sixty-nine consecutive patients identified;Median age at diagnosis:64 years.Males:63.8%.Localised disease(curable):53.6%.Commonest sites of origin:colon-rectum(43.5%)and oesophagus/oesophagogastric junction(15.9%).The neuroendocrine component was;predominant in 58.6%,poorly differentiated in 86.3%,and large cell in 81.25%,of cases analysed.Most distant metastases analysed(73.4%)were occupied only by a poorly differentiated neuroendocrine component.Ninety-four percent of patients with localised disease underwent curative surgery;53%also received perioperative treatment,most often in line with protocols for adenocarcinomas from the same sites of origin.Chemotherapy was offered to most patients(68.1%)with advanced disease,and followed protocols for pure neuroendocrine carcinomas or adenocarcinomas in equal proportion.In localised cases,median recurrence free survival(RFS);14.0 months(95%CI:9.2-24.4),and median overall survival(OS):28.6 months(95%CI:18.3-41.1).On univariate analysis,receipt of perioperative treatment(vs surgery alone)did not improve RFS(P=0.375),or OS(P=0.240).In advanced cases,median progression free survival(PFS);5.6 months(95%CI:4.4-7.4),and median OS;9.0 months(95%CI:5.2-13.4).On univariate analysis,receipt of palliative active treatment(vs best supportive care)prolonged PFS and OS(both,P<0.001).CONCLUSION MiNEN is most commonly driven by a poorly differentiated neuroendocrine component,and has poor prognosis.Advances in its biological understanding are needed to identify effective treatments and improve patient outcomes. | Melissa Frizziero Xin Wang Bipasha Chakrabarty Alexa Childs Tu V Luong Thomas Walter Mohid S Khan Meleri Morgan Adam Christian Mona Elshafie Tahir Shah Annamaria Minicozzi Wasat Mansoor Tim Meyer Angela Lamarca Richard A Hubner Juan W Valle Mairéad G McNamara | 2019 | World Journal of Gastroenterology2019，25，39： | 13 |
| 2 | Pancreatic cancer: Are 'liquid biopsies' ready for prime-time?显示文摘Pancreatic cancer is a disease that carries a poor prognosis. Accurate tissue diagnosis is required. Tumours contain a high content of stromal tissue and therefore biopsies may be inconclusive. Circulating tumour cells(CTCs) have been investigated as a potential 'liquid biopsy' in several malignancies and have proven to be of prognostic value in breast, prostate and colorectal cancers. They have been detected in patients with localised and metastatic pancreatic cancer with sensitivities ranging from 38%-100% using a variety of platforms. Circulating tumour DNA(ct DNA) has also been detected in pancreas cancer with a sensitivity ranging from 26%-100% in studies across different platforms and using different genetic markers. However, there is no clear consensus on which platform is the most effective for detection, nor which genetic markers are the most useful to use. Potential roles of liquid biopsies include diagnosis, screening, guiding therapies and prognosis. The presence of CTCs or ct DNA has been shown to be of prognostic value both at diagnosis and after treatment in patients with pancreatic cancer. However, more prospective studies are required before this promising technology is ready for adoption into routine clinical practice. | Alexandra R Lewis Juan W Valle Mairead G Mc Namara | 2016 | World Journal of Gastroenterology2016，22，32： | 5 |
| 3 | Role of serum cytokine profile in ulcerative colitis assessment显示文摘 | Manuel Luis Rodríguez‐Perlvárez Valle García‐Sánchez Carlos Manuel Villar‐Pastor Raál González Eva Iglesias‐Flores Jordi Muntane Federico Gómez‐Camacho | 2012 | Inflamm Bowel Dis2012，，10： | 2 |
| 4 | Laparoscopy-assisted versus open colectomy for treatment of colon cancer in the elderly: morbidity and mortality outcomes in 545 patients显示文摘 | Francesc Vallribera Valls Filippo Landi Eloy Espín Basany José Luis Sánchez García Luis Miguel Jiménez Gómez Marc Martí Gallostra Luis Salgado Cruz Manuel Armengol Carrasco | 2014 | Surgical Endoscopy2014，，12： | 2 |
| 5 | Extraction-atomic absorption method for the determination of arsenic,antimony,selenium and tellurium in geologic samples显示文摘 | Togov V G Vall G A Demidova M G | 1995 | Chem Geol1995，124，： | 1 |
| 6 | Impacts of land use conflicts on riverine ecosystems 显示文摘 | Renato F Valle Junior Simone G P Varandas Femando A L Pacheco | 2014 | Land Use Policy2014，43，： | 1 |
| 7 | Relation between the presence of inhibitors and deposit morphology in nickel deposition 显示文摘 | VALLéS E POLLINA R GóMEZ E | 1993 | Journal of Applied Electrochemistry1993，23，5： | 1 |
| 8 | Preparation of MoS2 and WS2 catalysts by in situ decomposition of ammonium thiosalts显示文摘 | Alonso G Del Valle M Cruz J Petranovskii V LiceaClaverie A Fuentes S | | 0，，： | 1 |
| 9 | Particle swarm optimization: basic concepts, variants and ap- plications in power systems 显示文摘 | del VALLE Y VENAYAGAMOORTHY G K MOHAGHEGHI S | 2008 | IEEE Transactions on Evolutionary Comoutation2008，12，2： | 1 |
| 10 | Chitosan as a potential natural compound to control pre and post - harvest diseases of horticultural commodities显示文摘 | Bautista - Banos S Hemandez - Lauzardo A N Velazquez - del Valle M G | 2006 | Crop Pro- tection2006，25，2： | 1 |
| 11 | Transparent and conductive ZnO:Al thin films prepared by Sol-gel dip-coating显示文摘 | HAMMER P | 2004 | Journal of the European Ceramic Society2004，24，： | 1 |
| 12 | Natural essential oils as reducing agents of peroxidase activity in leafy vegetables 显示文摘 | Ponce A G Valle C E Roura S I | 2004 | Lebensm Wiss U Techno2004，37，： | 1 |
| 13 | Particle swarm optimization: basic concepts, variants and applications in power systems显示文摘 | Valle Y Venayagamoorthy G K Mohagheghi S | 2008 | IEEE Transactions on EvolutionaryComputation2008，12，2： | 1 |
| 14 | Prenylalted Coumarins and Sesquiterpenoids from Ferula Communis 显示文摘 | Valle MG Appendino G Nano GM | 1987 | Phytochem1987，26，1： | 1 |
| 15 | Hypogastric vessel surgery in obstetrics and gynecology显示文摘 | Valle G Massone G | | Obstetrical and Gynecological Survey0，，： | 1 |
| 16 | A dual-band priority assignment algorithm for dynamic Qo S resource management显示文摘 | VALLS M G ALONSO A ANTONIO J | 2012 | Future Generation Computer Systems2012，28，6： | 1 |
| 17 | Wnt-7a induces presyn- aptic colocalization of alpha 7-nicotinic acetylcholine receptors and ade- nomatous polyposis coli in hippocampal neurons 显示文摘 | Farias G G Valles A S Colombres M | 2007 | J Neurosci2007，27，20： | 1 |
| 18 | Physical acitivity,body mass index,and risk显示文摘 | HU G Lindstrom J Valle TT | 2004 | Inter Med2004，164，8： | 1 |
| 19 | Relationship of extrusion variables with pressure and temperature during twin screw extrusion cooking of starch显示文摘 | Delia Valle G Tayeb J Melcion J P | 1987 | Journal of Food Engineering1987，6，6： | 1 |
| 20 | Technique and Complications of Percutaneous Nephroscopy: Experience with 557 Patients in the Supine Position显示文摘 | Valdivia Uria J G Valle Gerhold J Lopez Lopez J A | 1998 | J Urol1998，160，6： | 1 |
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