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| 1 | Failure of interferon-γ pre-treated mesenchymal stem cell treatment in a patient with crohn's disease显示文摘Mesenchymal stem cells(MSC) are cells of stromal origin which exhibit unlimited self-renewal capacity and pluripotency in vitro.It has recently been observed that MSC may also exert a profound immunosuppressive and anti-inflammatory effect both in vitro and in vivo with consequent potential use in autoimmune disorders.We present the case of a patient suffering from childhood-onset, multidrug resistant and steroiddependent Crohn's disease who underwent systemic infusions of MSC, which led to a temporary reduction in CCR4, CCR7 and CXCR4 expression by T-cells, and a temporary decrease in switched memory B-cells, In addition, following MSC infusion, lower doses of steroids were needed to inhibit proliferation of the patient's peripheral blood mononuclear cells.Despite these changes, no significant clinical benefit was observed, and the patient required rescue therapy with infliximab and subsequent autologous hematopoietic stem cell transplantation.The results of biological and in vitro observations after MSC use and the clinical effects of infusion are discussed, and a brief description is provided of previous data on MSC-based therapy in autoimmune disorders. | Andrea Taddio Alberto Tommasini Erica Valencic Ettore Biagi Giuliana Decorti Sara De Iudicibus Eva Cuzzoni Giuseppe Gaipa Raffaela Badolato Alberto Prandini Andrea Biondi Alessandro Ventura | 2015 | World Journal of Gastroenterology2015，21，14： | 2 |
| 2 | Evaluation of the ability to make non-invasive estimation of muscle contractile properties on the basis of the muscle belly response 显示文摘 | Dahmane R Valencic V Knez N Erzen | 2001 | Medical & Biological Engineering & Computing2001，39，1： | 1 |
| 3 | Long term performance of polycaprolactone vascular grafts in a rat ab- dominal aorta replacement model 显示文摘 | DE VALENCE S TILLE JC MUGNAI D | 2012 | 巳iomaterials2012，33，1： | 1 |
| 4 | PSMB8 (LMP7) but not PSMB9 (LMP2) genc polymorphisms are associated to pigeon breeder's hypersensitivity pneumonifis 显示文摘 | Camarena A C-alvez A Valenci RF | 2010 | Respiratory Medicine2010，104，2： | 1 |
| 5 | Advantages of Bilayered Vascular Grafts for Surgical Applicability and Tissue Regeneration 显示文摘 | de Valence S Tille J C Gifiberto J P | 2012 | Acta Biomaterialia2012，8，11： | 1 |
| 6 | Long term performance of polycaprolactone vascular grafts in a ratabdominal aorta replacement model 显示文摘 | de Valence S Tille J C Mugnai D | 2012 | Biomaterials2012，33，1： | 1 |
| 7 | VRML - Enhanced Learning in Biology and Medicine显示文摘 | Tomaz Amon Vojko Valencic | 2000 | Future Generation Computer Systems2000，17，1： | 1 |
| 8 | VRML-enhanced learning in biology and medicine显示文摘 | Amon T Valencic V | 2000 | Fut Generati Comp Syst2000，17，： | 1 |
| 9 | Zyrnogram and preliminary characterization of Lactobacillus helveticus autolysins显示文摘 | Valence F Lortal S | 1995 | Applied and Environmental Microbiology1995，61，9： | 1 |
| 10 | VRML-enhanced learning in biology and medicine显示文摘 | Tomaz Amon Vojko Valencic | 2000 | Future Generation Computer Systems2000，17，1： | 1 |
| 11 | A highthroughput microfluidic assay to study neurite response to growth factor gradients显示文摘 | Kothapalli C R van Veen E de Valence S | 2011 | Lab Chip2011，11，3： | 1 |
| 12 | Compulsive buying: Concept and measurement显示文摘 | Gilles Valence Alain d’Astous Louis Fortier | 1988 | Journal of Consumer Policy1988，，4： | 1 |
| 13 | Compulsive buying: Concept and measurement显示文摘 | Gilles Valence Alain d’Astous Louis Fortier | 1988 | Journal of Consumer Policy1988，，4： | 1 |
| 14 | Selective re- sistance to different glucocorticoids in severe autoim- mune disorders显示文摘 | Drigo I Piscianz E Valencic E | 2010 | Clin Immunol2010，134，3： | 1 |
| 15 | Measuring of skeletal muscles' dynamic properties显示文摘 | Valencic V Knez N | 1997 | Artif Organs1997，21，3： | 1 |
| 16 | Influence of soap/polymer concentration ratio on the rheological properties of lithium lubricating greases modified with virgin LDPE显示文摘 | MARTIN-ALFONSO J E MORENO J VALENCI C | | 0，，05： | 1 |
| 17 | The urban emergence of a new information industry: Sydney~s multi-media firms 显示文摘 | Glen Searle Gerard de Valence | 2005 | Geographical Research2005，43，2： | 1 |
| 18 | VRML--enhanced learning in biology and medicine显示文摘 | Tomaz Amon Vojko Valencic | 2000 | Future Generation Computer Systems2000，17，1： | 1 |
| 19 | Oculocutaneous albinism types 1 and 3 are ER retention diseases:mutation of tyrosinase or Tyrp1 can affect the processing of both mutant and wildtype protein显示文摘 | Kazutomo Toyofuku IW Julio C Valenci | 2001 | FASEB J2001，15，： | 1 |
| 20 | Compul- sive Buying:Concept and Measurement显示文摘 | Valence G D'Astous A Fortier L | 1988 | Journal of Consumer Policy1988，11，4： | 1 |
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